{"id":"https://openalex.org/W4404026008","doi":"https://doi.org/10.7326/m23-3179","title":"Effect of Weight Loss Interventions on the Symptomatic Burden and Biomarkers of Polycystic Ovary Syndrome","display_name":"Effect of Weight Loss Interventions on the Symptomatic Burden and Biomarkers of Polycystic Ovary Syndrome","publication_year":2024,"publication_date":"2024-11-04","ids":{"openalex":"https://openalex.org/W4404026008","doi":"https://doi.org/10.7326/m23-3179","pmid":"https://pubmed.ncbi.nlm.nih.gov/39496172"},"language":"en","primary_location":{"id":"doi:10.7326/m23-3179","doi":"https://doi.org/10.7326/m23-3179","is_oa":false,"landing_page_url":"https://doi.org/10.7326/m23-3179","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047197877","display_name":"Jadine Scragg","orcid":"https://orcid.org/0000-0003-1424-712X","observed_orcids":["https://orcid.org/0000-0003-1424-712X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210088942","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jadine Scragg","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford; and NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom (J.S., S.A.J.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford; and NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom (J.S., S.A.J.)","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021594160","display_name":"Alice Hobson","orcid":"https://orcid.org/0000-0001-7030-1106","observed_orcids":["https://orcid.org/0000-0001-7030-1106"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alice Hobson","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom (A.H., L.W., K.S.T., S.D.)"],"raw_orcid":"https://orcid.org/0000-0001-7030-1106","affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom (A.H., L.W., K.S.T., S.D.)","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036875745","display_name":"Lia Willis","orcid":"https://orcid.org/0009-0003-6014-5674","observed_orcids":["https://orcid.org/0009-0003-6014-5674"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lia Willis","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom (A.H., L.W., K.S.T., S.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom (A.H., L.W., K.S.T., S.D.)","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048147657","display_name":"Kathryn Taylor","orcid":"https://orcid.org/0000-0001-6589-5456","observed_orcids":["https://orcid.org/0000-0001-6589-5456"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kathryn S. Taylor","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom (A.H., L.W., K.S.T., S.D.)"],"raw_orcid":"https://orcid.org/0000-0001-6589-5456","affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom (A.H., L.W., K.S.T., S.D.)","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091733224","display_name":"Sharon Dixon","orcid":"https://orcid.org/0000-0002-7469-6093","observed_orcids":["https://orcid.org/0000-0002-7469-6093"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sharon Dixon","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom (A.H., L.W., K.S.T., S.D.)"],"raw_orcid":"https://orcid.org/0000-0002-7469-6093","affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom (A.H., L.W., K.S.T., S.D.)","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051779148","display_name":"Susan Ann Jebb","orcid":"https://orcid.org/0000-0001-9190-2920","observed_orcids":["https://orcid.org/0000-0001-9190-2920"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210088942","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Susan A. Jebb","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford; and NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom (J.S., S.A.J.)"],"raw_orcid":"https://orcid.org/0000-0001-9190-2920","affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford; and NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom (J.S., S.A.J.)","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051779148"],"corresponding_institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210088942","https://openalex.org/I4210147381"],"apc_list":null,"apc_paid":null,"fwci":1.6774,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.84960718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"177","issue":"12","first_page":"1664","last_page":"1674"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":1.0},{"id":"https://openalex.org/keywords/weight-loss-interventions","display_name":"weight loss interventions","score":0.9929999709129333},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.902999997138977},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9589999914169312},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.9269999861717224},{"id":"https://openalex.org/keywords/free-androgen-index","display_name":"free androgen index","score":0.875},{"id":"https://openalex.org/keywords/sex-hormones","display_name":"sex hormones","score":0.7710000276565552},{"id":"https://openalex.org/keywords/menstrual-frequency","display_name":"menstrual frequency","score":0.9459999799728394},{"id":"https://openalex.org/keywords/hirsutism","display_name":"hirsutism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8460000157356262},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9252464771270752},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.9105976819992065},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.5631334781646729},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.46052417159080505},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.43394774198532104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42029982805252075},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.35651665925979614},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.335465669631958},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.23903056979179382},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.1675364077091217},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10189312696456909}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