{"id":"https://openalex.org/W4404155513","doi":"https://doi.org/10.1101/2024.11.04.621884","title":"PAIRWISE: Deep Learning based Prediction of Effective Personalized Drug Combinations in Cancer","display_name":"PAIRWISE: Deep Learning based Prediction of Effective Personalized Drug Combinations in Cancer","publication_year":2024,"publication_date":"2024-11-06","ids":{"openalex":"https://openalex.org/W4404155513","doi":"https://doi.org/10.1101/2024.11.04.621884","pmid":"https://pubmed.ncbi.nlm.nih.gov/39574568","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11580853"},"language":"en","primary_location":{"id":"doi:10.1101/2024.11.04.621884","doi":"https://doi.org/10.1101/2024.11.04.621884","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1101/2024.11.04.621884","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-8518203/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102023479","display_name":"Chengqi Xu","orcid":"https://orcid.org/0000-0003-3361-8117","observed_orcids":["https://orcid.org/0000-0003-3361-8117"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chengqi Xu","raw_affiliation_strings":["Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA","Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA","Weill Cornell Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Weill Cornell Medicine","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014192350","display_name":"Ilkay Us","orcid":"https://orcid.org/0000-0003-4573-0210","observed_orcids":["https://orcid.org/0000-0003-4573-0210"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilkay Us","raw_affiliation_strings":["Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007936038","display_name":"Jake Cohen-Setton","orcid":"https://orcid.org/0009-0001-9585-1320","observed_orcids":["https://orcid.org/0009-0001-9585-1320"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jake Cohen-Setton","raw_affiliation_strings":["Oncology Data Science, AstraZeneca, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Data Science, AstraZeneca, Cambridge, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030562190","display_name":"Marta Milo","orcid":"https://orcid.org/0000-0002-6996-6431","observed_orcids":["https://orcid.org/0000-0002-6996-6431"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marta Milo","raw_affiliation_strings":["Oncology Data Science, AstraZeneca, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Data Science, AstraZeneca, Cambridge, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033816209","display_name":"Ben S. Sidders","orcid":"https://orcid.org/0000-0003-2733-3078","observed_orcids":["https://orcid.org/0000-0003-2733-3078"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ben Sidders","raw_affiliation_strings":["Oncology Data Science, AstraZeneca, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Data Science, AstraZeneca, Cambridge, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089462093","display_name":"Jude Fitzgibbon","orcid":"https://orcid.org/0000-0002-9069-1866","observed_orcids":["https://orcid.org/0000-0002-9069-1866","https://orcid.org/0000-0002-4986-8754"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jude Fitzgibbon","raw_affiliation_strings":["Hematology R&D, AstraZeneca, Waltham, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology R&D, AstraZeneca, Waltham, MA, USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019770989","display_name":"Ari M. Melnick","orcid":"https://orcid.org/0000-0002-8074-2287","observed_orcids":["https://orcid.org/0000-0002-8074-2287"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ari M. Melnick","raw_affiliation_strings":["Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054816559","display_name":"Heng Pan","orcid":"https://orcid.org/0000-0002-5407-5687","observed_orcids":["https://orcid.org/0000-0002-5407-5687"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Heng Pan","raw_affiliation_strings":["State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061702711","display_name":"Olivier Elemento","orcid":"https://orcid.org/0000-0002-8061-9617","observed_orcids":["https://orcid.org/0000-0002-8061-9617"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Olivier Elemento","raw_affiliation_strings":["Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA","Weill Cornell Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Weill Cornell Medicine","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023192928","display_name":"Krishna C. Bulusu","orcid":"https://orcid.org/0000-0002-5092-6640","observed_orcids":["https://orcid.org/0000-0002-5092-6640"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Krishna C. Bulusu","raw_affiliation_strings":["Oncology Data Science, AstraZeneca, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0002-5092-6640","affiliations":[{"raw_affiliation_string":"Oncology Data Science, AstraZeneca, Cambridge, UK","institution_ids":["https://openalex.org/I105036370"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5023192928","https://openalex.org/A5054816559","https://openalex.org/A5061702711"],"corresponding_institution_ids":["https://openalex.org/I105036370","https://openalex.org/I4210141942","https://openalex.org/I4387153466"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.9700000286102295},{"id":"https://openalex.org/keywords/transfer-learning","display_name":"transfer learning","score":0.6000000238418579},{"id":"https://openalex.org/keywords/tumor-transcriptome","display_name":"tumor transcriptome","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.9200000166893005},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase-inhibitors","display_name":"BTK inhibitors","score":0.9610000252723694},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9449999928474426},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.7971003651618958},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5614930987358093},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5426831841468811},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5326753854751587},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5108999609947205},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4766693413257599},{"id":"https://openalex.org/C3020340455","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer