{"id":"https://openalex.org/W4404128003","doi":"https://doi.org/10.1101/2024.11.07.622519","title":"Rad52 sorts and stacks Rad51 at the DNA junction to promote homologous recombination","display_name":"Rad52 sorts and stacks Rad51 at the DNA junction to promote homologous recombination","publication_year":2024,"publication_date":"2024-11-07","ids":{"openalex":"https://openalex.org/W4404128003","doi":"https://doi.org/10.1101/2024.11.07.622519","pmid":"https://pubmed.ncbi.nlm.nih.gov/39574592","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11580989"},"language":"en","primary_location":{"id":"doi:10.1101/2024.11.07.622519","doi":"https://doi.org/10.1101/2024.11.07.622519","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.11.07.622519","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/2024.11.07.622519","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029759089","display_name":"Jaigeeth Deveryshetty","orcid":"https://orcid.org/0000-0003-1979-4085","observed_orcids":["https://orcid.org/0000-0003-1979-4085"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaigeeth Deveryshetty","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO 63104","Saint Louis University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0003-1979-4085","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO 63104","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Saint Louis University School of Medicine","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064001359","display_name":"Ayush Mistry","orcid":"https://orcid.org/0000-0003-4755-6893","observed_orcids":["https://orcid.org/0000-0003-4755-6893"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayush Mistry","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO 63104","Saint Louis University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0003-4755-6893","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO 63104","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Saint Louis University School of Medicine","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055785947","display_name":"Sushil Pangeni","orcid":"https://orcid.org/0000-0002-6804-8794","observed_orcids":["https://orcid.org/0000-0002-6804-8794"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sushil Pangeni","raw_affiliation_strings":["Department of Biophysics, Johns Hopkins University, Baltimore, MD 21205","Johns Hopkins University"],"raw_orcid":"https://orcid.org/0000-0002-6804-8794","affiliations":[{"raw_affiliation_string":"Department of Biophysics, Johns Hopkins University, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013312751","display_name":"Mohamed Ghoneim","orcid":"https://orcid.org/0000-0003-2889-1039","observed_orcids":["https://orcid.org/0000-0003-2889-1039"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Ghoneim","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO 63104","Saint Louis University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0003-2889-1039","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO 63104","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Saint Louis University School of Medicine","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049391675","display_name":"Monika Tokmina\u2010Lukaszewska","orcid":"https://orcid.org/0000-0003-3298-8298","observed_orcids":["https://orcid.org/0000-0003-3298-8298"]},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Tokmina-Lukaszewska","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717"],"raw_orcid":"https://orcid.org/0000-0003-3298-8298","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717","institution_ids":["https://openalex.org/I23732399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004320475","display_name":"Vikas Kaushik","orcid":"https://orcid.org/0000-0001-6629-7693","observed_orcids":["https://orcid.org/0000-0001-6629-7693"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikas Kaushik","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO 63104","Saint Louis University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0001-6629-7693","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO 63104","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Saint Louis University School of Medicine","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040845783","display_name":"Angela Taddei","orcid":"https://orcid.org/0000-0002-3217-0739","observed_orcids":["https://orcid.org/0000-0002-3217-0739"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210142887","display_name":"Dynamique du noyau","ror":"https://ror.org/04team556","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210142887","https://openalex.org/I80043"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Angela Taddei","raw_affiliation_strings":["Institut Curie, Universit\u00e9 PSL, Sorbonne University, CNRS, Nuclear Dynamics, Paris, France","Institut Curie"],"raw_orcid":"https://orcid.org/0000-0002-3217-0739","affiliations":[{"raw_affiliation_string":"Institut Curie, Universit\u00e9 PSL, Sorbonne University, CNRS, Nuclear Dynamics, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I4210142887","https://openalex.org/I80043"]},{"raw_affiliation_string":"Institut Curie","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090048523","display_name":"Taekjip Ha","orcid":"https://orcid.org/0000-0003-2195-6258","observed_orcids":["https://orcid.org/0000-0003-2195-6258"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taekjip Ha","raw_affiliation_strings":["Howard Hughes Medical Institute, Baltimore, MD, USA","Program