{"id":"https://openalex.org/W4403828107","doi":"https://doi.org/10.1016/j.neurot.2024.e00470","title":"Gut microbial metabolism in Alzheimer's disease and related dementias","display_name":"Gut microbial metabolism in Alzheimer's disease and related dementias","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403828107","doi":"https://doi.org/10.1016/j.neurot.2024.e00470","pmid":"https://pubmed.ncbi.nlm.nih.gov/39462700","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11585892"},"language":"en","primary_location":{"id":"doi:10.1016/j.neurot.2024.e00470","doi":"https://doi.org/10.1016/j.neurot.2024.e00470","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neurot.2024.e00470","pdf_url":"https://www.neurotherapeuticsjournal.org/article/S1878-7479(24)00157-0/pdf","source":{"id":"https://openalex.org/S75519821","display_name":"Neurotherapeutics","issn_l":"1878-7479","issn":["1878-7479","1933-7213"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.neurotherapeuticsjournal.org/article/S1878-7479(24)00157-0/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046593503","display_name":"Jea Woo Kang","orcid":"https://orcid.org/0000-0003-1202-4432","observed_orcids":["https://orcid.org/0000-0003-1202-4432"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jea Woo Kang","raw_affiliation_strings":["Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093579527","display_name":"Vaibhav Vemuganti","orcid":"https://orcid.org/0009-0002-7353-9683","observed_orcids":["https://orcid.org/0009-0002-7353-9683"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vaibhav Vemuganti","raw_affiliation_strings":["Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088668333","display_name":"Jessamine F. Kuehn","orcid":"https://orcid.org/0000-0002-2719-2474","observed_orcids":["https://orcid.org/0000-0002-2719-2474"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessamine F. Kuehn","raw_affiliation_strings":["Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016691718","display_name":"Tyler Kent Ulland","orcid":"https://orcid.org/0000-0002-6507-4989","observed_orcids":["https://orcid.org/0000-0002-6507-4989"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler K. Ulland","raw_affiliation_strings":["Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018494115","display_name":"Federico E. Rey","orcid":"https://orcid.org/0000-0002-0239-7780","observed_orcids":["https://orcid.org/0000-0002-0239-7780"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Federico E. Rey","raw_affiliation_strings":["Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023997184","display_name":"Barbara B. Bendlin","orcid":"https://orcid.org/0000-0002-0580-9875","observed_orcids":["https://orcid.org/0000-0002-0580-9875"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210132596","display_name":"University of Wisconsin Health","ror":"https://ror.org/03e3qgk42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Barbara B. Bendlin","raw_affiliation_strings":["Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: bbb@medicine.wisc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: bbb@medicine.wisc.edu","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210132596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023997184"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210132596"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":1.9276,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.88919685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"21","issue":"6","first_page":"e00470","last_page":"e00470"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease-and-related-dementias","display_name":"Alzheimer's disease and related dementias","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9380000233650208},{"id":"https://openalex.org/keywords/microbial-metabolites","display_name":"microbial metabolites","score":0.906000018119812},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.8090000152587891},{"id":"https://openalex.org/keywords/secondary-bile-acids","display_name":"secondary bile acids","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.9309999942779541},{"id":"https://openalex.org/keywords/kynurenine","display_name":"kynurenine","score":0.8830000162124634},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.8199999928474426},{"id":"https://openalex.org/keywords/tryptamine","display_name":"tryptamine","score":0.8949999809265137},{"id":"https://openalex.org/keywords/indole","display_name":"indole","score":0.9459999799728394},{"id":"https://openalex.org/keywords/trimethylamine-n-oxide","display_name":"trimethylamine