{"id":"https://openalex.org/W4404064493","doi":"https://doi.org/10.1136/jitc-2024-sitc2024.0806","title":"806 Anti-tumor efficacy of ADT in combination with AR targeted therapies and anti-PD-1 is limited by regulatory T cells in murine prostate models","display_name":"806 Anti-tumor efficacy of ADT in combination with AR targeted therapies and anti-PD-1 is limited by regulatory T cells in murine prostate models","publication_year":2024,"publication_date":"2024-11-01","ids":{"openalex":"https://openalex.org/W4404064493","doi":"https://doi.org/10.1136/jitc-2024-sitc2024.0806"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2024-sitc2024.0806","doi":"https://doi.org/10.1136/jitc-2024-sitc2024.0806","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2024-sitc2024.0806","pdf_url":null,"source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1136/jitc-2024-sitc2024.0806","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070521827","display_name":"Anusha Muralidhar","orcid":"https://orcid.org/0000-0002-6710-1266","observed_orcids":["https://orcid.org/0000-0002-6710-1266"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anusha Muralidhar","raw_affiliation_strings":["Fred Hutchinson Cancer Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101501901","display_name":"Laura E. Johnson","orcid":"https://orcid.org/0000-0002-1277-2636","observed_orcids":["https://orcid.org/0000-0002-1277-2636"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura E Johnson","raw_affiliation_strings":["University of Wisconsin-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alec C Lewis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alec C Lewis","raw_affiliation_strings":["University of Wisconsin-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021686685","display_name":"Douglas G. McNeel","orcid":"https://orcid.org/0000-0003-1471-6723","observed_orcids":["https://orcid.org/0000-0003-1471-6723"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas G McNeel","raw_affiliation_strings":["University of Wisconsin-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A911","last_page":"A911"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.9049999713897705},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8500000238418579},{"id":"https://openalex.org/keywords/androgen-receptor-antagonists","display_name":"androgen receptor antagonists","score":0.9210000038146973},{"id":"https://openalex.org/keywords/enzalutamide","display_name":"enzalutamide","score":0.9150000214576721},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.847000002861023},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9100000262260437},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4480375647544861},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4442219138145447},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4136570990085602},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4030945301055908},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3567718267440796},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3562132716178894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21473470330238342},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1912572979927063},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10632872581481934}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jitc-2024-sitc2024.0806","doi":"https://doi.org/10.1136/jitc-2024-sitc2024.0806","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2024-sitc2024.0806","pdf_url":null,"source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2024-sitc2024.0806","doi":"https://doi.org/10.1136/jitc-2024-sitc2024.0806","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2024-sitc2024.0806","pdf_url":null,"source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2765723214","https://openalex.org/W4388080773","https://openalex.org/W4398185580","https://openalex.org/W2344594933","https://openalex.org/W2589240012","https://openalex.org/W1849327862","https://openalex.org/W2344590041","https://openalex.org/W4313408152","https://openalex.org/W3012105756","https://openalex.org/W4282967206"],"abstract_inverted_index":{"Background":[0],"Androgen":[1,425],"deprivation":[2,407],"therapy":[3,408],"(ADT)":[4],"is":[5,35,51],"the":[6,25,99,246,268,279,319,323,439],"cornerstone":[7],"treatment":[8,180,195,232],"for":[9,102,367,387],"recurrent":[10],"and":[11,27,53,86,118,153,169,175,217,224,237,242,287,312,352],"metastatic":[12],"prostate":[13,26,38,162,191,298,368,388,432],"cancer.":[14,299,389],"ADT":[15,34,45,70,81,149,213