{"id":"https://openalex.org/W4404451147","doi":"https://doi.org/10.1158/1538-7445.tumbody-c050","title":"Abstract C050: Leveraging ECM deposition by CAF-like Ewing sarcoma tumor cells to target micrometastases with matrix-binding VHHs","display_name":"Abstract C050: Leveraging ECM deposition by CAF-like Ewing sarcoma tumor cells to target micrometastases with matrix-binding VHHs","publication_year":2024,"publication_date":"2024-11-17","ids":{"openalex":"https://openalex.org/W4404451147","doi":"https://doi.org/10.1158/1538-7445.tumbody-c050"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.tumbody-c050","doi":"https://doi.org/10.1158/1538-7445.tumbody-c050","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.tumbody-c050","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012937907","display_name":"Emma D. Wrenn","orcid":"https://orcid.org/0000-0002-9643-457X","observed_orcids":["https://orcid.org/0000-0002-9643-457X"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma D. Wrenn","raw_affiliation_strings":["1Seattle Children's Research Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Seattle Children's Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109515116","display_name":"Jason P. Price","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason P. Price","raw_affiliation_strings":["1Seattle Children's Research Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Seattle Children's Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039168668","display_name":"Raymond O. Ruff","orcid":"https://orcid.org/0000-0002-7189-1221","observed_orcids":["https://orcid.org/0000-0002-7189-1221"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond O. Ruff","raw_affiliation_strings":["1Seattle Children's Research Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Seattle Children's Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nicolas M. Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas M. Garcia","raw_affiliation_strings":["1Seattle Children's Research Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Seattle Children's Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059868777","display_name":"James M. Olson","orcid":"https://orcid.org/0000-0001-5990-6534","observed_orcids":["https://orcid.org/0000-0001-5990-6534"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Olson","raw_affiliation_strings":["1Seattle Children's Research Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Seattle Children's Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024605312","display_name":"Elizabeth R. Lawlor","orcid":"https://orcid.org/0000-0002-2350-1540","observed_orcids":["https://orcid.org/0000-0002-2350-1540"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth R. Lawlor","raw_affiliation_strings":["1Seattle Children's Research Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Seattle Children's Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4405262941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405262941"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"22_Supplement","first_page":"C050","last_page":"C050"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.08739999681711197,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tenascin-c","display_name":"tenascin-C","score":0.9470000267028809},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.843999981880188},{"id":"https://openalex.org/keywords/vhh-single-domain-antibodies","display_name":"VHH single-domain antibodies","score":0.6940000057220459},{"id":"https://openalex.org/keywords/micrometastasis","display_name":"micrometastases","score":0.9259999990463257},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8659999966621399},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.847000002861023},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.6190000176429749},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.6060000061988831},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.5720000267028809},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6347958445549011},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.4928317368030548},{"id":"https://openalex.org/C64297162","wikidata":"https://www.wikidata.org/wiki/Q1987070","display_name":"Deposition (geology)","level":3,"score":0.4360066056251526},{"id":"https://openalex.org/C2777586341","wikidata":"https://www.wikidata.org/wiki/Q1138580","display_name":"Ewing's sarcoma","level":3,"score":0.43237677216529846},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3888981342315674},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3605627119541168},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3308194875717163},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25215452909469604},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2816523","wikidata":"https://www.wikidata.org/wiki/Q180184","display_name":"Sediment","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.tumbody-c050","doi":"https://doi.org/10.1158/1538-7445.tumbody-c050","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.tumbody-c050","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.699999988079071,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2182789434","https://openalex.org/W2078405839","https://openalex.org/W2347767060","https://openalex.org/W4379537877","https://openalex.org/W2040042473","https://openalex.org/W2414589069","https://openalex.org/W4223579060","https://openalex.org/W4377157499","https://openalex.org/W2163925767","https://openalex.org/W2129907328"],"abstract_inverted_index":{"Abstract":[0],"Ewing":[1,451],"sarcoma":[2,452],"(EwS)":[3],"is":[4,80,113,126,138],"an":[5],"aggressive":[6],"bone":[7],"and":[8,12,63,71,85,88,108,122,133