{"id":"https://openalex.org/W4404039733","doi":"https://doi.org/10.3390/biology13110899","title":"Generalized Ketogenic Diet Induced Liver Impairment and Reduced Probiotics Abundance of Gut Microbiota in Rat","display_name":"Generalized Ketogenic Diet Induced Liver Impairment and Reduced Probiotics Abundance of Gut Microbiota in Rat","publication_year":2024,"publication_date":"2024-11-04","ids":{"openalex":"https://openalex.org/W4404039733","doi":"https://doi.org/10.3390/biology13110899","pmid":"https://pubmed.ncbi.nlm.nih.gov/39596854"},"language":"en","primary_location":{"id":"doi:10.3390/biology13110899","doi":"https://doi.org/10.3390/biology13110899","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology13110899","pdf_url":"https://www.mdpi.com/2079-7737/13/11/899/pdf?version=1730717941","source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-7737/13/11/899/pdf?version=1730717941","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101787487","display_name":"Ge Song","orcid":"https://orcid.org/0000-0002-8245-8343","observed_orcids":["https://orcid.org/0000-0002-8245-8343"]},"institutions":[{"id":"https://openalex.org/I4210121215","display_name":"Academy of National Food and Strategic Reserves Administration","ror":"https://ror.org/01wp3d509","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210121215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ge Song","raw_affiliation_strings":["Key Laboratory of Grain and Oil Biotechnology, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Grain and Oil Biotechnology, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China","institution_ids":["https://openalex.org/I4210121215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102178343","display_name":"Dan Song","orcid":"https://orcid.org/0000-0002-7007-0720","observed_orcids":["https://orcid.org/0000-0002-7007-0720"]},"institutions":[{"id":"https://openalex.org/I4210121215","display_name":"Academy of National Food and Strategic Reserves Administration","ror":"https://ror.org/01wp3d509","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210121215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Song","raw_affiliation_strings":["Key Laboratory of Grain and Oil Biotechnology, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Grain and Oil Biotechnology, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China","institution_ids":["https://openalex.org/I4210121215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100664076","display_name":"Yongwei Wang","orcid":"https://orcid.org/0000-0001-9712-8964","observed_orcids":["https://orcid.org/0000-0001-9712-8964","https://orcid.org/0009-0007-0223-5152","https://orcid.org/0009-0004-5740-1099"]},"institutions":[{"id":"https://openalex.org/I4210121215","display_name":"Academy of National Food and Strategic Reserves Administration","ror":"https://ror.org/01wp3d509","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210121215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongwei Wang","raw_affiliation_strings":["Key Laboratory of Grain and Oil Biotechnology, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Grain and Oil Biotechnology, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China","institution_ids":["https://openalex.org/I4210121215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116319512","display_name":"Li Wang","orcid":"https://orcid.org/0000-0002-4658-2558","observed_orcids":["https://orcid.org/0000-0002-4658-2558"]},"institutions":[{"id":"https://openalex.org/I4210121215","display_name":"Academy of National Food and Strategic Reserves Administration","ror":"https://ror.org/01wp3d509","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210121215"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li Wang","raw_affiliation_strings":["Key Laboratory of Grain and Oil Biotechnology, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Grain and Oil Biotechnology, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China","institution_ids":["https://openalex.org/I4210121215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100333136","display_name":"Weiwei Wang","orcid":"https://orcid.org/0000-0002-3782-0825","observed_orcids":["https://orcid.org/0000-0002-3782-0825"]},"institutions":[{"id":"https://openalex.org/I4210121215","display_name":"Academy of National Food and Strategic Reserves Administration","ror":"https://ror.org/01wp3d509","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210121215"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weiwei Wang","raw_affiliation_strings":["Key Laboratory of Grain and Oil Biotechnology, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Grain and Oil Biotechnology, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China","institution_ids":["https://openalex.org/I4210121215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100333136","https://openalex.org/A5116319512"],"corresponding_institution_ids":["https://openalex.org/I4210121215"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3069},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3069},"fwci":1.8893,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.86277635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"13","issue":"11","first_page":"899","last_page":"899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0828000009059906,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketogenic-diet","display_name":"ketogenic diet","score":0.9950000047683716},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.7149999737739563},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.906000018119812},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.7850000262260437},{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.7950000166893005},{"id":"https://openalex.org/keywords/lipoidosis","display_name":"lipoidosis","score":0.6620000004768372},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.6079999804496765},{"id":"https://openalex.org/keywords/high-carbohydrate-diet","display_name":"high-carbohydrate diet","score":0.796999990940094},{"id":"https://openalex.org/keywords/pathogenic-bacteria","display_name":"pathogenic