{"id":"https://openalex.org/W4403971209","doi":"https://doi.org/10.1016/j.gene.2024.149050","title":"The link between the ANPEP gene and type 2 diabetes mellitus may be mediated by the disruption of glutathione metabolism and redox homeostasis","display_name":"The link between the ANPEP gene and type 2 diabetes mellitus may be mediated by the disruption of glutathione metabolism and redox homeostasis","publication_year":2024,"publication_date":"2024-11-01","ids":{"openalex":"https://openalex.org/W4403971209","doi":"https://doi.org/10.1016/j.gene.2024.149050","pmid":"https://pubmed.ncbi.nlm.nih.gov/39489227"},"language":"en","primary_location":{"id":"doi:10.1016/j.gene.2024.149050","doi":"https://doi.org/10.1016/j.gene.2024.149050","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gene.2024.149050","pdf_url":null,"source":{"id":"https://openalex.org/S75702506","display_name":"Gene","issn_l":"0378-1119","issn":["0378-1119","1879-0038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2024/03/18/2024.03.16.24304385.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063010762","display_name":"Yaroslava Korvyakova","orcid":"https://orcid.org/0000-0003-4756-9707","observed_orcids":["https://orcid.org/0000-0003-4756-9707"]},"institutions":[{"id":"https://openalex.org/I4210126689","display_name":"Research Centre for Medical Genetics","ror":"https://ror.org/03dhz7247","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126689"]},{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yaroslava Korvyakova","raw_affiliation_strings":["Laboratory of Biochemical Genetics and Metabolomics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russian Federation; Research Centre for Medical Genetics, 1 Moskvorechie St., Moscow 115522, Russian Federation. Electronic address: yasya_kursk@mail.ru"],"raw_orcid":"https://orcid.org/0000-0003-4756-9707","affiliations":[{"raw_affiliation_string":"Laboratory of Biochemical Genetics and Metabolomics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russian Federation; Research Centre for Medical Genetics, 1 Moskvorechie St., Moscow 115522, Russian Federation. Electronic address: yasya_kursk@mail.ru","institution_ids":["https://openalex.org/I4210126689","https://openalex.org/I44327541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073322825","display_name":"Iuliia E. Azarova","orcid":"https://orcid.org/0000-0001-8098-8052","observed_orcids":["https://orcid.org/0000-0001-8098-8052"]},"institutions":[{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Iuliia Azarova","raw_affiliation_strings":["Laboratory of Biochemical Genetics and Metabolomics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russian Federation; Department of Biological Chemistry, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russian Federation. Electronic address: azzzzar@yandex.ru"],"raw_orcid":"https://orcid.org/0000-0001-8098-8052","affiliations":[{"raw_affiliation_string":"Laboratory of Biochemical Genetics and Metabolomics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russian Federation; Department of Biological Chemistry, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russian Federation. Electronic address: azzzzar@yandex.ru","institution_ids":["https://openalex.org/I44327541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022444756","display_name":"Elena Yu. Klyosova","orcid":"https://orcid.org/0000-0002-1543-9230","observed_orcids":["https://orcid.org/0000-0002-1543-9230"]},"institutions":[{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elena Klyosova","raw_affiliation_strings":["Laboratory of Biochemical Genetics and Metabolomics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russian Federation; Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russian Federation. Electronic address: ecless@yandex.ru"],"raw_orcid":"https://orcid.org/0000-0002-1543-9230","affiliations":[{"raw_affiliation_string":"Laboratory of Biochemical Genetics and Metabolomics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russian Federation; Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russian Federation. Electronic address: ecless@yandex.ru","institution_ids":["https://openalex.org/I44327541"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria Postnikova","orcid":"https://orcid.org/0009-0007-8929-1594","observed_orcids":["https://orcid.org/0009-0007-8929-1594"]},"institutions":[{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maria Postnikova","raw_affiliation_strings":["Laboratory of Biochemical Genetics and Metabolomics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russian Federation. Electronic address: postnikova0700@icloud.com"],"raw_orcid":"https://orcid.org/0009-0007-8929-1594","affiliations":[{"raw_affiliation_string":"Laboratory of Biochemical Genetics and Metabolomics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russian Federation. Electronic address: postnikova0700@icloud.com","institution_ids":["https://openalex.org/I44327541"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Victor Makarenko","orcid":"https://orcid.org/0009-0002-9741-1051","observed_orcids":["https://orcid.org/0009-0002-9741-1051"]},"institutions":[{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Victor Makarenko","raw_affiliation_strings":["Laboratory of Biochemical Genetics and Metabolomics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russian Federation"],"raw_orcid":"https://orcid.org/0009-0002-9741-1051","affiliations":[{"raw_affiliation_string":"Laboratory of Biochemical Genetics and Metabolomics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russian Federation","institution_ids":["https://openalex.org/I44327541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009941415","display_name":"Olga