{"id":"https://openalex.org/W4403965597","doi":"https://doi.org/10.17116/klinderma202423051575","title":"Improvement of therapy of papillomavirus infection latent forms","display_name":"Improvement of therapy of papillomavirus infection latent forms","publication_year":2024,"publication_date":"2024-04-22","ids":{"openalex":"https://openalex.org/W4403965597","doi":"https://doi.org/10.17116/klinderma202423051575"},"language":"en","primary_location":{"id":"doi:10.17116/klinderma202423051575","doi":"https://doi.org/10.17116/klinderma202423051575","is_oa":false,"landing_page_url":"https://doi.org/10.17116/klinderma202423051575","pdf_url":null,"source":{"id":"https://openalex.org/S2764989259","display_name":"Russian Journal of Clinical Dermatology and Venereology","issn_l":"1997-2849","issn":["1997-2849","2309-4877"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Clinical Dermatology and Venereology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114482787","display_name":"D.A. Abukhaltam Akhmad","orcid":"https://orcid.org/0009-0002-7816-6054","observed_orcids":["https://orcid.org/0009-0002-7816-6054"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.A. Abukhaltam Akhmad","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-7816-6054","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013524064","display_name":"\u041f\u043e\u043b\u0435\u0441\u043a\u043e \u0418\u0440\u0438\u043d\u0430 \u0412\u0430\u0441\u0438\u043b\u044c\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-6041-717X","observed_orcids":["https://orcid.org/0000-0002-6041-717X","https://orcid.org/0000-0001-9480-1674"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I.V. Polesko","raw_affiliation_strings":["Pirogov Russian National Research Medical University"],"raw_orcid":"https://orcid.org/0000-0002-6041-717X","affiliations":[{"raw_affiliation_string":"Pirogov Russian National Research Medical University","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084984417","display_name":"\u0410. \u0410. \u0425\u0430\u043b\u0434\u0438\u043d","orcid":"https://orcid.org/0000-0002-3855-1655","observed_orcids":["https://orcid.org/0000-0002-3855-1655"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.A. Khaldin","raw_affiliation_strings":["Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology"],"raw_orcid":"https://orcid.org/0000-0002-3855-1655","affiliations":[{"raw_affiliation_string":"Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065944589","display_name":"D.G. Kim","orcid":"https://orcid.org/0000-0002-8704-7527","observed_orcids":["https://orcid.org/0000-0002-8704-7527"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.G. Kim","raw_affiliation_strings":["Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology"],"raw_orcid":"https://orcid.org/0000-0002-8704-7527","affiliations":[{"raw_affiliation_string":"Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2603,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.6009369,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"23","issue":"5","first_page":"575","last_page":"575"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.8769999742507935},{"id":"https://openalex.org/keywords/latent-hpv-infection","display_name":"latent HPV infection","score":0.9190000295639038},{"id":"https://openalex.org/keywords/interferon-alpha-2b","display_name":"interferon alfa-2b","score":0.9490000009536743},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.9190000295639038},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.9300000071525574},{"id":"https://openalex.org/keywords/rectal-suppositories","display_name":"rectal suppositories","score":0.8320000171661377},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.8330000042915344},{"id":"https://openalex.org/keywords/hpv-elimination","display_name":"HPV elimination","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.5756140947341919},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4895397126674652},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38133543729782104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13332372903823853}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17116/klinderma202423051575","doi":"https://doi.org/10.17116/klinderma202423051575","is_oa":false,"landing_page_url":"https://doi.org/10.17116/klinderma202423051575","pdf_url":null,"source":{"id":"https://openalex.org/S2764989259","display_name":"Russian Journal of Clinical Dermatology and Venereology","issn_l":"1997-2849","issn":["1997-2849","2309-4877"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Clinical Dermatology and Venereology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2963210586","https://openalex.org/W3095086510","https://openalex.org/W3104559630","https://openalex.org/W4323364033","https://openalex.org/W4367180990"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Background.":[0],"The":[1,150,178,214],"management":[2],"of":[3,20,29,40,57,63,77,89,102,111,120,126,135,152,163,172,180,190,221,227,248,258],"patients":[4,25,52,119,136,164,173],"with":[5,26,37,67,234,239],"asymptomatic":[6],"papillomavirus":[7,41,228],"infection":[8,229],"is":[9],"still":[10],"a":[11,75,108,187,217],"controversial":[12],"issue.":[13],"Previous":[14],"studies":[15],"have":[16],"demonstrated":[17,216],"the":[18,83,138,143,166,175,201,210,225],"potential":[19],"using":[21],"immunomodulatory":[22],"therapy":[23,34,233],"in":[24,35,74,118,133,137,142,147,155,161,165,170,174,200,209,224,246,254],"latent":[27,38,230],"form":[28,39],"HPV-infection.":[30],"Objective.":[31],"To":[32],"optimize":[33],"subjects":[36],"infection.":[42],"Material":[43],"and":[44,107,169,256],"methods.":[45],"Prospective":[46],"randomized":[47],"controlled":[48],"trial":[49],"included":[50],"66":[51],"infected":[53],"by":[54,69,197,261],"HPV.":[55],"Patients":[56,88],"study":[58,139,176,202,215],"group":[59,91,145,168],"received":[60],"3":[61,78],"courses":[62],"recombinant":[64,191,235],"IFN":[65,192,236],"alpha-2b":[66,237],"antioxidants":[68,240],"1":[70],"suppository":[71],"per":[72],"rectum":[73],"dose":[76],"000":[79,80],"IU":[81],"at":[82],"bedtime":[84],"for":[85],"10":[86],"days.":[87],"comparative":[90],"remained":[92],"under":[93],"medical":[94],"observation":[95],"without":[96],"pharmacological":[97],"intervention.":[98],"A":[99],"qualitative":[100,153],"change":[101,208],"HPV":[103,112,128,156,252],"content":[104,157],"was":[105,113],"identified":[106,127],"quantitative":[109],"load":[110,183,195,205,260],"monitored":[114],"after":[115,184],"4":[116],"weeks":[117],"both":[121],"groups.":[122],"Results.":[123],"Complete":[124],"elimination":[125,253],"genotypes":[129],"has":[130,158],"been":[131,159],"found":[132],"64.5%":[134,255],"group,":[140,203],"while":[141],"comparison":[144,167,211],"only":[146],"5.7%":[148],"(p<0.001).":[149],"lack":[151],"changes":[154],"revealed":[160],"68.6%":[162],"12.9%":[171],"group.":[177,212],"analysis":[179],"total":[181],"viral":[182,194,204,259],"treatment":[185,226],"showed":[186],"reliable":[188],"advantage":[189],"alpha-2b:":[193],"reduced":[196],"3.5":[198,262],"times":[199],"did":[206],"not":[207],"Conclusion.":[213],"pronounced":[218],"positive":[219,244],"effect":[220],"examined":[222],"drug":[223],"forms.":[231],"Course":[232],"combined":[238],"allowed":[241],"to":[242],"achieve":[243],"dynamics":[245],"80%":[247],"patients,":[249],"including":[250],"complete":[251],"reduction":[257],"times.":[263]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