,155,192,223,243,262,275,288,297,311,344,364,370,380,421,478],"soft":[9],"tissue":[10,224],"tumor":[11,57,67,99,107,172,232,298,453],"EwS":[13,83,171,231,260,332,346,386,398,424],"patients":[14],"often":[15],"succumb":[16],"to":[17,25,66,106,177,180,272,278,284,341,376,403,409,455],"their":[18,270],"disease":[19,41,420],"years":[20],"after":[21],"initial":[22],"treatment":[23,156],"due":[24],"relapses":[26],"at":[27,45],"metastatic":[28,142,153,423],"sites.":[29],"Novel":[30],"therapeutic":[31],"strategies":[32],"are":[33,93,102,212,374],"needed":[34],"that":[35,43,75,86,101,327,392],"can":[36,400],"successfully":[37],"eliminate":[38],"microscopic":[39,418],"residual":[40,183,419],"foci":[42,173],"persist":[44],"the":[46,56,76,159,166,362,393,465],"end":[47],"of":[48,97,120,131,152,169,182,339,382,396,464,476],"primary":[49],"therapy.":[50],"Extracellular":[51],"matrix":[52],"(ECM)":[53],"proteins":[54,92],"in":[55,82,104,141,234,249,255,301,317,348,357,367,385,469,480],"microenvironment":[58],"(TME)":[59],"provide":[60],"critical":[61],"pro-survival":[62],"pro-invasion":[64],"signals":[65],"cells.":[68,333],"Our":[69],"published":[70,209],"unpublished":[72],"data":[73],"show":[74],"glycoprotein":[77],"tenascin-C":[78],"(TNC)":[79],"enriched":[81,140],"metastases":[84],"TNC":[87,112,137,195],"other":[89],"pro-tumorigenic":[90],"ECM":[91,241,447],"deposited":[94],"by":[95,116,307,449],"subpopulations":[96],"CAF-like":[98,397,450],"cells":[100,399,454],"activated":[103],"response":[105],"TME-derived":[109],"TGF-beta":[110],"ligands.":[111],"abundantly":[114],"produced":[115],"multiple":[117,246],"human":[118],"tumors":[119],"epithelial":[121],"non-epithelial":[123],"lineage":[124],"but":[125,257],"otherwise":[127],"rarely":[128],"expressed":[129],"outside":[130],"development":[132],"wound":[134],"healing.":[135],"Importantly,":[136],"specifically":[139],"lesions":[143],"where":[144],"it":[145],"has":[146],"been":[147,329],"implicated":[148],"as":[149,305],"a":[150,199],"mediator":[151],"competence":[154],"resistance.":[157],"In":[158],"current":[160],"work":[161],"we":[162,189,281],"have":[163],"tested":[164],"whether":[165],"TNC-rich":[167,279],"TME":[168],"disseminated":[170],"could":[174,416],"be":[175,401],"leveraged":[176],"direct":[178],"therapies":[179,277],"sites":[181],"micrometastatic":[184],"disease.":[185],"To":[186,268,315],"achieve":[187],"this,":[188],"generated":[190],"monovalent":[191],"bivalent":[193],"anti-human":[194],"VHHs":[196,211,353,460],"(hTNC-VHH)":[197],"using":[198],"mammalian":[200],"expression":[201],"platform.":[202],"Camelid-derived":[203],"hTNC-VHH":[204,238,253,283,321,340,383],"sequences":[205],"were":[206,263,322,354],"sourced":[207],"from":[208],"literature.":[210],"single":[213],"domain":[214],"heavy":[215],"chain":[216],"only":[217],"antibody":[218],"fragments":[219],"with":[220,331,458],"higher":[221],"stability":[222],"penetration":[225],"than":[226,350],"conventional":[227],"monoclonal":[228],"antibodies.":[229],"Using":[230],"spheroids":[233,261],"collagen-rich":[235],"3D":[236],"culture,":[237],"penetrated":[239],"dense":[240],"matrices":[242],"bound":[244],"through":[245],"cell":[247,295,299],"layers":[248],"under":[250],"10":[251],"minutes.":[252],"accumulated":[254],"TNC-positive":[256],"not":[258,355],"TNC-knockout":[259],"retained":[264,356],"beyond":[265],"96":[266],"hours.":[267,352],"assess":[269,316,377],"potential":[271],"drive":[273],"protein":[274,407],"immune":[276,285,294],"TMEs,":[280],"fused":[282],"modulating":[286],"CD3-":[287],"CD28-activating":[289],"VHHs.":[290],"These":[291],"hTNC-VHH-CD3/CD28-conjugates":[292],"promoted":[293],"activation":[296],"death":[300],"PBMC-tumor":[302],"co-culture":[303],"assays":[304],"determined":[306],"CD25":[308],"flow":[309],"cytometry":[310],"fluorescence":[312],"microscopy,":[313],"respectively.":[314],"vivo":[318],"localization,":[319],"fluorescently-tagged":[320],"intravenously":[323],"injected":[324],"into":[325],"mice":[326],"had":[328],"xenografted":[330],"Tissue":[334],"microscopy":[335],"confirmed":[336],"selective":[337],"binding":[338],"small":[342],"lung":[343,369],"liver":[345,371],"micrometastases":[347,457],"less":[349],"4":[351],"non-tumor":[358],"bearing":[359],"organs":[360],"including":[361],"brain":[363],"heart":[365],"or":[366],"tumor-free":[368],"regions.":[372],"Experiments":[373],"ongoing":[375],"anti-tumor":[378],"efficacy":[379],"pharmacodynamics":[381],"conjugates":[384],"xenografts.":[387],"Together":[388],"these":[389],"findings":[390],"suggest":[391],"ECM-remodeling":[394],"properties":[395],"exploited":[402],"recruit":[404],"novel":[405],"ECM-targeting":[406],"therapeutics":[408],"micrometastases.":[410],"If":[411],"successful,":[412],"this":[413],"innovative":[414],"approach":[415],"eradicate":[417],"prevent":[422],"recurrence.":[425],"Citation":[426],"Format:":[427],"Emma":[428],"D.":[429],"Wrenn,":[430],"Jason":[431],"P.":[432],"Price,":[433],"Raymond":[434],"O.":[435],"Ruff,":[436],"Nicolas":[437],"M.":[438,441],"Garcia,":[439],"James":[440],"Olson,":[442],"Elizabeth":[443],"R.":[444],"Lawlor.":[445],"Leveraging":[446],"deposition":[448],"target":[456],"matrix-binding":[459],"[abstract].":[461],"In:":[462],"Proceedings":[463],"AACR":[466],"Special":[467],"Conference":[468],"Cancer":[470,490],"Research:":[471],"Tumor-body":[472],"Interactions:":[473],"The":[474],"Roles":[475],"Micro-":[477],"Macroenvironment":[479],"Cancer;":[481],"2024":[482],"Nov":[483],"17-20;":[484],"Boston,":[485],"MA.":[486],"Philadelphia":[487],"(PA):":[488],"AACR;":[489],"Res":[491],"2024;84(22_Suppl):Abstract":[492],"nr":[493],"C050.":[494]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
