{"id":"https://openalex.org/W4404136296","doi":"https://doi.org/10.1016/j.bone.2024.117325","title":"Multiple vertebral fractures after antiosteoporotic medications discontinuation: A comparative study to evaluate the potential rebound effect of denosumab","display_name":"Multiple vertebral fractures after antiosteoporotic medications discontinuation: A comparative study to evaluate the potential rebound effect of denosumab","publication_year":2024,"publication_date":"2024-11-07","ids":{"openalex":"https://openalex.org/W4404136296","doi":"https://doi.org/10.1016/j.bone.2024.117325","pmid":"https://pubmed.ncbi.nlm.nih.gov/39521365"},"language":"en","primary_location":{"id":"doi:10.1016/j.bone.2024.117325","doi":"https://doi.org/10.1016/j.bone.2024.117325","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bone.2024.117325","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012677155","display_name":"Mar Mart\u00edn\u2010P\u00e9rez","orcid":"https://orcid.org/0000-0002-5376-2549","observed_orcids":["https://orcid.org/0000-0002-5376-2549"]},"institutions":[{"id":"https://openalex.org/I4210142787","display_name":"Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios","ror":"https://ror.org/043fs9135","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210098440","https://openalex.org/I4210142787"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Mar Mart\u00edn-P\u00e9rez","raw_affiliation_strings":["Pharmacoepidemiology and Pharmacovigilance Department, Spanish Agency of Medicines and Medical Devices (AEMPS), Calle Campezo n\u00b0 1, Edificio 8, 28022 Madrid, Spain. Electronic address: mmmartinp@aemps.es"],"raw_orcid":"https://orcid.org/0000-0002-5376-2549","affiliations":[{"raw_affiliation_string":"Pharmacoepidemiology and Pharmacovigilance Department, Spanish Agency of Medicines and Medical Devices (AEMPS), Calle Campezo n\u00b0 1, Edificio 8, 28022 Madrid, Spain. Electronic address: mmmartinp@aemps.es","institution_ids":["https://openalex.org/I4210142787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114956608","display_name":"Beatriz S\u00e1nchez-Delgado","orcid":"https://orcid.org/0009-0000-1049-1876","observed_orcids":["https://orcid.org/0009-0000-1049-1876"]},"institutions":[{"id":"https://openalex.org/I4210142787","display_name":"Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios","ror":"https://ror.org/043fs9135","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210098440","https://openalex.org/I4210142787"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz S\u00e1nchez-Delgado","raw_affiliation_strings":["Pharmacoepidemiology and Pharmacovigilance Department, Spanish Agency of Medicines and Medical Devices (AEMPS), Calle Campezo n\u00b0 1, Edificio 8, 28022 Madrid, Spain. Electronic address: beatriz.sanchezd@maec.es"],"raw_orcid":"https://orcid.org/0009-0000-1049-1876","affiliations":[{"raw_affiliation_string":"Pharmacoepidemiology and Pharmacovigilance Department, Spanish Agency of Medicines and Medical Devices (AEMPS), Calle Campezo n\u00b0 1, Edificio 8, 28022 Madrid, Spain. Electronic address: beatriz.sanchezd@maec.es","institution_ids":["https://openalex.org/I4210142787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000012394","display_name":"Patricia Garc\u00eda-Poza","orcid":"https://orcid.org/0000-0002-9552-3992","observed_orcids":["https://orcid.org/0000-0002-9552-3992"]},"institutions":[{"id":"https://openalex.org/I4210142787","display_name":"Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios","ror":"https://ror.org/043fs9135","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210098440","https://openalex.org/I4210142787"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Patricia Garc\u00eda-Poza","raw_affiliation_strings":["Pharmacoepidemiology and Pharmacovigilance Department, Spanish Agency of Medicines and Medical Devices (AEMPS), Calle Campezo n\u00b0 1, Edificio 8, 28022 Madrid, Spain. Electronic address: pgarciap@aemps.es"],"raw_orcid":"https://orcid.org/0000-0002-9552-3992","affiliations":[{"raw_affiliation_string":"Pharmacoepidemiology and Pharmacovigilance Department, Spanish Agency of Medicines and Medical Devices (AEMPS), Calle Campezo n\u00b0 1, Edificio 8, 28022 Madrid, Spain. Electronic address: pgarciap@aemps.es","institution_ids":["https://openalex.org/I4210142787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114554921","display_name":"Sergio L\u00f3pez-\u00c1lvarez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2252096349","display_name":"Fujitsu (Japan)","ror":"https://ror.org/038e2g226","country_code":"JP","type":"company","lineage":["https://openalex.org/I2252096349"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sergio L\u00f3pez-\u00c1lvarez","raw_affiliation_strings":["Global CoE of Data Intelligence, Fujitsu, Camino Cerro de los Gamos, 1, 28224, Pozuelo de Alarc\u00f3n, Madrid, Spain. Electronic address: sergio.lopezalvarez@fujitsu.