{"id":"https://openalex.org/W4404058702","doi":"https://doi.org/10.1038/s44259-024-00054-3","title":"Cystic fibrosis sputum media induces an overall loss of antibiotic susceptibility in Mycobacterium abscessus","display_name":"Cystic fibrosis sputum media induces an overall loss of antibiotic susceptibility in Mycobacterium abscessus","publication_year":2024,"publication_date":"2024-11-05","ids":{"openalex":"https://openalex.org/W4404058702","doi":"https://doi.org/10.1038/s44259-024-00054-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/39843503"},"language":"en","primary_location":{"id":"doi:10.1038/s44259-024-00054-3","doi":"https://doi.org/10.1038/s44259-024-00054-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44259-024-00054-3","pdf_url":"https://www.nature.com/articles/s44259-024-00054-3.pdf","source":{"id":"https://openalex.org/S4387289274","display_name":"npj Antimicrobials and Resistance","issn_l":"2731-8745","issn":["2731-8745"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Antimicrobials and Resistance","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s44259-024-00054-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101656967","display_name":"Emily J. Baker","orcid":"https://orcid.org/0009-0000-2170-7177","observed_orcids":["https://orcid.org/0009-0000-2170-7177"]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emily J. Baker","raw_affiliation_strings":["College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK"],"raw_orcid":"https://orcid.org/0009-0000-2170-7177","affiliations":[{"raw_affiliation_string":"College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK","institution_ids":["https://openalex.org/I169199633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056961958","display_name":"Gemma J. Allcott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gemma Allcott","raw_affiliation_strings":["College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK","institution_ids":["https://openalex.org/I169199633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086089014","display_name":"Antonia Molloy","orcid":"https://orcid.org/0000-0002-2404-1478","observed_orcids":["https://orcid.org/0000-0002-2404-1478"]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Antonia Molloy","raw_affiliation_strings":["College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK","institution_ids":["https://openalex.org/I169199633"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012140483","display_name":"Jonathan A. G. Cox","orcid":"https://orcid.org/0000-0001-5208-4056","observed_orcids":["https://orcid.org/0000-0001-5208-4056"]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jonathan A. G. Cox","raw_affiliation_strings":["College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK. j.a.g.cox@aston.ac.uk","College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK"],"raw_orcid":"https://orcid.org/0000-0001-5208-4056","affiliations":[{"raw_affiliation_string":"College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK. j.a.g.cox@aston.ac.uk","institution_ids":["https://openalex.org/I169199633"]},{"raw_affiliation_string":"College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK","institution_ids":["https://openalex.org/I169199633"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012140483"],"corresponding_institution_ids":["https://openalex.org/I169199633"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":1.5688,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.84665548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"2","issue":"1","first_page":"34","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12317","display_name":"Actinomycetales infections and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-abscessus-complex","display_name":"Mycobacterium abscessus complex","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/antibiotic-susceptibility","display_name":"antibiotic susceptibility","score":0.9660000205039978},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.6060000061988831},{"id":"https://openalex.org/keywords/bronchiectasis","display_name":"bronchiectasis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/antibiotic-discovery","display_name":"antibiotic discovery","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2776111603","wikidata":"https://www.wikidata.org/wiki/Q6946978","display_name":"Mycobacterium abscessus","level":4,"score":0.9331122636795044},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.8470786809921265},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.7631080150604248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6557402014732361},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5822013020515442},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5795802474021912},{"id":"https://openalex.org/C2779912665","wikidata":"https://www.wikidata.org/wiki/Q7581635","display_name":"Sputum culture","level":4,"score":0.42737406492233276},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.4032563269138336},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3564072847366333},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24439331889152527},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22821712493896484},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.18905803561210632},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17955654859542847}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1038/s44259-024-00054-3","doi":"https://doi.org/10.1038/s44259-024-00054-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44259-024-00054-3","pdf_url":"https://www.nature.com/articles/s44259-024-00054-3.pdf","source":{"id":"https://openalex.org/S4387289274","display_name":"npj Antimicrobials and Resistance","issn_l":"2731-8745","issn":["2731-8745"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Antimicrobials and Resistance","raw_type":"journal-article"},{"id":"pmid:39843503","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39843503","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj antimicrobials and resistance","raw_type":"Journal Article"},{"id":"pmh:oai:publications.aston.ac.uk:46938","doi":null,"is_oa":true,"landing_page_url":"https://publications.aston.ac.uk/view/author/c5a750388a0a529ec770e4603c714ed3.html>","pdf_url":"https://publications.aston.ac.uk/id/eprint/46938/1/EJ_Baker_et_al_Cystic_fibrosis_sputum_media_induces_an_overall_loss_of_antibiotic_susceptibility_in_Mycobacterium_abscessus.pdf","source":{"id":"https://openalex.org/S4306400483","display_name":"Aston