{"id":"https://openalex.org/W4404095069","doi":"https://doi.org/10.1016/j.bbamcr.2024.119872","title":"Oncogenic KRAS mutations modulate BAX-mediated cell death","display_name":"Oncogenic KRAS mutations modulate BAX-mediated cell death","publication_year":2024,"publication_date":"2024-11-06","ids":{"openalex":"https://openalex.org/W4404095069","doi":"https://doi.org/10.1016/j.bbamcr.2024.119872","pmid":"https://pubmed.ncbi.nlm.nih.gov/39515665"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbamcr.2024.119872","doi":"https://doi.org/10.1016/j.bbamcr.2024.119872","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamcr.2024.119872","pdf_url":null,"source":{"id":"https://openalex.org/S4210226410","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","issn_l":"0167-4889","issn":["0167-4889","1879-2596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bbamcr.2024.119872","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087163353","display_name":"A I Ferreira","orcid":"https://orcid.org/0000-0002-1417-3418","observed_orcids":["https://orcid.org/0000-0002-1417-3418"]},"institutions":[{"id":"https://openalex.org/I4405252428","display_name":"Centro de Biologia Molecular e Ambiental","ror":"https://ror.org/03m3btt24","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252428"]},{"id":"https://openalex.org/I4405261181","display_name":"Instituto de Ci\u00eancia e Inova\u00e7\u00e3o para a Bio-Sustentabilidade","ror":"https://ror.org/04xhqj302","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405261181","https://openalex.org/I99682543"]},{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Anabela Ferreira","raw_affiliation_strings":["Centre of Molecular and Environmental Biology (CBMA), Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal; Institute of Science and Innovation for Bio-Sustainability (IB-S), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Molecular and Environmental Biology (CBMA), Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal; Institute of Science and Innovation for Bio-Sustainability (IB-S), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal","institution_ids":["https://openalex.org/I4405252428","https://openalex.org/I4405261181","https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033149357","display_name":"St\u00e9phen Manon","orcid":"https://orcid.org/0000-0002-5792-1084","observed_orcids":["https://orcid.org/0000-0002-5792-1084"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210140961","display_name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires","ror":"https://ror.org/048xwe611","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210140961"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phen Manon","raw_affiliation_strings":["UMR5095, CNRS, Universit\u00e9 de Bordeaux, 33000 Bordeaux, France. Electronic address: manon@ibgc.cnrs.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR5095, CNRS, Universit\u00e9 de Bordeaux, 33000 Bordeaux, France. Electronic address: manon@ibgc.cnrs.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210140961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084015389","display_name":"Akand\u00e9 Rouchidane Eyitayo","orcid":"https://orcid.org/0000-0002-2338-5156","observed_orcids":["https://orcid.org/0000-0002-2338-5156"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210140961","display_name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires","ror":"https://ror.org/048xwe611","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210140961"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Akand\u00e9 Rouchidane Eyitayo","raw_affiliation_strings":["UMR5095, CNRS, Universit\u00e9 de Bordeaux, 33000 Bordeaux, France. Electronic address: akande.rouchidane-eyitayo@ibgc.cnrs.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR5095, CNRS, Universit\u00e9 de Bordeaux, 33000 Bordeaux, France. Electronic address: akande.rouchidane-eyitayo@ibgc.cnrs.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210140961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020021717","display_name":"Susana Rodrigues Chaves","orcid":"https://orcid.org/0000-0002-6004-9872","observed_orcids":["https://orcid.org/0000-0002-6004-9872"]},"institutions":[{"id":"https://openalex.org/I4405261181","display_name":"Instituto de Ci\u00eancia e Inova\u00e7\u00e3o para a Bio-Sustentabilidade","ror":"https://ror.org/04xhqj302","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405261181","https://openalex.org/I99682543"]},{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Susana R. Chaves","raw_affiliation_strings":["Centre of Molecular and Environmental Biology (CBMA), Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal; Institute of Science and Innovation