{"id":"https://openalex.org/W4404170508","doi":"https://doi.org/10.4049/jimmunol.212.supp.0999.4801","title":"Hyaluronidase 2 induces pathogenicity in Th17 cells","display_name":"Hyaluronidase 2 induces pathogenicity in Th17 cells","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4404170508","doi":"https://doi.org/10.4049/jimmunol.212.supp.0999.4801"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.212.supp.0999.4801","doi":"https://doi.org/10.4049/jimmunol.212.supp.0999.4801","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.0999.4801","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026002521","display_name":"Laxmi Prasad Adhikari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189273616","display_name":"Rosalind Franklin University of Medicine and Science","ror":"https://ror.org/04fegvg32","country_code":"US","type":"education","lineage":["https://openalex.org/I189273616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laxmi Prasad Adhikari","raw_affiliation_strings":["Rosalind Franklin Univ. of Med. and Sci"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosalind Franklin Univ. of Med. and Sci","institution_ids":["https://openalex.org/I189273616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075226865","display_name":"Kaitlyn Woodman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189273616","display_name":"Rosalind Franklin University of Medicine and Science","ror":"https://ror.org/04fegvg32","country_code":"US","type":"education","lineage":["https://openalex.org/I189273616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaitlyn Woodman","raw_affiliation_strings":["Rosalind Franklin Univ. of Med. and Sci"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosalind Franklin Univ. of Med. and Sci","institution_ids":["https://openalex.org/I189273616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066853381","display_name":"Joseph Michael Reynolds","orcid":"https://orcid.org/0000-0003-3490-0544","observed_orcids":["https://orcid.org/0000-0003-3490-0544"]},"institutions":[{"id":"https://openalex.org/I189273616","display_name":"Rosalind Franklin University of Medicine and Science","ror":"https://ror.org/04fegvg32","country_code":"US","type":"education","lineage":["https://openalex.org/I189273616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Reynolds","raw_affiliation_strings":["Rosalind Franklin Univ. of Med. and Sci"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosalind Franklin Univ. of Med. and Sci","institution_ids":["https://openalex.org/I189273616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I189273616"],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"212","issue":"1_Supplement","first_page":"0999_4801","last_page":"0999_4801"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.20080000162124634,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.12080000340938568,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyal2","display_name":"HYAL2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9449999928474426},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.906000018119812},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.5379999876022339},{"id":"https://openalex.org/keywords/th17-differentiation","display_name":"Th17 cell differentiation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/adoptive-transfer","display_name":"adoptive transfer","score":0.8180000185966492},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C64502627","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogenicity","level":2,"score":0.7275280356407166},{"id":"https://openalex.org/C2780375986","wikidata":"https://www.wikidata.org/wiki/Q904015","display_name":"Hyaluronidase","level":3,"score":0.4464600682258606},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.417054682970047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3527766466140747},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3207436203956604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32048457860946655},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11076360940933228},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10576522350311279}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.212.supp.0999.4801","doi":"https://doi.org/10.4049/jimmunol.212.supp.0999.4801","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.212.supp.0999.4801","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416448063","https://openalex.org/W4313368668","https://openalex.org/W1677454726","https://openalex.org/W2261493323","https://openalex.org/W7067509765","https://openalex.org/W7155539866","https://openalex.org/W1979320108","https://openalex.org/W2320514527","https://openalex.org/W3043321092","https://openalex.org/W1862620122"],"abstract_inverted_index":{"Abstract":[0],"Autoreactive":[1],"Th17":[2,25,69,101,113,204],"cells":[3,26,70,114,129,145,175],"express":[4],"high":[5],"levels":[6,154,184],"of":[7,16,24,55,68,90,100,105,127,141,149,155,167,185,200],"inflammatory":[8,64,156],"cytokine":[9],"IL-17A":[10,116],"promoting":[11],"the":[12,95,147,170,178,193,198],"development":[13],"and":[14,29,59,66,81,98,124,195],"progression":[15],"autoimmune":[17,44,72,212],"diseases.":[18,73],"Previous":[19],"studies":[20],"show":[21,85],"that":[22,86,109,161,173],"differentiation":[23,77,97],"with":[27,79],"IL-1":[28],"IL-23":[30],"or":[31],"TLR2":[32],"activation":[33],"drives":[34],"their":[35],"aggressive":[36],"proliferation,":[37],"making":[38],"them":[39],"pathogenic":[40,203],"to":[41,49,132,210],"induce":[42,133,177],"experimental":[43],"encephalomyelitis":[45],"(EAE).":[46],"We":[47],"aim":[48],"study":[50],"a":[51,87,165],"previously":[52],"undefined":[53],"role":[54],"hyaluronic":[56],"acid":[57],"(HA)":[58],"its":[60,82],"modulation":[61],"in":[62,71,75,112,122,135,146],"influencing":[63],"potential":[65],"pathogenicity":[67,168],"Our":[74,158],"vitro":[76],"experiments":[78,189],"HA":[80,91,111,201],"modifying":[83],"enzymes":[84],"baseline":[88],"level":[89,166],"is":[92,130],"essential":[93],"for":[94],"normal":[96],"proliferation":[99,121],"cells.":[102],"The":[103],"overexpression":[104],"hyaluronidase":[106],"2":[107],"(Hyal2)":[108],"cleaves":[110],"decreases":[115],"production":[117],"but":[118],"increases":[119],"cell":[120],"vitro,":[123],"adoptive":[125],"transfer":[126],"these":[128,174],"sufficient":[131],"EAE":[134,150],"mice.":[136],"Furthermore,":[137],"flow":[138],"cytometric":[139],"analysis":[140],"infiltrated":[142],"CD4+":[143],"T":[144],"CNS":[148],"mice":[151],"indicates":[152],"lower":[153],"cytokines.":[157,187],"findings":[159],"suggest":[160],"Hyal2":[162],"itself":[163],"exhibits":[164],"challenging":[169],"prevailing":[171],"paradigm":[172],"can":[176],"disease":[179],"only":[180],"when":[181],"producing":[182],"higher":[183],"encephalitogenic":[186],"Future":[188],"will":[190],"delve":[191],"into":[192],"regulation":[194],"mechanisms":[196],"underlying":[197],"impact":[199],"on":[202],"cells,":[205],"potentially":[206],"identifying":[207],"target":[208],"molecules":[209],"treat":[211],"disorders.":[213]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-11-09T00:00:00"}