,236,283],"has":[16],"several":[17],"immunomodulatory":[18],"effects":[19],"including":[20,83],"T":[21,48,272],"cell":[22,49,75,112,171,316],"infiltration":[23,172,244,269,311],"into":[24,363],"enhancing":[28,103],"antigen":[29],"processing":[30],"and/or":[31],"presentation.1\u20133":[32],"While":[33,322],"pivotal":[36],"in":[37,124,160,186,189,220,233,267,297,308,340,431,435,438],"cancer":[39,111,369,433],"treatment,":[40],"its":[41],"effectiveness":[42],"with":[43,69,93,140,150,158,196,214,235,249,261,284,354,405,429],"different":[44],"agents":[46],"on":[47],"responses":[50,105,223,296],"complex":[52,347],"not":[54,200],"yet":[55],"fully":[56],"understood.3":[57],"Our":[58,276],"study":[59,359],"expands":[60],"upon":[61],"previous":[62],"research":[63],"indicating":[64],"that":[65,211],"combining":[66,148,212,282],"AR":[67,72,84,87,125,178,187,197,201,215,238,288],"vaccination":[68,152,216,239,286,404],"enhances":[71],"specific":[73],"CD8+T":[74,256,315],"infiltration.2":[76],"We":[77],"directly":[78],"compare":[79],"various":[80,141],"approaches,":[82],"degraders":[85],"antagonists,":[88,198],"to":[89,121,182,228,293,303,328,337],"determine":[90],"their":[91],"synergy":[92],"AR-specific":[94,130,204],"immunization.":[95],"Subsequently,":[96],"we":[97],"identify":[98],"optimal":[100],"combination":[101,234,330,355],"anti-tumor":[104,222,295],"using":[106],"checkpoint":[107],"blockade.":[108],"Methods":[109],"Prostate":[110],"lines":[113],"were":[114,134,173],"cultured":[115],"under":[116],"testosterone-replete":[117],"-deficient":[119],"conditions":[120],"assess":[122],"changes":[123],"expression":[126,188],"post-androgen":[127],"deprivation.":[128],"Subsequent":[129],"T-cell":[131,205,310],"recognition":[132],"assays":[133],"performed":[135],"after":[136],"treating":[137],"tumor":[138,163,192,247,320,411,440],"cells":[139,273],"AR-targeted":[142,151,285],"agents.":[143],"In":[144,207],"vivo":[145,208],"experiments":[146],"involved":[147],"either":[154],"enzalutamide":[155,218,292,430],"or":[156],"ARV110":[157],"anti-PD-1":[159],"murine":[161],"models.":[164],"Tumor":[165],"growth,":[166],"survival":[167,226],"rates,":[168],"immune":[170,350,441],"monitored":[174],"evaluated.":[176],"Results":[177],"antagonist":[179],"led":[181,336],"a":[183,250,346],"significant":[184],"increase":[185,266,339],"androgen-dependent":[190],"cells.":[193,257],"Additionally,":[194],"but":[199],"degraders,":[202],"augmented":[203],"recognition.":[206],"studies":[209],"demonstrated":[210,305],"resulted":[219],"superior":[221,306],"prolonged":[225],"compared":[227],"ARV110.":[229],"Furthermore,":[230],"Enzalutamide":[231],"increased":[240],"CD4+":[241],"CD8+T-cell":[243],"within":[245,318],"microenvironment,":[248],"notable":[251],"presence":[252],"of":[253,270,281,325,401],"effector":[254],"memory":[255,314],"However,":[258],"when":[259],"combined":[260],"anti-PD-1,":[262],"there":[263],"was":[264],"an":[265,338,381],"regulatory":[271,342],"(Tregs).":[274],"Conclusions":[275],"findings":[277],"highlight":[278],"potential":[280],"antagonists":[289],"such":[290],"as":[291,301],"enhance":[294],"Enzalutamide,":[300],"opposed":[302],"ARV110,":[304],"efficacy":[307],"improving":[309],"generating":[313],"populations":[317],"microenvironment.":[321,442],"addition":[324],"PD-1":[326],"blockade":[327,427],"this":[329],"showed":[331],"only":[332],"modest":[333],"benefits,":[334],"it":[335],"intratumoral":[341],"CD4+T":[343],"cells,":[344],"suggesting":[345],"interplay":[348],"between":[349],"activation":[351],"regulation":[353],"therapies.":[356],"Overall,":[357],"our":[358],"provides":[360],"valuable":[361],"insights":[362],"optimizing":[364],"therapeutic":[365],"strategies":[366],"treatment.":[370],"References":[371],"Neklesa":[372],"T,":[373],"Snyder":[374],"LB,":[375],"Willard":[376],"RR,":[377],"et":[378,423],"al.":[379,424],"ARV-110:":[380],"oral":[382],"androgen":[383,402,406],"receptor":[384,426],"PROTAC":[385],"degrader":[386],"JCO.":[390],"2019;37:259\u2013259.":[391],"Muralidhar":[392],"A,":[393],"Gamat-Huber":[394],"M,":[395],"Vakkalanka":[396],"S,":[397],"McNeel":[398],"DG.":[399],"Sequence":[400],"receptor-targeted":[403],"affects":[409],"anti-prostate":[410],"efficacy.":[412],"J":[413,443],"Immunother":[414,444],"Cancer.":[415,445],"2024;12:e008848.":[416],"Xu":[417],"P,":[418],"Yang":[419],"JC,":[420],"Chen":[421],"B,":[422],"resistance":[428],"results":[434],"immunosuppressive":[436],"alterations":[437],"2023;11:e006581.":[446]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2024-11-06T00:00:00"}
