{"id":"https://openalex.org/W4404126124","doi":"https://doi.org/10.1101/2024.11.05.24316768","title":"An Optimal Mass Transport Model for the Analysis of DCE-MRI and its Application to Breast Cancer Treatment Response","display_name":"An Optimal Mass Transport Model for the Analysis of DCE-MRI and its Application to Breast Cancer Treatment Response","publication_year":2024,"publication_date":"2024-11-07","ids":{"openalex":"https://openalex.org/W4404126124","doi":"https://doi.org/10.1101/2024.11.05.24316768"},"language":"en","primary_location":{"id":"doi:10.1101/2024.11.05.24316768","doi":"https://doi.org/10.1101/2024.11.05.24316768","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2024.11.05.24316768","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/11/07/2024.11.05.24316768.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2024/11/07/2024.11.05.24316768.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047084001","display_name":"Xinan Chen","orcid":"https://orcid.org/0000-0002-2418-5041","observed_orcids":["https://orcid.org/0000-0002-2418-5041"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xinan Chen","raw_affiliation_strings":["Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA","Memorial Sloan Kettering Cancer Center"],"raw_orcid":"https://orcid.org/0000-0002-2418-5041","affiliations":[{"raw_affiliation_string":"Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008791054","display_name":"Wei Gang Huang","orcid":"https://orcid.org/0000-0002-9744-8762","observed_orcids":["https://orcid.org/0000-0002-9744-8762"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4210161005","display_name":"Beaumont Hospital, Troy","ror":"https://ror.org/05x9ffc66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210161005","https://openalex.org/I4392738273"]},{"id":"https://openalex.org/I4210161894","display_name":"Corewell Health Trenton Hospital","ror":"https://ror.org/058sakv40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210161894","https://openalex.org/I4392738273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Huang","raw_affiliation_strings":["Advanced Imaging Research Center, Oregon Health & Science University, Oregon, USA","Department of Radiation Oncology, Corewell Health William Beaumont University Hospital, Michigan, USA","Oregon Health & Science University, Corewell Health William Beaumont\nUniversity Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Imaging Research Center, Oregon Health & Science University, Oregon, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Radiation Oncology, Corewell Health William Beaumont University Hospital, Michigan, USA","institution_ids":["https://openalex.org/I4210161894"]},{"raw_affiliation_string":"Oregon Health & Science University, Corewell Health William Beaumont\nUniversity Hospital","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4210161005","https://openalex.org/I4210161894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045599324","display_name":"Amita Shukla\u2010Dave","orcid":"https://orcid.org/0000-0001-7456-3197","observed_orcids":["https://orcid.org/0000-0001-7456-3197"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amita Shukla-Dave","raw_affiliation_strings":["Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA","Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA","Memorial Sloan Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021807836","display_name":"Ramesh Paudyal","orcid":"https://orcid.org/0000-0003-0302-211X","observed_orcids":["https://orcid.org/0000-0003-0302-211X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramesh Paudyal","raw_affiliation_strings":["Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA","Memorial Sloan Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005471188","display_name":"Roberto Lo Gullo","orcid":"https://orcid.org/0000-0001-6887-292X","observed_orcids":["https://orcid.org/0000-0001-6887-292X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto Lo Gullo","raw_affiliation_strings":["Department of Radiology, Columbia University, New York, USA","Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA","Memorial Sloan Kettering Cancer Center, Columbia University"],"raw_orcid":"https://orcid.org/0000-0001-6887-292X","affiliations":[{"raw_affiliation_string":"Department of Radiology, Columbia University, New York, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, Columbia University","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108386965","display_name":"Marcelina G. Perez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcelina Perez","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA","Memorial Sloan Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013701975","display_name":"Katja