{"id":"https://openalex.org/W4403836795","doi":"https://doi.org/10.7554/elife.101642.1","title":"Detection of changes in membrane potential by magnetic resonance imaging","display_name":"Detection of changes in membrane potential by magnetic resonance imaging","publication_year":2024,"publication_date":"2024-10-28","ids":{"openalex":"https://openalex.org/W4403836795","doi":"https://doi.org/10.7554/elife.101642.1"},"language":"en","primary_location":{"id":"doi:10.7554/elife.101642.1","doi":"https://doi.org/10.7554/elife.101642.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.101642.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.101642.1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055692234","display_name":"Kyeongseon Min","orcid":"https://orcid.org/0000-0001-7614-2089","observed_orcids":["https://orcid.org/0000-0001-7614-2089"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyeongseon Min","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Seoul National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Seoul National University","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089876636","display_name":"Sungkwon Chung","orcid":"https://orcid.org/0000-0003-0505-8773","observed_orcids":["https://orcid.org/0000-0003-0505-8773"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sungkwon Chung","raw_affiliation_strings":["Department of Physiology, Sungkyunkwan University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Sungkyunkwan University School of Medicine","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069678830","display_name":"Seung\u2010Kyun Lee","orcid":"https://orcid.org/0000-0001-7625-3141","observed_orcids":["https://orcid.org/0000-0001-7625-3141","https://orcid.org/0000-0001-9929-6080"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung-Kyun Lee","raw_affiliation_strings":["Department of Biomedical Engineering, Sungkyunkwan University","Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Sungkyunkwan University","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423379","display_name":"Jongho Lee","orcid":"https://orcid.org/0000-0002-9485-5434","observed_orcids":["https://orcid.org/0000-0002-9485-5434","https://orcid.org/0000-0001-9602-2244","https://orcid.org/0000-0003-0398-4220"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jongho Lee","raw_affiliation_strings":["Department of Biomedical Engineering, Sungkyunkwan University","Department of Electrical and Computer Engineering, Seoul National University","Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Sungkyunkwan University","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Seoul National University","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039763425","display_name":"Phan Tan Toi","orcid":"https://orcid.org/0000-0002-8073-2898","observed_orcids":["https://orcid.org/0000-0002-8073-2898"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Phan Tan Toi","raw_affiliation_strings":["Department of Biomedical Engineering, Sungkyunkwan University","Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University"],"raw_orcid":"https://orcid.org/0000-0002-8073-2898","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Sungkyunkwan University","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101864459","display_name":"Daehong Kim","orcid":"https://orcid.org/0000-0003-2169-6708","observed_orcids":["https://orcid.org/0000-0003-2169-6708"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daehong Kim","raw_affiliation_strings":["National Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045389714","display_name":"Jung Seung Lee","orcid":"https://orcid.org/0000-0002-7722-0461","observed_orcids":["https://orcid.org/0000-0002-7722-0461"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung Seung Lee","raw_affiliation_strings":["Department of Biomedical Engineering, Sungkyunkwan University","Department of Electrical and Computer Engineering, Seoul National University","Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Sungkyunkwan University","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Seoul National University","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067838206","display_name":"Jang\u2010Yeon Park","orcid":"https://orcid.org/0000-0002-0586-1606","observed_orcids":["https://orcid.org/0000-0002-0586-1606"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jang-Yeon Park","raw_affiliation_strings":["Department of Biomedical Engineering, Sungkyunkwan University","Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Sungkyunkwan University","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University","institution_ids":["https://openalex.org/I848706"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.7182999849319458,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.7182999849319458,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.23680000007152557,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.996999979019165},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"magnetic resonance imaging","score":0.8199999928474426},{"id":"https://openalex.org/keywords/t2-relaxation-time","display_name":"T2 relaxation time","score":0.8450000286102295},{"id":"https://openalex.org/keywords/free-and-bound-water","display_name":"bound and free water","score":0.6179999709129333},{"id":"https://openalex.org/keywords/depolarization","display_name":"depolarization","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hyperpolarization","display_name":"hyperpolarization","score":0.9800000190734863},{"id":"https://openalex.org/keywords/non-invasive-cell-imaging","display_name":"non-invasive cell imaging","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cultured-cells","display_name":"cultured cells","score":0.8009999990463257},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6465449929237366},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.5818577408790588},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32640814781188965},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3072977364063263},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22168028354644775},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.13080361485481262}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.101642.1","doi":"https://doi.org/10.7554/elife.101642.