{"id":"https://openalex.org/W4404173608","doi":"https://doi.org/10.4049/jimmunol.212.supp.0627.5497","title":"Neurokinin A reduces the influx of inflammatory cells into the skin in a mast-cell dependent manner","display_name":"Neurokinin A reduces the influx of inflammatory cells into the skin in a mast-cell dependent manner","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4404173608","doi":"https://doi.org/10.4049/jimmunol.212.supp.0627.5497"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.212.supp.0627.5497","doi":"https://doi.org/10.4049/jimmunol.212.supp.0627.5497","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.0627.5497","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Joharis Barreto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joharis Barreto","raw_affiliation_strings":["Univ. of Pittsburgh Sch. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh Sch. of Med","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103783427","display_name":"Shreya Bharadwaj","orcid":"https://orcid.org/0009-0000-5666-3186","observed_orcids":["https://orcid.org/0009-0000-5666-3186"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shreya Bharadwaj","raw_affiliation_strings":["Univ. of Pittsburgh Sch. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh Sch. of Med","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ahnika Hay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahnika Hay","raw_affiliation_strings":["Univ. of Pittsburgh Sch. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh Sch. of Med","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016846535","display_name":"Tina L. Sumpter","orcid":"https://orcid.org/0000-0001-9517-529X","observed_orcids":["https://orcid.org/0000-0001-9517-529X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina Sumpter","raw_affiliation_strings":["Univ. of Pittsburgh Sch. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh Sch. of Med","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"212","issue":"1_Supplement","first_page":"0627_5497","last_page":"0627_5497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurokinin-a","display_name":"neurokinin A","score":0.890999972820282},{"id":"https://openalex.org/keywords/skin-mast-cells","display_name":"skin mast cells","score":0.8429999947547913},{"id":"https://openalex.org/keywords/skin-inflammation","display_name":"skin inflammation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tachykinins","display_name":"tachykinins","score":0.8450000286102295},{"id":"https://openalex.org/keywords/contact-hypersensitivity","display_name":"contact hypersensitivity","score":0.7670000195503235},{"id":"https://openalex.org/keywords/2-4-dinitrofluorobenzene","display_name":"2,4-dinitrofluorobenzene","score":0.7760000228881836},{"id":"https://openalex.org/keywords/inflammatory-monocytes","display_name":"inflammatory monocytes","score":0.9610000252723694},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7210000157356262},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.6690000295639038},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/immune-resolution","display_name":"immune resolution","score":0.5120000243186951},{"id":"https://openalex.org/keywords/mast-cell-deficient-mice","display_name":"mast cell-deficient mice","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.7277442216873169},{"id":"https://openalex.org/C2779655021","wikidata":"https://www.wikidata.org/wiki/Q1907811","display_name":"Mast (botany)","level":3,"score":0.5793609023094177},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5403691530227661},{"id":"https://openalex.org/C2777056410","wikidata":"https://www.wikidata.org/wiki/Q408566","display_name":"Neurokinin A","level":5,"score":0.5040668249130249},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41157734394073486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35439008474349976},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33603227138519287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3336743116378784},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.2162572741508484},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.18450406193733215},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08257454633712769},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05852124094963074}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.212.supp.0627.5497","doi":"https://doi.org/10.4049/jimmunol.212.supp.0627.5497","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.0627.5497","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7300000190734863,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2342470484","https://openalex.org/W4313385592","https://openalex.org/W4319433877","https://openalex.org/W2935701511","https://openalex.org/W2907691876","https://openalex.org/W4313358976","https://openalex.org/W2662489469","https://openalex.org/W2123647567","https://openalex.org/W2039587362","https://openalex.org/W1598070106"],"abstract_inverted_index":{"Abstract":[0],"Cutaneous":[1],"mast":[2,25,129,139,185,203],"cells":[3,26,31,140,204],"promote":[4],"immune":[5,17],"responses":[6],"but":[7,70],"are":[8,27],"also":[9],"involved":[10],"in":[11,15,33,63,73,83,135,137,160,180,183,197],"reducing":[12],"inflammation":[13,62,72,85,179],"and":[14,38,108,113,122,134,155,166,189],"promoting":[16],"resolution.":[18],"Mechanisms":[19],"initiating":[20],"the":[21,46,78,103,126,148,181,198],"anti-inflammatory":[22],"function":[23,80],"of":[24,81,93,97,105,119],"poorly":[28],"defined.":[29],"Mast":[30],"reside":[32],"close":[34],"proximity":[35],"to":[36,100,125,152,205,209],"neurons":[37],"their":[39,207],"activation":[40],"is":[41,53,86],"modulated":[42],"by":[43],"neuropeptides,":[44],"including":[45,110],"tachykinin":[47,56],"family":[48,57],"members.":[49],"Neurokinin":[50],"A":[51],"(NKA)":[52],"an":[54],"understudied":[55],"member":[58],"that":[59,176,200],"limits":[60],"cutaneous":[61,84,211],"a":[64,90,184,191],"murine":[65],"contact":[66],"hypersensitivity":[67],"(CHS)":[68],"model":[69,92],"increases":[71],"colitis.":[74],"In":[75,128],"this":[76],"study,":[77],"regulatory":[79,193],"NKA":[82,98,116,151,163,177,196],"mechanistically":[87],"evaluated":[88],"using":[89],"robust":[91],"DNFB-induced":[94],"CHS.":[95],"Administration":[96],"prior":[99],"sensitization":[101],"inhibited":[102],"expression":[104],"inflammatory":[106,123],"cytokines":[107,154],"chemokines,":[109],"Il1b,":[111],"Il6":[112],"Ccl2.":[114],"Correspondingly,":[115],"reduced":[117],"recruitment":[118],"CCR2+":[120],"neutrophils":[121],"monocytes":[124],"skin.":[127],"cell-deficient":[130],"Mcpt5Cre+":[131],"x":[132,146],"Rosa26DTA":[133],"mice":[136],"which":[138],"do":[141],"not":[142],"produce":[143],"IL-10":[144],"(Mcpt5Cre+":[145],"Il10fl/fl)":[147],"capacity":[149],"for":[150,195],"reduce":[153,210],"chemokines":[156],"was":[157],"diminished.":[158],"Lastly,":[159],"skin":[161,182,199],"explant":[162],"diminished":[164],"IL-1b":[165],"CCL2,":[167],"genes":[168],"upregulated":[169],"after":[170],"DNFB-treatment.":[171],"Collectively,":[172],"these":[173],"data":[174],"suggest":[175],"reduces":[178],"cell/IL-10":[186],"dependent":[187],"manner":[188],"demonstrate":[190],"novel":[192],"pathway":[194],"acts":[201],"on":[202],"unleash":[206],"potential":[208],"inflammation.":[212]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-11-09T00:00:00"}