bacteria","score":0.6039999723434448},{"id":"https://openalex.org/keywords/enterococcus","display_name":"Enterococcus","score":0.6349999904632568},{"id":"https://openalex.org/keywords/enterorhabdus","display_name":"Enterorhabdus","score":0.7509999871253967},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.4390000104904175},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9594719409942627},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.7412705421447754},{"id":"https://openalex.org/C2778587478","wikidata":"https://www.wikidata.org/wiki/Q1070684","display_name":"Ketogenic diet","level":3,"score":0.6008287072181702},{"id":"https://openalex.org/C77077793","wikidata":"https://www.wikidata.org/wiki/Q336019","display_name":"Abundance (ecology)","level":2,"score":0.47790369391441345},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.40516141057014465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33679211139678955},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.332115113735199},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23805838823318481},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.2271077036857605},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.10019722580909729},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biology13110899","doi":"https://doi.org/10.3390/biology13110899","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology13110899","pdf_url":"https://www.mdpi.com/2079-7737/13/11/899/pdf?version=1730717941","source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},{"id":"pmid:39596854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39596854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11591927","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11591927","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11591927/pdf/biology-13-00899.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:489d1d12d6c948809f790e4933edb1e7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/489d1d12d6c948809f790e4933edb1e7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology, Vol 13, Iss 11, p 899 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biology13110899","doi":"https://doi.org/10.3390/biology13110899","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology13110899","pdf_url":"https://www.mdpi.com/2079-7737/13/11/899/pdf?version=1730717941","source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4011349148","display_name":null,"funder_award_id":"201513003-8","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5728179734","display_name":null,"funder_award_id":"2018YFC1604001","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6571773588","display_name":null,"funder_award_id":"ZX2410","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7929808031","display_name":null,"funder_award_id":"grant number 2018YFC1604001","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404039733.pdf","grobid_xml":"https://content.openalex.org/works/W4404039733.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W618747867","https://openalex.org/W1538872823","https://openalex.org/W1592407962","https://openalex.org/W1991311874","https://openalex.org/W2004944503","https://openalex.org/W2049455972","https://openalex.org/W2054472364","https://openalex.org/W2110483590","https://openalex.org/W2146577073","https://openalex.org/W2153389219","https://openalex.org/W2175425219","https://openalex.org/W2416152044","https://openalex.org/W2441277973","https://openalex.org/W2553009618","https://openalex.org/W2750582921","https://openalex.org/W2787647367","https://openalex.org/W2885743680","https://openalex.org/W2891542669","https://openalex.org/W2894654669","https://openalex.org/W2913914265","https://openalex.org/W2932368761","https://openalex.org/W2940972167","https://openalex.org/W2955697886","https://openalex.org/W2956498227","https://openalex.org/W2958485931","https://openalex.org/W2964654469","https://openalex.org/W2981885402","https://openalex.org/W2982359845","https://openalex.org/W2990060012","https://openalex.org/W2990967306","https://openalex.org/W2999624546","https://openalex.org/W3002968024","https://openalex.org/W3088983709"],"related_works":["https://openalex.org/W2032717379","https://openalex.org/W560058040","https://openalex.org/W4234791832","https://openalex.org/W4365482291","https://openalex.org/W3032461717","https://openalex.org/W4380899516","https://openalex.org/W2531423200","https://openalex.org/W2138322029","https://openalex.org/W3160107171","https://openalex.org/W2912270657"],"abstract_inverted_index":{"The":[0,66],"ketogenic":[1,27,61,71,127,149,160,189],"diet":[2,28,62,72,128,150,161],"is":[3,29],"becoming":[4],"an":[5,132],"assisted":[6],"treatment":[7],"to":[8,46,55,93,164,179],"control":[9],"weight,":[10],"obesity,":[11],"and":[12,32,78,87,97,121,142,151,169],"even":[13],"type":[14],"2":[15],"diabetes.":[16],"However,":[17],"there":[18],"has":[19],"been":[20],"no":[21],"scientific":[22],"proof":[23],"supporting":[24],"that":[25,69,158],"the":[26,49,57,70,80,103,107,112,126,148,152,159,173,183],"absolutely":[30],"safe":[31],"sustainable.":[33],"In":[34,110],"this":[35],"study,":[36],"Sprague\u2013Dawley":[37],"(SD)":[38],"rats":[39],"were":[40,123,144],"fed":[41],"different":[42],"ratios":[43],"of":[44,59,82,114,134,166,172,185],"fat":[45],"carbohydrates":[47],"under":[48],"same":[50],"apparent":[51],"metabolizable":[52],"energy":[53],"level":[54],"evaluate":[56],"effects":[58],"a":[60,187],"on":[63],"healthy":[64],"subjects.":[65],"results":[67],"showed":[68],"could":[73],"relatively":[74],"sustain":[75],"body":[76],"weight":[77],"enhance":[79],"levels":[81],"serum":[83,88],"alanine":[84],"aminotransferase":[85],"(ALT)":[86],"alkaline":[89],"phosphatase":[90],"(SAP),":[91],"leading":[92],"more":[94],"moderate":[95],"lipoidosis":[96],"milder":[98],"local":[99],"non-specific":[100],"inflammation":[101],"in":[102,129,176],"liver":[104,167],"compared":[105],"with":[106,125,146],"high-carbohydrate":[108,153],"diet.":[109,154,190],"addition,":[111],"abundance":[113,133],"probiotic":[115],"strains":[116,136],"such":[117,137],"as":[118,138],"Lactobacillus,":[119],"Lactococcus,":[120],"Faecalitalea":[122],"reduced":[124],"rats,":[130,177],"while":[131],"pathogenic":[135],"Anaerotruncus,":[139],"Enterococcus,":[140],"Rothia,":[141],"Enterorhabdus":[143],"increased":[145],"both":[147],"This":[155],"study":[156],"suggests":[157],"can":[162],"lead":[163],"impairments":[165],"function":[168],"changed":[170],"composition":[171],"gut":[174],"microbiota":[175],"which":[178],"some":[180],"extent":[181],"indicates":[182],"danger":[184],"consuming":[186],"generalized":[188]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}
