{"id":"https://openalex.org/W4404187828","doi":"https://doi.org/10.3390/cancers16223768","title":"Enhancing Tumor Targeted Therapy: The Role of iRGD Peptide in Advanced Drug Delivery Systems","display_name":"Enhancing Tumor Targeted Therapy: The Role of iRGD Peptide in Advanced Drug Delivery Systems","publication_year":2024,"publication_date":"2024-11-08","ids":{"openalex":"https://openalex.org/W4404187828","doi":"https://doi.org/10.3390/cancers16223768","pmid":"https://pubmed.ncbi.nlm.nih.gov/39594723"},"language":"en","primary_location":{"id":"doi:10.3390/cancers16223768","doi":"https://doi.org/10.3390/cancers16223768","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers16223768","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cancers16223768","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044109342","display_name":"Dragana Nikitovic","orcid":"https://orcid.org/0000-0003-3882-7399","observed_orcids":["https://orcid.org/0000-0003-3882-7399"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Dragana Nikitovic","raw_affiliation_strings":["Department of Histology-Embryology, Medical School, University of Crete, 71003 Heraklion, Greece"],"raw_orcid":"https://orcid.org/0000-0003-3882-7399","affiliations":[{"raw_affiliation_string":"Department of Histology-Embryology, Medical School, University of Crete, 71003 Heraklion, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093516910","display_name":"Ekaterina V. Kukovyakina","orcid":"https://orcid.org/0009-0008-2918-185X","observed_orcids":["https://orcid.org/0009-0008-2918-185X"]},"institutions":[{"id":"https://openalex.org/I137587207","display_name":"D. Mendeleyev University of Chemical Technology of Russia","ror":"https://ror.org/05w13qg40","country_code":"RU","type":"education","lineage":["https://openalex.org/I137587207"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ekaterina Kukovyakina","raw_affiliation_strings":["Department of Technology of Chemical Pharmaceutical and Cosmetic Products, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Technology of Chemical Pharmaceutical and Cosmetic Products, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia","institution_ids":["https://openalex.org/I137587207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001255911","display_name":"Aikaterini Berdiaki","orcid":"https://orcid.org/0009-0001-3996-9877","observed_orcids":["https://orcid.org/0009-0001-3996-9877"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Aikaterini Berdiaki","raw_affiliation_strings":["Department of Histology-Embryology, Medical School, University of Crete, 71003 Heraklion, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology-Embryology, Medical School, University of Crete, 71003 Heraklion, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123039011","display_name":"Alexandros Tzanakakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Alexandros Tzanakakis","raw_affiliation_strings":["School of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens, Greece","institution_ids":["https://openalex.org/I174458059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069197261","display_name":"Anna L. Luss","orcid":"https://orcid.org/0000-0001-8539-0252","observed_orcids":["https://orcid.org/0000-0001-8539-0252"]},"institutions":[{"id":"https://openalex.org/I137587207","display_name":"D. Mendeleyev University of Chemical Technology of Russia","ror":"https://ror.org/05w13qg40","country_code":"RU","type":"education","lineage":["https://openalex.org/I137587207"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anna Luss","raw_affiliation_strings":["Department of Technology of Chemical Pharmaceutical and Cosmetic Products, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Technology of Chemical Pharmaceutical and Cosmetic Products, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia","institution_ids":["https://openalex.org/I137587207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044945841","display_name":"Elizaveta R. Vlaskina","orcid":"https://orcid.org/0009-0001-4441-9706","observed_orcids":["https://orcid.org/0009-0001-4441-9706"]},"institutions":[{"id":"https://openalex.org/I137587207","display_name":"D. Mendeleyev University of Chemical Technology of Russia","ror":"https://ror.org/05w13qg40","country_code":"RU","type":"education","lineage":["https://openalex.org/I137587207"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elizaveta Vlaskina","raw_affiliation_strings":["Department of Technology of Chemical Pharmaceutical and Cosmetic Products, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia"],"raw_orcid":"https://orcid.org/0009-0001-4441-9706","affiliations":[{"raw_affiliation_string":"Department of Technology of Chemical Pharmaceutical and Cosmetic Products, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia","institution_ids":["https://openalex.org/I137587207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007062858","display_name":"Anne