{"id":"https://openalex.org/W4404171014","doi":"https://doi.org/10.4049/jimmunol.212.supp.1492.6003","title":"Modulating the epigenetic interplay in exhausted CD8 T cells for effective immunotherapy","display_name":"Modulating the epigenetic interplay in exhausted CD8 T cells for effective immunotherapy","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4404171014","doi":"https://doi.org/10.4049/jimmunol.212.supp.1492.6003"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.212.supp.1492.6003","doi":"https://doi.org/10.4049/jimmunol.212.supp.1492.6003","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.1492.6003","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018129944","display_name":"Amir Yousif","orcid":"https://orcid.org/0000-0002-7300-1667","observed_orcids":["https://orcid.org/0000-0002-7300-1667"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amir Yousif","raw_affiliation_strings":["Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069159268","display_name":"Abbey A. Saadey","orcid":"https://orcid.org/0009-0004-8473-1288","observed_orcids":["https://orcid.org/0009-0004-8473-1288"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abbey Saadey","raw_affiliation_strings":["Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069833433","display_name":"Ava M. Lowin","orcid":"https://orcid.org/0009-0004-6630-1364","observed_orcids":["https://orcid.org/0009-0004-6630-1364"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ava Lowin","raw_affiliation_strings":["Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029962747","display_name":"Chelsea Castillo","orcid":"https://orcid.org/0000-0002-0237-7755","observed_orcids":["https://orcid.org/0000-0002-0237-7755"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chelsea Castillo","raw_affiliation_strings":["Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104027578","display_name":"Ankita Saini","orcid":"https://orcid.org/0009-0000-3694-495X","observed_orcids":["https://orcid.org/0009-0000-3694-495X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ankita Saini","raw_affiliation_strings":["Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033742791","display_name":"Wing Keung Chan","orcid":"https://orcid.org/0000-0002-5257-1521","observed_orcids":["https://orcid.org/0000-0002-5257-1521"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wing Chan","raw_affiliation_strings":["Ohio State Univ. Comp. Cancer Ctr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Comp. Cancer Ctr","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054730003","display_name":"Lapo Alinari","orcid":"https://orcid.org/0000-0002-8870-4162","observed_orcids":["https://orcid.org/0000-0002-8870-4162"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lapo Alinari","raw_affiliation_strings":["Ohio State Univ. Comp. Cancer Ctr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Comp. Cancer Ctr","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075965119","display_name":"Amy Webb","orcid":"https://orcid.org/0000-0001-5503-7300","observed_orcids":["https://orcid.org/0000-0001-5503-7300"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Webb","raw_affiliation_strings":["Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076454649","display_name":"Eugene M. Oltz","orcid":"https://orcid.org/0000-0002-2513-7156","observed_orcids":["https://orcid.org/0000-0002-2513-7156"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene Oltz","raw_affiliation_strings":["Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027167333","display_name":"Hazem E. Ghoneim","orcid":"https://orcid.org/0000-0002-9816-4286","observed_orcids":["https://orcid.org/0000-0002-9816-4286"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hazem Ghoneim","raw_affiliation_strings":["Ohio State Univ. Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ. Col. of Med","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"212","issue":"1_Supplement","first_page":"1492_6003","last_page":"1492_6003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4616999924182892,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4616999924182892,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.413100004196167,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.07980000227689743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.8090000152587891},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.8700000047683716},{"id":"https://openalex.org/keywords/histone-modifying-enzymes","display_name":"histone-modifying