{"id":"https://openalex.org/W4404099720","doi":"https://doi.org/10.1183/13993003.congress-2024.pa2695","title":"The damage mechanism of intermittent hypoxia in disrupting the circadian rhythm and metabolism of idiopathic pulmonary interstitial fibrosis.","display_name":"The damage mechanism of intermittent hypoxia in disrupting the circadian rhythm and metabolism of idiopathic pulmonary interstitial fibrosis.","publication_year":2024,"publication_date":"2024-09-14","ids":{"openalex":"https://openalex.org/W4404099720","doi":"https://doi.org/10.1183/13993003.congress-2024.pa2695"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2024.pa2695","doi":"https://doi.org/10.1183/13993003.congress-2024.pa2695","is_oa":true,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2024.pa2695","pdf_url":null,"source":{"id":"https://openalex.org/S2898336971","display_name":"Sleep Science","issn_l":"1984-0063","issn":["1984-0063","1984-0659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310312138","host_organization_name":"Brazilian Association of Sleep and Latin American Federation of Sleep Societies","host_organization_lineage":["https://openalex.org/P4310312138"],"host_organization_lineage_names":["Brazilian Association of Sleep and Latin American Federation of Sleep Societies"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep science","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1183/13993003.congress-2024.pa2695","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115592970","display_name":"Dan Liu","orcid":"https://orcid.org/0009-0004-5649-3948","observed_orcids":["https://orcid.org/0009-0004-5649-3948"]},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Liu","raw_affiliation_strings":["1Tianjin Medical University General Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tianjin Medical University General Hospital, Tianjin, China","institution_ids":["https://openalex.org/I2802534033"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111040657","display_name":"Jing Feng","orcid":"https://orcid.org/0000-0003-0604-3581","observed_orcids":["https://orcid.org/0000-0003-0604-3581"]},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Feng","raw_affiliation_strings":["1Tianjin Medical University General Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tianjin Medical University General Hospital, Tianjin, China","institution_ids":["https://openalex.org/I2802534033"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802534033"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA2695","last_page":"PA2695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.024299999698996544,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intermittent-hypoxia","display_name":"intermittent hypoxia","score":0.8880000114440918},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.9509999752044678},{"id":"https://openalex.org/keywords/circadian-rhythm-disruption","display_name":"circadian rhythm disruption","score":0.8730000257492065},{"id":"https://openalex.org/keywords/metabolic-disruption","display_name":"metabolic disruption","score":0.5680000185966492},{"id":"https://openalex.org/keywords/bleomycin-induced-pulmonary-fibrosis","display_name":"bleomycin-induced lung fibrosis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.8980000019073486},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/l-carnitine","display_name":"L-carnitine","score":0.8289999961853027},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7450000047683716},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.699999988079071},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.7186585664749146},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6733297109603882},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5403133034706116},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.47177577018737793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46383437514305115},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.4477059841156006},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.41954505443573},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4127002954483032},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4079104959964752},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3543366491794586},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3203057646751404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2925347089767456},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.17402240633964539},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.1357041895389557},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10594552755355835},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2024.pa2695","doi":"https://doi.org/10.1183/13993003.congress-2024.pa2695","is_oa":true,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2024.pa2695","pdf_url":null,"source":{"id":"https://openalex.org/S2898336971","display_name":"Sleep