{"id":"https://openalex.org/W4404446406","doi":"https://doi.org/10.1101/2024.11.15.623810","title":"Structural basis for growth factor and nutrient signal integration on the lysosomal membrane by mTORC1","display_name":"Structural basis for growth factor and nutrient signal integration on the lysosomal membrane by mTORC1","publication_year":2024,"publication_date":"2024-11-15","ids":{"openalex":"https://openalex.org/W4404446406","doi":"https://doi.org/10.1101/2024.11.15.623810","pmid":"https://pubmed.ncbi.nlm.nih.gov/39605743"},"language":"en","primary_location":{"id":"doi:10.1101/2024.11.15.623810","doi":"https://doi.org/10.1101/2024.11.15.623810","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.11.15.623810","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/2024.11.15.623810","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086525063","display_name":"Zhicheng Cui","orcid":"https://orcid.org/0000-0003-2398-9344","observed_orcids":["https://orcid.org/0000-0003-2398-9344"]},"institutions":[{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhicheng Cui","raw_affiliation_strings":["California Institute for Quantitative Biosciences, University of California, Berkeley, CA, 94720, USA","Department of Molecular and Cell Biology, University of California Berkeley; Berkeley CA 94720, USA","University of California, Berkeley"],"raw_orcid":"https://orcid.org/0000-0003-2398-9344","affiliations":[{"raw_affiliation_string":"California Institute for Quantitative Biosciences, University of California, Berkeley, CA, 94720, USA","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California Berkeley; Berkeley CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California, Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037419952","display_name":"Alessandra Esposito","orcid":"https://orcid.org/0000-0002-3838-7242","observed_orcids":["https://orcid.org/0000-0002-3838-7242"]},"institutions":[{"id":"https://openalex.org/I4210149489","display_name":"Scuola Superiore Meridionale","ror":"https://ror.org/04swxte59","country_code":"IT","type":"education","lineage":["https://openalex.org/I4210149489"]},{"id":"https://openalex.org/I4210152213","display_name":"Telethon Institute Of Genetics And Medicine","ror":"https://ror.org/04xfdsg27","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210152213","https://openalex.org/I4210154366"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Esposito","raw_affiliation_strings":["Scuola Superiore Meridionale (SSM), School for Advanced Studies, Genomics and Experimental Medicine program, Naples, Italy","Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy","Telethon Institute of Genetics and Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scuola Superiore Meridionale (SSM), School for Advanced Studies, Genomics and Experimental Medicine program, Naples, Italy","institution_ids":["https://openalex.org/I4210149489"]},{"raw_affiliation_string":"Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy","institution_ids":["https://openalex.org/I4210152213"]},{"raw_affiliation_string":"Telethon Institute of Genetics and Medicine","institution_ids":["https://openalex.org/I4210152213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048399399","display_name":"Gennaro Napolitano","orcid":"https://orcid.org/0000-0002-8615-4654","observed_orcids":["https://orcid.org/0000-0002-8615-4654"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I4210149489","display_name":"Scuola Superiore Meridionale","ror":"https://ror.org/04swxte59","country_code":"IT","type":"education","lineage":["https://openalex.org/I4210149489"]},{"id":"https://openalex.org/I4210152213","display_name":"Telethon Institute Of Genetics And Medicine","ror":"https://ror.org/04xfdsg27","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210152213","https://openalex.org/I4210154366"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gennaro Napolitano","raw_affiliation_strings":["Medical Genetics Unit, Department of Medical and Translational Science, Federico II University, Naples, Italy","Scuola Superiore Meridionale (SSM), School for Advanced Studies, Genomics and Experimental Medicine program, Naples, Italy","Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy","TIGEM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genetics Unit, Department of Medical and Translational Science, Federico II University, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"raw_affiliation_string":"Scuola Superiore Meridionale (SSM), School for Advanced Studies, Genomics and Experimental Medicine program, Naples, Italy","institution_ids":["https://openalex.org/I4210149489"]},{"raw_affiliation_string":"Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy","institution_ids":["https://openalex.org/I4210152213"]},{"raw_affiliation_string":"TIGEM","institution_ids":["https://openalex.org/I4210152213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077487765","display_name":"Andrea Ballabio","orcid":"https://orcid.org/0000-0003-1381-4604","observed_orcids":["https://orcid.org/0000-0003-1381-4604","https://orcid.org/0000-0001-5627-7744"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]},{"id":"https://openalex.org/I4210149489","display_name":"Scuola Superiore Meridionale","ror":"https://ror.org/04swxte59","country_code":"IT","type":"education","lineage":["https://openalex.org/I4210149489"]},{"id":"https://openalex.org/I4210152213","display_name":"Telethon Institute Of Genetics And Medicine","ror":"https://ror.org/04xfdsg27","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210152213","https://openalex.org/I4210154366"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Andrea