{"id":"https://openalex.org/W4404099484","doi":"https://doi.org/10.1183/13993003.congress-2024.pa2994","title":"Sputum cytokine repeatability in COPD","display_name":"Sputum cytokine repeatability in COPD","publication_year":2024,"publication_date":"2024-09-14","ids":{"openalex":"https://openalex.org/W4404099484","doi":"https://doi.org/10.1183/13993003.congress-2024.pa2994"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2024.pa2994","doi":"https://doi.org/10.1183/13993003.congress-2024.pa2994","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2024.pa2994","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway pharmacology and treatment","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.dovepress.com/sputum-cytokine-repeatability-in-copd-peer-reviewed-fulltext-article-COPD","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018565174","display_name":"Alex Mulvanny","orcid":"https://orcid.org/0000-0001-9751-6940","observed_orcids":["https://orcid.org/0000-0001-9751-6940"]},"institutions":[{"id":"https://openalex.org/I4210151016","display_name":"Medicines Evaluation Unit","ror":"https://ror.org/05e497m36","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210151016"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alex Mulvanny","raw_affiliation_strings":["1Medicines Evaluation Unit, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medicines Evaluation Unit, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210151016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051357401","display_name":"Augusta S. Beech","orcid":"https://orcid.org/0000-0002-2690-5364","observed_orcids":["https://orcid.org/0000-0002-2690-5364"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Augusta Beech","raw_affiliation_strings":["2University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tatiana Infante Parra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151016","display_name":"Medicines Evaluation Unit","ror":"https://ror.org/05e497m36","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210151016"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tatiana Infante Parra","raw_affiliation_strings":["1Medicines Evaluation Unit, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medicines Evaluation Unit, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210151016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068917661","display_name":"Dave Singh","orcid":"https://orcid.org/0000-0001-8918-7075","observed_orcids":["https://orcid.org/0000-0001-8918-7075"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dave Singh","raw_affiliation_strings":["2University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA2994","last_page":"PA2994"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sputum-cytokines","display_name":"sputum cytokines","score":0.9369999766349792},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/sputum-supernatant","display_name":"sputum supernatant","score":0.878000020980835},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.5199999809265137},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.7570000290870667},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.6869999766349792},{"id":"https://openalex.org/keywords/mip-1alpha","display_name":"MIP-1\u03b1","score":0.7300000190734863},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7760000228881836},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.6869999766349792},{"id":"https://openalex.org/keywords/eotaxin","display_name":"eotaxin","score":0.781000018119812},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9380000233650208},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C154020017","wikidata":"https://www.wikidata.org/wiki/Q520171","display_name":"Repeatability","level":2,"score":0.7563955187797546},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7470542788505554},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.652729868888855},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4915247857570648},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48748135566711426},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28944525122642517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21270373463630676},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12215358018875122},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10926425457000732},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07674738764762878},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.05374753475189209}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1183/13993003.congress-2024.pa2994","doi":"https://doi.org/10.1183/13993003.congress-2024.pa2994","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2024.pa2994","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway pharmacology and treatment","raw_type":"proceedings-article"},{"id":"pmh:oai:dovepress.com/109142","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/sputum-cytokine-repeatability-in-copd-peer-reviewed-fulltext-article-COPD","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/746e9715-ecc8-4688-b641-50c3e09ec7d1","doi":null,"is_oa":false,"landing_page_url":"https://publons.com/wos-op/publon/73340428/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mulvanny, A, Beech, A, Parra, T I & Singh, D 2024, 'Sputum cytokine repeatability in COPD', European Respiratory Journal. https://doi.org/10.1183/13993003.CONGRESS-2024.PA2994","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:dovepress.com/109142","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/sputum-cytokine-repeatability-in-copd-peer-reviewed-fulltext-article-COPD","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2990980088","https://openalex.org/W4291000621","https://openalex.org/W2331590563","https://openalex.org/W4312865593","https://openalex.org/W2136564431","https://openalex.org/W4225763932","https://openalex.org/W2097547390","https://openalex.org/W7098363143","https://openalex.org/W2008831005","https://openalex.org/W2157187720"],"abstract_inverted_index":{"Background:":[0],"Immunoassays":[1],"are":[2],"commonly":[3],"used":[4],"to":[5,23,31,124],"assess":[6],"airway":[7],"inflammation":[8],"in":[9,27,43,53,129],"sputum":[10,28,55,82,133],"samples":[11,57],"from":[12,58],"COPD":[13,44,59],"patients.":[14],"We":[15],"have":[16],"previously":[17],"validated":[18,73,139],"a":[19,86,130,138],"Luminex":[20,140],"assay":[21],"able":[22],"quantify":[24],"20":[25],"analytes":[26,78,97,109],"supernatant":[29,56,134],"according":[30],"current":[32],"regulatory":[33],"standards":[34],"[1].":[35],"The":[36],"repeatability":[37,105,126],"of":[38,132],"these":[39],"biomarkers":[40,135],"over":[41,127],"time":[42,128],"patients":[45,60],"is":[46],"not":[47],"known.":[48],"Methods:":[49],"Biomarkers":[50],"were":[51,79,114],"measured":[52],"paired":[54],"collected":[61],"6":[62,93,157],"and":[63,68,92],"12":[64,117],"months":[65,94],"apart":[66],"(n=48":[67],"18":[69],"respectively)":[70],"using":[71,137],"the":[72],"assay.":[74,141],"Results:":[75],"14":[76],"panel":[77,131],"detectable.":[80],"Repeated":[81],"biomarker":[83],"measurements":[84],"showed":[85],"significant":[87],"positive":[88],"correlation":[89,100],"between":[90],"baseline":[91],"for":[95,107],"13":[96],"with":[98],"intraclass":[99],"coefficient":[101],"(ICC)":[102],"indicating":[103],"excellent":[104,125],"(>0.75)":[106],"7":[108],"(Table":[110],"1).":[111],"Similar":[112],"results":[113],"observed":[115],"at":[116],"months.":[118],"Conclusion:":[119],"This":[120],"study":[121],"demonstrates":[122],"good":[123],"quantified":[136],"[1]":[142],"Mulvanny,":[143],"A":[144],"et":[145],"al,":[146],"Biomedicines":[147],"2022;":[148],"10,":[149],"1949.":[150],"Table":[151],"1":[152],"erj;64/suppl_68/PA2994/TB1":[153],"T1":[154],"TB1":[155],"Analyte":[156],"Month":[158],"Repeatability":[159],"(n=48)":[160],"Correlations":[161],"(Rho)":[162],"ICC":[163],"IL-1\u03b2":[164],"0.62***":[165],"0.78":[166],"IL-1RA":[167],"0.26":[168],"0.42":[169],"IL-2":[170],"0.67***":[171],"0.80":[172],"IL-4":[173],"0.54***":[174],"0.63":[175],"IL-6":[176],"0.50**":[177,183],"0.72":[178],"IL-8":[179],"0.57***":[180,204],"0.71":[181],"Eotaxin":[182],"0.67":[184],"G-CSF":[185],"0.64***":[186,198],"0.85":[187],"IFN-\u03b3":[188],"0.37*":[189],"0.41":[190],"IP-10":[191],"0.72***":[192,201],"0.83":[193],"MCP-1":[194],"0.44*":[195],"0.55":[196],"MIP-1\u03b1":[197],"0.79":[199,205],"MIP-1\u03b2":[200],"0.86":[202],"TNF-\u03b1":[203],"*p<0.01,":[206],"**p<0.001,":[207],"***p<0.0001":[208]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-11-07T00:00:00"}