Publications Explorer (Aston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169199633","host_organization_name":"Aston University","host_organization_lineage":["https://openalex.org/I169199633"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:wrap.eprints.org:16481","doi":null,"is_oa":true,"landing_page_url":"https://orcid.org/0009-0000-2170-7177","pdf_url":"https://eprints.worc.ac.uk/16481/1/s44259-024-00054-3.pdf","source":{"id":"https://openalex.org/S4306400296","display_name":"Worcester Research and Publications (University of Worcester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I808010","host_organization_name":"University of Worcester","host_organization_lineage":["https://openalex.org/I808010"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11721417","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11721417","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11721417/pdf/44259_2024_Article_54.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Antimicrob Resist","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:45693e7559ab4d60be972d92b6a1b48e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/45693e7559ab4d60be972d92b6a1b48e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Antimicrobials and Resistance, Vol 2, Iss 1, Pp 1-8 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s44259-024-00054-3","doi":"https://doi.org/10.1038/s44259-024-00054-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44259-024-00054-3","pdf_url":"https://www.nature.com/articles/s44259-024-00054-3.pdf","source":{"id":"https://openalex.org/S4387289274","display_name":"npj Antimicrobials and Resistance","issn_l":"2731-8745","issn":["2731-8745"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Antimicrobials and Resistance","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Life on land","score":0.41999998688697815,"id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4549780052","display_name":"'EPSRC and SFI Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine","funder_award_id":"EP/S02347X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G679713082","display_name":null,"funder_award_id":"EP/S02347X/1","funder_id":"https://openalex.org/F4320320240","funder_display_name":"Research Councils UK"}],"funders":[{"id":"https://openalex.org/F4320320240","display_name":"Research Councils UK","ror":"https://ror.org/00dq2kk65"},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320323026","display_name":"Aston University","ror":"https://ror.org/05j0ve876"},{"id":"https://openalex.org/F4320325861","display_name":"Comvita","ror":"https://ror.org/0576se461"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404058702.pdf","grobid_xml":"https://content.openalex.org/works/W4404058702.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1556539514","https://openalex.org/W1955626095","https://openalex.org/W2031213868","https://openalex.org/W2066318082","https://openalex.org/W2066495315","https://openalex.org/W2085630244","https://openalex.org/W2088923911","https://openalex.org/W2097944090","https://openalex.org/W2113926700","https://openalex.org/W2119683141","https://openalex.org/W2122060678","https://openalex.org/W2122908084","https://openalex.org/W2132211475","https://openalex.org/W2142447693","https://openalex.org/W2163458252","https://openalex.org/W2177935900","https://openalex.org/W2506753654","https://openalex.org/W2560723352","https://openalex.org/W2613799876","https://openalex.org/W2766733233","https://openalex.org/W2792867540","https://openalex.org/W2921372111","https://openalex.org/W2936346157","https://openalex.org/W2952404779","https://openalex.org/W2969286984","https://openalex.org/W3027033549","https://openalex.org/W3038160084","https://openalex.org/W3049339260","https://openalex.org/W3122815012","https://openalex.org/W3164174932","https://openalex.org/W3185888127","https://openalex.org/W3189939557","https://openalex.org/W3207515529","https://openalex.org/W3208666630","https://openalex.org/W4200155515","https://openalex.org/W4205973300","https://openalex.org/W4206677002","https://openalex.org/W4221040250"],"related_works":["https://openalex.org/W2621362154","https://openalex.org/W4399426700","https://openalex.org/W2621343284","https://openalex.org/W1992649333","https://openalex.org/W2367868412","https://openalex.org/W195559998","https://openalex.org/W2339248656","https://openalex.org/W2107714373","https://openalex.org/W2022840048","https://openalex.org/W2134468770"],"abstract_inverted_index":{"Mycobacterium":[0],"abscessus":[1,132],"complex":[2],"(MABSC)":[3],"comprises":[4],"a":[5,12,37,124],"group":[6],"of":[7,15,28,51,76,130],"environmental":[8],"microorganisms,":[9],"which":[10],"are":[11,31],"concerning":[13],"cause":[14],"opportunistic":[16],"respiratory":[17],"infections":[18],"in":[19,99,102,115],"patients":[20],"with":[21,111],"cystic":[22],"fibrosis":[23],"or":[24],"bronchiectasis.":[25],"Only":[26],"45.6%":[27],"MABSC":[29,83],"treatments":[30],"successful,":[32],"and":[33,80,95],"therefore":[34],"this":[35],"is":[36,56],"need":[38,138],"to":[39,53,61,82,127],"discover":[40],"new":[41],"antimicrobials":[42],"that":[43],"can":[44],"treat":[45],"these":[46],"pathogens.":[47],"However,":[48],"the":[49,54,64,68,118,128,137],"transferability":[50],"outcomes":[52],"clinic":[55],"flawed":[57],"by":[58,135],"an":[59,112],"inability":[60],"accurately":[62],"represent":[63],"lung":[65],"environment":[66],"within":[67,117],"laboratory.":[69],"Herein,":[70],"we":[71,91],"apply":[72],"two":[73],"preestablished":[74],"formulations":[75],"sputum":[77,104],"media":[78,105,109],"(ACFS":[79],"SCFM1)":[81],"antibiotic":[84,96,133],"susceptibility":[85,116],"testing.":[86],"Using":[87],"conventional":[88],"broth":[89],"microdilution,":[90],"have":[92],"observed":[93],"strain":[94],"dependent":[97],"alterations":[98],"antimicrobial":[100],"sensitivity":[101],"each":[103],"compared":[106],"standard":[107],"laboratory":[108],"(7H9),":[110],"overall":[113],"reduction":[114],"physiologically":[119],"relevant":[120],"conditions.":[121],"We":[122],"provide":[123],"timely":[125],"contribution":[126],"field":[129],"M.":[131],"discovery":[134],"emphasising":[136],"for":[139],"improved":[140],"physiological":[141],"relevance.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}