{"id":"https://openalex.org/W4404292064","doi":"https://doi.org/10.1016/j.npep.2024.102483","title":"Protective effect of Apelin-13 on D-glutamic acid-induced excitotoxicity in SH-SY5Y cell line: An in-vitro study","display_name":"Protective effect of Apelin-13 on D-glutamic acid-induced excitotoxicity in SH-SY5Y cell line: An in-vitro study","publication_year":2024,"publication_date":"2024-11-12","ids":{"openalex":"https://openalex.org/W4404292064","doi":"https://doi.org/10.1016/j.npep.2024.102483","pmid":"https://pubmed.ncbi.nlm.nih.gov/39547009"},"language":"en","primary_location":{"id":"doi:10.1016/j.npep.2024.102483","doi":"https://doi.org/10.1016/j.npep.2024.102483","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.npep.2024.102483","pdf_url":null,"source":{"id":"https://openalex.org/S86238769","display_name":"Neuropeptides","issn_l":"0143-4179","issn":["0143-4179","1532-2785"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropeptides","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074508334","display_name":"Kadriye Ya\u011fmur Oru\u00e7","orcid":"https://orcid.org/0000-0002-3747-5136","observed_orcids":["https://orcid.org/0000-0002-3747-5136"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I4210121333","display_name":"Istinye University","ror":"https://ror.org/03081nz23","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210121333"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Kadriye Ya\u011fmur Oru\u00e7","raw_affiliation_strings":["Istanbul University-Cerrahpa\u015fa, Cerrahpa\u015fa Faculty of Medicine, Department of Physiology, Istanbul, Turkey; Istinye University, Faculty of Medicine, Department of Physiology, Istanbul, Turkey. Electronic address: kyagmurd@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul University-Cerrahpa\u015fa, Cerrahpa\u015fa Faculty of Medicine, Department of Physiology, Istanbul, Turkey; Istinye University, Faculty of Medicine, Department of Physiology, Istanbul, Turkey. Electronic address: kyagmurd@gmail.com","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I4210121333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073949710","display_name":"G\u00f6khan A\u011ft\u00fcrk","orcid":"https://orcid.org/0000-0002-5573-6715","observed_orcids":["https://orcid.org/0000-0002-5573-6715"]},"institutions":[{"id":"https://openalex.org/I25010766","display_name":"Hali\u00e7 University","ror":"https://ror.org/022xhck05","country_code":"TR","type":"education","lineage":["https://openalex.org/I25010766"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G\u00f6khan A\u011ft\u00fcrk","raw_affiliation_strings":["Hali\u00e7 University, Faculty of Medicine, Department of Physiology, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hali\u00e7 University, Faculty of Medicine, Department of Physiology, Istanbul, Turkey","institution_ids":["https://openalex.org/I25010766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087487985","display_name":"Aykut Oru\u00e7","orcid":"https://orcid.org/0000-0001-8043-7971","observed_orcids":["https://orcid.org/0000-0001-8043-7971","https://orcid.org/0000-0002-9562-7695"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Aykut Oru\u00e7","raw_affiliation_strings":["Istanbul University-Cerrahpa\u015fa, Cerrahpa\u015fa Faculty of Medicine, Department of Physiology, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul University-Cerrahpa\u015fa, Cerrahpa\u015fa Faculty of Medicine, Department of Physiology, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064705780","display_name":"Karolin Yanar","orcid":"https://orcid.org/0000-0001-6571-415X","observed_orcids":["https://orcid.org/0000-0001-6571-415X"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Karolin Yanar","raw_affiliation_strings":["Istanbul University-Cerrahpa\u015fa, Cerrahpa\u015fa Faculty of Medicine, Department of Medical Biochemistry, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul University-Cerrahpa\u015fa, Cerrahpa\u015fa Faculty of Medicine, Department of Medical Biochemistry, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044982157","display_name":"Hakk\u0131 Oktay Seymen","orcid":"https://orcid.org/0000-0001-5096-747X","observed_orcids":["https://orcid.org/0000-0001-5096-747X"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hakk\u0131 Oktay Seymen","raw_affiliation_strings":["Istanbul University-Cerrahpa\u015fa, Cerrahpa\u015fa Faculty of Medicine, Department of Physiology, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul University-Cerrahpa\u015fa, Cerrahpa\u015fa Faculty of Medicine, Department of Physiology, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5074508334"],"corresponding_institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I4210121333"],"apc_list":{"value":3280,"currency":"USD","value_usd":3280},"apc_paid":null,"fwci":1.0296,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.70800097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"109","issue":null,"first_page":"102483","last_page":"102483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apelin-13","display_name":"apelin-13","score":0.9620000123977661},{"id":"https://openalex.org/keywords/d-glutamate","display_name":"D-glutamic acid","score":0.9890000224113464},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9879999756813049},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7979999780654907},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.7570000290870667},{"id":"https://openalex.org/keywords/camp-pka-signaling","display_name":"cAMP/PKA