{"id":"https://openalex.org/W4404386937","doi":"https://doi.org/10.1016/j.bpj.2024.11.010","title":"Mammalian PIEZO channels rectify anionic currents","display_name":"Mammalian PIEZO channels rectify anionic currents","publication_year":2024,"publication_date":"2024-11-14","ids":{"openalex":"https://openalex.org/W4404386937","doi":"https://doi.org/10.1016/j.bpj.2024.11.010","pmid":"https://pubmed.ncbi.nlm.nih.gov/39543876","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12820994"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2024.11.010","doi":"https://doi.org/10.1016/j.bpj.2024.11.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bpj.2024.11.010","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/2024.08.23.609388","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059238278","display_name":"Tharaka Darshana Wijerathne","orcid":"https://orcid.org/0000-0002-6900-3272","observed_orcids":["https://orcid.org/0000-0002-6900-3272"]},"institutions":[{"id":"https://openalex.org/I93393672","display_name":"Western University of Health Sciences","ror":"https://ror.org/05167c961","country_code":"US","type":"education","lineage":["https://openalex.org/I93393672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tharaka D. Wijerathne","raw_affiliation_strings":["Department of Biomedical Sciences, Western University of Health Sciences, Pomona, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Western University of Health Sciences, Pomona, California","institution_ids":["https://openalex.org/I93393672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084662664","display_name":"Aashish Bhatt","orcid":"https://orcid.org/0000-0003-4393-2070","observed_orcids":["https://orcid.org/0000-0003-4393-2070"]},"institutions":[{"id":"https://openalex.org/I93393672","display_name":"Western University of Health Sciences","ror":"https://ror.org/05167c961","country_code":"US","type":"education","lineage":["https://openalex.org/I93393672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aashish Bhatt","raw_affiliation_strings":["Department of Biotechnology and Pharmaceutical Sciences, Western University of Health Sciences, Pomona, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Pharmaceutical Sciences, Western University of Health Sciences, Pomona, California","institution_ids":["https://openalex.org/I93393672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056421111","display_name":"Wenjuan Jiang","orcid":"https://orcid.org/0000-0002-6360-3875","observed_orcids":["https://orcid.org/0000-0002-6360-3875"]},"institutions":[{"id":"https://openalex.org/I93393672","display_name":"Western University of Health Sciences","ror":"https://ror.org/05167c961","country_code":"US","type":"education","lineage":["https://openalex.org/I93393672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenjuan Jiang","raw_affiliation_strings":["Department of Biotechnology and Pharmaceutical Sciences, Western University of Health Sciences, Pomona, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Pharmaceutical Sciences, Western University of Health Sciences, Pomona, California","institution_ids":["https://openalex.org/I93393672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101602550","display_name":"Yun Luo","orcid":"https://orcid.org/0000-0003-3581-754X","observed_orcids":["https://orcid.org/0000-0003-3581-754X","https://orcid.org/0000-0002-1948-5832"]},"institutions":[{"id":"https://openalex.org/I93393672","display_name":"Western University of Health Sciences","ror":"https://ror.org/05167c961","country_code":"US","type":"education","lineage":["https://openalex.org/I93393672"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yun L. Luo","raw_affiliation_strings":["Department of Biotechnology and Pharmaceutical Sciences, Western University of Health Sciences, Pomona, California. Electronic address: luoy@westernu.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Pharmaceutical Sciences, Western University of Health Sciences, Pomona, California. Electronic address: luoy@westernu.edu","institution_ids":["https://openalex.org/I93393672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019413362","display_name":"J\u00e9r\u00f4me J. Lacroix","orcid":"https://orcid.org/0000-0001-5687-0652","observed_orcids":["https://orcid.org/0000-0001-5687-0652"]},"institutions":[{"id":"https://openalex.org/I93393672","display_name":"Western University of Health Sciences","ror":"https://ror.org/05167c961","country_code":"US","type":"education","lineage":["https://openalex.org/I93393672"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jerome J. Lacroix","raw_affiliation_strings":["Department of Biomedical Sciences, Western University of Health Sciences, Pomona, California. Electronic address: jlacroix@westernu.