{"id":"https://openalex.org/W4404172270","doi":"https://doi.org/10.4049/jimmunol.212.supp.0236.4847","title":"Human Immune repertoire and gene expression in pediatric and adult SARS-CoV-2 infected patients using single cell multi-omics approaches","display_name":"Human Immune repertoire and gene expression in pediatric and adult SARS-CoV-2 infected patients using single cell multi-omics approaches","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4404172270","doi":"https://doi.org/10.4049/jimmunol.212.supp.0236.4847"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.212.supp.0236.4847","doi":"https://doi.org/10.4049/jimmunol.212.supp.0236.4847","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.0236.4847","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050399447","display_name":"Xuhuai Ji","orcid":"https://orcid.org/0000-0002-1768-6403","observed_orcids":["https://orcid.org/0000-0002-1768-6403"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"xuhuai ji","raw_affiliation_strings":["Stanford Univ. Sch. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ. Sch. of Med","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019729863","display_name":"Lael M. Yonker","orcid":"https://orcid.org/0000-0003-1711-8227","observed_orcids":["https://orcid.org/0000-0003-1711-8227"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lael Yonker","raw_affiliation_strings":["Massachusetts Gen. Hosp., Harvard Med. Sch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Gen. Hosp., Harvard Med. Sch","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108509708","display_name":"Molly Miranda","orcid":"https://orcid.org/0000-0003-1975-207X","observed_orcids":["https://orcid.org/0000-0003-1975-207X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molly Miranda","raw_affiliation_strings":["Stanford Univ. Sch. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ. Sch. of Med","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103243047","display_name":"Thomas Bernard Kinane","orcid":"https://orcid.org/0000-0002-5668-1066","observed_orcids":["https://orcid.org/0000-0002-5668-1066"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Bernard Kinane","raw_affiliation_strings":["Massachusetts Gen. Hosp., Harvard Med. Sch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Gen. Hosp., Harvard Med. Sch","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056291527","display_name":"Matthew E.K. Chang","orcid":"https://orcid.org/0000-0001-5859-388X","observed_orcids":["https://orcid.org/0000-0001-5859-388X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Chang","raw_affiliation_strings":["BD BioSci"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BD BioSci","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057737880","display_name":"Sundari Suresh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sundari Suresh","raw_affiliation_strings":["Stanford Univ. Sch. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ. Sch. of Med","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Samaneh Kiany","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samaneh Kiany","raw_affiliation_strings":["Stanford Univ. Sch. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ. Sch. of Med","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014258631","display_name":"Katja Gabriele Weinacht","orcid":"https://orcid.org/0000-0002-4907-8293","observed_orcids":["https://orcid.org/0000-0002-4907-8293"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katja Weinacht","raw_affiliation_strings":["Stanford Univ. Sch. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ. Sch. of Med","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068399737","display_name":"Holden Terry Maecker","orcid":"https://orcid.org/0000-0003-0795-9946","observed_orcids":["https://orcid.org/0000-0003-0795-9946","https://orcid.org/0000-0001-5389-0906"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holden Maecker","raw_affiliation_strings":["Stanford Univ. Sch. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ. Sch. of Med","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"212","issue":"1_Supplement","first_page":"0236_4847","last_page":"0236_4847"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.051500000059604645,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.04399999976158142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9620000123977661},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immune-repertoire","display_name":"immune repertoire","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.9079999923706055},{"id":"https://openalex.org/keywords/b-cell-repertoire","display_name":"B cell receptor repertoire","score":1.0},{"id":"https://openalex.org/keywords/single-cell-multi-omics","display_name":"single-cell