{"id":"https://openalex.org/W4403828362","doi":"https://doi.org/10.1111/apt.18363","title":"Validating Simple Modifications to the Rome IV Criteria for the Diagnosis of Irritable Bowel Syndrome in Secondary Care","display_name":"Validating Simple Modifications to the Rome IV Criteria for the Diagnosis of Irritable Bowel Syndrome in Secondary Care","publication_year":2024,"publication_date":"2024-10-28","ids":{"openalex":"https://openalex.org/W4403828362","doi":"https://doi.org/10.1111/apt.18363","pmid":"https://pubmed.ncbi.nlm.nih.gov/39466700"},"language":"en","primary_location":{"id":"doi:10.1111/apt.18363","doi":"https://doi.org/10.1111/apt.18363","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apt.18363","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apt.18363","source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology & Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apt.18363","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027634696","display_name":"Vivek Chand Goodoory","orcid":"https://orcid.org/0000-0001-9483-5604","observed_orcids":["https://orcid.org/0000-0001-9483-5604"]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vivek C. Goodoory","raw_affiliation_strings":["Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK","Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK","institution_ids":["https://openalex.org/I2801331674"]},{"raw_affiliation_string":"Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018298635","display_name":"Christy Riggott","orcid":"https://orcid.org/0000-0002-6927-9498","observed_orcids":["https://orcid.org/0000-0002-6927-9498"]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christy Riggott","raw_affiliation_strings":["Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK","Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK","institution_ids":["https://openalex.org/I2801331674"]},{"raw_affiliation_string":"Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080696080","display_name":"Mais Khasawneh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mais Khasawneh","raw_affiliation_strings":["Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK","Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK","institution_ids":["https://openalex.org/I2801331674"]},{"raw_affiliation_string":"Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006062033","display_name":"Christopher J. Black","orcid":"https://orcid.org/0000-0001-5449-3603","observed_orcids":["https://orcid.org/0000-0001-5449-3603"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher J. Black","raw_affiliation_strings":["Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK","Leeds Institute for Medical Research at St. James's University of Leeds  Leeds UK","Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK","Leeds Institute for Medical Research at St. James's, University of Leeds, Leeds, UK"],"raw_orcid":"https://orcid.org/0000-0001-5449-3603","affiliations":[{"raw_affiliation_string":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK","institution_ids":["https://openalex.org/I2801331674"]},{"raw_affiliation_string":"Leeds Institute for Medical Research at St. James's University of Leeds  Leeds UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK","institution_ids":["https://openalex.org/I2801331674"]},{"raw_affiliation_string":"Leeds Institute for Medical Research at St. James's, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044392782","display_name":"Alexander Charles Ford","orcid":"https://orcid.org/0000-0001-6371-4359","observed_orcids":["https://orcid.org/0000-0001-6371-4359"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alexander C. Ford","raw_affiliation_strings":["Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK","Leeds Institute for Medical Research at St. James's University of Leeds  Leeds UK","Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK","Leeds Institute for Medical Research at St. James's, University of Leeds, Leeds, UK"],"raw_orcid":"https://orcid.org/0000-0001-6371-4359","affiliations":[{"raw_affiliation_string":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK","institution_ids":["https://openalex.org/I2801331674"]},{"raw_affiliation_string":"Leeds Institute for Medical Research at St. James's University of Leeds  Leeds UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK","institution_ids":["https://openalex.org/I2801331674"]},{"raw_affiliation_string":"Leeds Institute for Medical Research at St. James's, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044392782"],"corresponding_institution_ids":["https://openalex.org/I130828816","https://openalex.org/I2801331674"],"apc_list":{"value":5250,"currency":"USD","value_usd":5250},"apc_paid":{"value":5250,"currency":"USD","value_usd":5250},"fwci":4.1617,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.94219895,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"61","issue":"2","first_page":"354","last_page":"362"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13289","display_name":"Infant Health and Development","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.996999979019165},{"id":"https://openalex.org/keywords/rome-iv-criteria","display_name":"Rome IV criteria","score":0.9869999885559082},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.7149999737739563},{"id":"https://openalex.org/keywords/abdominal-discomfort","display_name":"abdominal discomfort","score":0.9549999833106995},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/likelihood-ratios","display_name":"likelihood ratios","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9379590749740601},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.9169993996620178},{"id":"https://openalex.org/C2780955771","wikidata":"https://www.wikidata.org/wiki/Q183425","display_name":"Abdominal