{"id":"https://openalex.org/W4404172865","doi":"https://doi.org/10.4049/jimmunol.212.supp.0080.5945","title":"Modulation of neuroinflammation by interleukin-10 in mouse microglial cells","display_name":"Modulation of neuroinflammation by interleukin-10 in mouse microglial cells","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4404172865","doi":"https://doi.org/10.4049/jimmunol.212.supp.0080.5945"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.212.supp.0080.5945","doi":"https://doi.org/10.4049/jimmunol.212.supp.0080.5945","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.0080.5945","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048806888","display_name":"Kathryn Nelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149757","display_name":"R&D Systems (United States)","ror":"https://ror.org/05k887p27","country_code":"US","type":"company","lineage":["https://openalex.org/I4210149757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Nelson","raw_affiliation_strings":["R&D Sys., Bio-Techne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Sys., Bio-Techne","institution_ids":["https://openalex.org/I4210149757"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nichole Schrantz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149757","display_name":"R&D Systems (United States)","ror":"https://ror.org/05k887p27","country_code":"US","type":"company","lineage":["https://openalex.org/I4210149757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nichole Schrantz","raw_affiliation_strings":["R&D Sys., Bio-Techne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Sys., Bio-Techne","institution_ids":["https://openalex.org/I4210149757"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jim Rivard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149757","display_name":"R&D Systems (United States)","ror":"https://ror.org/05k887p27","country_code":"US","type":"company","lineage":["https://openalex.org/I4210149757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jim Rivard","raw_affiliation_strings":["R&D Sys., Bio-Techne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Sys., Bio-Techne","institution_ids":["https://openalex.org/I4210149757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114566496","display_name":"Callie Sagarsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149757","display_name":"R&D Systems (United States)","ror":"https://ror.org/05k887p27","country_code":"US","type":"company","lineage":["https://openalex.org/I4210149757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Callie Sagarsky","raw_affiliation_strings":["R&D Sys., Bio-Techne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Sys., Bio-Techne","institution_ids":["https://openalex.org/I4210149757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081466751","display_name":"Rainer Grant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149757","display_name":"R&D Systems (United States)","ror":"https://ror.org/05k887p27","country_code":"US","type":"company","lineage":["https://openalex.org/I4210149757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rainer Grant","raw_affiliation_strings":["R&D Sys., Bio-Techne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Sys., Bio-Techne","institution_ids":["https://openalex.org/I4210149757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114566497","display_name":"Makenna Carlson-Habegger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149757","display_name":"R&D Systems (United States)","ror":"https://ror.org/05k887p27","country_code":"US","type":"company","lineage":["https://openalex.org/I4210149757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Makenna Carlson-Habegger","raw_affiliation_strings":["R&D Sys., Bio-Techne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Sys., Bio-Techne","institution_ids":["https://openalex.org/I4210149757"]}]},{"author_position":"last","author":{"id":null,"display_name":"Megan Larson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149757","display_name":"R&D Systems (United States)","ror":"https://ror.org/05k887p27","country_code":"US","type":"company","lineage":["https://openalex.org/I4210149757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan Larson","raw_affiliation_strings":["R&D Sys., Bio-Techne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Sys., Bio-Techne","institution_ids":["https://openalex.org/I4210149757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210149757"],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"212","issue":"1_Supplement","first_page":"0080_5945","last_page":"0080_5945"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9679999947547913},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bv2-cells","display_name":"BV-2 cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/primary-microglia","display_name":"primary