{"id":"https://openalex.org/W4404236502","doi":"https://doi.org/10.1093/neuonc/noae165.0978","title":"EXTH-47. ENHANCING GD2.CART THERAPY FOR DIFFUSE MIDLINE GLIOMA WITH LSD1 AND HDAC INHIBITORS","display_name":"EXTH-47. ENHANCING GD2.CART THERAPY FOR DIFFUSE MIDLINE GLIOMA WITH LSD1 AND HDAC INHIBITORS","publication_year":2024,"publication_date":"2024-11-01","ids":{"openalex":"https://openalex.org/W4404236502","doi":"https://doi.org/10.1093/neuonc/noae165.0978"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noae165.0978","doi":"https://doi.org/10.1093/neuonc/noae165.0978","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1093/neuonc/noae165.0978","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11553469/pdf/noae165.0978.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073226762","display_name":"Rebecca L. Murdaugh","orcid":"https://orcid.org/0000-0002-9950-8634","observed_orcids":["https://orcid.org/0000-0002-9950-8634"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Murdaugh","raw_affiliation_strings":["Baylor College of Medicine , Houston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine , Houston,","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073797473","display_name":"Meghan Shekar","orcid":"https://orcid.org/0000-0002-6711-9896","observed_orcids":["https://orcid.org/0000-0002-6711-9896"]},"institutions":[{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghan Shekar","raw_affiliation_strings":["Texas Children\u2019s Hospital , Houston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Children\u2019s Hospital , Houston,","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099184194","display_name":"Brittany R Eberl","orcid":"https://orcid.org/0000-0002-2584-4969","observed_orcids":["https://orcid.org/0000-0002-2584-4969"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brittany Eberl","raw_affiliation_strings":["Baylor College of Medicine , Houston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine , Houston,","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037941324","display_name":"Jack R Tremblay","orcid":"https://orcid.org/0009-0008-5249-1514","observed_orcids":["https://orcid.org/0009-0008-5249-1514"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack Tremblay","raw_affiliation_strings":["Baylor College of Medicine , Houston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine , Houston,","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114179079","display_name":"Rosemary U. Richard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosemary Richard","raw_affiliation_strings":["Baylor College of Medicine , Houston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine , Houston,","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063617115","display_name":"Akdes Serin Harmanc\u0131","orcid":"https://orcid.org/0000-0001-6374-9041","observed_orcids":["https://orcid.org/0000-0001-6374-9041"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akdes Serin Harmanci","raw_affiliation_strings":["Baylor College of Medicine , Houston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine , Houston,","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044253645","display_name":"Bilal A. Omer","orcid":"https://orcid.org/0000-0002-1479-5305","observed_orcids":["https://orcid.org/0000-0002-1479-5305"]},"institutions":[{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bilal Omer","raw_affiliation_strings":["Texas Children\u2019s Hospital , Houston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Children\u2019s Hospital , Houston,","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079320246","display_name":"Jamie N. Anastas","orcid":"https://orcid.org/0000-0002-5317-5352","observed_orcids":["https://orcid.org/0000-0002-5317-5352"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie Anastas","raw_affiliation_strings":["Baylor College of Medicine , Houston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine , Houston,","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5389,"currency":"USD","value_usd":5389},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"Supplement_8","first_page":"viii247","last_page":"viii247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.03579999879002571,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-midline-glioma","display_name":"diffuse midline glioma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gd2","display_name":"GD2","score":0.7039999961853027},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/lsd1-inhibitors","display_name":"LSD1 inhibitors","score":0.7279999852180481},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9419999718666077},{"id":"https://openalex.org/keywords/h3k27m-mutation","display_name":"H3K27M mutation","score":0.949999988079071},{"id":"https://openalex.org/keywords/tumor-escape","display_name":"tumor