{"id":"https://openalex.org/W4404516352","doi":"https://doi.org/10.1016/j.ijbiomac.2024.137863","title":"Extraction, purification, and mechanism of immunomodulatory peptides obtained from silkworm pupa protein hydrolysate","display_name":"Extraction, purification, and mechanism of immunomodulatory peptides obtained from silkworm pupa protein hydrolysate","publication_year":2024,"publication_date":"2024-11-19","ids":{"openalex":"https://openalex.org/W4404516352","doi":"https://doi.org/10.1016/j.ijbiomac.2024.137863","pmid":"https://pubmed.ncbi.nlm.nih.gov/39566776"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijbiomac.2024.137863","doi":"https://doi.org/10.1016/j.ijbiomac.2024.137863","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2024.137863","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101997489","display_name":"Yan Long Guo","orcid":"https://orcid.org/0000-0002-0886-6621","observed_orcids":["https://orcid.org/0000-0002-0886-6621"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]},{"id":"https://openalex.org/I4405260818","display_name":"Jinfeng Laboratory","ror":"https://ror.org/04amdcz96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405260818"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Guo","raw_affiliation_strings":["State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China","institution_ids":["https://openalex.org/I142108993","https://openalex.org/I4405260818"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Man Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260818","display_name":"Jinfeng Laboratory","ror":"https://ror.org/04amdcz96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405260818"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Man Xu","raw_affiliation_strings":["Jinfeng Laboratory, Chongqing 401329, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jinfeng Laboratory, Chongqing 401329, China","institution_ids":["https://openalex.org/I4405260818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054020363","display_name":"Xin Hu","orcid":"https://orcid.org/0000-0002-7403-8808","observed_orcids":["https://orcid.org/0000-0002-7403-8808"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]},{"id":"https://openalex.org/I4405260818","display_name":"Jinfeng Laboratory","ror":"https://ror.org/04amdcz96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405260818"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Hu","raw_affiliation_strings":["State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China","institution_ids":["https://openalex.org/I142108993","https://openalex.org/I4405260818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101006680","display_name":"Liang Cen","orcid":"https://orcid.org/0009-0002-5091-2529","observed_orcids":["https://orcid.org/0009-0002-5091-2529"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]},{"id":"https://openalex.org/I4405260818","display_name":"Jinfeng Laboratory","ror":"https://ror.org/04amdcz96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405260818"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Cen","raw_affiliation_strings":["State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China","institution_ids":["https://openalex.org/I142108993","https://openalex.org/I4405260818"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dakun Pei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]},{"id":"https://openalex.org/I4405260818","display_name":"Jinfeng Laboratory","ror":"https://ror.org/04amdcz96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405260818"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dakun Pei","raw_affiliation_strings":["State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China","institution_ids":["https://openalex.org/I142108993","https://openalex.org/I4405260818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100386780","display_name":"Dandan Zhang","orcid":"https://orcid.org/0000-0003-1869-4699","observed_orcids":["https://orcid.org/0000-0003-1869-4699"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]},{"id":"https://openalex.org/I4405260818","display_name":"Jinfeng Laboratory","ror":"https://ror.org/04amdcz96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405260818"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dandan Zhang","raw_affiliation_strings":["State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China","institution_ids":["https://openalex.org/I142108993","https://openalex.org/I4405260818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100784501","display_name":"Jie Xu","orcid":"https://orcid.org/0000-0003-4574-4698","observed_orcids":["https://orcid.org/0000-0003-4574-4698","https://orcid.org/0000-0002-2131-141X"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]},{"id":"https://openalex.org/I4405260818","display_name":"Jinfeng Laboratory","ror":"https://ror.org/04amdcz96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405260818"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Xu","raw_affiliation_strings":["State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China","institution_ids":["https://openalex.org/I142108993","https://openalex.org/I4405260818"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pengfei Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]},{"id":"https://openalex.org/I4405260818","display_name":"Jinfeng Laboratory","ror":"https://ror.org/04amdcz96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405260818"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengfei Shi","raw_affiliation_strings":["State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China","institution_ids":["https://openalex.org/I142108993","https://openalex.org/I4405260818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101808216","display_name":"Liqun Yang","orcid":"https://orcid.org/0000-0003-4357-3469","observed_orcids":["https://orcid.org/0000-0003-4357-3469"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]},{"id":"https://openalex.org/I4405260818","display_name":"Jinfeng Laboratory","ror":"https://ror.org/04amdcz96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405260818"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liqun Yang","raw_affiliation_strings":["State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China. Electronic address: cysylq@swu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China. Electronic address: cysylq@swu.edu.cn","institution_ids":["https://openalex.org/I142108993","https://openalex.org/I4405260818"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046447304","display_name":"Hongjuan Cui","orcid":"https://orcid.org/0000-0003-1178-1570","observed_orcids":["https://orcid.org/0000-0003-1178-1570","https://orcid.org/0000-0002-9069-8670"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]},{"id":"https://openalex.org/I4405260818","display_name":"Jinfeng