for Bio-Sustainability (IB-S), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal. Electronic address: suchaves@bio.uminho.pt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Molecular and Environmental Biology (CBMA), Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal; Institute of Science and Innovation for Bio-Sustainability (IB-S), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal. Electronic address: suchaves@bio.uminho.pt","institution_ids":["https://openalex.org/I4405261181","https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063607135","display_name":"Manuela C\u00f4rte\u2010Real","orcid":"https://orcid.org/0000-0002-1423-1331","observed_orcids":["https://orcid.org/0000-0002-1423-1331"]},"institutions":[{"id":"https://openalex.org/I4405261181","display_name":"Instituto de Ci\u00eancia e Inova\u00e7\u00e3o para a Bio-Sustentabilidade","ror":"https://ror.org/04xhqj302","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405261181","https://openalex.org/I99682543"]},{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Manuela C\u00f4rte-Real","raw_affiliation_strings":["Centre of Molecular and Environmental Biology (CBMA), Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal; Institute of Science and Innovation for Bio-Sustainability (IB-S), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal. Electronic address: mcortereal@bio.uminho.pt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Molecular and Environmental Biology (CBMA), Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal; Institute of Science and Innovation for Bio-Sustainability (IB-S), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal. Electronic address: mcortereal@bio.uminho.pt","institution_ids":["https://openalex.org/I4405261181","https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014938313","display_name":"Ana Preto","orcid":"https://orcid.org/0000-0002-7302-0630","observed_orcids":["https://orcid.org/0000-0002-7302-0630"]},"institutions":[{"id":"https://openalex.org/I4405261181","display_name":"Instituto de Ci\u00eancia e Inova\u00e7\u00e3o para a Bio-Sustentabilidade","ror":"https://ror.org/04xhqj302","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405261181","https://openalex.org/I99682543"]},{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Preto","raw_affiliation_strings":["Centre of Molecular and Environmental Biology (CBMA), Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal; Institute of Science and Innovation for Bio-Sustainability (IB-S), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal. Electronic address: apreto@bio.uminho.pt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Molecular and Environmental Biology (CBMA), Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal; Institute of Science and Innovation for Bio-Sustainability (IB-S), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal. Electronic address: apreto@bio.uminho.pt","institution_ids":["https://openalex.org/I4405261181","https://openalex.org/I99682543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075202441","display_name":"Maria Jo\u00e3o Sousa","orcid":"https://orcid.org/0000-0001-9424-4150","observed_orcids":["https://orcid.org/0000-0001-9424-4150"]},"institutions":[{"id":"https://openalex.org/I4405261181","display_name":"Instituto de Ci\u00eancia e Inova\u00e7\u00e3o para a Bio-Sustentabilidade","ror":"https://ror.org/04xhqj302","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405261181","https://openalex.org/I99682543"]},{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Maria Jo\u00e3o Sousa","raw_affiliation_strings":["Centre of Molecular and Environmental Biology (CBMA), Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal; Institute of Science and Innovation for Bio-Sustainability (IB-S), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal. Electronic address: mjsousa@bio.uminho.pt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Molecular and Environmental Biology (CBMA), Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal; Institute of Science and Innovation for Bio-Sustainability (IB-S), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal. Electronic address: mjsousa@bio.uminho.pt","institution_ids":["https://openalex.org/I4405261181","https://openalex.org/I99682543"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5075202441"],"corresponding_institution_ids":["https://openalex.org/I4405261181","https://openalex.org/I99682543"],"apc_list":{"value":3510,"currency":"USD","value_usd":3510},"apc_paid":{"value":3510,"currency":"USD","value_usd":3510},"fwci":0.4448,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.49928362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"1872","issue":"1","first_page":"119872","last_page":"119872"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9380000233650208},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9639999866485596},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.9390000104904175},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.7429999709129333},{"id":"https://openalex.org/keywords/kras-g12v","display_name":"KRAS