{"id":"https://openalex.org/W4404449092","doi":"https://doi.org/10.1016/j.jgeb.2024.100439","title":"Exploring advanced genomic and immunoinformatics techniques for identifying drug and vaccine targets against SARS-CoV-2","display_name":"Exploring advanced genomic and immunoinformatics techniques for identifying drug and vaccine targets against SARS-CoV-2","publication_year":2024,"publication_date":"2024-11-16","ids":{"openalex":"https://openalex.org/W4404449092","doi":"https://doi.org/10.1016/j.jgeb.2024.100439","pmid":"https://pubmed.ncbi.nlm.nih.gov/39674651","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11615475"},"language":"en","primary_location":{"id":"doi:10.1016/j.jgeb.2024.100439","doi":"https://doi.org/10.1016/j.jgeb.2024.100439","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jgeb.2024.100439","pdf_url":null,"source":{"id":"https://openalex.org/S2764867799","display_name":"Journal of Genetic Engineering and Biotechnology","issn_l":"1687-157X","issn":["1687-157X","2090-5920"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Genetic Engineering and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jgeb.2024.100439","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101854396","display_name":"Syed Luqman Ali","orcid":"https://orcid.org/0000-0002-0298-1848","observed_orcids":["https://orcid.org/0000-0002-0298-1848"]},"institutions":[{"id":"https://openalex.org/I181063083","display_name":"Abdul Wali Khan University Mardan","ror":"https://ror.org/03b9y4e65","country_code":"PK","type":"education","lineage":["https://openalex.org/I181063083"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Syed Luqman Ali","raw_affiliation_strings":["Department of Biochemistry, Abdul Wali Khan University Mardan (AWKUM), Mardan 23200, Paksitan. Electronic address: syedluqmanali5@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Abdul Wali Khan University Mardan (AWKUM), Mardan 23200, Paksitan. Electronic address: syedluqmanali5@gmail.com","institution_ids":["https://openalex.org/I181063083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091776365","display_name":"Awais Ali","orcid":"https://orcid.org/0000-0002-4514-9509","observed_orcids":["https://orcid.org/0000-0002-4514-9509"]},"institutions":[{"id":"https://openalex.org/I181063083","display_name":"Abdul Wali Khan University Mardan","ror":"https://ror.org/03b9y4e65","country_code":"PK","type":"education","lineage":["https://openalex.org/I181063083"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Awais Ali","raw_affiliation_strings":["Department of Biochemistry, Abdul Wali Khan University Mardan (AWKUM), Mardan 23200, Paksitan. Electronic address: awaisali@awkum.edu.pk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Abdul Wali Khan University Mardan (AWKUM), Mardan 23200, Paksitan. Electronic address: awaisali@awkum.edu.pk","institution_ids":["https://openalex.org/I181063083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111340604","display_name":"Waseef Ullah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181063083","display_name":"Abdul Wali Khan University Mardan","ror":"https://ror.org/03b9y4e65","country_code":"PK","type":"education","lineage":["https://openalex.org/I181063083"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Waseef Ullah","raw_affiliation_strings":["Department of Biochemistry, Abdul Wali Khan University Mardan (AWKUM), Mardan 23200, Paksitan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Abdul Wali Khan University Mardan (AWKUM), Mardan 23200, Paksitan","institution_ids":["https://openalex.org/I181063083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085232741","display_name":"Abdulaziz Mohammed Alamri","orcid":"https://orcid.org/0009-0002-3942-5455","observed_orcids":["https://orcid.org/0009-0002-3942-5455"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Abdulaziz Alamri","raw_affiliation_strings":["Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: abalamri@ksu.edu.sa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: abalamri@ksu.edu.sa","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065933412","display_name":"Elham Mohammed Khatrawi","orcid":"https://orcid.org/0000-0003-1340-4437","observed_orcids":["https://orcid.org/0000-0003-1340-4437"]},"institutions":[{"id":"https://openalex.org/I23075662","display_name":"Taibah University","ror":"https://ror.org/01xv1nn60","country_code":"SA","type":"education","lineage":["https://openalex.org/I23075662"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Elham Mohammed Khatrawi","raw_affiliation_strings":["Department of Medical Microbiology