Ballabio","raw_affiliation_strings":["Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA","Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA","Medical Genetics Unit, Department of Medical and Translational Science, Federico II University, Naples, Italy","Scuola Superiore Meridionale (SSM), School for Advanced Studies, Genomics and Experimental Medicine program, Naples, Italy","Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy","Telethon Institute of Genetics and Medicine"],"raw_orcid":"https://orcid.org/0000-0003-1381-4604","affiliations":[{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA","institution_ids":["https://openalex.org/I4210147586"]},{"raw_affiliation_string":"Medical Genetics Unit, Department of Medical and Translational Science, Federico II University, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"raw_affiliation_string":"Scuola Superiore Meridionale (SSM), School for Advanced Studies, Genomics and Experimental Medicine program, Naples, Italy","institution_ids":["https://openalex.org/I4210149489"]},{"raw_affiliation_string":"Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy","institution_ids":["https://openalex.org/I4210152213"]},{"raw_affiliation_string":"Telethon Institute of Genetics and Medicine","institution_ids":["https://openalex.org/I4210152213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061450716","display_name":"James H. Hurley","orcid":"https://orcid.org/0000-0001-5054-5445","observed_orcids":["https://orcid.org/0000-0001-5054-5445"]},"institutions":[{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James H. Hurley","raw_affiliation_strings":["California Institute for Quantitative Biosciences, University of California, Berkeley, CA, 94720, USA","Department of Molecular and Cell Biology, University of California Berkeley; Berkeley CA 94720, USA","Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA","UC Berkeley"],"raw_orcid":"https://orcid.org/0000-0001-5054-5445","affiliations":[{"raw_affiliation_string":"California Institute for Quantitative Biosciences, University of California, Berkeley, CA, 94720, USA","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California Berkeley; Berkeley CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"UC Berkeley","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5061450716"],"corresponding_institution_ids":["https://openalex.org/I103922791","https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lysosomal-membrane","display_name":"lysosomal membrane","score":0.9620000123977661},{"id":"https://openalex.org/keywords/rheb","display_name":"Rheb","score":0.6470000147819519},{"id":"https://openalex.org/keywords/rag-gtpases","display_name":"Rag GTPases","score":0.8009999990463257},{"id":"https://openalex.org/keywords/raptors","display_name":"raptors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mtor-kinase","display_name":"mTOR kinase","score":0.703000009059906},{"id":"https://openalex.org/keywords/growth-factor-signaling","display_name":"growth factor signaling","score":0.6869999766349792},{"id":"https://openalex.org/keywords/nutrient-signaling","display_name":"nutrient signaling","score":0.878000020980835},{"id":"https://openalex.org/keywords/signal-integration","display_name":"signal integration","score":0.8759999871253967},{"id":"https://openalex.org/keywords/membrane-anchoring","display_name":"membrane anchoring","score":0.5130000114440918},{"id":"https://openalex.org/keywords/cryo-em-structure","display_name":"cryo-EM structure","score":0.7889999747276306},{"id":"https://openalex.org/keywords/membrane-reconstitution","display_name":"membrane reconstitution","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.8346193432807922},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.508150577545166},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4704994857311249},{"id":"https://openalex.org/C2781039887","wikidata":"https://www.wikidata.org/wiki/Q1391724","display_name":"Factor (programming language)","level":2,"score":0.4685077965259552},{"id":"https://openalex.org/C12426560","wikidata":"https://www.wikidata.org/wiki/Q189569","display_name":"Basis (linear algebra)","level":2,"score":0.44239112734794617},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40840327739715576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2873411178588867},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28570759296417236},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2315884530544281},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1811521351337433},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.09161049127578735},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07841667532920837},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2024.11.15.623810","doi":"https://doi.org/10.1101/2024.11.15.623810","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.11.15.623810","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:39605743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39605743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11601357","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11601357","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11601357/pdf/nihpp-2024.11.15.623810v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2024.11.15.623810","doi":"https://doi.org/10.1101/2024.11.15.623810","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.11.15.623810","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4418636461","display_name":null,"funder_award_id":"P2022T4PKT","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G4881083045","display_name":null,"funder_award_id":"202032AZT3","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G5240942243","display_name":"Molecular and structural mechanisms of mTORC1 regulation in