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global CoE of Data Intelligence, Fujitsu, Camino Cerro de los Gamos, 1, 28224, Pozuelo de Alarc\u00f3n, Madrid, Spain. Electronic address: sergio.lopezalvarez@fujitsu.com","institution_ids":["https://openalex.org/I2252096349"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006989637","display_name":"Elisa Mart\u00edn\u2010Merino","orcid":"https://orcid.org/0000-0002-3576-8605","observed_orcids":["https://orcid.org/0000-0002-3576-8605"]},"institutions":[{"id":"https://openalex.org/I4210142787","display_name":"Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios","ror":"https://ror.org/043fs9135","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210098440","https://openalex.org/I4210142787"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elisa Mart\u00edn-Merino","raw_affiliation_strings":["Pharmacoepidemiology and Pharmacovigilance Department, Spanish Agency of Medicines and Medical Devices (AEMPS), Calle Campezo n\u00b0 1, Edificio 8, 28022 Madrid, Spain. Electronic address: emartinm@aemps.es"],"raw_orcid":"https://orcid.org/0000-0002-3576-8605","affiliations":[{"raw_affiliation_string":"Pharmacoepidemiology and Pharmacovigilance Department, Spanish Agency of Medicines and Medical Devices (AEMPS), Calle Campezo n\u00b0 1, Edificio 8, 28022 Madrid, Spain. Electronic address: emartinm@aemps.es","institution_ids":["https://openalex.org/I4210142787"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012677155"],"corresponding_institution_ids":["https://openalex.org/I4210142787"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":null,"fwci":3.1207,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.90455336,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"190","issue":null,"first_page":"117325","last_page":"117325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-vertebral-fractures","display_name":"multiple vertebral fractures","score":0.9610000252723694},{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.8529999852180481},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.781000018119812},{"id":"https://openalex.org/keywords/teriparatide","display_name":"teriparatide","score":0.9049999713897705},{"id":"https://openalex.org/keywords/strontium-ranelate","display_name":"strontium ranelate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.6660000085830688},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.7689999938011169},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/fracture-risk","display_name":"fracture risk","score":0.4830000102519989},{"id":"https://openalex.org/keywords/pharmacoepidemiology","display_name":"pharmacoepidemiology","score":0.7179999947547913},{"id":"https://openalex.org/keywords/spain","display_name":"Spain","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8446335792541504},{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.8335723876953125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6402559280395508},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5504364967346191},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3550609052181244}],"mesh":[{"descriptor_ui":"D000069448","descriptor_name":"Denosumab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000069448","descriptor_name":"Denosumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016103","descriptor_name":"Spinal Fractures","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D019379","descriptor_name":"Teriparatide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019379","descriptor_name":"Teriparatide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bone.2024.117325","doi":"https://doi.org/10.1016/j.bone.2024.117325","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bone.2024.117325","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"},{"id":"pmid:39521365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39521365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1600041372","https://openalex.org/W1970468151","https://openalex.org/W2015350578","https://openalex.org/W2031453471","https://openalex.org/W2033248671","https://openalex.org/W2038375374","https://openalex.org/W2096555945","https://openalex.org/W2134910437","https://openalex.org/W2163058169","https://openalex.org/W2220606005","https://openalex.org/W2467654445","https://openalex.org/W2531903877","https://openalex.org/W2584827529","https://openalex.org/W2594420699","https://openalex.org/W2606524950","https://openalex.org/W2607192853","https://openalex.org/W2743295977","https://openalex.org/W2750743835","https://openalex.org/W2766957057","https://openalex.org/W2771455692","https://openalex.org/W2787273932","https://openalex.org/W2793418708","https://openalex.org/W2939770243","https://openalex.org/W2954352310","https://openalex.org/W2982252132","https://openalex.org/W2985815801","https://openalex.org/W3005832046","https://openalex.org/W3019049808","https://openalex.org/W3046030160","https://openalex.org/W3094494322","https://openalex.org/W3116358764","https://openalex.org/W3120383256","https://openalex.org/W3134532066","https://openalex.org/W3162326693","https://openalex.org/W3178898664","https://openalex.org/W3200474062","https://openalex.org/W3200825747","https://openalex.org/W3205127768","https://openalex.org/W3214276446","https://openalex.org/W4205446266","https://openalex.org/W4224038286","https://openalex.org/W4295152004","https://openalex.org/W4297900878","https://openalex.org/W4311081935","https://openalex.org/W4312660990","https://openalex.org/W4312840855","https://openalex.org/W4365504970","https://openalex.org/W4387340435"],"related_works":["https://openalex.org/W2985815801","https://openalex.org/W2912223367","https://openalex.org/W2787743849","https://openalex.org/W3132139696","https://openalex.org/W4295152004","https://openalex.org/W3175974264","https://openalex.org/W3116358764","https://openalex.org/W2909361549","https://openalex.org/W3178898664","https://openalex.org/W2557028722"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-11-08T00:00:00"}