{"id":"https://openalex.org/W4404472070","doi":"https://doi.org/10.31234/osf.io/u9dw5","title":"Childhood gut microbiome is linked to mental health at school age via the functional connectome","display_name":"Childhood gut microbiome is linked to mental health at school age via the functional connectome","publication_year":2024,"publication_date":"2024-11-18","ids":{"openalex":"https://openalex.org/W4404472070","doi":"https://doi.org/10.31234/osf.io/u9dw5"},"language":"en","primary_location":{"id":"doi:10.31234/osf.io/u9dw5","doi":"https://doi.org/10.31234/osf.io/u9dw5","is_oa":true,"landing_page_url":"https://doi.org/10.31234/osf.io/u9dw5","pdf_url":null,"source":null,"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.31234/osf.io/u9dw5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034178521","display_name":"Francesca Ruth Querdasi","orcid":"https://orcid.org/0000-0002-3267-0848","observed_orcids":["https://orcid.org/0000-0002-3267-0848"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesca Ruth Querdasi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3267-0848","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079770927","display_name":"Jessica Phuong Uy","orcid":"https://orcid.org/0000-0001-7316-3562","observed_orcids":["https://orcid.org/0000-0001-7316-3562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica P. Uy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7316-3562","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063830894","display_name":"Jennifer S. Labus","orcid":"https://orcid.org/0000-0002-6634-2551","observed_orcids":["https://orcid.org/0000-0002-6634-2551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer S. Labus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080697479","display_name":"Neerja Karnani","orcid":"https://orcid.org/0000-0002-5301-409X","observed_orcids":["https://orcid.org/0000-0002-5301-409X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neerja Karnani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003963269","display_name":"Ai Peng Tan","orcid":"https://orcid.org/0000-0001-7660-6322","observed_orcids":["https://orcid.org/0000-0001-7660-6322"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ai Peng Tan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101428997","display_name":"Birit F.P. Broekman","orcid":"https://orcid.org/0000-0002-4378-4103","observed_orcids":["https://orcid.org/0000-0002-4378-4103"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Birit Broekman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111176316","display_name":"Peter D. Gluckman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Gluckman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011331709","display_name":"Yap Seng Chong","orcid":"https://orcid.org/0000-0002-7232-8473","observed_orcids":["https://orcid.org/0000-0002-7232-8473"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yap Seng Chong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032326517","display_name":"Helen Y. Chen","orcid":"https://orcid.org/0000-0003-2923-943X","observed_orcids":["https://orcid.org/0000-0003-2923-943X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090150991","display_name":"Marielle Valerie Fortier","orcid":"https://orcid.org/0000-0002-3294-1054","observed_orcids":["https://orcid.org/0000-0002-3294-1054"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marielle V. Fortier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052774074","display_name":"Mary Daniel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary Daniel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074315202","display_name":"Fabian K. P. Yap","orcid":"https://orcid.org/0000-0003-1083-7958","observed_orcids":["https://orcid.org/0000-0003-1083-7958"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabian Yap","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011338575","display_name":"Johan Gunnar Eriksson","orcid":"https://orcid.org/0000-0002-2516-2060","observed_orcids":["https://orcid.org/0000-0002-2516-2060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johan G. Eriksson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Shirong Cai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shirong Cai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018515534","display_name":"Mary Chong Foong Fong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary Chong Foong Fong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039874371","display_name":"Jia Ying Toh","orcid":"https://orcid.org/0000-0001-7734-7465","observed_orcids":["https://orcid.org/0000-0001-7734-7465"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia Ying Toh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031184713","display_name":"Keith M. Godfrey","orcid":"https://orcid.org/0000-0002-4643-0618","observed_orcids":["https://orcid.org/0000-0002-4643-0618"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith Godfrey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4643-0618","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034400760","display_name":"Michael Joseph Meaney","orcid":"https://orcid.org/0000-0002-8605-1997","observed_orcids":["https://orcid.org/0000-0002-8605-1997"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J Meaney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022834577","display_name":"Bridget L. Callaghan","orcid":"https://orcid.org/0000-0001-5736-2510","observed_orcids":["https://orcid.org/0000-0001-5736-2510"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bridget Callaghan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5736-2510","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9369999766349792},{"id":"https://openalex.org/keywords/microbiome-gut-brain-axis","display_name":"microbiome-gut-brain