Pinker","orcid":"https://orcid.org/0000-0002-2722-7331","observed_orcids":["https://orcid.org/0000-0002-2722-7331"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katja Pinker","raw_affiliation_strings":["Department of Radiology, Columbia University, New York, USA","Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA","Memorial Sloan Kettering Cancer Center, Columbia University"],"raw_orcid":"https://orcid.org/0000-0002-2722-7331","affiliations":[{"raw_affiliation_string":"Department of Radiology, Columbia University, New York, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, Columbia University","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026159944","display_name":"Joseph O. Deasy","orcid":"https://orcid.org/0000-0002-9437-266X","observed_orcids":["https://orcid.org/0000-0002-9437-266X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph O. Deasy","raw_affiliation_strings":["Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA","Memorial Sloan Kettering Cancer Center"],"raw_orcid":"https://orcid.org/0000-0002-9437-266X","affiliations":[{"raw_affiliation_string":"Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5047084001"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dce-mri","display_name":"DCE-MRI","score":0.8740000128746033},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8450000286102295},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.765999972820282},{"id":"https://openalex.org/keywords/contrast-agent-kinetics","display_name":"contrast agent kinetics","score":0.8610000014305115},{"id":"https://openalex.org/keywords/convection-diffusion","display_name":"advection-diffusion","score":0.8240000009536743},{"id":"https://openalex.org/keywords/flow-visualization","display_name":"flow visualization","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tumor-perfusion","display_name":"tumor perfusion","score":0.6079999804496765},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.9020000100135803},{"id":"https://openalex.org/keywords/imaging-biomarkers","display_name":"imaging biomarkers","score":0.8349999785423279},{"id":"https://openalex.org/keywords/computational-fluid-dynamics","display_name":"computational fluid dynamics","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6393781900405884},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4496208429336548},{"id":"https://openalex.org/C2989209122","wikidata":"https://www.wikidata.org/wiki/Q178512","display_name":"Mass transport","level":2,"score":0.43450793623924255},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4292870759963989},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3511331081390381},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3432774543762207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27893394231796265},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.17383894324302673},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.05934375524520874}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2024.11.05.24316768","doi":"https://doi.org/10.1101/2024.11.05.24316768","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2024.11.05.24316768","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/11/07/2024.11.05.24316768.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2024.11.05.24316768","doi":"https://doi.org/10.1101/2024.11.05.24316768","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2024.11.05.24316768","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/11/07/2024.11.05.24316768.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2018489790","display_name":"Multicenter Quantitative MRI Assessment of Breast Cancer Therapy Response","funder_award_id":"R01CA248192","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3978591521","display_name":null,"funder_award_id":"CA008748","funder_id":"https://openalex.org/F4320306260","funder_display_name":"Breast Cancer Research Foundation"},{"id":"https://openalex.org/G4490691666","display_name":"Shutter-Speed Model DCE-MRI for Assessment of Response to Cancer Therapy","funder_award_id":"U01CA154602","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G782458776","display_name":null,"funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320306260","funder_display_name":"Breast Cancer Research Foundation"},{"id":"https://openalex.org/G9000003249","display_name":null,"funder_award_id":"CA008748","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306164","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727"},{"id":"https://openalex.org/F4320306260","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404126124.pdf","grobid_xml":"https://content.openalex.org/works/W4404126124.