Y. Bushueva","orcid":"https://orcid.org/0000-0003-3333-0623","observed_orcids":["https://orcid.org/0000-0003-3333-0623"]},"institutions":[{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olga Bushueva","raw_affiliation_strings":["Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russian Federation; Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russian Federation. Electronic address: olga.bushueva@inbox.ru"],"raw_orcid":"https://orcid.org/0000-0003-3333-0623","affiliations":[{"raw_affiliation_string":"Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russian Federation; Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russian Federation. Electronic address: olga.bushueva@inbox.ru","institution_ids":["https://openalex.org/I44327541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056854844","display_name":"Maria A. Solodilova","orcid":"https://orcid.org/0000-0003-4607-4913","observed_orcids":["https://orcid.org/0000-0003-4607-4913"]},"institutions":[{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maria Solodilova","raw_affiliation_strings":["Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russian Federation. Electronic address: solodilovama@kursksmu.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russian Federation. Electronic address: solodilovama@kursksmu.net","institution_ids":["https://openalex.org/I44327541"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020440584","display_name":"Alexey Polonikov","orcid":"https://orcid.org/0000-0001-6280-247X","observed_orcids":["https://orcid.org/0000-0001-6280-247X"]},"institutions":[{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Alexey Polonikov","raw_affiliation_strings":["Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russian Federation; Laboratory of Statistical Genetics and Bioinformatics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russian Federation. Electronic address: polonikov@rambler.ru"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russian Federation; Laboratory of Statistical Genetics and Bioinformatics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russian Federation. Electronic address: polonikov@rambler.ru","institution_ids":["https://openalex.org/I44327541"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020440584"],"corresponding_institution_ids":["https://openalex.org/I44327541"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":null,"fwci":0.8049,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.64688256,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"935","issue":null,"first_page":"149050","last_page":"149050"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8809999823570251},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.671999990940094},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9929999709129333},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.8399999737739563},{"id":"https://openalex.org/keywords/diplotypes","display_name":"diplotypes","score":0.8740000128746033},{"id":"https://openalex.org/keywords/glutathione-metabolism","display_name":"glutathione metabolism","score":0.9639999866485596},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9810000061988831},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.9829999804496765},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.8679999709129333},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.847000002861023},{"id":"https://openalex.org/keywords/plasma-protein-levels","display_name":"plasma protein levels","score":0.44999998807907104},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9183402061462402},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.6110028028488159},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5210894346237183},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.514975368976593},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5064307451248169},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4631611108779907},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.44374096393585205},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.4292013347148895},{"id":"https://openalex.org/C2909018721","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione metabolism","level":4,"score":0.4285510182380676},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35070279240608215},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.335274338722229},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3149883449077606},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.262764036655426},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.22450658679008484},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16022074222564697}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004150","descriptor_name":"Dipeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.gene.2024.149050","doi":"https://doi.org/10.1016/j.gene.2024.149050","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gene.2024.149050","pdf_url":null,"source":{"id":"https://openalex.org/S75702506","display_name":"Gene","issn_l":"0378-1119","issn":["0378-1119","1879-0038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"journal-article"},{"id":"doi:10.1101/2024.03.16.24304385","doi":"https://doi.org/10.1101/2024.03.16.24304385","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2024.03.16.24304385","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/03/18/2024.03.16.24304385.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:39489227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39489227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/2024.03.16.24304385","doi":"https://doi.org/10.1101/2024.03.16.24304385","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2024.03.16.24304385","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/03/18/2024.03.16.24304385.