drugs","level":3,"score":0.4420925974845886},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.43404683470726013},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4333956837654114},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4116944670677185},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3845173120498657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3101230263710022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30868375301361084},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17860975861549377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15270286798477173},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12248343229293823},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11468160152435303}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1101/2024.11.04.621884","doi":"https://doi.org/10.1101/2024.11.04.621884","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1101/2024.11.04.621884","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"doi:10.21203/rs.3.rs-8518203/v1","doi":"https://doi.org/10.21203/rs.3.rs-8518203/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8518203/v1","pdf_url":"https://www.researchsquare.com/article/rs-8518203/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:39574568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39574568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:41646323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41646323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11677522","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12869695","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:11580853","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11580853","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-8518203/v1","doi":"https://doi.org/10.21203/rs.3.rs-8518203/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8518203/v1","pdf_url":"https://www.researchsquare.com/article/rs-8518203/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9508000016212463}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3013966608","display_name":"The identification and validation of mechanisms and biomarkers for relapse in diffuse large B-cell lymphoma","funder_award_id":"R01CA194547","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4061278372","display_name":"Intercepting progression from pre-invasive to invasive lung adenocarcinoma","funder_award_id":"UG3CA244697","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8202621267","display_name":"Mechanism-Based Targeting of Mantle Cell Lymphoma","funder_award_id":"P01CA214274","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000857426","display_name":"Clinical and Translational Science Award","funder_award_id":"UL1TR001873","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000867119","display_name":"Clinical and Translational Science Center","funder_award_id":"UL1TR002384","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334978","display_name":"Beijing Nova Program","ror":"https://ror.org/034k14f91"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404155513.pdf","grobid_xml":"https://content.openalex.org/works/W4404155513.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1578932543","https://openalex.org/W1975147762","https://openalex.org/W2010457001","https://openalex.org/W2038702914","https://openalex.org/W2061136308","https://openalex.org/W2079012552","https://openalex.org/W2187351898","https://openalex.org/W2299045691","https://openalex.org/W2299417213","https://openalex.org/W2554598612","https://openalex.org/W2605510569","https://openalex.org/W2608863179","https://openalex.org/W2610860012","https://openalex.org/W2617974048","https://openalex.org/W2767891136","https://openalex.org/W2774112395","https://openalex.org/W2775061087","https://openalex.org/W2777884179","https://openalex.org/W2791203167","https://openalex.org/W2795686629","https://openalex.org/W2797584152","https://openalex.org/W2811415290","https://openalex.org/W2895489266","https://openalex.org/W2906092989","https://openalex.org/W2912978357","https://openalex.org/W2920837834","https://openalex.org/W2944727022","https://openalex.org/W2949524414","https://openalex.org/W2950860419","https://openalex.org/W2951449549","https://openalex.org/W2960155897","https://openalex.org/W2960677646","https://openalex.org/W2982537632","https://openalex.org/W2992010506","https://openalex.org/W3006386963","https://openalex.org/W3016041832","https://openalex.org/W3092034553","https://openalex.org/W3101620381","https://openalex.org/W3102269903","https://openalex.org/W3127930610","https://openalex.org/W3164087725","https://openalex.org/W3172530361","https://openalex.org/W3177840694","https://openalex.org/W3203908308","https://openalex.org/W4205686435","https://openalex.org/W4206718607","https://openalex.org/W4212966936","https://openalex.org/W4310107747","https://openalex.org/W4366835631","https://openalex.org/W4378470974","https://openalex.org/W4387356945","https://openalex.org/W4401793615","https://openalex.org/W4401793664"],"related_works":["https://openalex.org/W4393088325","https://openalex.org/W4362657842","https://openalex.org/W4381149253","https://openalex.org/W4406298483","https://openalex.org/W2775061087","https://openalex.org/W4223639137","https://openalex.org/W4396720067","https://openalex.org/W2793608852","https://openalex.org/W4311505031","https://openalex.org/W3086347240"],"abstract_inverted_index":{"Abstract":[0],"Combination":[1],"therapies":[2],"offer":[3],"promise":[4],"for":[5,114],"improving":[6],"cancer":[7,28,60,77],"treatment":[8,116],"efficacy":[9],"and":[10,30,41,117],"preventing":[11],"recurrence.":[12],"Preclinical":[13],"screening":[14,131],"strategies":[15],"can":[16],"prioritize":[17],"synergistic":[18,54,100],"drug":[19,57,144],"combinations.":[20],"However,":[21],"identifying":[22],"optimal":[23],"combinations":[24,58,101],"tailored":[25],"to":[26,35,82,140],"specific":[27],"subtypes":[29],"patients":[31],"is":[32],"challenging":[33],"due":[34],"the":[36,136],"vast":[37],"number":[38],"of":[39,56,73,105,138],"possibilities":[40],"tumor":[42,64],"heterogeneity.":[43],"To":[44],"address":[45],"this":[46],"gap,":[47],"we":[48],"developed":[49],"PAIRWISE":[50,66,97,124,139],"which":[51],"explicitly":[52],"modeled":[53],"effects":[55],"in":[59,91,122,129],"cell":[61,78],"lines":[62],"or":[63,111],"samples.":[65],"outperformed":[67],"competing":[68],"models":[69],"with":[70,86,102,120,128],"an":[71,83,103],"AUROC":[72,104],"0.847":[74],"on":[75],"held-out":[76],"lines.":[79],"When":[80],"applied":[81],"independent":[84],"dataset":[85],"Bruton":[87],"Tyrosine":[88],"Kinase":[89],"inhibitors":[90],"Diffuse":[92],"Large":[93],"B":[94],"Cell":[95],"Lymphoma,":[96],"accurately":[98],"predicted":[99],"0.720.":[106],"We":[107],"validated":[108],"30":[109],"approved":[110],"investigational":[112],"agents":[113],"DLBCL":[115],"their":[118],"synergy":[119],"BTKi":[121],"HTS.":[123],"showed":[125],"strong":[126],"concordance":[127],"vitro":[130],"results.":[132],"These":[133],"findings":[134],"demonstrate":[135],"ability":[137],"nominate":[141],"effective":[142],"personalized":[143],"combinations,":[145],"accelerating":[146],"precision":[147],"oncology":[148],"development.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-11-08T00:00:00"}