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1498429448","https://openalex.org/W1525308795","https://openalex.org/W1585160083","https://openalex.org/W1602426655","https://openalex.org/W1976054009","https://openalex.org/W1985506636","https://openalex.org/W1991530707","https://openalex.org/W2022365036","https://openalex.org/W2026027375","https://openalex.org/W2026616100","https://openalex.org/W2032558189","https://openalex.org/W2034612745","https://openalex.org/W2036996178","https://openalex.org/W2042098439","https://openalex.org/W2048590751","https://openalex.org/W2072626310","https://openalex.org/W2093755327","https://openalex.org/W2099303263","https://openalex.org/W2145859152","https://openalex.org/W2161240017","https://openalex.org/W2396647838","https://openalex.org/W2528005577","https://openalex.org/W2626618681","https://openalex.org/W2773521565","https://openalex.org/W2786753426","https://openalex.org/W2809188379","https://openalex.org/W2888590242","https://openalex.org/W2910570496","https://openalex.org/W2911279170","https://openalex.org/W2979750740","https://openalex.org/W2990957769","https://openalex.org/W3010367887","https://openalex.org/W3046908166","https://openalex.org/W3092241499","https://openalex.org/W3095894407","https://openalex.org/W3110744452","https://openalex.org/W3190759848","https://openalex.org/W4220659688","https://openalex.org/W4220932623","https://openalex.org/W4280510990","https://openalex.org/W4288010179","https://openalex.org/W4306893562","https://openalex.org/W4309642842","https://openalex.org/W4310530587","https://openalex.org/W4311186657","https://openalex.org/W4313029060","https://openalex.org/W4317757307","https://openalex.org/W4321019150","https://openalex.org/W4375956000","https://openalex.org/W4386747641","https://openalex.org/W4386864546","https://openalex.org/W4387783876","https://openalex.org/W4388304797","https://openalex.org/W4390011845","https://openalex.org/W4390740076","https://openalex.org/W4392980204","https://openalex.org/W4393408245"],"related_works":["https://openalex.org/W4393408245","https://openalex.org/W4404747334","https://openalex.org/W2955194079","https://openalex.org/W2620907044","https://openalex.org/W1982425190","https://openalex.org/W4396230081","https://openalex.org/W2956017792","https://openalex.org/W2501213755","https://openalex.org/W2032558189","https://openalex.org/W2110029723"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"Dynamic":[2],"contrast-enhanced":[3],"MR":[4],"imaging":[5,189,210],"(DCE-MRI)":[6],"is":[7],"widely":[8],"deployed":[9],"in":[10,171,195,203],"cancer":[11,90,174,209],"care":[12],"and":[13,34,48,112,117,122,132,166,181],"research,":[14],"but":[15,213],"the":[16,28,66,76,119,130],"methods":[17],"conventionally":[18],"used":[19,45,163],"to":[20,46,149,155,164,191,207],"quantify":[21,47,102],"contrast":[22,51,115],"agent":[23,52],"kinetics":[24],"do":[25],"not":[26],"account":[27],"cross-voxel":[29],"movement":[30],"characterized":[31],"by":[32],"advection":[33],"diffusion.":[35],"We":[36,58,74],"hypothesized":[37],"that":[38,145],"unbalanced":[39,67],"optimal":[40,69],"mass":[41,70],"transport":[42,71,105],"could":[43],"be":[44,147,162,184],"visualize":[49,129,167],"such":[50,107],"flows":[53],"across":[54],"tumor":[55,120],"volumes.":[56],"Methods":[57],"developed":[59],"a":[60,79],"computational":[61],"fluid":[62,104,136,169],"dynamics":[63],"model":[64,100,126,160,202],"termed":[65],"regularized":[68],"(urOMT)":[72],"model.":[73],"tested":[75,185],"urOMT":[77,99,125,141,159,201],"on":[78],"multi-institutional":[80],"dataset":[81],"of":[82,114,134,178],"153":[83],"longitudinal":[84],"DCE-MRI":[85,172],"scans":[86],"from":[87,140],"39":[88],"breast":[89,173],"patients":[91,196],"treated":[92,197],"with":[93,198],"neoadjuvant":[94],"chemotherapy":[95],"(NACT.)":[96],"Results":[97],"The":[98,124,158,200],"can":[101,127,161],"dynamic":[103],"properties":[106],"as":[108,186],"net":[109,135],"speed,":[110],"flux":[111],"rates":[113],"entering":[116],"leaving":[118],"(influx":[121],"efflux).":[123],"also":[128],"trajectories":[131],"directions":[133],"flows.":[137],"Quantitative":[138],"metrics":[139],"exhibited":[142],"distinct":[143],"patterns":[144],"may":[146],"relevant":[148],"predicting":[150],"pathological":[151],"complete":[152],"response":[153],"(pCR)":[154],"NACT.":[156,199],"Conclusion":[157],"estimate":[165],"local":[168],"flow":[170],"images.":[175],"Model-based":[176],"estimates":[177],"flux,":[179],"influx":[180],"efflux":[182],"should":[183],"potential":[187],"predictive":[188],"biomarkers":[190],"measure":[192],"treatment":[193],"effectiveness":[194],"principle":[204],"has":[205],"applicability":[206],"other":[208],"use":[211],"cases,":[212],"this":[214],"will":[215],"require":[216],"further":[217],"testing.":[218]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-11-07T00:00:00"}