and Immunology, Taibah University, College of Medicine, Madinah 42353, Saudi Arabia. Electronic address: ekhatrawi@taibahu.edu.sa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, Taibah University, College of Medicine, Madinah 42353, Saudi Arabia. Electronic address: ekhatrawi@taibahu.edu.sa","institution_ids":["https://openalex.org/I23075662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030176851","display_name":"Gulzira Sagimova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141757","display_name":"Astana Medical University","ror":"https://ror.org/038mavt60","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210141757"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"Gulzira Sagimova","raw_affiliation_strings":["Department of Human Anatomy, Astana Medical University, Astana 010000, Kazakhstan. Electronic address: sagimova.g@amu.kz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Astana Medical University, Astana 010000, Kazakhstan. Electronic address: sagimova.g@amu.kz","institution_ids":["https://openalex.org/I4210141757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020042329","display_name":"Aigul Almabayeva","orcid":"https://orcid.org/0000-0002-5633-2245","observed_orcids":["https://orcid.org/0000-0002-5633-2245"]},"institutions":[{"id":"https://openalex.org/I4210141757","display_name":"Astana Medical University","ror":"https://ror.org/038mavt60","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210141757"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"Aigul Almabayeva","raw_affiliation_strings":["Department of Human Anatomy, Astana Medical University, Astana 010000, Kazakhstan. Electronic address: almabaeva.a@amu.kz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Astana Medical University, Astana 010000, Kazakhstan. Electronic address: almabaeva.a@amu.kz","institution_ids":["https://openalex.org/I4210141757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001449944","display_name":"Farida S. Rakhimzhanova","orcid":"https://orcid.org/0000-0003-1711-2167","observed_orcids":["https://orcid.org/0000-0003-1711-2167"]},"institutions":[{"id":"https://openalex.org/I4210135680","display_name":"Semey Medical University","ror":"https://ror.org/03kg5qh91","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210135680"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"Farida Rakhimzhanova","raw_affiliation_strings":["Department of Microbiology, Semey Medical University, Semey, Kazakhstan. Electronic address: farida.rakhimzhanova@smu.edu.kz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Semey Medical University, Semey, Kazakhstan. Electronic address: farida.rakhimzhanova@smu.edu.kz","institution_ids":["https://openalex.org/I4210135680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097481201","display_name":"Gulsum Askarova","orcid":"https://orcid.org/0000-0001-5019-8957","observed_orcids":["https://orcid.org/0000-0001-5019-8957"]},"institutions":[{"id":"https://openalex.org/I185571130","display_name":"Al-Farabi Kazakh National University","ror":"https://ror.org/03q0vrn42","country_code":"KZ","type":"education","lineage":["https://openalex.org/I185571130"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"Gulsum Askarova","raw_affiliation_strings":["Department of Clinical Disciplines, Al Farabi Kazakh National University, Almaty 050000, Kazakhstan. Electronic address: gkaskarova@mail.ru"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Disciplines, Al Farabi Kazakh National University, Almaty 050000, Kazakhstan. Electronic address: gkaskarova@mail.ru","institution_ids":["https://openalex.org/I185571130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054032185","display_name":"\u0424\u0430\u0442\u0438\u043c\u0430 \u041c\u0430\u0448\u0438\u043c\u043e\u0432\u043d\u0430 \u0421\u0443\u043b\u0435\u0439\u043c\u0435\u043d\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-9075-1876","observed_orcids":["https://orcid.org/0000-0001-9075-1876"]},"institutions":[{"id":"https://openalex.org/I4210141757","display_name":"Astana Medical University","ror":"https://ror.org/038mavt60","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210141757"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"Fatima Suleimenova","raw_affiliation_strings":["Department of Human Anatomy, Astana Medical University, Astana 010000, Kazakhstan. Electronic address: suleymenova.f@amu.kz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Astana Medical University, Astana 010000, Kazakhstan. Electronic address: suleymenova.f@amu.kz","institution_ids":["https://openalex.org/I4210141757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099075629","display_name":"Nabras