N-oxide","score":0.9890000224113464},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9739999771118164},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.968999981880188},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.5429999828338623},{"id":"https://openalex.org/keywords/glial-activation","display_name":"glial activation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/intestinal-barrier","display_name":"intestinal barrier","score":0.6489999890327454},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.641948401927948},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6102586388587952},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5418248176574707},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4982428550720215},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4743337035179138},{"id":"https://openalex.org/C39920043","wikidata":"https://www.wikidata.org/wiki/Q786278","display_name":"Neurochemistry","level":3,"score":0.4242037236690521},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3945280611515045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28452712297439575},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19533193111419678}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000087502","descriptor_name":"Brain-Gut Axis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.neurot.2024.e00470","doi":"https://doi.org/10.1016/j.neurot.2024.e00470","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neurot.2024.e00470","pdf_url":"https://www.neurotherapeuticsjournal.org/article/S1878-7479(24)00157-0/pdf","source":{"id":"https://openalex.org/S75519821","display_name":"Neurotherapeutics","issn_l":"1878-7479","issn":["1878-7479","1933-7213"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11585892","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11585892","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11585892/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"Text"},{"id":"pmid:39462700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39462700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.neurot.2024.e00470","doi":"https://doi.org/10.1016/j.neurot.2024.e00470","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neurot.2024.e00470","pdf_url":"https://www.neurotherapeuticsjournal.org/article/S1878-7479(24)00157-0/pdf","source":{"id":"https://openalex.org/S75519821","display_name":"Neurotherapeutics","issn_l":"1878-7479","issn":["1878-7479","1933-7213"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3374083592","display_name":"Maximizing Power in AD Clinical Trials via Multimodal Machine Learning","funder_award_id":"R01AG040396","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5344177518","display_name":"CRCNS: Repurposing Transformers to Characterize Gut Microbiome & Aging Brain Axis","funder_award_id":"1r01ag092220-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6387946390","display_name":null,"funder_award_id":"R01 AG092220","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000883796","display_name":"Exploring the role of Imidazole Propionate on Alzheimer\u2019s Disease and Related Dementias","funder_award_id":"R21AG089348","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000902315","display_name":"Gut barrier function in Alzheimer\u2019s disease","funder_award_id":"R01AG070973","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000907065","display_name":"Wisconsin Alzheimer's Disease Research Center","funder_award_id":"P30AG062715","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000911325","display_name":"\u00df-hydroxybutyrate inhibition of pathology in Alzheimer's disease","funder_award_id":"R01AG083883","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403828107.pdf","grobid_xml":"https://content.openalex.org/works/W4403828107.grobid-xml"},"referenced_works_count":395,"referenced_works":["https://openalex.org/W36228569","https://openalex.org/W152513719","https://openalex.org/W171134882","https://openalex.org/W1487339845","https://openalex.org/W1569473466","https://openalex.org/W1617526274","https://openalex.org/W1811212287","https://openalex.org/W1965021718","https://openalex.org/W1975561334","https://openalex.org/W1976114760","https://openalex.org/W1983972858","https://openalex.org/W1984475571","https://openalex.org/W1987184081","https://openalex.org/W1993359155","https://openalex.org/W1997608252","https://openalex.org/W1999376421","https://openalex.org/W2003153796","https://openalex.org/W2004784996","https://openalex.org/W2006119667","https://openalex.org