Science","issn_l":"1984-0063","issn":["1984-0063","1984-0659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310312138","host_organization_name":"Brazilian Association of Sleep and Latin American Federation of Sleep Societies","host_organization_lineage":["https://openalex.org/P4310312138"],"host_organization_lineage_names":["Brazilian Association of Sleep and Latin American Federation of Sleep Societies"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep science","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1183/13993003.congress-2024.pa2695","doi":"https://doi.org/10.1183/13993003.congress-2024.pa2695","is_oa":true,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2024.pa2695","pdf_url":null,"source":{"id":"https://openalex.org/S2898336971","display_name":"Sleep Science","issn_l":"1984-0063","issn":["1984-0063","1984-0659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310312138","host_organization_name":"Brazilian Association of Sleep and Latin American Federation of Sleep Societies","host_organization_lineage":["https://openalex.org/P4310312138"],"host_organization_lineage_names":["Brazilian Association of Sleep and Latin American Federation of Sleep Societies"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep science","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3195765690","https://openalex.org/W2395497249","https://openalex.org/W3153505006","https://openalex.org/W2153916146","https://openalex.org/W2106786363","https://openalex.org/W3014745437","https://openalex.org/W4309181476","https://openalex.org/W2743918347","https://openalex.org/W4372342327","https://openalex.org/W2078658994"],"abstract_inverted_index":{"Clinically,":[0],"IPF":[1],"overlapping":[2,16,173,220],"OSA":[3],"has":[4],"a":[5,118,183,202],"high":[6],"incidence,":[7],"few":[8],"studies":[9],"have":[10],"conducted":[11],"in-depth":[12],"research":[13],"on":[14],"the":[15,27,32,45,50,54,73,100,115,132,169,194,223],"mechanism":[17],"of":[18,87,106,120,127,196],"them.73":[19],"male":[20],"4-6-week-old":[21],"C57":[22],"mouse":[23,40,75,224],"were":[24,81,129,162],"divided":[25,83],"into":[26,84],"normobic":[28],"feeding":[29],"group,":[30],"and":[31,53,90,95,103,159,190,231],"intermittent":[33,58,174,221],"hypoxia(IH)":[34],"group.":[35],"After":[36,70],"14":[37],"days,":[38,72],"some":[39],"underwent":[41],"bleomycin(BLM)":[42],"injection":[43],"for":[44,206],"pulmonary":[46,107,133,207,226],"fibrosis":[47,108,134,209,227],"model.":[48],"On":[49],"second":[51],"day,":[52],"IH":[55,62,68,116,137],"group":[56],"resumed":[57],"hypoxic":[59],"exposure":[60],"(including":[61],"as":[63,65],"well":[64],"BLM":[66,111,146],"+":[67],"groups).":[69],"21":[71],"remaining":[74],"(CTRL,":[76],"BLM,":[77],"IH,":[78],"BLM+":[79],"IH)":[80],"randomly":[82],"two":[85],"groups":[86],"each":[88],"module":[89],"sacrificed":[91],"at":[92,166],"8:00":[93,96],"a.m.":[94],"p.m.IH":[97],"could":[98],"aggravate":[99],"pathological":[101],"damage":[102],"collagen":[104],"synthesis":[105,178],"caused":[109],"by":[110],"in":[112,141,152],"mouse.":[113],"Under":[114],"model,":[117],"variety":[119],"metabolites":[121],"losed":[122],"their":[123],"circadian":[124],"rhythms,":[125],"mainly":[126],"which":[128],"lipids.":[130],"Overlapping":[131],"model":[135,171],"after":[136,172,219],"showed":[138,228],"significant":[139,150],"changes":[140],"metabolic":[142],"pathways.":[143],"At":[144],"night,":[145],"vs":[147],"BLM+IH":[148],"had":[149],"differences":[151],"lipids,":[153],"especially":[154],"fatty":[155,176],"acyl,":[156],"glycerol":[157],"phospholipids,":[158],"sterol":[160],"esters":[161],"most":[163],"obviously":[164],"downregulated":[165],"night.":[167],"In":[168],"bleomycin":[170],"hypoxia,":[175,222],"acid":[177],"is":[179],"inhibited.":[180],"There":[181],"was":[182,215],"positive":[184],"correlation":[185],"between":[186],"3-hydroxydecanoylcarnitine,":[187],"L-caprylylcarnitine,":[188],"oleoylcarnitine,":[189],"tetradecanoylcarnitine,":[191],"suggesting":[192],"that":[193,218],"decline":[195],"these":[197],"four":[198],"substances":[199],"may":[200],"be":[201],"potentially":[203],"specific":[204],"biomarker":[205],"interstitial":[208],"combined":[210],"with":[211,225],"sleep":[212],"apnea.":[213],"It":[214],"also":[216],"suggested":[217],"abnormal":[229],"metabolism":[230],"energy":[232],"supply":[233],"disruption.":[234]},"counts_by_year":[],"updated_date":"2026-09-01T08:31:24.195828","created_date":"2025-10-10T00:00:00"}