V. Yagolovich","orcid":"https://orcid.org/0000-0003-3145-3726","observed_orcids":["https://orcid.org/0000-0003-3145-3726"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anne Yagolovich","raw_affiliation_strings":["Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073434880","display_name":"Aristidis Michael Tsatsakis","orcid":"https://orcid.org/0000-0003-3824-2462","observed_orcids":["https://orcid.org/0000-0003-3824-2462"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Aristides Tsatsakis","raw_affiliation_strings":["Forensic Medicine Department, Medical School, University of Crete, 71003 Heraklion, Greece"],"raw_orcid":"https://orcid.org/0000-0003-3824-2462","affiliations":[{"raw_affiliation_string":"Forensic Medicine Department, Medical School, University of Crete, 71003 Heraklion, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028052265","display_name":"\u041a\u0443\u0441\u043a\u043e\u0432 \u0410\u043d\u0434\u0440\u0435\u0439 \u041d\u0438\u043a\u043e\u043b\u0430\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0001-8140-2754","observed_orcids":["https://orcid.org/0000-0001-8140-2754"]},"institutions":[{"id":"https://openalex.org/I137587207","display_name":"D. Mendeleyev University of Chemical Technology of Russia","ror":"https://ror.org/05w13qg40","country_code":"RU","type":"education","lineage":["https://openalex.org/I137587207"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Andrey Kuskov","raw_affiliation_strings":["Department of Technology of Chemical Pharmaceutical and Cosmetic Products, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0001-8140-2754","affiliations":[{"raw_affiliation_string":"Department of Technology of Chemical Pharmaceutical and Cosmetic Products, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia","institution_ids":["https://openalex.org/I137587207"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5044109342"],"corresponding_institution_ids":["https://openalex.org/I142617266"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":6.0924,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.98411517,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"16","issue":"22","first_page":"3768","last_page":"3768"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8910999894142151,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8910999894142151,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.08500000089406967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irgd-peptide","display_name":"iRGD peptide","score":1.0},{"id":"https://openalex.org/keywords/cell-penetrating-peptides","display_name":"cell-penetrating peptides","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7360000014305115},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.7179999947547913},{"id":"https://openalex.org/keywords/dual-receptor-targeting","display_name":"dual receptor targeting","score":0.8349999785423279},{"id":"https://openalex.org/keywords/tumor-vascular-permeability","display_name":"tumor vascular permeability","score":0.7139999866485596},{"id":"https://openalex.org/keywords/drug-penetration","display_name":"drug penetration","score":0.5479999780654907},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.7102117538452148},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.61890709400177},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6100365519523621},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5829745531082153},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5340076684951782},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5293455719947815},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5076802968978882},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4347839951515198},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41688498854637146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4105416536331177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3539608120918274},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29435995221138},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2167489230632782},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.15798726677894592},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13105708360671997},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12307277321815491},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/cancers16223768","doi":"https://doi.org/10.3390/cancers16223768","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers16223768","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmid:39594723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39594723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11592346","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11592346","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11592346/pdf/cancers-16-03768.