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.101642.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.101642.1","doi":"https://doi.org/10.7554/elife.101642.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.101642.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3400907639","display_name":null,"funder_award_id":"NTIS1711198890","funder_id":"https://openalex.org/F4320332128","funder_display_name":"Commercializations Promotion Agency for R and D Outcomes"},{"id":"https://openalex.org/G4026557671","display_name":null,"funder_award_id":"NRF-2019M3C7A1031994","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4367809434","display_name":null,"funder_award_id":"2019M3C7A1031994","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5234284214","display_name":null,"funder_award_id":"2023R1A2C3007075","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5244811108","display_name":null,"funder_award_id":"2019M3C7A1031993","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6617616902","display_name":null,"funder_award_id":"NRF-2019M3C7A1031993","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320332128","display_name":"Commercializations Promotion Agency for R and D Outcomes","ror":"https://ror.org/05tz27s69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1605985077","https://openalex.org/W1963787523","https://openalex.org/W1970208116","https://openalex.org/W1971880089","https://openalex.org/W1975346322","https://openalex.org/W1976638109","https://openalex.org/W1977858525","https://openalex.org/W1982321167","https://openalex.org/W1994042872","https://openalex.org/W2005304998","https://openalex.org/W2005447722","https://openalex.org/W2009667219","https://openalex.org/W2016291243","https://openalex.org/W2019851584","https://openalex.org/W2046371195","https://openalex.org/W2048499335","https://openalex.org/W2052197158","https://openalex.org/W2052471278","https://openalex.org/W2056236589","https://openalex.org/W2057629693","https://openalex.org/W2058449890","https://openalex.org/W2064226140","https://openalex.org/W2065113098","https://openalex.org/W2068698274","https://openalex.org/W2068802695","https://openalex.org/W2070356578","https://openalex.org/W2081895884","https://openalex.org/W2086942319","https://openalex.org/W2087571852","https://openalex.org/W2096154018","https://openalex.org/W2097152573","https://openalex.org/W2103632755","https://openalex.org/W2103681669","https://openalex.org/W2110102561","https://openalex.org/W2112307156","https://openalex.org/W2114104729","https://openalex.org/W2117791332","https://openalex.org/W2125588561","https://openalex.org/W2134330663","https://openalex.org/W2143034423","https://openalex.org/W2144437938","https://openalex.org/W2149900207","https://openalex.org/W2153757289","https://openalex.org/W2160607236","https://openalex.org/W2160611014","https://openalex.org/W2161567464","https://openalex.org/W2165061320","https://openalex.org/W2171810634","https://openalex.org/W2224021986","https://openalex.org/W2274138287","https://openalex.org/W2288465029","https://openalex.org/W2469916649","https://openalex.org/W2482593790","https://openalex.org/W2790994475","https://openalex.org/W2901217622","https://openalex.org/W2908859727","https://openalex.org/W3015480100","https://openalex.org/W3177142956","https://openalex.org/W4305082891","https://openalex.org/W4318049660","https://openalex.org/W6941287690"],"related_works":["https://openalex.org/W4409527852","https://openalex.org/W4401574581","https://openalex.org/W1156745749","https://openalex.org/W4406471157","https://openalex.org/W1937929632","https://openalex.org/W2023839478","https://openalex.org/W2013502821","https://openalex.org/W4385543055","https://openalex.org/W7096310971","https://openalex.org/W1972534242"],"abstract_inverted_index":{"Abstract":[0],"Membrane":[1],"potential":[2,17,53,63,82,116],"plays":[3],"a":[4,107],"crucial":[5],"role":[6],"in":[7,64,68,114],"various":[8],"cellular":[9],"functions.":[10],"However,":[11],"existing":[12],"techniques":[13],"for":[14],"measuring":[15,56],"membrane":[16,52,62,81,115],"are":[18],"often":[19],"invasive":[20],"or":[21],"have":[22],"limited":[23],"recording":[24],"depth.":[25],"In":[26],"contrast,":[27],"magnetic":[28,57],"resonance":[29,58],"imaging":[30,34],"(MRI)":[31],"offers":[32],"noninvasive":[33],"with":[35],"desirable":[36],"spatial":[37],"resolution":[38],"over":[39],"large":[40],"areas.":[41],"This":[42],"study":[43],"investigates":[44],"the":[45,80,86,91,100],"feasibility":[46],"of":[47,79,93],"utilizing":[48],"MRI":[49],"to":[50,95,110],"detect":[51,112],"changes":[54,113],"by":[55],"parameters":[59],"while":[60,90],"manipulating":[61],"cultured":[65],"cells":[66],"and":[67],"vivo":[69],"rat":[70],"models.":[71],"Our":[72],"findings":[73,104],"reveal":[74],"that":[75],"depolarization":[76],"(or":[77,84],"hyperpolarization)":[78],"increases":[83],"decreases)":[85],"T2":[87],"relaxation":[88],"time,":[89],"ratio":[92],"bound":[94],"free":[96],"water":[97],"proton":[98],"shows":[99],"opposite":[101],"trend.":[102],"These":[103],"also":[105],"suggest":[106],"pioneering":[108],"approach":[109],"noninvasively":[111],"using":[117],"MRI.":[118]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-10-29T00:00:00"}