/W2014682848","https://openalex.org/W2014711343","https://openalex.org/W2014775641","https://openalex.org/W2016019060","https://openalex.org/W2016319251","https://openalex.org/W2016546278","https://openalex.org/W2016586816","https://openalex.org/W2018528537","https://openalex.org/W2019946207","https://openalex.org/W2023968928","https://openalex.org/W2027187941","https://openalex.org/W2031050244","https://openalex.org/W2033386838","https://openalex.org/W2033863805","https://openalex.org/W2037347206","https://openalex.org/W2042398122","https://openalex.org/W2043900297","https://openalex.org/W2044216294","https://openalex.org/W2044518579","https://openalex.org/W2045387428","https://openalex.org/W2045979765","https://openalex.org/W2046316092","https://openalex.org/W2046971089","https://openalex.org/W2047420624","https://openalex.org/W2048502267","https://openalex.org/W2049821596","https://openalex.org/W2051089741","https://openalex.org/W2052391479","https://openalex.org/W2066410861","https://openalex.org/W2066517796","https://openalex.org/W2071810366","https://openalex.org/W2073359524","https://openalex.org/W2073714219","https://openalex.org/W2078599166","https://openalex.org/W2078967065","https://openalex.org/W2079515425","https://openalex.org/W2082494455","https://openalex.org/W2084287384","https://openalex.org/W2085139899","https://openalex.org/W2085302232","https://openalex.org/W2086817396","https://openalex.org/W2089298736","https://openalex.org/W2098038381","https://openalex.org/W2100324626","https://openalex.org/W2106225067","https://openalex.org/W2106829739","https://openalex.org/W2110389012","https://openalex.org/W2112265988","https://openalex.org/W2114102190","https://openalex.org/W2117744314","https://openalex.org/W2119343060","https://openalex.org/W2122219120","https://openalex.org/W2123934417","https://openalex.org/W2126051108","https://openalex.org/W2128005399","https://openalex.org/W2129263431","https://openalex.org/W2135672838","https://openalex.org/W2137437179","https://openalex.org/W2142536690","https://openalex.org/W2142942734","https://openalex.org/W2148239264","https://openalex.org/W2150968312","https://openalex.org/W2152200355","https://openalex.org/W2152417392","https://openalex.org/W2154905690","https://openalex.org/W2155058651","https://openalex.org/W2162871918","https://openalex.org/W2164149639","https://openalex.org/W2164342861","https://openalex.org/W2164386968","https://openalex.org/W2165008361","https://openalex.org/W2167062509","https://openalex.org/W2168842536","https://openalex.org/W2171413866","https://openalex.org/W2175855318","https://openalex.org/W2182683962","https://openalex.org/W2188930066","https://openalex.org/W2193546234","https://openalex.org/W2209613548","https://openalex.org/W2230400342","https://openalex.org/W2238691813","https://openalex.org/W2274927794","https://openalex.org/W2287133098","https://openalex.org/W2295882128","https://openalex.org/W2297901344","https://openalex.org/W2335805754","https://openalex.org/W2343758687","https://openalex.org/W2345604850","https://openalex.org/W2345619279","https://openalex.org/W2346752870","https://openalex.org/W2371807656","https://openalex.org/W2393115371","https://openalex.org/W2400938511","https://openalex.org/W2401857311","https://openalex.org/W2407875089","https://openalex.org/W2409727515","https://openalex.org/W2469159017","https://openalex.org/W2473313434","https://openalex.org/W2500169107","https://openalex.org/W2508203511","https://openalex.org/W2508213551","https://openalex.org/W2508485654","https://openalex.org/W2547640677","https://openalex.org/W2558941943","https://openalex.org/W2581302565","https://openalex.org/W2582290224","https://openalex.org/W2586322440","https://openalex.org/W2592980662","https://openalex.org/W2606493877","https://openalex.org/W2612115087","https://openalex.org/W2614013403","https://openalex.org/W2615406383","https://openalex.org/W2622468178","https://openalex.org/W2741302852","https://openalex.org/W2741509806","https://openalex.org/W2742482801","https://openalex.org/W2744805498","https://openalex.org/W2751157908","https://openalex.org/W2755118309","https://openalex.org/W2755486443","https://openalex.org/W2759635061","https://openalex.org/W2761210275","https://openalex.org/W2767624273","https://openalex.org/W2769517706","https://openalex.org/W2769629043","https://openalex.org/W2773916510","https://openalex.org/W2780799404","https://openalex.org/W2781627604","https://openalex.org/W2783990112","https://openalex.org/W2789794205","https://openalex.org/W2790289132","https://openalex.org/W2790