{"id":"https://openalex.org/W4403979254","doi":"https://doi.org/10.1021/acs.chemrestox.4c00316","title":"Practical Aspects of Flavin-Containing Monooxygenase-Mediated Metabolism","display_name":"Practical Aspects of Flavin-Containing Monooxygenase-Mediated Metabolism","publication_year":2024,"publication_date":"2024-11-01","ids":{"openalex":"https://openalex.org/W4403979254","doi":"https://doi.org/10.1021/acs.chemrestox.4c00316","pmid":"https://pubmed.ncbi.nlm.nih.gov/39485380"},"language":"en","primary_location":{"id":"doi:10.1021/acs.chemrestox.4c00316","doi":"https://doi.org/10.1021/acs.chemrestox.4c00316","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.chemrestox.4c00316","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028469156","display_name":"John Richard Cashman","orcid":"https://orcid.org/0000-0002-8628-9129","observed_orcids":["https://orcid.org/0000-0002-8628-9129"]},"institutions":[{"id":"https://openalex.org/I4210110847","display_name":"Human BioMolecular Research Institute","ror":"https://ror.org/018m20m74","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210110847"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John R. Cashman","raw_affiliation_strings":["Human BioMolecular Research Institute. 6351 Nancy Ridge Road, Suite B, San Diego, California 92121, United States"],"raw_orcid":"https://orcid.org/0000-0002-8628-9129","affiliations":[{"raw_affiliation_string":"Human BioMolecular Research Institute. 6351 Nancy Ridge Road, Suite B, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4210110847"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028469156"],"corresponding_institution_ids":["https://openalex.org/I4210110847"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.4563,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.3718593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"37","issue":"11","first_page":"1776","last_page":"1793"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fmo3","display_name":"FMO3","score":0.9900000095367432},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6740000247955322},{"id":"https://openalex.org/keywords/liver-metabolism","display_name":"hepatic metabolism","score":0.5920000076293945},{"id":"https://openalex.org/keywords/human-liver","display_name":"human liver","score":0.4950000047683716},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.777999997138977},{"id":"https://openalex.org/keywords/heat-lability","display_name":"heat lability","score":0.6470000147819519},{"id":"https://openalex.org/keywords/cardiometabolic-disease","display_name":"cardiometabolic disease","score":0.6850000023841858},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7120000123977661},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C13002179","wikidata":"https://www.wikidata.org/wiki/Q6901821","display_name":"Monooxygenase","level":4,"score":0.7734087705612183},{"id":"https://openalex.org/C33093398","wikidata":"https://www.wikidata.org/wiki/Q174337","display_name":"Flavin group","level":3,"score":0.7224694490432739},{"id":"https://openalex.org/C2776146729","wikidata":"https://www.wikidata.org/wiki/Q3860935","display_name":"Flavin-containing monooxygenase","level":5,"score":0.7223988771438599},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5592930912971497},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5263946056365967},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46563923358917236},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4150097668170929},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3037402927875519},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21479126811027527},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.20668190717697144}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.chemrestox.4c00316","doi":"https://doi.org/10.1021/acs.chemrestox.4c00316","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.chemrestox.4c00316","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},{"id":"pmid:39485380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39485380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical research in toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":136,"referenced_works":["https://openalex.org/W37542439","https://openalex.org/W60110147","https://openalex.org/W184291365","https://openalex.org/W1499968189","https://openalex.org/W1522757325","https://openalex.org/W1528937233","https://openalex.org/W1963516367","https://openalex.org/W1968195869","https://openalex.org/W1970543610","https://openalex.org/W1975091639","https://openalex.org/W1975683573","https://openalex.org/W1979384978","https://openalex.org/W1984216178","https://openalex.org/W1984588031","https://openalex.org/W1985656867","https://openalex.org/W1986934398","https://openalex.org/W1989360506","https://openalex.org/W1991874860","https://openalex.org/W1993358760","https://openalex.org/W1993445042","https://openalex.org/W1997115553","https://openalex.org/W2001172275","https://openalex.org/W2004338542","https://openalex.org/W2005846619","https://openalex.org/W2007291093","https://openalex.org/W2010547715","https://openalex.org/W2013050566","https://openalex.org/W2014761142","https://openalex.org/W2014953916","https://openalex.org/W2017941804","https://openalex.org/W2018159164","https://openalex.org/W2018227