Laboratory","ror":"https://ror.org/04amdcz96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405260818"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongjuan Cui","raw_affiliation_strings":["State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China. Electronic address: hcui@swu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing 401329, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China. Electronic address: hcui@swu.edu.cn","institution_ids":["https://openalex.org/I142108993","https://openalex.org/I4405260818"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046447304","https://openalex.org/A5101808216"],"corresponding_institution_ids":["https://openalex.org/I142108993","https://openalex.org/I4405260818"],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":2.619,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.88025146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"283","issue":"Pt 3","first_page":"137863","last_page":"137863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunomodulatory-peptides","display_name":"immunomodulatory peptides","score":0.9480000138282776},{"id":"https://openalex.org/keywords/enzymatic-hydrolysis","display_name":"enzymatic hydrolysis","score":0.75},{"id":"https://openalex.org/keywords/peptide-purification","display_name":"peptide purification","score":0.6919999718666077},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tlr4-md-2-complex","display_name":"TLR4/MD-2 complex","score":0.9909999966621399},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.859000027179718},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/functional-food-ingredients","display_name":"functional food ingredients","score":0.7049999833106995},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.593999981880188},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9670000076293945}],"concepts":[{"id":"https://openalex.org/C28800991","wikidata":"https://www.wikidata.org/wiki/Q15634405","display_name":"Hydrolysate","level":3,"score":0.9234832525253296},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.6895526647567749},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6125029921531677},{"id":"https://openalex.org/C175734852","wikidata":"https://www.wikidata.org/wiki/Q170595","display_name":"Pupa","level":3,"score":0.6113216876983643},{"id":"https://openalex.org/C8985478","wikidata":"https://www.wikidata.org/wiki/Q903485","display_name":"Protein purification","level":2,"score":0.5743297338485718},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.525281548500061},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5087302327156067},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4085336923599243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2175574004650116},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.09125766158103943},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.0884348452091217},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.04512086510658264}],"mesh":[{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011492","descriptor_name":"Protein Hydrolysates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011492","descriptor_name":"Protein Hydrolysates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011679","descriptor_name":"Pupa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012831","descriptor_name":"Bombyx","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019476","descriptor_name":"Insect Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D019476","descriptor_name":"Insect Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019476","descriptor_name":"Insect Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijbiomac.2024.137863","doi":"https://doi.org/10.1016/j.ijbiomac.2024.137863","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2024.137863","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},{"id":"pmid:39566776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39566776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological macromolecules","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1439614824","display_name":null,"funder_award_id":"SWU-XDZD22006","funder_id":"https://openalex.org/F4320323711","funder_display_name":"Southwest University"},{"id":"https://openalex.org/G2456693872","display_name":null,"funder_award_id":"CSTB2023TIAD-STX0007","funder_id":"https://openalex.org/F4320323172","funder_display_name":"Natural Science Foundation of Chongqing"},{"id":"https://openalex.org/G2585462449","display_name":null,"funder_award_id":"cstc2022ycjh-bgzxm0145","funder_id":"https://openalex.org/F4320323172","funder_display_name":"Natural Science Foundation of Chongqing"}],"funders":[{"id":"https://openalex.org/F4320323172","display_name":"Natural Science Foundation of Chongqing","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323711","display_name":"Southwest University","ror":"https://ror.org/01kj4z117"},{"id":"https://openalex.org/F4320327726","display_name":"Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1988166376","https://openalex.org/W1990981539","https://openalex.org/W2000711213","https://openalex.org/W2002976335","https://openalex.org/W2039149253","https://openalex.org/W2056651318","https://openalex.org/W2061238159","https://openalex.org/W2085633748","https://openalex.org/W2158123586","https://openalex.org/W2275572833","https://openalex.org/W2319425357","https://openalex.org/W2329654044","https://openalex.org/W2333410119","https://openalex.org/W2521275557","https://openalex.org/W2622117483","https://openalex.org/W2734382072","https://openalex.org/W2765898479","https://openalex.org/W2773269495","https://openalex.org/W2794738702","https://openalex.org/W2895780859","https://openalex.org/W2921569846","https://openalex.org/W2959363000","https://openalex.org/W3011663976","https://openalex.org/W3092182220","https://openalex.org/W3112316016","https://openalex.org/W3126629551","https://openalex.org/W3156779796","https://openalex.org/W3217545445","https://openalex.org/W4220778889","https://openalex.org/W4225932724","https://openalex.org/W4226020120","https://openalex.org/W4281669344","https://openalex.org/W4283263140","https://openalex.org/W4307273408"],"related_works":["https://openalex.org/W2921756216","https://openalex.org/W2938601845","https://openalex.org/W7124983980","https://openalex.org/W7118547517","https://openalex.org/W7155068833","https://openalex.org/W4408730474","https://openalex.org/W4392965277","https://openalex.org/W4225932724","https://openalex.org/W7196989796","https://openalex.org/W3112316016"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-11-20T00:00:00"}