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Western University of Health Sciences, Pomona, California. Electronic address: jlacroix@westernu.edu","institution_ids":["https://openalex.org/I93393672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019413362","https://openalex.org/A5101602550"],"corresponding_institution_ids":["https://openalex.org/I93393672"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":1.3563,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.80389657,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"124","issue":"24","first_page":"4424","last_page":"4431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.54830002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.54830002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.13619999587535858,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.10130000114440918,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piezo1","display_name":"Piezo1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/piezo2","display_name":"Piezo2","score":1.0},{"id":"https://openalex.org/keywords/mechanosensitive-channels","display_name":"mechanosensitive ion channels","score":0.7870000004768372},{"id":"https://openalex.org/keywords/anion-permeation","display_name":"anion permeation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/chloride-currents","display_name":"chloride currents","score":0.8149999976158142},{"id":"https://openalex.org/keywords/sodium-current","display_name":"sodium current","score":0.7620000243186951},{"id":"https://openalex.org/keywords/inward-rectification","display_name":"inward rectification","score":0.7099999785423279},{"id":"https://openalex.org/keywords/outward-rectification","display_name":"outward rectification","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.573689341545105},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4725841283798218},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.4192085862159729},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19477403163909912},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17160794138908386},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08410924673080444}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000838","descriptor_name":"Anions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bpj.2024.11.010","doi":"https://doi.org/10.1016/j.bpj.2024.11.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bpj.2024.11.010","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},{"id":"doi:10.1101/2024.08.23.609388","doi":"https://doi.org/10.1101/2024.08.23.609388","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.08.23.609388","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:39543876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39543876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12820994","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12820994/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophys J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2024.08.23.609388","doi":"https://doi.org/10.1101/2024.08.23.609388","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.08.23.609388","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G788693111","display_name":null,"funder_award_id":"GM130834","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000860883","display_name":"PHARMACOLOGICAL MODULATION OF PIEZO1 CHANNELS","funder_award_id":"R01GM130834","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320322392","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W800350851","https://openalex.org/W1145321347","https://openalex.org/W1508759451","https://openalex.org/W1559960422","https://openalex.org/W1976111797","https://openalex.org/W1982780003","https://openalex.org/W1997883766","https://openalex.org/W1999720993","https://openalex.org/W2026506975","https://openalex.org/W2029087863","https://openalex.org/W2052163800","https://openalex.org/W2063048094","https://openalex.org/W2077034707","https://openalex.org/W2077082977","https://openalex.org/W2077666330","https://openalex.org/W2077984228","https://openalex.org/W2098481065","https://openalex.org/W2103265928","https://openalex.org/W2120336502","https://openalex.org/W2139852988","https://openalex.org/W2156294657","https://openalex.org/W2165327829","https://openalex.org/W2175682714","https://openalex.org/W2379125756","https://openalex.org/W2411195256","https://openalex.org/W2769558023","https://openalex.org/W3001537456","https://openalex.org/W3009937536","https://openalex.org/W3027999390","https://openalex.org/W3109143003","https://openalex.org/W3119693934","https://openalex.org/W3122270077","https://openalex.org/W4212813785","https://openalex.org/W4281654480","https://openalex.org/W4285014866","https://openalex.org/W4318542901","https://openalex.org/W4380854044","https://openalex.org/W4384925925","https://openalex.org/W4389429767","https://openalex.org/W4390149981","https://openalex.org/W4400567564","https://openalex.org/W4403172556","https://openalex.org/W4404865250"],"related_works":["https://openalex.org/W1974214830","https://openalex.org/W800350851","https://openalex.org/W2577626853","https://openalex.org/W7097807421","https://openalex.org/W2286255985","https://openalex.org/W4404865250","https://openalex.org/W1980793667","https://openalex.org/W2039888556","https://openalex.org/W2070968635","https://openalex.org/W4400567564"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2024-11-15T00:00:00"}