G12V","score":0.9929999709129333},{"id":"https://openalex.org/keywords/kras-g13d","display_name":"KRAS G13D","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7179999947547913},{"id":"https://openalex.org/keywords/acetic-acid","display_name":"acetic acid","score":0.7300000190734863},{"id":"https://openalex.org/keywords/yeast-model","display_name":"yeast model","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8409715890884399},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5906915664672852},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.531647264957428},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44347497820854187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42355582118034363},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.41263464093208313},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4050768315792084},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33189302682876587},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.280846506357193}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bbamcr.2024.119872","doi":"https://doi.org/10.1016/j.bbamcr.2024.119872","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamcr.2024.119872","pdf_url":null,"source":{"id":"https://openalex.org/S4210226410","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","issn_l":"0167-4889","issn":["0167-4889","1879-2596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","raw_type":"journal-article"},{"id":"pmid:39515665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39515665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta. Molecular cell research","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04299505v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04299505v1/document","pdf_url":"https://hal.science/hal-04299505/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochimica et Biophysica Acta - Molecular Cell Research, 2024, 1872, pp.119872. &#x27E8;10.1016/j.bbamcr.2024.119872&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorium.uminho.pt:1822/101207","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/101207","pdf_url":"https://repositorium.uminho.pt/bitstreams/6bf7ed7d-66ae-47e2-92a1-2246bfbce55c/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1016/j.bbamcr.2024.119872","doi":"https://doi.org/10.1016/j.bbamcr.2024.119872","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamcr.2024.119872","pdf_url":null,"source":{"id":"https://openalex.org/S4210226410","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","issn_l":"0167-4889","issn":["0167-4889","1879-2596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2862788351","display_name":"The role of Bcl-2 protein family and Beclin-1 in KRAS-mediated regulation of apoptosis/autophagy using yeast and colorectal cancer as models","funder_award_id":"COVID/BD/153012/2022","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3471088420","display_name":null,"funder_award_id":"2022\\u20132023","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5454278309","display_name":null,"funder_award_id":"/2017","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5590178551","display_name":"The role of Bcl-2 protein family and Beclin-1 in KRAS-mediated regulation of apoptosis/autophagy using yeast and colorectal cancer as models","funder_award_id":"SFRH/BD/142486/2018","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G618120736","display_name":null,"funder_award_id":"2022\\u20132023 - 2021.09253","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G8063566437","display_name":"Combate aos cancros metast\u00e1ticos: o palco \u00e9 do rut\u00e9nio","funder_award_id":"PTDC/QUI-QIN/28662/2017","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320318579","display_name":"China Building Materials Academy","ror":"https://ror.org/020q9r015"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404095069.pdf","grobid_xml":"https://content.openalex.org/works/W4404095069.