signaling","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.996999979019165},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9079999923706055},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2779083432","wikidata":"https://www.wikidata.org/wiki/Q7390126","display_name":"SH-SY5Y","level":4,"score":0.8537204265594482},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.8259472846984863},{"id":"https://openalex.org/C2779546753","wikidata":"https://www.wikidata.org/wiki/Q2386988","display_name":"Apelin","level":3,"score":0.7535125017166138},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6379828453063965},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.633240818977356},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.42253443598747253},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3508630692958832},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32947179675102234},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.258759081363678},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24299699068069458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21326017379760742},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.059110164642333984},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05501624941825867},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.npep.2024.102483","doi":"https://doi.org/10.1016/j.npep.2024.102483","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.npep.2024.102483","pdf_url":null,"source":{"id":"https://openalex.org/S86238769","display_name":"Neuropeptides","issn_l":"0143-4179","issn":["0143-4179","1532-2785"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropeptides","raw_type":"journal-article"},{"id":"pmid:39547009","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39547009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropeptides","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4328664826","display_name":null,"funder_award_id":"TSA-2023-37","funder_id":"https://openalex.org/F4320329283","funder_display_name":"Istanbul \u00dcniversitesi-Cerrahpasa"},{"id":"https://openalex.org/G5979140579","display_name":null,"funder_award_id":"TSA-2023-37,359","funder_id":"https://openalex.org/F4320329283","funder_display_name":"Istanbul \u00dcniversitesi-Cerrahpasa"}],"funders":[{"id":"https://openalex.org/F4320329283","display_name":"Istanbul \u00dcniversitesi-Cerrahpasa","ror":"https://ror.org/01dzn5f42"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W1590640462","https://openalex.org/W1926095516","https://openalex.org/W1963844828","https://openalex.org/W1993839684","https://openalex.org/W1999883073","https://openalex.org/W2009827445","https://openalex.org/W2017326328","https://openalex.org/W2021811697","https://openalex.org/W2034824174","https://openalex.org/W2035036667","https://openalex.org/W2042641359","https://openalex.org/W2046962004","https://openalex.org/W2047119422","https://openalex.org/W2055319034","https://openalex.org/W2060050678","https://openalex.org/W2063576996","https://openalex.org/W2064283504","https://openalex.org/W2089559840","https://openalex.org/W2114918609","https://openalex.org/W2122002245","https://openalex.org/W2212369426","https://openalex.org/W2219514114","https://openalex.org/W2259262031","https://openalex.org/W2484423289","https://openalex.org/W2592354080","https://openalex.org/W2606880127","https://openalex.org/W2806292632","https://openalex.org/W2808486824","https://openalex.org/W2902460584","https://openalex.org/W2912702481","https://openalex.org/W2935756319","https://openalex.org/W2950277409","https://openalex.org/W2952578649","https://openalex.org/W2958936896","https://openalex.org/W2970878132","https://openalex.org/W2974852113","https://openalex.org/W2977394861","https://openalex.org/W2992679405","https://openalex.org/W2994276827","https://openalex.org/W3005184394","https://openalex.org/W3008174509","https://openalex.org/W3012018614","https://openalex.org/W3028081071","https://openalex.org/W3041707034","https://openalex.org/W3046860178","https://openalex.org/W3083653831","https://openalex.org/W3094053673","https://openalex.org/W3095047659","https://openalex.org/W3108095894","https://openalex.org/W3109958687","https://openalex.org/W3111355345","https://openalex.org/W3130189365","https://openalex.org/W3131099976","https://openalex.org/W3156214565","https://openalex.org/W3163285023","https://openalex.org/W4200539104","https://openalex.org/W4205924630","https://openalex.org/W4213228732","https://openalex.org/W4214535886","https://openalex.org/W4220658702","https://openalex.org/W4220786028","https://openalex.org/W4232534952","https://openalex.org/W4283796427","https://openalex.org/W4296241715","https://openalex.org/W4304166008","https://openalex.org/W4309242758","https://openalex.org/W4309455306","https://openalex.org/W4310205552","https://openalex.org/W4319294294","https://openalex.org/W4321372477","https://openalex.org/W4324129240","https://openalex.org/W4366236802","https://openalex.org/W4377969053","https://openalex.org/W4379875696","https://openalex.org/W4380049982","https://openalex.org/W4382938117","https://openalex.org/W4383533832","https://openalex.org/W4385507200","https://openalex.org/W4385607030","https://openalex.org/W4385999933","https://openalex.org/W4386600679","https://openalex.org/W4388766239","https://openalex.org/W4389114816","https://openalex.org/W4390702749","https://openalex.org/W4393863331","https://openalex.org/W4394747404","https://openalex.org/W4396868062","https://openalex.org/W4399097239","https://openalex.org/W6752500206"],"related_works":["https://openalex.org/W7125515615","https://openalex.org/W1988487044","https://openalex.org/W7163549534","https://openalex.org/W2558354356","https://openalex.org/W3097301146","https://openalex.org/W4214545262","https://openalex.org/W4404801686","https://openalex.org/W2097724095","https://openalex.org/W7172539467","https://openalex.org/W1972030842"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-11-13T00:00:00"}