{"id":"https://openalex.org/W4404172668","doi":"https://doi.org/10.4049/jimmunol.212.supp.0410.4149","title":"IL-22 is required for preserving tissue integrity and host-microbe homeostasis in the peridontium","display_name":"IL-22 is required for preserving tissue integrity and host-microbe homeostasis in the peridontium","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4404172668","doi":"https://doi.org/10.4049/jimmunol.212.supp.0410.4149"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.212.supp.0410.4149","doi":"https://doi.org/10.4049/jimmunol.212.supp.0410.4149","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.0410.4149","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032490869","display_name":"Gundappa Saha","orcid":"https://orcid.org/0000-0002-5235-3428","observed_orcids":["https://orcid.org/0000-0002-5235-3428"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gundappa Saha","raw_affiliation_strings":["Univ. of Pennsylvania Sch. of Dent. Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pennsylvania Sch. of Dent. Med","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033164005","display_name":"Xiaofei Li","orcid":"https://orcid.org/0000-0002-9585-8661","observed_orcids":["https://orcid.org/0000-0002-9585-8661","https://orcid.org/0009-0009-7142-2386"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofei Li","raw_affiliation_strings":["Univ. of Pennsylvania Sch. of Dent. Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pennsylvania Sch. of Dent. Med","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100386332","display_name":"Lu Li","orcid":"https://orcid.org/0000-0002-7302-8528","observed_orcids":["https://orcid.org/0000-0002-7302-8528","https://orcid.org/0009-0009-1265-9797"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Li","raw_affiliation_strings":["Univ. at Buffalo, SUNY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. at Buffalo, SUNY","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078839621","display_name":"Patricia I. Diaz","orcid":"https://orcid.org/0000-0002-9501-1145","observed_orcids":["https://orcid.org/0000-0002-9501-1145"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Diaz","raw_affiliation_strings":["Univ. at Buffalo, SUNY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. at Buffalo, SUNY","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084031628","display_name":"George Hajishengallis","orcid":"https://orcid.org/0000-0001-7392-8852","observed_orcids":["https://orcid.org/0000-0001-7392-8852"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Hajishengallis","raw_affiliation_strings":["Univ. of Pennsylvania Sch. of Dent. Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pennsylvania Sch. of Dent. Med","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"212","issue":"1_Supplement","first_page":"0410_4149","last_page":"0410_4149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-22","display_name":"IL-22","score":0.9990000128746033},{"id":"https://openalex.org/keywords/periodontal-disease","display_name":"periodontal disease","score":0.9810000061988831},{"id":"https://openalex.org/keywords/periodontium","display_name":"periodontium","score":0.9340000152587891},{"id":"https://openalex.org/keywords/host-microbe-homeostasis","display_name":"host-microbe homeostasis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/periodontal-microbiota","display_name":"periodontal microbiota","score":0.6439999938011169},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.871999979019165},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.7820000052452087},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.996999979019165},{"id":"https://openalex.org/keywords/s100-protein","display_name":"S-100 protein","score":0.953000009059906},{"id":"https://openalex.org/keywords/periodontal-inflammation","display_name":"periodontal inflammation","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.6150788068771362},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5605992078781128},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46458131074905396},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41801977157592773},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.12880292534828186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.212.supp.0410.4149","doi":"https://doi.org/10.4049/jimmunol.212.supp.0410.4149","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.0410.4149","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2591053671","https://openalex.org/W7172014739","https://openalex.org/W2765624283","https://openalex.org/W2185841581","https://openalex.org/W3204381826","https://openalex.org/W2943420193","https://openalex.org/W3047047753","https://openalex.org/W1969746289","https://openalex.org/W1969304029","https://openalex.org/W3000181643"],"abstract_inverted_index":{"Abstract":[0],"Periodontal":[1],"Disease":[2],"(PD)":[3],"is":[4,56],"a":[5,35,152],"dysbiotic":[6],"inflammatory":[7,47],"condition":[8],"of":[9,79,99,129,180],"the":[10,100,130,156,163,177,181],"periodontium":[11],"(tooth-supporting":[12],"tissues)":[13],"that":[14,185],"exerts":[15],"an":[16],"adverse":[17],"impact":[18],"on":[19],"systemic":[20],"health.":[21,194],"IL-22":[22,55,117,147,170,190],"mediates":[23],"unidirectional":[24],"communication":[25],"from":[26],"immune":[27],"cells":[28,32],"to":[29,162,172],"tissue":[30,60,127],"stromal":[31],"and":[33,69,88,92,133,138,143,160],"plays":[34],"key":[36],"role":[37],"in":[38,45,77,103,155,175,189],"promoting":[39],"homeostatic":[40,178],"immunity":[41],"with":[42,123,136,151,167],"some":[43],"implications":[44],"certain":[46],"disorders.":[48],"In":[49],"this":[50],"study,":[51],"we":[52],"investigated":[53],"whether":[54],"required":[57,174],"for":[58],"periodontal":[59,157,182,193],"homeostasis":[61],"at":[62],"steady":[63],"state":[64],"using":[65],"IL-22-deficient":[66],"(IL-22\u2013/\u2013)":[67],"mice":[68,74,106],"IL-22+/+":[70],"littermate":[71],"controls.":[72,115],"The":[73,116],"were":[75],"analyzed":[76],"terms":[78],"disease":[80],"phenotype,":[81],"gingival":[82,126],"transcriptomic":[83],"profile":[84],"(bulk":[85],"RNA":[86],"sequencing":[87],"quantitative":[89],"real-time":[90],"PCR)":[91],"microbiota":[93,164],"composition":[94,165],"(16S":[95],"rRNA":[96],"sequencing).":[97],"Analysis":[98],"bone":[101,112,119],"levels":[102],"10-week-old":[104],"IL-22\u2013/\u2013":[105],"revealed":[107],"significantly":[108,124],"increased":[109,125],"naturally":[110],"occurring":[111],"loss":[113,120],"vs":[114],"deficiency-induced":[118],"was":[121,149],"associated":[122,150],"expression":[128],"pro-inflammatorycytokine":[131],"IL-17":[132],"several":[134],"molecules":[135],"pro-inflammatory":[137],"antimicrobial":[139],"properties":[140],"(e.g.,":[141],"S100":[142],"Reg3":[144],"proteins).":[145],"Moreover,":[146],"deficiency":[148],"significant":[153],"increase":[154],"microbial":[158],"burden":[159],"alterations":[161],"consistent":[166],"dysbiosis.":[168],"Therefore,":[169],"appears":[171],"be":[173],"setting":[176],"tone":[179],"tissue,":[183],"suggesting":[184],"loss-of-function":[186],"genetic":[187],"polymorphisms":[188],"may":[191],"affect":[192]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2024-11-09T00:00:00"}