cancer","funder_award_id":"1r01ca285366-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8136289162","display_name":null,"funder_award_id":"PRIN 202032AZT3","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G994635524","display_name":"TARGETING INHERITED CANCER SYNDROMES","funder_award_id":"101097752","funder_id":"https://openalex.org/F4320338453","funder_display_name":"HORIZON EUROPE European Research Council"}],"funders":[{"id":"https://openalex.org/F4320314489","display_name":"World Cancer Research Fund International","ror":"https://ror.org/02747h926"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320328034","display_name":"Wereld Kanker Onderzoek Fonds","ror":"https://ror.org/017fdbp82"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320334633","display_name":"World Cancer Research Fund","ror":"https://ror.org/02gc7qc02"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338453","display_name":"HORIZON EUROPE European Research Council","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W63180726","https://openalex.org/W1521429682","https://openalex.org/W1804602290","https://openalex.org/W1977747566","https://openalex.org/W1977893138","https://openalex.org/W2004582874","https://openalex.org/W2005066107","https://openalex.org/W2016311464","https://openalex.org/W2025176940","https://openalex.org/W2027785297","https://openalex.org/W2056137479","https://openalex.org/W2066659565","https://openalex.org/W2075824676","https://openalex.org/W2089632625","https://openalex.org/W2109263914","https://openalex.org/W2114031931","https://openalex.org/W2136676465","https://openalex.org/W2138044466","https://openalex.org/W2142161929","https://openalex.org/W2144081223","https://openalex.org/W2152562710","https://openalex.org/W2207318443","https://openalex.org/W2463789383","https://openalex.org/W2587625522","https://openalex.org/W2734356283","https://openalex.org/W2757150230","https://openalex.org/W2767139423","https://openalex.org/W2767173427","https://openalex.org/W2768374432","https://openalex.org/W2773300145","https://openalex.org/W2780007428","https://openalex.org/W2793402357","https://openalex.org/W2801376357","https://openalex.org/W2887001097","https://openalex.org/W2973278134","https://openalex.org/W2973457155","https://openalex.org/W2979459757","https://openalex.org/W2979884643","https://openalex.org/W3031078526","https://openalex.org/W3031513718","https://openalex.org/W3040600898","https://openalex.org/W3095141346","https://openalex.org/W3098923693","https://openalex.org/W3102367786","https://openalex.org/W3103292928","https://openalex.org/W3156151969","https://openalex.org/W3177828909","https://openalex.org/W4221117452","https://openalex.org/W4280560201","https://openalex.org/W4281681825","https://openalex.org/W4313556798","https://openalex.org/W4317952732","https://openalex.org/W4321014279","https://openalex.org/W4376507169","https://openalex.org/W4386098024","https://openalex.org/W4387092068","https://openalex.org/W4388895493","https://openalex.org/W4391379655","https://openalex.org/W4400588907"],"related_works":["https://openalex.org/W3209849004","https://openalex.org/W3168080635","https://openalex.org/W2091377796","https://openalex.org/W1967584365","https://openalex.org/W4318982706","https://openalex.org/W3173493060","https://openalex.org/W2022984399","https://openalex.org/W3162623911","https://openalex.org/W2051648135","https://openalex.org/W2170373549"],"abstract_inverted_index":{"Mechanistic":[0],"target":[1],"of":[2,9,42,51,59,95,110,152,160,176,185],"rapamycin":[3],"complex":[4],"1":[5],"(mTORC1),":[6],"which":[7,35,104],"consists":[8],"mTOR,":[10],"Raptor,":[11],"and":[12,21,30,62,69,73,126,135,141,171,178,187,202],"mLST8,":[13],"receives":[14],"signaling":[15],"inputs":[16],"from":[17,132],"growth":[18,133,200],"factor":[19,201],"signals":[20,24,131],"nutrients.":[22],"These":[23],"are":[25],"mediated":[26],"by":[27,55,84,108],"the":[28,39,43,49,66,78,90,96,111,115,124,144,161,181,207],"Rheb":[29,186],"Rag":[31],"small":[32],"GTPases,":[33],"respectively,":[34],"activate":[36],"mTORC1":[37,52,138],"on":[38,53,143],"cytosolic":[40],"face":[41],"lysosome":[44],"membrane.":[45,182],"We":[46,64],"biochemically":[47],"reconstituted":[48],"activation":[50,142],"membranes":[54],"physiological":[56],"submicromolar":[57],"concentrations":[58],"Rheb,":[60],"Rags,":[61],"Ragulator.":[63],"determined":[65],"cryo-EM":[67],"structure":[68],"found":[70],"that":[71],"Raptor":[72,179],"mTOR":[74,116,177],"directly":[75],"interact":[76],"with":[77,180],"membrane":[79,91,97,146,188],"at":[80,123,206],"anchor":[81],"points":[82],"separated":[83],"up":[85],"to":[86,140,156,167,191],"230":[87],"\u00c5":[88,159],"across":[89],"surface.":[92],"Full":[93],"engagement":[94,175,189],"anchors":[98],"is":[99,105],"required":[100],"for":[101,199],"maximal":[102],"activation,":[103,194],"brought":[106],"about":[107],"alignment":[109],"catalytic":[112,193],"residues":[113],"in":[114,147],"kinase":[117],"active":[118],"site.":[119],"The":[120,183],"observations":[121],"show":[122],"molecular":[125],"atomic":[127],"scale":[128],"how":[129],"converging":[130],"factors":[134],"nutrients":[136],"drive":[137],"recruitment":[139,155,166],"lysosomal":[145,162],"a":[148,196],"three-step":[149],"process,":[150],"consisting":[151],"(1)":[153],"Rag-Ragulator-driven":[154],"within":[157,168],"~100":[158],"membrane,":[163],"(2)":[164],"Rheb-driven":[165],"~40":[169],"\u00c5,":[170],"finally":[172],"(3)":[173],"direct":[174],"combination":[184],"leads":[190],"full":[192],"providing":[195],"structural":[197],"explanation":[198],"nutrient":[203],"signal":[204],"integration":[205],"lysosome.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2025-10-10T00:00:00"}