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/cancers16223768","doi":"https://doi.org/10.3390/cancers16223768","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers16223768","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1450070392","display_name":null,"funder_award_id":"23-15-00468","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":167,"referenced_works":["https://openalex.org/W1576773659","https://openalex.org/W1781867156","https://openalex.org/W1825085207","https://openalex.org/W1894181275","https://openalex.org/W1918337600","https://openalex.org/W1964128680","https://openalex.org/W1972135632","https://openalex.org/W1975088956","https://openalex.org/W1981988157","https://openalex.org/W1985416071","https://openalex.org/W1989658253","https://openalex.org/W1993006648","https://openalex.org/W2010320204","https://openalex.org/W2013214195","https://openalex.org/W2019144805","https://openalex.org/W2022084143","https://openalex.org/W2023026872","https://openalex.org/W2025344276","https://openalex.org/W2029773366","https://openalex.org/W2031630601","https://openalex.org/W2033181361","https://openalex.org/W2033278321","https://openalex.org/W2033612573","https://openalex.org/W2035183057","https://openalex.org/W2037418365","https://openalex.org/W2043481243","https://openalex.org/W2044383142","https://openalex.org/W2056688534","https://openalex.org/W2063335180","https://openalex.org/W2064006344","https://openalex.org/W2065051915","https://openalex.org/W2067817921","https://openalex.org/W2069472625","https://openalex.org/W2070994004","https://openalex.org/W2073676627","https://openalex.org/W2076226743","https://openalex.org/W2076859770","https://openalex.org/W2077874637","https://openalex.org/W2079548558","https://openalex.org/W2084925759","https://openalex.org/W2086950114","https://openalex.org/W2088037057","https://openalex.org/W2091394849","https://openalex.org/W2094550799","https://openalex.org/W2107441200","https://openalex.org/W2115124692","https://openalex.org/W2120353663","https://openalex.org/W2123647020","https://openalex.org/W2124523818","https://openalex.org/W2125728464","https://openalex.org/W2137006980","https://openalex.org/W2137480391","https://openalex.org/W2147000598","https://openalex.org/W2147932335","https://openalex.org/W2157200572","https://openalex.org/W2158303916","https://openalex.org/W2163326536","https://openalex.org/W2167357429","https://openalex.org/W2171275402","https://openalex.org/W2186361084","https://openalex.org/W2264334467","https://openalex.org/W2328511806","https://openalex.org/W2344433860","https://openalex.org/W2416156664","https://openalex.org/W2417710457","https://openalex.org/W2419221324","https://openalex.org/W2438888815","https://openalex.org/W2461848956","https://openalex.org/W2512899508","https://openalex.org/W2521355376","https://openalex.org/W2600221025","https://openalex.org/W2649656222","https://openalex.org/W2737081976","https://openalex.org/W2740881791","https://openalex.org/W2749323330","https://openalex.org/W2773944633","https://openalex.org/W2793485037","https://openalex.org/W2867022353","https://openalex.org/W2889029945","https://openalex.org/W2891662274","https://openalex.org/W2901313844","https://openalex.org/W2942294266","https://openalex.org/W2944761160","https://openalex.org/W2952209472","https://openalex.org/W2955459703","https://openalex.org/W2968917807","https://openalex.org/W2989331657","https://openalex.org/W2992566202","https://openalex.org/W2998375205","https://openalex.org/W2999855934","https://openalex.org/W3001744100","https://openalex.org/W3004060585","https://openalex.org/W3021233745","https://openalex.org/W3026323285","https://openalex.org/W3041026308","https://openalex.org/W3042669434","https://openalex.org/W3080874026","https://openalex.org/W3081158869","https://openalex.org/W3082319821","https://openalex.org/W3084190006","https://openalex.org/W3088594225","https://openalex.org/W3097206347","https://openalex.org/W3101861808","https://openalex.org/W3105329007","https://openalex.org/W3113211589","https://openalex.org/W3114990296","https://openalex.org/W3126299920","https://openalex.org/W3128410443","https://openalex.org/W3134197434","https://openalex.org/W3152677481","https://openalex.org/W3176704516","https://openalex.org/W3180233907","https://openalex.org/W3191662917","https://openalex.org/W3201196341","https://openalex.org/W3213583095","https://openalex.org/W4200611067","https://openalex.org/W4205154707","https://openalex.org/W4205951370","https://openalex.org/W4211263609","https://openalex.org/W4220822124","https://openalex.org/W4225158336","https://openalex.org/W4281754067","https://openalex.org/W4283833207","https://openalex.org/W4286297014","https://openalex.org/W4287009821","https://openalex.org/W4289518510","https://openalex.org/W4292996430","https://openalex.org/W4294023672","https://openalex.org/W4296043184","https://openalex.org/W4307049316","https://openalex.org/W4307649467","https://openalex.org/W4307878660","https://