Al-Mahrami","orcid":"https://orcid.org/0009-0003-0328-2883","observed_orcids":["https://orcid.org/0009-0003-0328-2883"]},"institutions":[{"id":"https://openalex.org/I4210130707","display_name":"Ministry of Health","ror":"https://ror.org/0362za439","country_code":"OM","type":"government","lineage":["https://openalex.org/I4210130707"]},{"id":"https://openalex.org/I4210133575","display_name":"Royal Hospital","ror":"https://ror.org/03cht9689","country_code":"OM","type":"healthcare","lineage":["https://openalex.org/I4210130707","https://openalex.org/I4210133575"]}],"countries":["OM"],"is_corresponding":false,"raw_author_name":"Nabras Al-Mahrami","raw_affiliation_strings":["Bioinformatician, National Genetic Center, Royal Hospital, Ministry of Health, Muscat, Oman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatician, National Genetic Center, Royal Hospital, Ministry of Health, Muscat, Oman","institution_ids":["https://openalex.org/I4210130707","https://openalex.org/I4210133575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084218949","display_name":"Prasanta Kumar Parida","orcid":"https://orcid.org/0000-0001-9699-8319","observed_orcids":["https://orcid.org/0000-0001-9699-8319"]},"institutions":[{"id":"https://openalex.org/I67357951","display_name":"KIIT University","ror":"https://ror.org/00k8zt527","country_code":"IN","type":"education","lineage":["https://openalex.org/I67357951"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prasanta Kumar Parida","raw_affiliation_strings":["Department of KIIT School of Rural Management, KIIT University, Bhubaneswar 751024, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of KIIT School of Rural Management, KIIT University, Bhubaneswar 751024, India","institution_ids":["https://openalex.org/I67357951"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5085232741","https://openalex.org/A5091776365","https://openalex.org/A5101854396"],"corresponding_institution_ids":["https://openalex.org/I181063083","https://openalex.org/I28022161"],"apc_list":{"value":1000,"currency":"USD","value_usd":1000},"apc_paid":{"value":1000,"currency":"USD","value_usd":1000},"fwci":2.0017,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.87378793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"22","issue":"4","first_page":"100439","last_page":"100439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":1.0},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.8159999847412109},{"id":"https://openalex.org/keywords/vaccine-design","display_name":"vaccine design","score":0.9079999923706055},{"id":"https://openalex.org/keywords/reverse-vaccinology","display_name":"reverse vaccinology","score":0.9350000023841858},{"id":"https://openalex.org/keywords/multiepitope-vaccine","display_name":"multi-epitope vaccine","score":0.9390000104904175},{"id":"https://openalex.org/keywords/b-cell-epitopes","display_name":"B-cell epitopes","score":0.878000020980835},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/surface-proteins","display_name":"surface proteins","score":0.675000011920929},{"id":"https://openalex.org/keywords/cytosolic-proteins","display_name":"cytosolic proteins","score":0.9380000233650208},{"id":"https://openalex.org/keywords/metabolic-pathways","display_name":"metabolic pathways","score":0.6869999766349792},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.843999981880188},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6940000057220459},{"id":"https://openalex.org/keywords/immune-simulation","display_name":"immune simulation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.8420000076293945},{"id":"https://openalex.org/keywords/doxycycline","display_name":"doxycycline","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.609790563583374},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5715281963348389},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5278047323226929},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.514859139919281},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.504400372505188},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5029518008232117},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.4767262041568756},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.4481389820575714},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30491355061531067},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20109689235687256},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.11915203928947449},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.06777533888816833},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06712168455123901},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jgeb.2024.100439","doi":"https://doi.org/10.1016/j.jgeb.2024.100439","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jgeb.2024.100439","pdf_url":null,"source":{"id":"https://openalex.org/S2764867799","display_name":"Journal