{"id":"https://openalex.org/W4404178679","doi":"https://doi.org/10.4049/jimmunol.212.supp.0854.6161","title":"Rapid non-invasive tracking of splenomegaly with hands-free 3D ultrasound for on-demand assessment of immune disorders and cancer","display_name":"Rapid non-invasive tracking of splenomegaly with hands-free 3D ultrasound for on-demand assessment of immune disorders and cancer","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4404178679","doi":"https://doi.org/10.4049/jimmunol.212.supp.0854.6161"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.212.supp.0854.6161","doi":"https://doi.org/10.4049/jimmunol.212.supp.0854.6161","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.0854.6161","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062728145","display_name":"Zachary H. Houston","orcid":"https://orcid.org/0000-0001-9738-4917","observed_orcids":["https://orcid.org/0000-0001-9738-4917"]},"institutions":[{"id":"https://openalex.org/I4405255244","display_name":"Revvity (United States)","ror":"https://ror.org/02sbvqb41","country_code":"US","type":"company","lineage":["https://openalex.org/I43591049","https://openalex.org/I4405255244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary Houston","raw_affiliation_strings":["Revvity"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revvity","institution_ids":["https://openalex.org/I4405255244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038024313","display_name":"Julie Braza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255244","display_name":"Revvity (United States)","ror":"https://ror.org/02sbvqb41","country_code":"US","type":"company","lineage":["https://openalex.org/I43591049","https://openalex.org/I4405255244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Braza","raw_affiliation_strings":["Revvity"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revvity","institution_ids":["https://openalex.org/I4405255244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017090511","display_name":"Jen\u2010Chieh Tseng","orcid":"https://orcid.org/0000-0002-1463-3955","observed_orcids":["https://orcid.org/0000-0002-1463-3955"]},"institutions":[{"id":"https://openalex.org/I4405255244","display_name":"Revvity (United States)","ror":"https://ror.org/02sbvqb41","country_code":"US","type":"company","lineage":["https://openalex.org/I43591049","https://openalex.org/I4405255244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jen-Chieh Tseng","raw_affiliation_strings":["Revvity"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revvity","institution_ids":["https://openalex.org/I4405255244"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alexis Stanley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255244","display_name":"Revvity (United States)","ror":"https://ror.org/02sbvqb41","country_code":"US","type":"company","lineage":["https://openalex.org/I43591049","https://openalex.org/I4405255244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis Stanley","raw_affiliation_strings":["Revvity"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revvity","institution_ids":["https://openalex.org/I4405255244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058653267","display_name":"Craig McMannus","orcid":"https://orcid.org/0000-0001-5364-1512","observed_orcids":["https://orcid.org/0000-0001-5364-1512"]},"institutions":[{"id":"https://openalex.org/I4405255244","display_name":"Revvity (United States)","ror":"https://ror.org/02sbvqb41","country_code":"US","type":"company","lineage":["https://openalex.org/I43591049","https://openalex.org/I4405255244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig McMannus","raw_affiliation_strings":["Revvity"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revvity","institution_ids":["https://openalex.org/I4405255244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060284177","display_name":"Tomasz J. Czernuszewicz","orcid":"https://orcid.org/0000-0002-5493-4058","observed_orcids":["https://orcid.org/0000-0002-5493-4058"]},"institutions":[{"id":"https://openalex.org/I4405255244","display_name":"Revvity (United States)","ror":"https://ror.org/02sbvqb41","country_code":"US","type":"company","lineage":["https://openalex.org/I43591049","https://openalex.org/I4405255244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomasz Czernuszewicz","raw_affiliation_strings":["Revvity"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revvity","institution_ids":["https://openalex.org/I4405255244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056941159","display_name":"Ryan C. Gessner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255244","display_name":"Revvity (United States)","ror":"https://ror.org/02sbvqb41","country_code":"US","type":"company","lineage":["https://openalex.org/I43591049","https://openalex.org/I4405255244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Gessner","raw_affiliation_strings":["Revvity"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revvity","institution_ids":["https://openalex.org/I4405255244"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017239432","display_name":"Jeffrey D. Peterson","orcid":"https://orcid.org/0000-0002-2733-0742","observed_orcids":["https://orcid.org/0000-0002-2733-0742"]},"institutions":[{"id":"https://openalex.org/I4405255244","display_name":"Revvity (United States)","ror":"https://ror.org/02sbvqb41","country_code":"US","type":"company","lineage":["https://openalex.org/I43591049","https://openalex.org/I4405255244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Peterson","raw_affiliation_strings":["Revvity"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revvity","institution_ids":["https://openalex.org/I4405255244"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405255244"],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"212","issue":"1_Supplement","first_page":"0854_6161","last_page":"0854_6161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11738","display_name":"Ultrasound