341","https://openalex.org/W2019051233","https://openalex.org/W2020697761","https://openalex.org/W2021789029","https://openalex.org/W2022500927","https://openalex.org/W2026306647","https://openalex.org/W2026677874","https://openalex.org/W2026955254","https://openalex.org/W2027224416","https://openalex.org/W2027424128","https://openalex.org/W2027816981","https://openalex.org/W2028036197","https://openalex.org/W2028978506","https://openalex.org/W2034961850","https://openalex.org/W2037169401","https://openalex.org/W2038985100","https://openalex.org/W2039633568","https://openalex.org/W2040145728","https://openalex.org/W2042042120","https://openalex.org/W2042120587","https://openalex.org/W2042561904","https://openalex.org/W2042849268","https://openalex.org/W2044706951","https://openalex.org/W2045520814","https://openalex.org/W2048048104","https://openalex.org/W2048630454","https://openalex.org/W2050816569","https://openalex.org/W2051914430","https://openalex.org/W2052420233","https://openalex.org/W2052908544","https://openalex.org/W2055666951","https://openalex.org/W2058735127","https://openalex.org/W2059149449","https://openalex.org/W2060277219","https://openalex.org/W2065359722","https://openalex.org/W2067071188","https://openalex.org/W2067739339","https://openalex.org/W2069252522","https://openalex.org/W2070471626","https://openalex.org/W2070816189","https://openalex.org/W2072029836","https://openalex.org/W2079678142","https://openalex.org/W2080852909","https://openalex.org/W2081056949","https://openalex.org/W2081063003","https://openalex.org/W2081384413","https://openalex.org/W2082334357","https://openalex.org/W2084878744","https://openalex.org/W2086208850","https://openalex.org/W2091809403","https://openalex.org/W2091822207","https://openalex.org/W2092213784","https://openalex.org/W2095385830","https://openalex.org/W2098383397","https://openalex.org/W2104613616","https://openalex.org/W2105916116","https://openalex.org/W2109178647","https://openalex.org/W2114017745","https://openalex.org/W2116393547","https://openalex.org/W2118180263","https://openalex.org/W2119340775","https://openalex.org/W2121190044","https://openalex.org/W2121902079","https://openalex.org/W2121948279","https://openalex.org/W2134076947","https://openalex.org/W2134332000","https://openalex.org/W2138685029","https://openalex.org/W2138821763","https://openalex.org/W2141360442","https://openalex.org/W2151144360","https://openalex.org/W2151877060","https://openalex.org/W2152633089","https://openalex.org/W2155201524","https://openalex.org/W2162782043","https://openalex.org/W2162866166","https://openalex.org/W2163604084","https://openalex.org/W2164320843","https://openalex.org/W2169957245","https://openalex.org/W2171989101","https://openalex.org/W2289228320","https://openalex.org/W2319311314","https://openalex.org/W2319904269","https://openalex.org/W2322012164","https://openalex.org/W2331484215","https://openalex.org/W2343660944","https://openalex.org/W2411106870","https://openalex.org/W2460134072","https://openalex.org/W2487080409","https://openalex.org/W2490746400","https://openalex.org/W2494562948","https://openalex.org/W2497438609","https://openalex.org/W2502793954","https://openalex.org/W2564730406","https://openalex.org/W2795836324","https://openalex.org/W2950830767","https://openalex.org/W2988947275","https://openalex.org/W3175384082","https://openalex.org/W4211088252","https://openalex.org/W4230113182","https://openalex.org/W4254612589","https://openalex.org/W4281714399","https://openalex.org/W4321748913","https://openalex.org/W4379197299","https://openalex.org/W4392752911","https://openalex.org/W4398133467"],"related_works":["https://openalex.org/W2352999168","https://openalex.org/W2058735127","https://openalex.org/W2042849268","https://openalex.org/W2171100136","https://openalex.org/W2378988410","https://openalex.org/W2963028651","https://openalex.org/W2147834020","https://openalex.org/W2018159164","https://openalex.org/W2111899360","https://openalex.org/W2083264903"],"abstract_inverted_index":{"Hepatic":[0],"flavin-containing":[1],"monooxygenase":[2],"3":[3],"(FMO3)":[4],"is":[5,78],"arguably":[6],"the":[7,14,40,69,86],"most":[8],"important":[9],"FMO":[10],"in":[11,36,44,85],"humans":[12],"from":[13],"standpoint":[15],"of":[16,42,71,88],"drug":[17,45,60],"metabolism.":[18,63],"Recently,":[19],"adult":[20],"hepatic":[21,73,90,104],"FMO3":[22,43,77,91,105],"has":[23],"been":[24,57],"linked":[25],"to":[26,50,68],"several":[27],"conditions":[28],"including":[29],"cardiometabolic":[30],"diseases,":[31],"aging,":[32],"obesity,":[33],"and":[34,46,61,81,106],"atherosclerosis":[35],"small":[37],"animals.":[38],"Despite":[39],"importance":[41],"chemical":[47,62],"metabolism,":[48],"relative":[49],"cytochrome":[51],"P-450":[52],"(CYP),":[53],"fewer":[54],"studies":[55],"have":[56],"published":[58],"describing":[59],"This":[64],"may":[65],"be":[66],"due":[67],"properties":[70],"human":[72,89,103],"FMO3.":[74],"For":[75],"example,":[76],"thermally":[79],"labile,":[80],"often":[82],"methods":[83],"reported":[84],"study":[87],"are":[92],"not":[93],"optimal.":[94],"Herein,":[95],"I":[96],"describe":[97],"some":[98],"practical":[99],"aspects":[100],"for":[101],"studying":[102],"other":[107],"FMOs.":[108]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-11-02T00:00:00"}