in Cellular and Molecular Medicine, Childrens Hospital, Boston, MA","Boston Children's Hospital"],"raw_orcid":"https://orcid.org/0000-0003-2195-6258","affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Baltimore, MD, USA","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Program in Cellular and Molecular Medicine, Childrens Hospital, Boston, MA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Boston Children's Hospital","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059277072","display_name":"Brian B. Bothner","orcid":"https://orcid.org/0000-0003-1295-9609","observed_orcids":["https://orcid.org/0000-0003-1295-9609"]},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Bothner","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717","Montana State University"],"raw_orcid":"https://orcid.org/0000-0003-1295-9609","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717","institution_ids":["https://openalex.org/I23732399"]},{"raw_affiliation_string":"Montana State University","institution_ids":["https://openalex.org/I23732399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083534168","display_name":"Edwin Antony","orcid":"https://orcid.org/0000-0002-1888-054X","observed_orcids":["https://orcid.org/0000-0002-1888-054X"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edwin Antony","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO 63104","Saint Louis University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-1888-054X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO 63104","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Saint Louis University School of Medicine","institution_ids":["https://openalex.org/I47838141"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5083534168"],"corresponding_institution_ids":["https://openalex.org/I47838141"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rad52","display_name":"RAD52","score":0.9760000109672546},{"id":"https://openalex.org/keywords/rad51","display_name":"RAD51","score":0.9959999918937683},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9769999980926514},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8270000219345093},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.6980000138282776},{"id":"https://openalex.org/keywords/dna-junctions","display_name":"DNA junctions","score":0.6200000047683716},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8130000233650208},{"id":"https://openalex.org/keywords/single-molecule-fluorescence-imaging","display_name":"single-molecule fluorescence microscopy","score":0.6110000014305115},{"id":"https://openalex.org/keywords/optical-tweezers","display_name":"optical tweezers","score":0.8659999966621399},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C2779012473","wikidata":"https://www.wikidata.org/wiki/Q3235015","display_name":"RAD51","level":4,"score":0.9047303199768066},{"id":"https://openalex.org/C2776630724","wikidata":"https://www.wikidata.org/wiki/Q18031020","display_name":"RAD52","level":5,"score":0.8434950113296509},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.8094732761383057},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.5774816274642944},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.5066702961921692},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4525264799594879},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.401431143283844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28563714027404785},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16056105494499207}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2024.11.07.622519","doi":"https://doi.org/10.1101/2024.11.07.622519","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.11.07.622519","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:39574592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39574592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11580989","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11580989","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11580989/pdf/nihpp-2024.11.07.622519v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2024.11.07.622519","doi":"https://doi.org/10.1101/2024.11.07.622519","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.11.07.622519","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3011141824","display_name":"Acquisition of an Optima Analytical Ultracentrifuge","funder_award_id":"1s10od030343-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4250843317","display_name":"Ultra Performance Liquid Chromatography Tandem Mass Spectrometer for Metabolomics","funder_award_id":"1s10od028650-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4933603664","display_name":null,"funder_award_id":"S10OD28650","funder_id":"https://openalex.org/F4320306203","funder_display_name":"M.J. Murdock Charitable Trust"},{"id":"https://openalex.org/G515965682","display_name":null,"funder_award_id":"P20GM103474","funder_id":"https://openalex.org/F4320306203","funder_display_name":"M.J. Murdock Charitable Trust"},{"id":"https://openalex.org/G8306589951","display_name":null,"funder_award_id":"S10OD28650","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000866290","display_name":"Coordination of DNA Metabolism by Replication Protein A","funder_award_id":"R35GM149320","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000867577","display_name":"MT INBRE: A Multidisciplinary Research Network","funder_award_id":"P20GM103474","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306203","display_name":"M.J. Murdock Charitable Trust","ror":"https://ror.org/02hxgd925"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404128003.pdf","grobid_xml":"https://content.openalex.org/works/W4404128003.