in Clinical Applications","score":0.4528999924659729,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11738","display_name":"Ultrasound in Clinical Applications","score":0.4528999924659729,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.3621000051498413,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.08370000123977661,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.996999979019165},{"id":"https://openalex.org/keywords/spleen-volume","display_name":"spleen volume","score":0.8970000147819519},{"id":"https://openalex.org/keywords/non-invasive-imaging","display_name":"non-invasive imaging","score":0.6579999923706055},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.640999972820282},{"id":"https://openalex.org/keywords/4t1-breast-cancer-model","display_name":"4T1 breast cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/lupus","display_name":"lupus","score":0.781000018119812},{"id":"https://openalex.org/keywords/mrl-lpr-mice","display_name":"MRL/lpr mice","score":0.996999979019165},{"id":"https://openalex.org/keywords/lymphoproliferation","display_name":"lymphoproliferation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/kidney-volume","display_name":"kidney volume","score":0.8849999904632568},{"id":"https://openalex.org/keywords/vessel-density","display_name":"vessel density","score":0.8180000185966492},{"id":"https://openalex.org/keywords/acoustic-angiography","display_name":"acoustic angiography","score":0.9210000038146973},{"id":"https://openalex.org/keywords/disease-progression-monitoring","display_name":"disease progression monitoring","score":0.8059999942779541},{"id":"https://openalex.org/keywords/immune-disorders","display_name":"immune disorders","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.596269428730011},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5829837918281555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5454824566841125},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.5334698557853699},{"id":"https://openalex.org/C2775936607","wikidata":"https://www.wikidata.org/wiki/Q466845","display_name":"Tracking (education)","level":2,"score":0.42687681317329407},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28669866919517517},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.28121164441108704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23942142724990845},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.13444405794143677},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.212.supp.0854.6161","doi":"https://doi.org/10.4049/jimmunol.212.supp.0854.6161","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.0854.6161","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5899999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404052748","https://openalex.org/W4393089007","https://openalex.org/W4409630520","https://openalex.org/W4411166121","https://openalex.org/W4376850372","https://openalex.org/W4206464278","https://openalex.org/W6927081628","https://openalex.org/W4406303883","https://openalex.org/W4224879697","https://openalex.org/W2537968706"],"abstract_inverted_index":{"Abstract":[0],"Splenomegaly":[1],"is":[2],"an":[3],"important":[4],"measure":[5],"of":[6,53,67,112,138,150,192,198,217],"cancer":[7],"progression":[8,200],"and":[9,16,40,75,131,161,220],"immune":[10],"disorders.":[11],"Magnetic":[12],"resonance":[13],"imaging":[14],"(MRI)":[15],"computed":[17],"tomography":[18],"(CT)":[19],"are":[20,27],"the":[21,24,51,64,215],"standard":[22],"in":[23,70,143,152,166,210],"field":[25],"but":[26],"not":[28],"optimal":[29],"for":[30,45,63,181,225],"preclinical":[31],"studies":[32],"due":[33],"to":[34,101,106,123,202],"their":[35],"high":[36],"cost,":[37],"low":[38],"throughput":[39,227],"reliance":[41],"on":[42],"contrast":[43],"agents":[44],"soft":[46],"tissue.":[47],"Here,":[48],"we":[49],"report":[50],"use":[52],"a":[54,162,196],"novel":[55],"3D":[56],"automated":[57],"ultrasound":[58],"scanner":[59],"(Vega,":[60],"Revvity":[61],"Inc.)":[62],"rapid":[65],"assessment":[66],"spleen":[68,145,193],"volume":[69,98,146,159,194],"two":[71],"murine":[72],"models":[73],"(cancer":[74],"lupus).":[76],"Cancer":[77],"cohort:":[78,118],"Tumor-bearing":[79],"(4T1":[80],"breast":[81],"cancer,":[82],"right":[83],"flank)":[84],"mice":[85,90,120,155],"were":[86,121,184],"imaged":[87,133],"alongside":[88],"control":[89],"at":[91],"five":[92],"timepoints":[93],"over":[94],"25":[95,110],"days.":[96],"Spleen":[97],"was":[99,156,169],"found":[100],"increase":[102,142,164],"18-fold":[103],"(30\u00b13":[104],"mm3":[105],"545\u00b1105":[107],"mm3)":[108],"after":[109],"days":[111],"tumor":[113],"growth":[114],"(938\u00b177":[115],"mm3).":[116],"Lupus":[117],"MRL/lpr":[119],"allowed":[122],"age":[124,151],"until":[125,135],"they":[126],"developed":[127],"lymphoproliferation":[128],"(12-14":[129],"weeks)":[130],"then":[132],"biweekly":[134],"20":[136],"weeks":[137,149],"age.":[139],"A":[140],"300-fold":[141],"calculated":[144],"by":[147],"18":[148],"MRL/":[153],"lpr":[154],"observed.":[157],"Kidney":[158],"doubled":[160],"statistical":[163],"(p<0.05)":[165],"vascular":[167],"density":[168],"observed":[170],"(using":[171],"acoustic":[172],"angiography),":[173],"indicating":[174],"systemic":[175],"disease":[176,199],"progression.":[177],"Average":[178],"acquisition":[179],"times":[180],"both":[182],"cohorts":[183],"30":[185],"seconds":[186],"per":[187],"mouse,":[188],"showing":[189],"excellent":[190],"applicability":[191],"as":[195],"measurement":[197],"compared":[201],"more":[203],"laborious":[204],"techniques":[205],"(e.g.":[206],"MRI).":[207],"Future":[208],"work":[209],"this":[211],"area":[212],"will":[213],"explore":[214],"application":[216],"machine":[218],"learning":[219],"AI-assisted":[221],"auto":[222],"segmentation":[223],"tools":[224],"higher":[226],"data":[228],"analysis.":[229]},"counts_by_year":[],"updated_date":"2026-09-22T17:25:34.749102","created_date":"2024-11-09T00:00:00"}