{"id":"https://openalex.org/W4404170816","doi":"https://doi.org/10.4049/jimmunol.212.supp.0557.4547","title":"Modulation of IL-13 signal in allergic asthma.","display_name":"Modulation of IL-13 signal in allergic asthma.","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4404170816","doi":"https://doi.org/10.4049/jimmunol.212.supp.0557.4547"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.212.supp.0557.4547","doi":"https://doi.org/10.4049/jimmunol.212.supp.0557.4547","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.0557.4547","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102752494","display_name":"Archana Shankar","orcid":"https://orcid.org/0000-0002-8870-9262","observed_orcids":["https://orcid.org/0000-0002-8870-9262"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Archana Shankar","raw_affiliation_strings":["Cincinnati Children\u2019s Hosp. Med. Ctr","Univ. of Cincinnati Col. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children\u2019s Hosp. Med. Ctr","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Univ. of Cincinnati Col. of Med","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042337733","display_name":"Jaclyn W. McAlees","orcid":"https://orcid.org/0000-0002-2589-5010","observed_orcids":["https://orcid.org/0000-0002-2589-5010"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaclyn McAlees","raw_affiliation_strings":["Cincinnati Children\u2019s Hosp. Med. Ctr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children\u2019s Hosp. Med. Ctr","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058780043","display_name":"Julie M. Hargis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Hargis","raw_affiliation_strings":["Cincinnati Children\u2019s Hosp. Med. Ctr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children\u2019s Hosp. Med. Ctr","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047392866","display_name":"Ian Paul Lewkowich","orcid":"https://orcid.org/0000-0001-8133-3568","observed_orcids":["https://orcid.org/0000-0001-8133-3568"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Lewkowich","raw_affiliation_strings":["Cincinnati Children\u2019s Hosp. Med. Ctr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children\u2019s Hosp. Med. Ctr","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"212","issue":"1_Supplement","first_page":"0557_4547","last_page":"0557_4547"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.052799999713897705,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.8059999942779541},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.953000009059906},{"id":"https://openalex.org/keywords/il-13-signaling","display_name":"IL-13 signaling","score":0.8330000042915344},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.8109999895095825},{"id":"https://openalex.org/keywords/stat6","display_name":"STAT6","score":0.7889999747276306},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.6959999799728394},{"id":"https://openalex.org/keywords/airway-epithelial-cells","display_name":"airway epithelial cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/phosphoproteomics","display_name":"phosphoproteomics","score":0.8460000157356262},{"id":"https://openalex.org/keywords/non-receptor-tyrosine-kinase","display_name":"non-receptor tyrosine kinase","score":0.7710000276565552},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7098937034606934},{"id":"https://openalex.org/C3020633164","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Allergic asthma","level":3,"score":0.6386631727218628},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.5535014867782593},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.544235110282898},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44166359305381775},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34251701831817627},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2821683883666992},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20832392573356628},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.1607673168182373},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.212.supp.0557.4547","doi":"https://doi.org/10.4049/jimmunol.212.supp.0557.4547","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.0557.4547","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416083534","https://openalex.org/W1989882955","https://openalex.org/W2070009273","https://openalex.org/W7095715209","https://openalex.org/W2065801967","https://openalex.org/W2061303778","https://openalex.org/W1991284962","https://openalex.org/W1970681891","https://openalex.org/W1521447050","https://openalex.org/W2162200106"],"abstract_inverted_index":{"Abstract":[0],"Allergic":[1],"asthma,":[2],"a":[3,28,63,79,117,176],"chronic":[4],"airway":[5,65],"inflammatory":[6],"disease":[7],"affecting":[8],"over":[9],"300":[10],"million":[11],"people":[12],"worldwide,":[13],"is":[14,136],"primarily":[15],"driven":[16],"by":[17,50,87],"Th2":[18],"cytokines":[19],"such":[20],"as":[21,116],"interleukin-13":[22],"(IL-13).":[23],"Although":[24],"IL-13":[25,72,141],"signals":[26],"through":[27],"Jak1/Tyk2/STAT6-driven":[29],"pathway,":[30],"activation":[31,132,146,148],"of":[32,46,130,140,149,160,196],"other":[33],"pathways":[34],"has":[35],"been":[36],"reported":[37],"(e.g.,":[38],"STAT3,":[39],"SRC).":[40],"To":[41,58],"better":[42],"understand":[43],"the":[44,194],"totality":[45],"signaling":[47,121,151,178],"intermediates":[48,152],"activated":[49,123,137,180],"IL-13,":[51,184],"we":[52],"employed":[53],"an":[54],"unbiased,":[55],"phospho-proteomics":[56],"approach.":[57],"this":[59],"end":[60],"A549":[61,166],"cells,":[62],"human":[64],"epithelial":[66],"cell":[67],"line,":[68],"were":[69,85,93,98],"stimulated":[70],"with":[71],"for":[73],"15":[74],"minutes,":[75],"and":[76,95,143,185],"peptides":[77],"containing":[78],"phosphorylated":[80],"Serine,":[81],"or":[82],"Threonine":[83],"reside":[84],"identified":[86,115],"mass":[88],"spectrometry.":[89],">1,200":[90],"individual":[91],"phospho-peptides":[92],"identified,":[94],"108":[96],"residues":[97],"found":[99],"to":[100,126,183],"be":[101],"differentially":[102],"phosphorylated.":[103],"Based":[104],"on":[105],"string":[106],"DB":[107],"results,":[108],"SRC":[109,131,156,173,187],"(a":[110],"non-receptor":[111],"tyrosine":[112],"kinase)":[113],"was":[114],"potentially":[118],"novel":[119,177],"IL-13-induced":[120,162],"intermediate":[122,179],"in":[124,164,181,193],"response":[125,182],"IL-13.":[127],"Kinetic":[128],"assessment":[129],"suggested":[133],"that":[134,144,172,186],"it":[135],"within":[138],"seconds":[139],"stimulation,":[142],"its":[145],"preceded":[147],"canonical":[150],"like":[153],"STAT6.":[154],"Functionally,":[155],"antagonists":[157],"reduced":[158],"expression":[159],"multiple":[161],"gene":[163],"IL-13-treated":[165],"cells.":[167],"Collectively,":[168],"these":[169],"data":[170],"suggest":[171],"may":[174,189],"represent":[175],"antagonism":[188],"have":[190],"therapeutic":[191],"benefit":[192],"treatment":[195],"asthma.":[197]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-11-09T00:00:00"}