of Genetic Engineering and Biotechnology","issn_l":"1687-157X","issn":["1687-157X","2090-5920"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Genetic Engineering and Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11615475","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11615475","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11615475/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Genet Eng Biotechnol","raw_type":"Text"},{"id":"pmid:39674651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39674651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal, genetic engineering & biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8df15db546ef4346837f461d0f9092e7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8df15db546ef4346837f461d0f9092e7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Genetic Engineering and Biotechnology, Vol 22, Iss 4, Pp 100439- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jgeb.2024.100439","doi":"https://doi.org/10.1016/j.jgeb.2024.100439","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jgeb.2024.100439","pdf_url":null,"source":{"id":"https://openalex.org/S2764867799","display_name":"Journal of Genetic Engineering and Biotechnology","issn_l":"1687-157X","issn":["1687-157X","2090-5920"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Genetic Engineering and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3409584486","display_name":null,"funder_award_id":"RSPD2024R552","funder_id":"https://openalex.org/F4320321145","funder_display_name":"King Saud University"},{"id":"https://openalex.org/G8537788683","display_name":null,"funder_award_id":"RSPD2023R552","funder_id":"https://openalex.org/F4320321145","funder_display_name":"King Saud University"}],"funders":[{"id":"https://openalex.org/F4320321145","display_name":"King Saud University","ror":"https://ror.org/02f81g417"},{"id":"https://openalex.org/F4320322802","display_name":"Abdul Wali Khan University Mardan","ror":"https://ror.org/03b9y4e65"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404449092.pdf","grobid_xml":"https://content.openalex.org/works/W4404449092.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W16356324","https://openalex.org/W97672621","https://openalex.org/W301739539","https://openalex.org/W1957438118","https://openalex.org/W1995310343","https://openalex.org/W2001330064","https://openalex.org/W2003805630","https://openalex.org/W2011006965","https://openalex.org/W2025190578","https://openalex.org/W2025980739","https://openalex.org/W2030675030","https://openalex.org/W2036807187","https://openalex.org/W2038504235","https://openalex.org/W2055869272","https://openalex.org/W2062287458","https://openalex.org/W2075527971","https://openalex.org/W2083564022","https://openalex.org/W2086364561","https://openalex.org/W2102367710","https://openalex.org/W2107247090","https://openalex.org/W2110120447","https://openalex.org/W2130833873","https://openalex.org/W2142529984","https://openalex.org/W2154241726","https://openalex.org/W2155023096","https://openalex.org/W2161257366","https://openalex.org/W2162792752","https://openalex.org/W2166550586","https://openalex.org/W2168036974","https://openalex.org/W2170747616","https://openalex.org/W2176718959","https://openalex.org/W2179438025","https://openalex.org/W2193456973","https://openalex.org/W2340217599","https://openalex.org/W2444393251","https://openalex.org/W2615136515","https://openalex.org/W2767331836","https://openalex.org/W2767891136","https://openalex.org/W2883137045","https://openalex.org/W2898389621","https://openalex.org/W2900569176","https://openalex.org/W2945172910","https://openalex.org/W2971886252","https://openalex.org/W2972046964","https://openalex.org/W3012310845","https://openalex.org/W3013232761","https://openalex.org/W3013800395","https://openalex.org/W3092750669","https://openalex.org/W3112990668","https://openalex.org/W3168943842","https://openalex.org/W3188197748","https://openalex.org/W3204529400","https://openalex.org/W3211795435","https://openalex.org/W4200166435","https://openalex.org/W4294216483","https://openalex.org/W4296242361","https://openalex.org/W4381158474","https://openalex.org/W4382064797","https://openalex.org/W4386836766","https://openalex.org/W