{"id":"https://openalex.org/W4404330833","doi":"https://doi.org/10.3389/fdsfr.2024.1428831","title":"Integrating electronic health records with other data sources for postmarket drug safety signal identification: a review","display_name":"Integrating electronic health records with other data sources for postmarket drug safety signal identification: a review","publication_year":2024,"publication_date":"2024-11-13","ids":{"openalex":"https://openalex.org/W4404330833","doi":"https://doi.org/10.3389/fdsfr.2024.1428831","pmid":"https://pubmed.ncbi.nlm.nih.gov/40979389","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12443085"},"language":"en","primary_location":{"id":"doi:10.3389/fdsfr.2024.1428831","doi":"https://doi.org/10.3389/fdsfr.2024.1428831","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdsfr.2024.1428831","pdf_url":"https://www.frontiersin.org/journals/drug-safety-and-regulation/articles/10.3389/fdsfr.2024.1428831/pdf","source":{"id":"https://openalex.org/S4210181589","display_name":"Frontiers in Drug Safety and Regulation","issn_l":"2674-0869","issn":["2674-0869"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Drug Safety and Regulation","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/drug-safety-and-regulation/articles/10.3389/fdsfr.2024.1428831/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Julie V. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101790","display_name":"VA Tennessee Valley Healthcare System","ror":"https://ror.org/01c9rqr26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie V. Kim","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States","Geriatric Research, Education, and Clinical Center (GRECC), VA Tenneesee Valley Healthcare System, Nashville, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center (GRECC), VA Tenneesee Valley Healthcare System, Nashville, TN, United States","institution_ids":["https://openalex.org/I4210101790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063516544","display_name":"Sharon E. Davis","orcid":"https://orcid.org/0000-0003-0792-8867","observed_orcids":["https://orcid.org/0000-0003-0792-8867"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon E. Davis","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011689338","display_name":"Michael Edwin Matheny","orcid":"https://orcid.org/0000-0003-3217-4147","observed_orcids":["https://orcid.org/0000-0003-3217-4147"]},"institutions":[{"id":"https://openalex.org/I4210101790","display_name":"VA Tennessee Valley Healthcare System","ror":"https://ror.org/01c9rqr26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E. Matheny","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States","Geriatric Research, Education, and Clinical Center (GRECC), VA Tenneesee Valley Healthcare System, Nashville, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center (GRECC), VA Tenneesee Valley Healthcare System, Nashville, TN, United States","institution_ids":["https://openalex.org/I4210101790"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102928402","display_name":"Joshua Smith","orcid":"https://orcid.org/0000-0003-2661-3203","observed_orcids":["https://orcid.org/0000-0003-2661-3203"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua C. Smith","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102928402"],"corresponding_institution_ids":["https://openalex.org/I901861585"],"apc_list":{"value":2125,"currency":"USD","value_usd":2125},"apc_paid":{"value":2125,"currency":"USD","value_usd":2125},"fwci":0.7523,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.65753425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"4","issue":null,"first_page":"1428831","last_page":"1428831"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11819","display_name":"Data-Driven Disease Surveillance","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14400","display_name":"Medical Coding and Health Information","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electronic-health-records","display_name":"electronic health records","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"pharmacovigilance","score":0.8809999823570251},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.9779999852180481},{"id":"https://openalex.org/keywords/spontaneous-reports","display_name":"spontaneous reports","score":0.8180000185966492},{"id":"https://openalex.org/keywords/health-insurance-claims-data","display_name":"health insurance claims data","score":0.9430000185966492},{"id":"https://openalex.org/keywords/real-world-data-integration","display_name":"real-world data integration","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C3019952477","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Health records","level":3,"score":0.6974139213562012},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5945183634757996},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4855670630931854},{"id":"https://openalex.org/C3020144179","wikidata":"https://www.wikidata.org/wiki/Q10871684","display_name":"Electronic health record","level":3,"score":0.4144713282585144},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3720378875732422},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36691975593566895},{"id":"https://openalex.org/C108827166","wikidata":"https://www.wikidata.org/wiki/Q175975","display_name":"Internet privacy","level":1,"score":0.35719430446624756},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.33665385842323303},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33212000131607056},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2912505269050598},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.1825571060180664},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fdsfr.2024.1428831","doi":"https://doi.org/10.3389/fdsfr.2024.1428831","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdsfr.2024.1428831","pdf_url":"https://www.frontiersin.org/journals/drug-safety-and-regulation/articles/10.3389/fdsfr.2024.1428831/pdf","source":{"id":"https://openalex.org/S4210181589","display_name":"Frontiers in Drug Safety and Regulation","issn_l":"2674-0869","issn":["2674-0869"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Drug Safety and Regulation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12443085","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40979389/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12443085/pdf/fdsfr-04-1428831.