axis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/child-mental-health","display_name":"child mental health","score":0.8379999995231628},{"id":"https://openalex.org/keywords/internalizing-problems","display_name":"internalizing problems","score":0.9769999980926514},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.8949999809265137},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9959999918937683},{"id":"https://openalex.org/keywords/functional-connectome","display_name":"functional connectome","score":0.9020000100135803},{"id":"https://openalex.org/keywords/sparse-partial-least-squares-regression","display_name":"sparse partial least squares regression","score":0.871999979019165},{"id":"https://openalex.org/keywords/clostridiales","display_name":"Clostridiales","score":0.9129999876022339},{"id":"https://openalex.org/keywords/lachnospiraceae","display_name":"Lachnospiraceae","score":1.0},{"id":"https://openalex.org/keywords/alpha-diversity","display_name":"alpha diversity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/middle-childhood","display_name":"middle childhood","score":0.5580000281333923},{"id":"https://openalex.org/keywords/brain-signatures","display_name":"brain signatures","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.9036989212036133},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.7055261135101318},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.6708930134773254},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.58521968126297},{"id":"https://openalex.org/C134362201","wikidata":"https://www.wikidata.org/wiki/Q317309","display_name":"Mental health","level":2,"score":0.5668801665306091},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.49443626403808594},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3920694887638092},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.38997456431388855},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3751811981201172},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3297775685787201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3227996826171875},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.18124693632125854}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.31234/osf.io/u9dw5","doi":"https://doi.org/10.31234/osf.io/u9dw5","is_oa":true,"landing_page_url":"https://doi.org/10.31234/osf.io/u9dw5","pdf_url":null,"source":null,"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:share.osf.io:caed629c-7f40-4773-a6c6-5a4944e3bc5b","doi":null,"is_oa":true,"landing_page_url":"https://osf.io/u9dw5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401687","display_name":"PsyArXiv (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.31234/osf.io/u9dw5","doi":"https://doi.org/10.31234/osf.io/u9dw5","is_oa":true,"landing_page_url":"https://doi.org/10.31234/osf.io/u9dw5","pdf_url":null,"source":null,"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4415692504","https://openalex.org/W4392285480","https://openalex.org/W7111864506","https://openalex.org/W4311770297","https://openalex.org/W1968087230","https://openalex.org/W4313200609","https://openalex.org/W2977548244","https://openalex.org/W3217395463","https://openalex.org/W4402644434","https://openalex.org/W3199457729"],"abstract_inverted_index":{"The":[0],"brain":[1,22,54,110,147,169,196],"and":[2,37,44,53,60,67,125,179],"the":[3,13,19,51,96,168,176],"gut":[4,52],"microbiome":[5,20,32,154],"play":[6],"critical":[7],"roles":[8],"in":[9,49,94,175,187,192],"mental":[10,39],"health":[11,40],"through":[12,190],"microbiome-gut-brain-axis":[14],"(MGBA).":[15],"However,":[16],"research":[17],"linking":[18],"to":[21,57,105],"function":[23],"is":[24,34],"limited,":[25],"particularly":[26],"during":[27],"child":[28],"development,":[29],"when":[30],"tremendous":[31],"plasticity":[33],"taking":[35],"place":[36],"many":[38],"issues,":[41],"like":[42],"depression":[43],"anxiety,":[45],"initially":[46],"manifest.Challenges":[47],"arise":[48],"studying":[50],"together":[55],"due":[56],"their":[58],"complex":[59],"multidimensional":[61],"nature,":[62],"which":[63],"complicates":[64],"feature":[65],"selection":[66],"data":[68],"analysis.":[69],"Multivariate":[70],"machine":[71],"learning":[72],"techniques,":[73],"such":[74],"as":[75],"sparse":[76],"partial":[77],"least":[78],"squares":[79],"(sPLS)":[80],"regression,":[81],"offer":[82],"potential":[83],"solutions":[84],"by":[85],"identifying":[86,133],"combinations":[87,108],"of":[88,109],"variables":[89],"that":[90,118,142,173],"best":[91],"explain":[92],"variance":[93],"outcomes.In":[95],"current":[97],"study":[98],"(N":[99],"=":[100],"55),":[101],"we":[102,150],"used":[103],"sPLS":[104],"identify":[106],"linear":[107],"networks":[111],"(\u201cbrain":[112],"signatures\u201d)":[113],"at":[114,128,138],"age":[115,129,139],"6":[116],"years":[117,141],"maximally":[119,143],"covaried":[120,144],"with":[121,145,164,184],"internalizing":[122,165,185],"symptoms":[123,166,186],"(anxiety":[124],"depression)":[126],"measured":[127],"7.5":[130],"years,":[131],"before":[132],"microbe":[134],"abundances":[135],"(\u201cmicrobial":[136],"profiles\u201d)":[137],"2":[140],"those":[146],"signatures.":[148,170],"Finally,":[149],"tested":[151],"whether":[152],"any":[153],"features":[155],"(microbial":[156],"profiles":[157],"or":[158],"alpha":[159],"diversity)":[160],"were":[161,182],"indirectly":[162],"associated":[163,183],"via":[167],"We":[171],"found":[172],"microbes":[174],"Clostridiales":[177],"order":[178],"Lachnospiraceae":[180],"family":[181],"middle":[188],"childhood":[189],"alterations":[191],"connectivity":[193],"within":[194],"emotion-related":[195],"networks.":[197]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2024-11-19T00:00:00"}