multi-omics","score":0.7269999980926514},{"id":"https://openalex.org/keywords/pediatric-covid-19","display_name":"pediatric COVID-19","score":0.7289999723434448},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cd14-monocytes","display_name":"CD14+ monocytes","score":0.828000009059906},{"id":"https://openalex.org/keywords/t-cell-clonotypes","display_name":"T cell clonotypes","score":0.722000002861023},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.6702755689620972},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.6375613808631897},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6068257093429565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5908589363098145},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.574876606464386},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5264901518821716},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5133125185966492},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4929647445678711},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.4874120056629181},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48016753792762756},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45749717950820923},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.43145036697387695},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29709678888320923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26561233401298523},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.24060922861099243},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2216845154762268},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1336551010608673},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.10127615928649902},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08865964412689209},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.212.supp.0236.4847","doi":"https://doi.org/10.4049/jimmunol.212.supp.0236.4847","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.0236.4847","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3183269926","https://openalex.org/W3116751540","https://openalex.org/W3213542994","https://openalex.org/W4200078198","https://openalex.org/W4280586623","https://openalex.org/W3020090938","https://openalex.org/W3091531527","https://openalex.org/W4410275609","https://openalex.org/W4286513839","https://openalex.org/W3134078202"],"abstract_inverted_index":{"Abstract":[0],"SARS-CoV-2":[1],"represents":[2],"a":[3,45],"global":[4],"health":[5],"crisis,":[6],"yet":[7,194],"major":[8],"knowledge":[9],"gaps":[10],"remain":[11],"about":[12],"the":[13,18,203],"human":[14],"immune":[15,63,220],"response":[16],"against":[17],"virus":[19,53],"infection":[20,50],"and":[21,27,33,35,51,65,72,79,86,95,118,133,146,164,178,215],"related":[22,36],"treatment":[23],"in":[24,48,68,97,129,175,190,206,222],"both":[25,176],"pediatric":[26,101,177],"adult":[28,99,130,179],"patients.":[29,181],"Immune":[30],"repertoires":[31],"(TCR":[32],"BCR)":[34],"gene":[37,66],"expression":[38,67,82],"at":[39],"massive":[40],"single":[41,57],"cell":[42,58],"level":[43],"play":[44],"crucial":[46],"role":[47],"early-stage":[49],"late":[52],"clearance.":[54],"By":[55],"using":[56,149,160],"multi-omics":[59],"approaches,":[60],"we":[61],"analyzed":[62],"repertoire":[64,148,221],"9":[69],"COVID-19":[70,102,131,180,207],"patients":[71,104,132],"3":[73],"controls.":[74,107],"We":[75,140,182],"used":[76],"single-cell":[77,150],"mRNAseq":[78],"observed":[80],"increased":[81],"of":[83,144],"inflammatory":[84],"cytokines":[85],"transcription":[87],"factors":[88],"such":[89,111],"as":[90,112],"CXCL1,":[91],"RNASE2,":[92],"EGR1,":[93],"CXCL2,":[94],"CXCL8":[96],"either":[98,161],"or":[100,167],"infected":[103],"compared":[105],"to":[106],"Ten":[108],"surface":[109],"proteins":[110],"CD62L,":[113],"CD16,":[114],"CD20,":[115],"CD56,":[116],"CD14,":[117],"CD45RA":[119],"were":[120,126,137,157,173],"quantitated":[121],"by":[122,159],"AbSeq.":[123],"CD14+":[124],"cells":[125,136],"more":[127],"prevalent":[128],"CD3+":[134],"T":[135],"less":[138],"prevalent.":[139],"conducted":[141],"comparative":[142],"analyses":[143],"TCR":[145],"BCR":[147],"V":[151],"(D)J":[152],"sequencing":[153],"approach.":[154],"The":[155,200],"clonotypes":[156,172],"defined":[158],"combined":[162],"alpha":[163],"beta":[165,168],"chains":[166,169],"only.":[170],"Distinct":[171],"identified":[174],"did":[183],"not":[184],"see":[185],"any":[186],"significant":[187],"clonotype":[188],"expansion":[189],"this":[191],"sample":[192],"set":[193],"but":[195],"further":[196],"analysis":[197,217],"is":[198],"warranted.":[199],"combination":[201],"with":[202],"highest":[204],"frequency":[205],"was":[208],"TRAV29-TRBV27.":[209],"Our":[210],"study":[211],"provides":[212],"novel":[213],"insights":[214],"bioinformatic":[216],"tools":[218],"on":[219],"COVID-19.":[223]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-11-09T00:00:00"}