pain","level":2,"score":0.7059080004692078},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6018106937408447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5816709399223328},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5272171497344971}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063127","descriptor_name":"Secondary Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063127","descriptor_name":"Secondary Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063127","descriptor_name":"Secondary Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063127","descriptor_name":"Secondary Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063127","descriptor_name":"Secondary Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/apt.18363","doi":"https://doi.org/10.1111/apt.18363","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apt.18363","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apt.18363","source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology & Therapeutics","raw_type":"journal-article"},{"id":"pmid:39466700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39466700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary pharmacology & therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11671724","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11671724","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11671724/pdf/APT-61-354.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aliment Pharmacol Ther","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/apt.18363","doi":"https://doi.org/10.1111/apt.18363","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apt.18363","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apt.18363","source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology & Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6299999952316284}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403828362.pdf","grobid_xml":"https://content.openalex.org/works/W4403828362.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1764139713","https://openalex.org/W2000891332","https://openalex.org/W2001929187","https://openalex.org/W2002493891","https://openalex.org/W2012842548","https://openalex.org/W2024947408","https://openalex.org/W2052724916","https://openalex.org/W2064201279","https://openalex.org/W2065019547","https://openalex.org/W2066299684","https://openalex.org/W2083493752","https://openalex.org/W2099964125","https://openalex.org/W2112193322","https://openalex.org/W2112992146","https://openalex.org/W2146589073","https://openalex.org/W2166281097","https://openalex.org/W2316878322","https://openalex.org/W2342528407","https://openalex.org/W2463239941","https://openalex.org/W2484479140","https://openalex.org/W2533980158","https://openalex.org/W2795702526","https://openalex.org/W2947862867","https://openalex.org/W3016136018","https://openalex.org/W3020992444","https://openalex.org/W3042758557","https://openalex.org/W3089239219","https://openalex.org/W3115867544","https://openalex.org/W3159143441","https://openalex.org/W3216400540","https://openalex.org/W4211073917","https://openalex.org/W4380202602","https://openalex.org/W4392184822","https://openalex.org/W4396229361"],"related_works":["https://openalex.org/W3140310969","https://openalex.org/W126739309","https://openalex.org/W2014202481","https://openalex.org/W2375687360","https://openalex.org/W3185999389","https://openalex.org/W2098500838","https://openalex.org/W4281868032","https://openalex.org/W2370025972","https://openalex.org/W2350043805","https://openalex.org/W2802379714"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,226],"Rome":[2,23,83,165,227],"IV":[3,24,84,166,228],"criteria":[4,25,167,190,229],"for":[5,14,100,145],"irritable":[6],"bowel":[7],"syndrome":[8],"(IBS)":[9],"may":[10],"be":[11],"too":[12],"restrictive":[13],"clinical":[15],"practice":[16],"and":[17,26,104,133,135,161,170,174,182,218],"research.":[18],"AIMS:":[19],"To":[20],"validate":[21],"the":[22,28,164,189,193,205,239],"study":[27],"diagnostic":[29,147],"performance":[30,207],"of":[31,61,74,163,195,242],"simple":[32,236],"modifications":[33],"to":[34,57,106,124,198,204],"them.":[35],"METHODS:":[36],"We":[37,52,81,129,150],"collected":[38],"symptom":[39,97,121],"data":[40],"from":[41],"consecutive":[42],"adults":[43],"with":[44,66,140],"suspected":[45],"IBS":[46,59],"seen":[47],"in":[48,232],"a":[49,54],"single":[50],"clinic.":[51],"used":[53],"reference":[55],"standard":[56],"confirm":[58],"(presence":[60],"lower":[62],"abdominal":[63,93,102,117,196,243],"pain":[64,103,118,197,244],"associated":[65],"altered":[67],"stool":[68],"form":[69],"or":[70],"frequency;":[71],"no":[72],"evidence":[73],"organic":[75],"gastrointestinal":[76],"disease":[77],"after":[78],"limited":[79],"investigation).":[80],"applied":[82],"criteria,":[85],"but":[86,95,119],"also":[87],"two":[88],"modifications.":[89],"First,":[90],"we":[91,114],"re-incorporated":[92],"discomfort":[94,105],"kept":[96],"frequency":[98,122,194,241],"required":[99,240],"both":[101],"at":[107],"least":[108],"1":[109],"day":[110],"per":[111,127,201],"week.":[112],"Second,":[113],"included":[115],"only":[116],"relaxed":[120],"back":[123],"3":[125,199],"days":[126,200],"month.":[128],"calculated":[130],"sensitivity,":[131],"specificity":[132,162,210],"positive":[134,173,212],"negative":[136,175,219],"likelihood":[137],"ratios":[138],"(LRs),":[139],"95%":[141],"confidence":[142],"intervals":[143],"(CIs),":[144],"each":[146],"criterion.":[148],"RESULTS:":[149],"recruited":[151],"170":[152],"patients":[153],"(76.5%":[154],"female,":[155],"mean":[156],"age":[157],"37.9":[158],"years).":[159],"Sensitivity":[160],"were":[168,177],"82.1%":[169],"85.1%,":[171,211],"respectively;":[172],"LRs":[176],"5.51":[178],"(95%":[179,184,215,222],"CI":[180,185,216,223],"2.95-11.3)":[181],"0.21":[183],"0.14-0.31),":[186],"respectively.":[187],"Modifying":[188],"by":[191],"relaxing":[192,238],"month":[202],"led":[203],"best":[206],"[sensitivity":[208],"90.2%,":[209],"LR":[213,220],"6.06":[214],"3.25-12.2),":[217],"0.11":[221],"0.07-0.19)].":[224],"CONCLUSIONS:":[225],"performed":[230],"well":[231],"diagnosing":[233],"IBS.":[234],"A":[235],"modification":[237],"improved":[245],"their":[246],"performance.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-10-29T00:00:00"}