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1521408970","https://openalex.org/W1538419182","https://openalex.org/W1921676712","https://openalex.org/W1967307497","https://openalex.org/W1969839636","https://openalex.org/W1973721031","https://openalex.org/W1975317507","https://openalex.org/W1987988513","https://openalex.org/W1990897819","https://openalex.org/W2012351403","https://openalex.org/W2012635057","https://openalex.org/W2020715816","https://openalex.org/W2029871027","https://openalex.org/W2036685117","https://openalex.org/W2040681936","https://openalex.org/W2041604608","https://openalex.org/W2066616729","https://openalex.org/W2067786593","https://openalex.org/W2068545892","https://openalex.org/W2079659589","https://openalex.org/W2081465448","https://openalex.org/W2084295015","https://openalex.org/W2085544302","https://openalex.org/W2089841991","https://openalex.org/W2104629684","https://openalex.org/W2109879947","https://openalex.org/W2126984010","https://openalex.org/W2133323814","https://openalex.org/W2140036600","https://openalex.org/W2143361185","https://openalex.org/W2148772646","https://openalex.org/W2156003892","https://openalex.org/W2160445124","https://openalex.org/W2169741450","https://openalex.org/W2171775098","https://openalex.org/W2558818939","https://openalex.org/W2736020863","https://openalex.org/W2771890328","https://openalex.org/W2795227812","https://openalex.org/W2854373346","https://openalex.org/W2886597733","https://openalex.org/W2950118063","https://openalex.org/W3042430778","https://openalex.org/W3082190483","https://openalex.org/W3118998329","https://openalex.org/W3128084429","https://openalex.org/W3130496509","https://openalex.org/W3153706506","https://openalex.org/W3172714052","https://openalex.org/W3197825729","https://openalex.org/W3213983027","https://openalex.org/W3214309340","https://openalex.org/W4205310907","https://openalex.org/W4294242824","https://openalex.org/W4320896410","https://openalex.org/W4361219120","https://openalex.org/W4384498466","https://openalex.org/W4385271141","https://openalex.org/W4386033619","https://openalex.org/W4386453372","https://openalex.org/W4387164156","https://openalex.org/W4387377961","https://openalex.org/W4388223682","https://openalex.org/W4391365349","https://openalex.org/W4391818088","https://openalex.org/W4396721167","https://openalex.org/W4399283768","https://openalex.org/W4401610270","https://openalex.org/W4407083549"],"related_works":["https://openalex.org/W4412514882","https://openalex.org/W4319261926","https://openalex.org/W4387377961","https://openalex.org/W3082439163","https://openalex.org/W2955403902","https://openalex.org/W4389553027","https://openalex.org/W2769899187","https://openalex.org/W2006857908","https://openalex.org/W2344511585","https://openalex.org/W2616208596"],"abstract_inverted_index":{"Abstract":[0],"Homologous":[1],"recombination":[2],"(HR)":[3],"repairs":[4],"double-stranded":[5],"DNA":[6,16],"breaks":[7],"(DSBs).":[8],"The":[9,102],"DSBs":[10],"are":[11,19,55,187,195],"resected":[12],"to":[13,42,57,61,180],"yield":[14],"single-stranded":[15],"(ssDNA)":[17],"that":[18,85],"coated":[20],"by":[21],"Replication":[22],"Protein":[23],"A":[24],"(RPA).":[25],"Rad51":[26,59,76,98,104,147,174,178],"is":[27,162],"a":[28,153,199],"recombinase":[29],"and":[30,34,176,185],"catalyzes":[31,146],"strand":[32],"invasion":[33],"the":[35,65,86,90,109,125,166],"search":[36],"for":[37,156,205],"homology.":[38],"However,":[39],"it":[40],"binds":[41],"ssDNA":[43],"with":[44,75,134,152],"lower":[45],"affinity":[46],"than":[47],"RPA.":[48],"Thus,":[49],"mediator":[50,206],"proteins":[51,207],"such":[52],"as":[53],"Rad52/BRCA2":[54],"required":[56],"promote":[58],"binding":[60,80,105,179],"RPA-coated":[62,150,181],"ssDNA,":[63,151],"but":[64,116,158],"underlying":[66],"mechanisms":[67],"remain":[68],"poorly":[69],"understood.":[70],"Saccharomyces":[71],"cerevisiae":[72],"Rad52":[73,94,114,145,169,186],"interacts":[74],"through":[77],"two":[78],"distinct":[79,154],"modes.":[81],"We":[82,197],"here":[83],"uncover":[84],"Rad51-binding":[87],"site":[88,106],"in":[89,108,171,208],"disordered":[91],"C-terminus":[92,167],"of":[93,113,165,168,173,191],"(mode-1)":[95],"sorts":[96],"polydisperse":[97],"into":[99],"discrete":[100],"monomers.":[101],"second":[103],"resides":[107],"ordered":[110],"N-terminal":[111],"ring":[112],"(mode-2),":[115],"this":[117],"interaction":[118],"occurs":[119],"at":[120],"only":[121],"one":[122],"position":[123],"on":[124],"ring.":[126],"In":[127],"single":[128],"molecule":[129],"confocal":[130],"fluorescence":[131],"microscopy":[132],"combined":[133],"optical":[135],"tweezer":[136],"analysis,":[137],"we":[138],"directly":[139],"visualize":[140],"filament":[141,160],"formation":[142],"using":[143],"fluorescent-Rad51.":[144],"loading":[148],"onto":[149],"preference":[155],"junctions,":[157],"no":[159],"growth":[161],"observed.":[163],"Deletion":[164],"results":[170],"loss":[172],"sorting":[175],"abrogates":[177],"DNA.":[182],"While":[183],"BRCA2":[184],"structurally":[188],"unrelated,":[189],"many":[190],"these":[192],"functional":[193],"features":[194],"conserved.":[196],"describe":[198],"concerted":[200],"Sort":[201],"&":[202],"Stack":[203],"mechanism":[204],"promoting":[209],"HR.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-11-08T00:00:00"}