416725","https://openalex.org/W2790545717","https://openalex.org/W2790659853","https://openalex.org/W2790722255","https://openalex.org/W2791998898","https://openalex.org/W2792133920","https://openalex.org/W2794227656","https://openalex.org/W2795001242","https://openalex.org/W2795389370","https://openalex.org/W2798054687","https://openalex.org/W2799884346","https://openalex.org/W2799913710","https://openalex.org/W2800609088","https://openalex.org/W2801763052","https://openalex.org/W2802844035","https://openalex.org/W2802894273","https://openalex.org/W2807728333","https://openalex.org/W2807927929","https://openalex.org/W2863269164","https://openalex.org/W2884566703","https://openalex.org/W2886401819","https://openalex.org/W2892119478","https://openalex.org/W2892844483","https://openalex.org/W2897616897","https://openalex.org/W2898876242","https://openalex.org/W2898905022","https://openalex.org/W2900275225","https://openalex.org/W2903641122","https://openalex.org/W2904165696","https://openalex.org/W2904239670","https://openalex.org/W2906377431","https://openalex.org/W2912898974","https://openalex.org/W2917298154","https://openalex.org/W2919328337","https://openalex.org/W2919947473","https://openalex.org/W2922056291","https://openalex.org/W2929916017","https://openalex.org/W2939407924","https://openalex.org/W2939575977","https://openalex.org/W2942873194","https://openalex.org/W2944838918","https://openalex.org/W2946264652","https://openalex.org/W2946372752","https://openalex.org/W2946719617","https://openalex.org/W2948909067","https://openalex.org/W2949260349","https://openalex.org/W2953864347","https://openalex.org/W2954248757","https://openalex.org/W2958301851","https://openalex.org/W2965398438","https://openalex.org/W2968259240","https://openalex.org/W2970686316","https://openalex.org/W2970854520","https://openalex.org/W2979675761","https://openalex.org/W2981115487","https://openalex.org/W2981163416","https://openalex.org/W2989281229","https://openalex.org/W2992318817","https://openalex.org/W2992896690","https://openalex.org/W2994191294","https://openalex.org/W2997791567","https://openalex.org/W2999283181","https://openalex.org/W2999495572","https://openalex.org/W2999676104","https://openalex.org/W3001000734","https://openalex.org/W3002445804","https://openalex.org/W3003912482","https://openalex.org/W3006557860","https://openalex.org/W3006889435","https://openalex.org/W3007904732","https://openalex.org/W3012252805","https://openalex.org/W3013198098","https://openalex.org/W3016826587","https://openalex.org/W3017160392","https://openalex.org/W3019362303","https://openalex.org/W3022164397","https://openalex.org/W3022747103","https://openalex.org/W3026140883","https://openalex.org/W3027658010","https://openalex.org/W3028036404","https://openalex.org/W3033622977","https://openalex.org/W3034121529","https://openalex.org/W3037122402","https://openalex.org/W3039498906","https://openalex.org/W3040580248","https://openalex.org/W3045170495","https://openalex.org/W3046275966","https://openalex.org/W3046382238","https://openalex.org/W3048918321","https://openalex.org/W3049328559","https://openalex.org/W3087077238","https://openalex.org/W3087399555","https://openalex.org/W3087596326","https://openalex.org/W3088203083","https://openalex.org/W3092682035","https://openalex.org/W3093277171","https://openalex.org/W3094346505","https://openalex.org/W3096586635","https://openalex.org/W3099584915","https://openalex.org/W3107364628","https://openalex.org/W3110478820","https://openalex.org/W3110715890","https://openalex.org/W3110862190","https://openalex.org/W3111509171","https://openalex.org/W3120104891","https://openalex.org/W3121949934","https://openalex.org/W3123198870","https://openalex.org/W3127826052","https://openalex.org/W3131342463","https://openalex.org/W3131584903","https://openalex.org/W3132024224","https://openalex.org/W3133399234","https://openalex.org/W3137258609","https://openalex.org/W3139169691","https://openalex.org/W3146488742","https://openalex.org/W3146836254","https://openalex.org/W3153691725","https://openalex.org/W3155677729","https://openalex.org/W3158814312","https://openalex.org/W3161711140","https://openalex.org/W3162054665","https://openalex.org/W3164142207","https://openalex.org/W3164612418","https://openalex.org/W3168099987","https://openalex.org/W3173482446","https://openalex.org/W3173524456","https://openalex.org/W3175685877","https://openalex.org/W3179732585","https://openalex.org/W3185110408","https://openalex.org/W3186170050","https://openalex.org/W3186566903","https://openalex.org/W3190387101