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Drug Saf Regul","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11253121","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12443085","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40979389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40979389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in drug safety and regulation","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8b86ed7aeb82437fba2d0273e12a669d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8b86ed7aeb82437fba2d0273e12a669d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Drug Safety and Regulation, Vol 4 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fdsfr.2024.1428831","doi":"https://doi.org/10.3389/fdsfr.2024.1428831","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdsfr.2024.1428831","pdf_url":"https://www.frontiersin.org/journals/drug-safety-and-regulation/articles/10.3389/fdsfr.2024.1428831/pdf","source":{"id":"https://openalex.org/S4210181589","display_name":"Frontiers in Drug Safety and Regulation","issn_l":"2674-0869","issn":["2674-0869"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Drug Safety and Regulation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6000000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4725597257","display_name":"Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt","funder_award_id":"P50HD103537","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404330833.pdf","grobid_xml":"https://content.openalex.org/works/W4404330833.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1479774051","https://openalex.org/W1915502973","https://openalex.org/W1977063484","https://openalex.org/W2005259267","https://openalex.org/W2009890917","https://openalex.org/W2010725925","https://openalex.org/W2057676788","https://openalex.org/W2087351221","https://openalex.org/W2164105883","https://openalex.org/W2184328676","https://openalex.org/W2232325453","https://openalex.org/W2253570087","https://openalex.org/W2530398232","https://openalex.org/W2792151316","https://openalex.org/W2803582169","https://openalex.org/W2885743806","https://openalex.org/W2886698710","https://openalex.org/W2951726803","https://openalex.org/W3029827228","https://openalex.org/W3047562657","https://openalex.org/W3130502793","https://openalex.org/W3155338345","https://openalex.org/W3162256912","https://openalex.org/W3165943181","https://openalex.org/W3169738411","https://openalex.org/W3186707781","https://openalex.org/W3202670020","https://openalex.org/W4200121889","https://openalex.org/W4300688604","https://openalex.org/W4381328386","https://openalex.org/W4391253596","https://openalex.org/W4401635636","https://openalex.org/W4407802583"],"related_works":["https://openalex.org/W4381328386","https://openalex.org/W4396973361","https://openalex.org/W7097061438","https://openalex.org/W2184328676","https://openalex.org/W3029827228","https://openalex.org/W2360157598","https://openalex.org/W2077391407","https://openalex.org/W2950653980","https://openalex.org/W192495716","https://openalex.org/W1977063484"],"abstract_inverted_index":{"Electronic":[0],"health":[1,20,49],"records":[2],"(EHRs)":[3],"have":[4,55,66,112,165,171],"emerged":[5],"as":[6],"resources":[7],"for":[8,32,106,186,195],"both":[9],"the":[10,38,67,73,88,128,136],"identification":[11,42,155],"of":[12,40,72,75,85,87,130],"adverse":[13],"drug":[14,33,107,196],"events":[15],"(ADEs)":[16],"and":[17,48,101,120,168,182],"general":[18],"population":[19],"surveillance,":[21],"however":[22,135],"questions":[23],"remain":[24],"around":[25],"how":[26,150],"best":[27],"to":[28,69,81,127],"utilize":[29],"EHR":[30,60,92,116,151],"data":[31,53,61,64,93,104,117,152,193],"safety":[34,108,197],"signal":[35,41,109,154],"identification.":[36,110],"While":[37],"majority":[39],"research":[43,90,181],"has":[44],"utilized":[45],"spontaneous":[46,97],"reports":[47],"insurance":[50],"claims,":[51],"these":[52,119],"also":[54],"limitations.":[56],"Pharmacovigilance":[57],"approaches":[58],"combining":[59,115],"with":[62,96,118,160],"other":[63,102,121,161],"sources":[65,105,122,194],"potential":[68],"address":[70],"many":[71],"shortcomings":[74],"individual":[76],"sources.":[77],"This":[78],"mini-review":[79],"seeks":[80],"provide":[82],"an":[83],"overview":[84],"some":[86],"recent":[89],"leveraging":[91],"in":[94,144,158,179],"combination":[95,159],"reports,":[98],"claims":[99],"data,":[100],"pharmacovigilance":[103],"Studies":[111],"shown":[113],"that":[114],"is":[123,141],"often":[124],"beneficial":[125],"compared":[126],"use":[129],"a":[131],"single":[132],"source":[133],"alone,":[134],"synergism":[137],"or":[138],"friction":[139],"introduced":[140],"insufficiently":[142],"explored":[143],"current":[145,180],"literature.":[146],"Our":[147],"review":[148],"explores":[149],"benefits":[153],"when":[156],"used":[157],"sources,":[162],"what":[163,169],"methods":[164],"been":[166,173],"applied,":[167],"considerations":[170,185],"previously":[172],"noted.":[174],"Finally,":[175],"we":[176],"identify":[177],"gaps":[178],"highlight":[183],"important":[184],"future":[187],"work":[188],"using":[189],"multiple":[190],"real":[191],"world":[192],"surveillance.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-11-14T00:00:00"}