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1775749144","https://openalex.org/W1827289386","https://openalex.org/W1870460044","https://openalex.org/W1946100424","https://openalex.org/W1946591681","https://openalex.org/W1980345051","https://openalex.org/W1980644634","https://openalex.org/W1992304591","https://openalex.org/W1994924949","https://openalex.org/W1996952569","https://openalex.org/W2000093730","https://openalex.org/W2001258296","https://openalex.org/W2001746497","https://openalex.org/W2003138081","https://openalex.org/W2004098285","https://openalex.org/W2018821302","https://openalex.org/W2021817438","https://openalex.org/W2027044610","https://openalex.org/W2030760558","https://openalex.org/W2033093469","https://openalex.org/W2033873142","https://openalex.org/W2035176534","https://openalex.org/W2037471311","https://openalex.org/W2049186397","https://openalex.org/W2058374459","https://openalex.org/W2063349947","https://openalex.org/W2063582775","https://openalex.org/W2071523919","https://openalex.org/W2079513929","https://openalex.org/W2098210382","https://openalex.org/W2107951449","https://openalex.org/W2134872883","https://openalex.org/W2140318778","https://openalex.org/W2140860403","https://openalex.org/W2147001490","https://openalex.org/W2161475018","https://openalex.org/W2522907513","https://openalex.org/W2557651986","https://openalex.org/W2792018238","https://openalex.org/W2885738414","https://openalex.org/W2922251729","https://openalex.org/W2950829626","https://openalex.org/W4220657294","https://openalex.org/W4306955728","https://openalex.org/W4307921919","https://openalex.org/W6638687431","https://openalex.org/W6651490244"],"related_works":["https://openalex.org/W7024376834","https://openalex.org/W7084310620","https://openalex.org/W4285393971","https://openalex.org/W2298104452","https://openalex.org/W2891666832","https://openalex.org/W4391130928","https://openalex.org/W7098226891","https://openalex.org/W4313490766","https://openalex.org/W4310572294","https://openalex.org/W2593124968"],"abstract_inverted_index":{"Kirsten":[0],"rat":[1],"sarcoma":[2],"viral":[3],"oncogene":[4],"homolog":[5],"(KRAS)":[6],"belongs":[7],"to":[8,70,159,177,240,245],"the":[9,20,34,59,72,79,88,98,109,124,190,230],"GTPase":[10],"RAS":[11,48,112],"superfamily,":[12],"which":[13],"regulates":[14],"several":[15],"cell-signaling":[16],"pathways":[17],"involved":[18],"in":[19,30,64,78,108,130,149,210,258],"control":[21],"of":[22,42,61,74,81,87,97,171,233,249],"important":[23],"cellular":[24],"functions,":[25],"including":[26],"apoptosis.":[27],"Oncogenic":[28],"mutations":[29,63,128],"KRAS":[31,62,77,119,127,133,136,139,152,155,174,217,221,251],"are":[32],"considered":[33],"most":[35,125],"common":[36],"gain-of-function":[37],"mutations,":[38],"affecting":[39],"30\u201350":[40],"%":[41],"colorectal":[43],"cancer":[44],"(CRC)":[45],"patients.":[46],"While":[47],"proteins":[49],"usually":[50],"play":[51],"an":[52],"anti-apoptotic":[53],"role,":[54],"little":[55],"is":[56,194],"known":[57],"about":[58],"involvement":[60],"apoptosis":[65],"regulation.":[66],"Here,":[67],"we":[68,94],"aimed":[69],"elucidate":[71],"role":[73],"mutated":[75],"human":[76,144],"regulation":[80],"BAX,":[82],"a":[83,180,226,237,246,255],"key":[84],"pro-apoptotic":[85],"member":[86],"Bcl-2":[89],"family.":[90],"For":[91],"this":[92],"purpose,":[93],"took":[95],"advantage":[96],"simpler":[99],"yeast":[100,111],"model":[101],"Saccharomyces":[102],"cerevisiae":[103],",":[104,135,141,154],"using":[105],"cells":[106,211,235],"deficient":[107],"main":[110],"isoform":[113],"(":[114],"ras2":[115],"\u0394)":[116],"co-expressing":[117,215],"wild-type":[118],"(KRAS":[120],"WT":[121,153,222],")":[122,167],"or":[123,138],"frequent":[126],"found":[129],"CRC":[131,234],"-":[132],"G12D":[134],"G12V":[137],"G13D":[140],"along":[142],"with":[143,151],"BAX.":[145],"We":[146,200],"show":[147,202],"that,":[148],"comparison":[150],"mutants":[156],"confer":[157],"resistance":[158],"BAX-induced":[160],"death":[161,209],"and":[162,192,214],"cytochrome":[163],"c":[164,166],"(cyt":[165],"release.":[168],"The":[169],"modulation":[170],"BAX":[172,213,253],"by":[173],"isoforms":[175],"seems":[176],"result":[178],"from":[179],"direct":[181],"interaction":[182],"between":[183],"these":[184],"proteins,":[185],"as":[186],"they":[187,196],"co-localize":[188],"at":[189],"mitochondria":[191],"there":[193],"evidence":[195],"may":[197],"physically":[198],"interact.":[199],"further":[201],"that":[203],"acetic":[204],"acid":[205],"significantly":[206],"increased":[207,231],"cell":[208],"expressing":[212],"oncogenic":[216],"mutants,":[218],"but":[219],"not":[220],".":[223],"This":[224],"suggests":[225],"potential":[227],"mechanism":[228],"explaining":[229],"sensitivity":[232],"harboring":[236],"KRAS-activated":[238],"pathway":[239],"acetate.":[241],"These":[242],"findings":[243],"contribute":[244],"clearer":[247],"understanding":[248],"how":[250],"regulate":[252],"function,":[254],"relevant":[256],"aspect":[257],"tumor":[259],"progression.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2024-11-07T00:00:00"}