enzymes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.8799999952316284},{"id":"https://openalex.org/keywords/pd-l1-inhibitors","display_name":"PD-L1 inhibitors","score":0.8960000276565552},{"id":"https://openalex.org/keywords/chronic-viral-infection","display_name":"chronic viral infection","score":0.8069999814033508},{"id":"https://openalex.org/keywords/lymphocytic-choriomeningitis-virus","display_name":"lymphocytic choriomeningitis virus","score":0.8619999885559082},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.7990000247955322},{"id":"https://openalex.org/keywords/crispr-gene-editing","display_name":"CRISPR gene editing","score":0.7960000038146973},{"id":"https://openalex.org/keywords/t-cell-reinvigoration","display_name":"T cell reinvigoration","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7208530902862549},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6738247871398926},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5552642345428467},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.467877596616745},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42872267961502075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3947376608848572},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3458753824234009},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34087079763412476},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.28188198804855347},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22486993670463562},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08697038888931274},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.212.supp.1492.6003","doi":"https://doi.org/10.4049/jimmunol.212.supp.1492.6003","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.1492.6003","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385686967","https://openalex.org/W7171550858","https://openalex.org/W4206700306","https://openalex.org/W4415373288","https://openalex.org/W1998458019","https://openalex.org/W3015331858","https://openalex.org/W4249279146","https://openalex.org/W4313407886","https://openalex.org/W4313585693","https://openalex.org/W3013540258"],"abstract_inverted_index":{"Abstract":[0],"Epigenetic":[1],"imprinting":[2],"of":[3,87,111,172,189,197],"terminal":[4,72,145],"exhaustion":[5,73],"in":[6,84,103,116,125,157],"chronically":[7],"stimulated":[8],"CD8":[9,31,127,190],"T":[10,17,32,45,89,128,160,191,203],"cells":[11,33],"is":[12],"a":[13,100,119],"major":[14],"impediment":[15],"to":[16,50,71,98],"cell":[18,46,90,192,204],"immunotherapies":[19],"during":[20,68,144,178],"chronic":[21,94,179],"viral":[22,180],"infections":[23],"or":[24,122],"cancer.":[25],"Foundational":[26],"work":[27],"establishes":[28],"that":[29,40,139],"exhausted":[30],"(TEX)":[34],"acquire":[35],"heritable":[36],"DNA":[37,66,114,141],"methylation":[38,67,115,142],"programs":[39],"silence":[41],"genes":[42],"critical":[43],"for":[44],"stemness/function,":[47],"restraining":[48],"responses":[49,171],"immune":[51],"checkpoint":[52],"blockade":[53],"(ICB).":[54],"However,":[55],"the":[56,69,93,109,149,169,199],"molecular":[57],"interplay":[58],"between":[59],"histone":[60,106],"post-translational":[61],"modifications":[62],"and":[63,92,155,166,175],"de":[64,112],"novo":[65,113],"progression":[70],"remains":[74],"poorly":[75],"understood.":[76],"To":[77],"address":[78],"this,":[79],"we":[80,130],"employ":[81],"our":[82,183],"novel":[83,186],"vitro":[85],"model":[86,97],"human":[88,126,159],"dysfunction":[91],"LCMV":[95],"infection":[96],"reveal":[99,185],"temporal":[101],"linkage":[102],"which":[104],"progressive":[105],"changes":[107],"prime":[108],"acquisition":[110],"TEX.":[117],"Via":[118],"selective":[120],"inhibitor":[121],"CRISPR":[123],"editing":[124],"cells,":[129],"identify":[131],"specific":[132],"histone-modifying":[133,150],"enzymes":[134,151],"as":[135],"key":[136],"epigenetic":[137,164,187,200],"drivers":[138,188],"orchestrate":[140],"programming":[143],"exhaustion.":[146,205],"Notably,":[147],"targeting":[148,198],"reinvigorated":[152],"effector":[153],"function":[154],"cytotoxicity":[156],"dysfunctional":[158],"cells.":[161],"Moreover,":[162],"combined":[163],"therapy":[165],"anti-PD-L1":[167],"enhanced":[168],"ICB":[170],"both":[173],"progenitor":[174],"cytolytic":[176],"TEX":[177],"infection.":[181],"Collectively,":[182],"findings":[184],"dysfunction,":[193],"supporting":[194],"therapeutic":[195],"potential":[196],"crosstalk":[201],"underpinning":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-11-09T00:00:00"}