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4645515137","display_name":null,"funder_award_id":"20-15-00227","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403971209.pdf","grobid_xml":"https://content.openalex.org/works/W4403971209.grobid-xml"},"referenced_works_count":144,"referenced_works":["https://openalex.org/W44958236","https://openalex.org/W184962995","https://openalex.org/W830232628","https://openalex.org/W1531821806","https://openalex.org/W1891967301","https://openalex.org/W1968273304","https://openalex.org/W1976499979","https://openalex.org/W1982069260","https://openalex.org/W1983342808","https://openalex.org/W1984313459","https://openalex.org/W1987777772","https://openalex.org/W1989970381","https://openalex.org/W1992325070","https://openalex.org/W1995319895","https://openalex.org/W1996054359","https://openalex.org/W2000298219","https://openalex.org/W2001248887","https://openalex.org/W2002800164","https://openalex.org/W2006017390","https://openalex.org/W2008932788","https://openalex.org/W2012267770","https://openalex.org/W2014021791","https://openalex.org/W2016574612","https://openalex.org/W2026657835","https://openalex.org/W2032451121","https://openalex.org/W2035104998","https://openalex.org/W2035712885","https://openalex.org/W2040608878","https://openalex.org/W2045017910","https://openalex.org/W2053524551","https://openalex.org/W2054129051","https://openalex.org/W2054506138","https://openalex.org/W2057576995","https://openalex.org/W2063535842","https://openalex.org/W2065145370","https://openalex.org/W2077177261","https://openalex.org/W2082571116","https://openalex.org/W2083653517","https://openalex.org/W2085490648","https://openalex.org/W2094262092","https://openalex.org/W2094542518","https://openalex.org/W2095608650","https://openalex.org/W2102016205","https://openalex.org/W2109552315","https://openalex.org/W2112317405","https://openalex.org/W2116210078","https://openalex.org/W2122929112","https://openalex.org/W2128704535","https://openalex.org/W2135409065","https://openalex.org/W2139698840","https://openalex.org/W2145665725","https://openalex.org/W2146107508","https://openalex.org/W2148327131","https://openalex.org/W2149118429","https://openalex.org/W2156472431","https://openalex.org/W2158468809","https://openalex.org/W2161633633","https://openalex.org/W2162530578","https://openalex.org/W2165987645","https://openalex.org/W2166337262","https://openalex.org/W2167121173","https://openalex.org/W2237544788","https://openalex.org/W2290292445","https://openalex.org/W2293182033","https://openalex.org/W2338627428","https://openalex.org/W2417463814","https://openalex.org/W2466763536","https://openalex.org/W2563050266","https://openalex.org/W2566820606","https://openalex.org/W2594936766","https://openalex.org/W2606288020","https://openalex.org/W2607840011","https://openalex.org/W2613232859","https://openalex.org/W2724740917","https://openalex.org/W2741900582","https://openalex.org/W2745493480","https://openalex.org/W2766147673","https://openalex.org/W2776802713","https://openalex.org/W2783296927","https://openalex.org/W2793770019","https://openalex.org/W2803406529","https://openalex.org/W2806063230","https://openalex.org/W2883622734","https://openalex.org/W2906383167","https://openalex.org/W2919811956","https://openalex.org/W2936057232","https://openalex.org/W2946821913","https://openalex.org/W2952506610","https://openalex.org/W2964014519","https://openalex.org/W2980543834","https://openalex.org/W3016932261","https://openalex.org/W3022160542","https://openalex.org/W3031739230","https://openalex.org/W3035629014","https://openalex.org/W3042905841","https://openalex.org/W3044147841","https://openalex.org/W3044703600","https://openalex.org/W3081655479","https://openalex.org/W3088230086","https://openalex.org/W3127106206","https://openalex.org/W3136160512","https://openalex.org/W3158921277","https://openalex.org/W3163828332","https://openalex.org/W3196839800","https://openalex.org/W3200483660","https://openalex.org/W3212963660","https://openalex.org/W3214055065","https://openalex.org/W3216366140","https://openalex.org/W3216856793","https://openalex.org/W4200026682","https://openalex.org/W4200099691","https://openalex.org/W4211058450","https://openalex.org/W4211242412","https://openalex.org/W4220682865","https://openalex.org/W4220716839","https://openalex.org/W4223549611","https://openalex.org/W4223578002","https://openalex.org/W4224304539","https://openalex.org/W4240986128","https://openalex.org/W4280552086","https://openalex.org/W4281398671","https://openalex.org/W4281477345","https://openalex.org/W4285741822","https://openalex.org/W4287447663","https://openalex.org/W4302305224","https://openalex.org/W4307862344","https://openalex.org/W4313495054","https://openalex.org/W4316095922","https://openalex.org/W4322741374","https://openalex.org/W4380576366","https://openalex.org/W4385346935","https://openalex.org/W4386939684","https://openalex.org/W4391231331","https://openalex.org/W4391432257","https://openalex.org/W6601798483","https://openalex.org/W6675290381","https://openalex.org/W6766615579","https://openalex.org/W6789561498","https://openalex.org/W6794117534","https://openalex.org/W6801102348","https://openalex.org/W6840721764","https://openalex.org/W6842567727","https://openalex.org/W6845589044","https://openalex.org/W6861356238"],"related_works":["https://openalex.org/W3196839800","https://openalex.org/W4404614357","https://openalex.org/W4401977143","https://openalex.org/W3044703600","https://openalex.org/W2059618531","https://openalex.org/W2283717346","https://openalex.org/W1979553949","https://openalex.org/W2124388986","https://openalex.org/W3128839426","https://openalex.org/W3212963660"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-11-02T00:00:00"}