microglia","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.5830000042915344},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.902999997138977},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7979999780654907},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mln4924","display_name":"MLN4924","score":0.949999988079071},{"id":"https://openalex.org/keywords/tofacitinib","display_name":"tofacitinib","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cardamonin","display_name":"cardamonin","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.8629999756813049},{"id":"https://openalex.org/keywords/mcp-1-ccl2","display_name":"CCL2/MCP-1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ccl5-rantes","display_name":"CCL5/RANTES","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8149999976158142},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9120000004768372},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8721047639846802},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6525589227676392},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.611494779586792},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4735400080680847},{"id":"https://openalex.org/C3020625565","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin 1\u03b2","level":4,"score":0.44894102215766907},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.4412325620651245},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.42952263355255127},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40236231684684753},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.354275107383728},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3269481062889099},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.302224338054657},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1993287205696106},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.17808568477630615},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.17450875043869019},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.132094144821167},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.212.supp.0080.5945","doi":"https://doi.org/10.4049/jimmunol.212.supp.0080.5945","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.0080.5945","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2621724054","https://openalex.org/W4415764614","https://openalex.org/W2162390271","https://openalex.org/W2806573774","https://openalex.org/W6962344528","https://openalex.org/W2613996502","https://openalex.org/W1793538934","https://openalex.org/W1957201434","https://openalex.org/W2149071520","https://openalex.org/W2885257639"],"abstract_inverted_index":{"Abstract":[0],"Microglia":[1],"are":[2,11,188],"resident":[3],"macrophages":[4],"of":[5,19,77,98,118,139,174,196],"the":[6,49,116,133,154,194],"central":[7],"nervous":[8],"system":[9],"that":[10],"important":[12],"for":[13,63,192],"maintaining":[14],"brain":[15],"homeostasis.":[16],"Persistent":[17],"activation":[18],"microglia":[20,31,83,178],"is":[21],"associated":[22],"with":[23,52,108],"neuroinflammation":[24,45,197],"in":[25,29,44,48,60,198],"neurodegenerative":[26],"disorders.":[27],"Interest":[28],"immortalized":[30,201],"cell":[32,35,202],"lines":[33],"as":[34,58],"culture":[36],"models":[37],"to":[38,67,81,93],"study":[39],"their":[40],"biology":[41],"and":[42,102,110,126,136,142,150,181,184,200],"role":[43],"has":[46],"increased":[47,172],"past":[50],"decade,":[51],"mouse":[53,69],"microglial":[54,70],"BV-2":[55,78],"cells":[56,79,106],"emerging":[57],"an":[59,176],"vitro":[61],"model":[62],"neuronal":[64],"inflammation":[65],"similar":[66],"primary":[68,82,199],"cells.":[71],"We":[72],"report":[73],"here":[74],"IL-10":[75,95,129,166,170],"pretreatment":[76,96,171],"compared":[80],"from":[84,105],"CD-1":[85],"mice.":[86],"A":[87],"45-plex":[88],"Luminex":[89],"immunoassay":[90],"was":[91],"used":[92],"measure":[94],"attenuation":[97],"TNF-a,":[99,145],"IL-6,":[100,146],"CCL5/RANTES,":[101],"G-CSF":[103],"secretion":[104,138,173],"treated":[107],"IFN-g":[109],"LPS.":[111],"In":[112],"addition,":[113],"we":[114],"demonstrate":[115],"effects":[117],"small":[119],"molecule":[120],"inhibitors":[121],"MLN4924,":[122],"tofacitinib":[123],"(CP":[124],"690550),":[125],"Cardamonin":[127],"on":[128,165],"pretreatment.":[130],"MLN4924":[131],"inhibits":[132,153],"NFkB":[134],"pathway":[135],"decreased":[137],"multiple":[140],"cytokines":[141],"chemokines,":[143],"including":[144],"CCL2/MCP-1,":[147],"CCL5,":[148],"CCL3/MIP-1a,":[149],"CCL4/MIP-1b.":[151],"Tofacitinib":[152],"Jak1/Tyk2-STAT3":[155],"pathway,":[156],"decreasing":[157],"STAT-3":[158],"TYR705":[159],"phosphorylation,":[160],"but":[161],"had":[162],"little":[163],"effect":[164],"cytokine":[167],"suppression.":[168],"Interestingly,":[169],"IL-1ra,":[175],"M2b":[177],"phenotype":[179],"marker,":[180],"chemokines":[182],"CCL2":[183],"CCL3.":[185],"Multiplex":[186],"immunoassays":[187],"a":[189],"valuable":[190],"tool":[191],"investigating":[193],"mechanisms":[195],"lines.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-11-09T00:00:00"}