escape","score":0.5410000085830688},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.6880000233650208},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.777999997138977},{"id":"https://openalex.org/keywords/mouse-xenograft-model","display_name":"xenograft mouse model","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C2777275308","wikidata":"https://www.wikidata.org/wiki/Q234668","display_name":"Cart","level":2,"score":0.9453753232955933},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5912010669708252},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43430525064468384},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39895448088645935},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.339616060256958},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19515764713287354},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0523209273815155},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/neuonc/noae165.0978","doi":"https://doi.org/10.1093/neuonc/noae165.0978","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1093/neuonc/noae165.0978","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11407070","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11553469","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11553469/pdf/noae165.0978.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:11553469","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11553469/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:11407070","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11553469","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11553469/pdf/noae165.0978.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404236502.pdf","grobid_xml":"https://content.openalex.org/works/W4404236502.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4400093351","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3193909393","https://openalex.org/W3108674512"],"abstract_inverted_index":{"Abstract":[0],"Chimeric":[1],"antigen":[2,27,259],"receptor":[3],"T":[4],"cells":[5,36,101,131,158,203,224],"against":[6],"the":[7,63,72],"glycolipid":[8],"GD2":[9,43,69,97,155,195],"(GD2.CARTs)":[10],"are":[11,20],"showing":[12],"promise":[13],"in":[14,87,112,129,135,144,214],"diffuse":[15],"midline":[16],"glioma":[17],"(DMG)":[18],"but":[19],"not":[21],"yet":[22],"curative.":[23],"Since":[24],"low":[25,77,96],"target":[26,258],"expression":[28,44,70,98,137,196],"is":[29,197,207],"one":[30],"potential":[31],"mechanism":[32],"by":[33,162,212,228,256],"which":[34],"tumor":[35,104,139,157,209,236],"can":[37,153],"escape":[38,106],"CART":[39],"therapy,":[40],"we":[41,93],"profiled":[42],"levels":[45],"on":[46,99,156,199],"9":[47,64],"different":[48],"H3K27M-mutant":[49],"DMG":[50,100,130,172,184,202,223,250],"cell":[51,65,83,105,140,173,210],"lines":[52,66,75,84,174],"using":[53],"flow":[54,190],"cytometry.":[55],"This":[56],"analysis":[57],"shows":[58],"that":[59,95,118,148,194,205,241],"only":[60],"5":[61],"of":[62,121,177],"exhibit":[67],"high":[68],"while":[71],"remaining":[73],"4":[74],"have":[76],"GD2-expressing":[78],"cells.":[79],"When":[80],"treating":[81,170],"these":[82],"with":[85,103,175,221,225],"GD2.CARTs":[86,108,213],"co-culture":[88,216],"assays":[89],"and":[90,109,125,138,159,181,189,204],"xenograft":[91],"mice,":[92],"find":[94],"correlates":[102],"from":[107],"therapeutic":[110],"resistance":[111],"vivo.":[113],"Our":[114],"lab":[115],"previously":[116],"found":[117],"simultaneous":[119],"inhibition":[120],"histone":[122],"deacetylases":[123],"(HDACs)":[124],"lysine-demethylase":[126],"1":[127],"(LSD1)":[128],"causes":[132],"synergistic":[133],"increases":[134],"gene":[136],"death.":[141],"Previous":[142],"studies":[143],"neuroblastoma":[145],"also":[146,232],"demonstrate":[147],"HDAC":[149],"inhibitor":[150],"(HDACi)":[151],"treatment":[152],"increase":[154],"improve":[160,249],"targeting":[161,211],"GD2.CARTs.":[163,187],"We":[164],"therefore":[165],"decided":[166],"to":[167,186,234,248,253],"assess":[168],"whether":[169],"GD2-low":[171,201,222],"combinations":[176],"LSD1":[178],"inhibitors":[179],"(LSD1i)":[180],"HDACi":[182],"improves":[183],"response":[185],"Immunofluorescence":[188],"cytometric":[191],"analyses":[192],"show":[193],"increased":[198],"LSD1i+HDACi-treated":[200],"there":[206],"enhanced":[208],"subsequent":[215],"assays.":[217],"Treating":[218],"mice":[219],"transplanted":[220],"LSD1i+HDACi":[226,242],"followed":[227],"intravenous":[229],"GD2.CART":[230,254],"infusion":[231],"led":[233],"reduced":[235],"growth.":[237],"These":[238],"results":[239],"suggest":[240],"pre-treatment":[243],"may":[244],"provide":[245],"a":[246],"way":[247],"patient":[251],"responses":[252],"therapy":[255],"increasing":[257],"expression.":[260]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}