4388701258","https://openalex.org/W4391817699","https://openalex.org/W4400864148","https://openalex.org/W4401671077","https://openalex.org/W4402833073","https://openalex.org/W4404003280","https://openalex.org/W4404205605","https://openalex.org/W6687125952","https://openalex.org/W6742068889","https://openalex.org/W6774954352","https://openalex.org/W6790889656","https://openalex.org/W6873847923"],"related_works":["https://openalex.org/W3153258864","https://openalex.org/W3138006395","https://openalex.org/W4280624612","https://openalex.org/W3113090860","https://openalex.org/W4289529257","https://openalex.org/W3035209939","https://openalex.org/W4285590574","https://openalex.org/W3199856422","https://openalex.org/W3119596459","https://openalex.org/W3131569516"],"abstract_inverted_index":{"The":[0,188],"coronavirus":[1,12],"that":[2,43,193,290],"causes":[3],"serious":[4],"acute":[5,9],"respiratory":[6,10],"syndrome.":[7],"Severe":[8],"syndrome":[11],"2":[13],"(SARS-CoV-2)":[14],"is":[15,28,35,51,60,181,295],"still":[16,36],"a":[17,154,184,279,286],"major":[18],"problem":[19],"in":[20,183,281],"public":[21],"health":[22],"and":[23,39,76,115,133,137,143,152,208,219,227,250,288],"biomedicine.":[24],"Even":[25],"if":[26],"there":[27],"no":[29],"cure":[30],"for":[31,102,124,176],"it,":[32],"the":[33,40,53,56,66,70,77,90,160,165,194,245,263,282],"infection":[34],"progressing":[37],"naturally,":[38],"only":[41],"time":[42],"optimal":[44],"treatment":[45],"choices,":[46],"such":[47],"as":[48,171,200,214],"doxycycline,":[49],"work":[50],"at":[52,84],"beginning":[54],"of":[55,72,135,179,269],"infection.":[57],"Our":[58],"project":[59],"structured":[61],"into":[62],"two":[63],"critical":[64,173],"parts:":[65],"first":[67],"focuses":[68],"on":[69,79,107,241],"identification":[71,134],"potential":[73,103,172],"drug":[74,104],"targets,":[75],"second":[78],"vaccine":[80,201,212,246,287],"design,":[81],"both":[82],"aimed":[83],"exploring":[85],"new":[86],"ways":[87],"to":[88,150,168,284,297],"treat":[89],"disease.":[91],"Initially,":[92],"cytoplasmic":[93],"proteins":[94,120,170,196],"identified":[95],"through":[96],"subtractive":[97],"analysis":[98,191],"underwent":[99,121],"comprehensive":[100],"evaluation":[101],"targeting,":[105],"focusing":[106],"metabolic":[108,186],"pathways,":[109],"homology":[110],"prediction,":[111],"drugability":[112],"assessment,":[113],"essentiality,":[114],"protein-protein":[116],"interactions.":[117],"Subsequently,":[118],"surface":[119],"rigorous":[122],"assessment":[123],"allergenicity,":[125],"antigenicity,":[126],"physiochemical":[127],"attributes,":[128],"conserved":[129],"regions,":[130],"protein":[131],"interactions,":[132],"B":[136,229],"T":[138],"cell":[139,230],"epitopes.":[140],"Molecular":[141],"docking":[142],"immunological":[144],"simulation":[145,243],"analyses":[146],"were":[147,234],"then":[148],"employed":[149],"develop":[151,285],"characterize":[153],"multi-epitope":[155,211],"vaccine,":[156],"integrating":[157],"findings":[158],"from":[159,164,236,274],"aforementioned":[161],"evaluations.":[162],"Findings":[163,273],"study":[166,276],"point":[167],"six":[169],"therapeutic":[174],"targets":[175],"SARS-CoV-2,":[177],"each":[178],"which":[180,233,270],"involved":[182],"distinct":[185],"process.":[187],"reverse":[189],"vaccinology":[190],"suggested":[192],"following":[195],"could":[197,277],"be":[198,278],"used":[199],"candidates:":[202],"sp|P05106,":[203],"sp|O00187,":[204],"sp|Q9NYK1,":[205],"sp|P05556,":[206],"sp|P09958,":[207],"sp|Q9HC29.":[209],"Four":[210],"named":[213],"SARS-COV-2-,":[215],"C1,":[216],"C2,":[217],"C3,":[218],"C4":[220],"was":[221],"designed":[222],"by":[223],"utilizing":[224],"different":[225],"adjuvants":[226],"eighteen":[228],"overlapped":[231],"epitopes":[232],"predicted":[235],"top":[237],"ranked":[238],"protiens.":[239],"Based":[240],"immune":[242],"study,":[244],"exhibited":[247],"adequate":[248],"immune-reactivity":[249],"favorable":[251],"encounters":[252],"with":[253],"toll-type":[254],"receptors":[255],"(TLR4,":[256],"TLR8,":[257],"HLA,":[258],"etc":[259],"ACE),":[260],"Among":[261],"them":[262],"SARS-COV-2-C2":[264],"showed":[265],"best":[266],"binding":[267],"affinity":[268],"all":[271],"receptors.":[272],"this":[275],"game-changer":[280],"quest":[283],"medication":[289],"effectively":[291],"combat":[292],"SARS-CoV-2.":[293],"It":[294],"necessary":[296],"do":[298],"additional":[299],"experimental":[300],"analyses,":[301],"nevertheless.":[302]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":9}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-11-17T00:00:00"}