openalex.org/W4309786536","https://openalex.org/W4310502906","https://openalex.org/W4315470987","https://openalex.org/W4317035972","https://openalex.org/W4320492438","https://openalex.org/W4321112406","https://openalex.org/W4324092493","https://openalex.org/W4327811722","https://openalex.org/W4360814074","https://openalex.org/W4377965215","https://openalex.org/W4379209844","https://openalex.org/W4379376944","https://openalex.org/W4382679852","https://openalex.org/W4383723318","https://openalex.org/W4383912288","https://openalex.org/W4384694752","https://openalex.org/W4385249069","https://openalex.org/W4386336912","https://openalex.org/W4386602168","https://openalex.org/W4386914374","https://openalex.org/W4387300084","https://openalex.org/W4387434673","https://openalex.org/W4387653564","https://openalex.org/W4391529720","https://openalex.org/W4391716224","https://openalex.org/W4392558605","https://openalex.org/W4393308007","https://openalex.org/W4396554333","https://openalex.org/W4399367088","https://openalex.org/W4399662074","https://openalex.org/W4400735427","https://openalex.org/W4401369094","https://openalex.org/W4402677103","https://openalex.org/W6783649893","https://openalex.org/W7075699175"],"related_works":["https://openalex.org/W4366318089","https://openalex.org/W2068721292","https://openalex.org/W4225584766","https://openalex.org/W2145545797","https://openalex.org/W2764950946","https://openalex.org/W2952148578","https://openalex.org/W2014118959","https://openalex.org/W1585685362","https://openalex.org/W3013564512","https://openalex.org/W3006386809"],"abstract_inverted_index":{"Chemotherapy":[0],"remains":[1],"the":[2,14,49,69,79,83,91,95,106,136,172,181,188,205,209,218,228,252],"primary":[3],"therapeutic":[4,92,109],"approach":[5,103],"in":[6,193,243,256,262],"treating":[7],"cancer.":[8],"The":[9,42,66],"tumor":[10,18,54,151,168,178,206],"microenvironment":[11],"(TME)":[12],"is":[13,74,143],"complex":[15],"network":[16,47],"surrounding":[17],"cells,":[19,27,31,55,169],"comprising":[20],"various":[21],"cell":[22,124],"types,":[23],"such":[24],"as":[25,32,34],"immune":[26,59],"fibroblasts,":[28],"and":[29,39,45,62,158,216,236,239],"endothelial":[30],"well":[33],"ECM":[35],"components,":[36],"blood":[37,191],"vessels,":[38],"signaling":[40],"molecules.":[41],"often":[43],"stiff":[44],"dense":[46],"of":[48,68,71,82,108,141,190,199,220,231,254],"TME":[50],"interacts":[51],"dynamically":[52],"with":[53,132],"influencing":[56],"cancer":[57,263],"growth,":[58],"response,":[60],"metastasis,":[61],"resistance":[63],"to":[64,78,87,122,128,148,175,259,264],"therapy.":[65],"effectiveness":[67],"treatment":[70,266],"solid":[72],"tumors":[73],"frequently":[75],"reduced":[76],"due":[77],"poor":[80],"penetration":[81,215],"drug,":[84],"which":[85,112,170],"leads":[86],"attaining":[88],"concentrations":[89],"below":[90],"levels":[93],"at":[94],"site.":[96],"Cell-penetrating":[97],"peptides":[98],"(CPPs)":[99],"present":[100],"a":[101,119,139],"promising":[102],"that":[104],"improves":[105,217],"internalization":[107],"agents.":[110],"CPPs,":[111,142],"are":[113,164],"short":[114],"amino":[115],"acid":[116],"sequences,":[117],"exhibit":[118],"high":[120],"ability":[121],"pass":[123],"membranes,":[125],"enabling":[126,195],"them":[127],"deliver":[129],"drugs":[130,201],"efficiently":[131],"minimal":[133],"toxicity.":[134],"Specifically,":[135],"iRGD":[137,173,210,229,255],"peptide,":[138],"member":[140],"notable":[144],"for":[145],"its":[146],"capacity":[147],"deeply":[149],"penetrate":[150],"tissues":[152],"by":[153,167],"binding":[154],"simultaneously":[155],"integrins":[156,163],"\u03b1\u03bd\u03b23/\u03b1\u03bd\u03b25":[157,162],"neuropilin":[159],"receptors.":[160],"Indeed,":[161],"characteristically":[165],"expressed":[166],"allows":[171],"peptide":[174,211],"home":[176],"onto":[177],"cells.":[179],"Notably,":[180],"respective":[182],"dual-receptor":[183],"targeting":[184],"mechanism":[185,230],"considerably":[186],"increases":[187],"permeability":[189],"vessels":[192],"tumors,":[194],"an":[196],"efficient":[197],"delivery":[198,234,261],"co-administered":[200,221],"or":[202],"nanoparticles":[203],"into":[204],"mass.":[207],"Therefore,":[208],"facilitates":[212],"deeper":[213],"drug":[214,233,260],"efficacy":[219],"therapies.":[222],"Distinctively,":[223],"we":[224],"will":[225],"focus":[226],"on":[227],"action,":[232],"systems":[235],"their":[237],"application,":[238],"deliberate":[240],"future":[241],"perspectives":[242],"developing":[244],"iRGD-conjugated":[245],"therapeutics.":[246],"In":[247],"summary,":[248],"this":[249],"review":[250],"discusses":[251],"potential":[253],"overcoming":[257],"barriers":[258],"maximize":[265],"efficiency":[267],"while":[268],"minimizing":[269],"side":[270],"effects.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":31},{"year":2025,"cited_by_count":42}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