006628","descriptor_name":"Hirsutism","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.7326/m23-3179","doi":"https://doi.org/10.7326/m23-3179","is_oa":false,"landing_page_url":"https://doi.org/10.7326/m23-3179","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:39496172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39496172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1876350695","https://openalex.org/W1904748619","https://openalex.org/W1943352132","https://openalex.org/W1968831324","https://openalex.org/W1972667006","https://openalex.org/W1981107929","https://openalex.org/W1997599105","https://openalex.org/W2001380683","https://openalex.org/W2009155872","https://openalex.org/W2018636623","https://openalex.org/W2020357473","https://openalex.org/W2036756589","https://openalex.org/W2043228530","https://openalex.org/W2077421021","https://openalex.org/W2107080737","https://openalex.org/W2126930838","https://openalex.org/W2133253662","https://openalex.org/W2142157239","https://openalex.org/W2145555293","https://openalex.org/W2153353583","https://openalex.org/W2154022707","https://openalex.org/W2154336270","https://openalex.org/W2164376387","https://openalex.org/W2165010366","https://openalex.org/W2166606476","https://openalex.org/W2169205464","https://openalex.org/W2171294019","https://openalex.org/W2331571007","https://openalex.org/W2403512510","https://openalex.org/W2535276877","https://openalex.org/W2555053373","https://openalex.org/W2609988692","https://openalex.org/W2610544411","https://openalex.org/W2773791657","https://openalex.org/W2789900453","https://openalex.org/W2794964999","https://openalex.org/W2799507126","https://openalex.org/W2808702457","https://openalex.org/W2885579274","https://openalex.org/W2904076083","https://openalex.org/W2919006646","https://openalex.org/W2972318476","https://openalex.org/W3005880799","https://openalex.org/W3091243250","https://openalex.org/W3113549027","https://openalex.org/W3123779620","https://openalex.org/W3209468918","https://openalex.org/W4282831965","https://openalex.org/W4294215472","https://openalex.org/W4362602529","https://openalex.org/W4379537672","https://openalex.org/W4385804356","https://openalex.org/W4386483859","https://openalex.org/W4389721104"],"related_works":["https://openalex.org/W3143641493","https://openalex.org/W3049194228","https://openalex.org/W3135023887","https://openalex.org/W4387492111","https://openalex.org/W2001450760","https://openalex.org/W7217731814","https://openalex.org/W3163858782","https://openalex.org/W4383197376","https://openalex.org/W4411744162","https://openalex.org/W4414028257"],"abstract_inverted_index":{"BACKGROUND:":[0],"Polycystic":[1],"ovary":[2],"syndrome":[3],"(PCOS)":[4],"is":[5,13,31],"common":[6],"in":[7,90,183,208,229],"women":[8],"of":[9,29,38,45,59,105,115,149,198,233],"reproductive":[10],"age":[11],"and":[12,61,112,131,139,146,212,218,235,255],"associated":[14,176,226],"with":[15,48,92,95,97,160,177,227,246],"obesity.":[16],"Clinical":[17],"guidelines":[18],"recommend":[19],"weight":[20,39,81,87,172],"loss,":[21],"but":[22],"the":[23,26,36,100,195,199,209],"impact":[24],"on":[25,42],"clinical":[27,43],"manifestations":[28],"PCOS":[30,98,234],"unclear.":[32],"PURPOSE:":[33],"To":[34],"quantify":[35],"effect":[37],"loss":[40,88,173,223],"interventions":[41,77,89,174,224],"features":[44,232],"PCOS,":[46],"compared":[47],"usual":[49,83],"care.":[50],"DATA":[51,102,163],"SOURCES:":[52],"MEDLINE,":[53],"Embase,":[54],"PsycINFO,":[55],"CINAHL,":[56],"Cochrane,":[57],"Web":[58],"Science,":[60],"trial":[62],"registries":[63],"were":[64,155,175,225],"searched":[65],"from":[66,157],"inception":[67],"through":[68],"June":[69],"2024.":[70],"STUDY":[71],"SELECTION:":[72],"Randomized":[73],"controlled":[74],"trials":[75],"comparing":[76],"aiming":[78],"to":[79,194],"reduce":[80],"against":[82],"care,":[84],"including":[85],"lower-intensity":[86],"people":[91,96,245],"PCOS.":[93,247],"Conversations":[94],"informed":[99],"outcomes.":[101],"EXTRACTION:":[103],"Pairs":[104],"independent":[106],"reviewers":[107],"screened":[108],"studies,":[109],"extracted":[110],"data,":[111],"assessed":[113],"risk":[114],"bias":[116],"(RoB).":[117],"Outcomes":[118],"included":[119],"glycemic":[120],"control":[121],"(Homeostasis":[122],"Model":[123],"Assessment":[124],"for":[125,244,253,259],"Insulin":[126],"Resistance":[127],"[HOMA-IR],":[128],"fasting":[129],"insulin":[130],"glucose),":[132],"hormonal":[133],"markers":[134],"(free":[135],"androgen":[136],"index":[137],"[FAI]":[138],"other":[140,187],"sex":[141,188],"hormones),":[142],"menstrual":[143],"frequency,":[144],"hirsutism,":[145,184],"PCOS-related":[147],"quality":[148],"life":[150],"(QoL).":[151],"Pooled":[152],"mean":[153],"differences":[154],"obtained":[156],"random-effects":[158],"meta-analysis":[159],"Knapp-Hartung":[161],"adjustment.":[162],"SYNTHESIS:":[164],"=":[165],"43%).":[166],"There":[167,203],"was":[168,204],"no":[169],"evidence":[170],"that":[171],"clinically":[178],"or":[179,186],"statistically":[180],"significant":[181],"improvements":[182,228],"QoL,":[185],"hormones,":[189],"which":[190],"may":[191],"be":[192,237],"due":[193],"limited":[196],"power":[197],"available":[200],"data.":[201],"LIMITATION:":[202],"high":[205],"statistical":[206],"heterogeneity":[207],"interventions,":[210],"comparators,":[211],"outcomes,":[213],"largely":[214],"unexplained":[215],"by":[216],"sensitivity":[217],"subgroup":[219],"analyses.":[220],"CONCLUSION:":[221],"Weight":[222],"some":[230],"important":[231],"should":[236],"considered":[238],"as":[239],"a":[240],"routine":[241],"treatment":[242],"option":[243],"PRIMARY":[248],"FUNDING":[249],"SOURCE:":[250],"National":[251],"Institute":[252],"Health":[254],"Care":[256,261],"Research":[257],"School":[258],"Primary":[260],"Research.":[262],"(PROSPERO:":[263],"CRD42022367488).":[264]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":15}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-11-04T00:00:00"}