","https://openalex.org/W3191012379","https://openalex.org/W3202593794","https://openalex.org/W3202683854","https://openalex.org/W3203565491","https://openalex.org/W3205394101","https://openalex.org/W3206290564","https://openalex.org/W3206302034","https://openalex.org/W3206984927","https://openalex.org/W3207690139","https://openalex.org/W3210237178","https://openalex.org/W3211936564","https://openalex.org/W3216621316","https://openalex.org/W3216888705","https://openalex.org/W4200359472","https://openalex.org/W4205124233","https://openalex.org/W4205450561","https://openalex.org/W4206447491","https://openalex.org/W4207012211","https://openalex.org/W4210560728","https://openalex.org/W4213263592","https://openalex.org/W4220735064","https://openalex.org/W4220789397","https://openalex.org/W4220835202","https://openalex.org/W4220868537","https://openalex.org/W4220904562","https://openalex.org/W4223421819","https://openalex.org/W4223454405","https://openalex.org/W4223595127","https://openalex.org/W4224238989","https://openalex.org/W4224436908","https://openalex.org/W4224868124","https://openalex.org/W4225554953","https://openalex.org/W4229024985","https://openalex.org/W4281491216","https://openalex.org/W4281647100","https://openalex.org/W4282555635","https://openalex.org/W4283020259","https://openalex.org/W4283367198","https://openalex.org/W4283396332","https://openalex.org/W4283811133","https://openalex.org/W4283820390","https://openalex.org/W4285740412","https://openalex.org/W4285891880","https://openalex.org/W4291123984","https://openalex.org/W4292589907","https://openalex.org/W4293288643","https://openalex.org/W4295484465","https://openalex.org/W4295560725","https://openalex.org/W4295845630","https://openalex.org/W4297251675","https://openalex.org/W4304190408","https://openalex.org/W4308119200","https://openalex.org/W4309730087","https://openalex.org/W4309825678","https://openalex.org/W4309884182","https://openalex.org/W4310461604","https://openalex.org/W4312211449","https://openalex.org/W4313414699","https://openalex.org/W4313471861","https://openalex.org/W4315928364","https://openalex.org/W4317738851","https://openalex.org/W4318481494","https://openalex.org/W4318680477","https://openalex.org/W4318997179","https://openalex.org/W4319294868","https://openalex.org/W4319461701","https://openalex.org/W4321018263","https://openalex.org/W4321447147","https://openalex.org/W4322720275","https://openalex.org/W4323539013","https://openalex.org/W4324334438","https://openalex.org/W4362602430","https://openalex.org/W4364377365","https://openalex.org/W4367692803","https://openalex.org/W4377090840","https://openalex.org/W4378219872","https://openalex.org/W4379093499","https://openalex.org/W4379466814","https://openalex.org/W4380551368","https://openalex.org/W4381149331","https://openalex.org/W4383711104","https://openalex.org/W4384665281","https://openalex.org/W4385330162","https://openalex.org/W4385971890","https://openalex.org/W4385986371","https://openalex.org/W4386028473","https://openalex.org/W4386045943","https://openalex.org/W4386056632","https://openalex.org/W4386769064","https://openalex.org/W4387105231","https://openalex.org/W4387116892","https://openalex.org/W4387729030","https://openalex.org/W4387953225","https://openalex.org/W4388006742","https://openalex.org/W4388446531","https://openalex.org/W4388454249","https://openalex.org/W4388657686","https://openalex.org/W4389060592","https://openalex.org/W4390006444","https://openalex.org/W4391899254","https://openalex.org/W4392200554","https://openalex.org/W4392454669","https://openalex.org/W4393181106","https://openalex.org/W4394683622","https://openalex.org/W4394837461","https://openalex.org/W4395085030","https://openalex.org/W4396575704","https://openalex.org/W4396912157","https://openalex.org/W4398137527","https://openalex.org/W4400207662","https://openalex.org/W6722666752","https://openalex.org/W6743749709","https://openalex.org/W6782508780"],"related_works":["https://openalex.org/W4378009114","https://openalex.org/W7164414144","https://openalex.org/W4403687184","https://openalex.org/W4224211832","https://openalex.org/W4413106888","https://openalex.org/W4414020134","https://openalex.org/W4402606289","https://openalex.org/W7204572331","https://openalex.org/W7172025878","https://openalex.org/W4404060907"],"abstract_inverted_index":{"Multiple":[0],"studies":[1],"over":[2],"the":[3,20,32,38,60,71,124,132,136,157,174,185,201,204],"last":[4],"decade":[5],"have":[6,81,86,128],"established":[7],"that":[8,65,206],"Alzheimer's":[9],"disease":[10,48],"and":[11,55,62,69,113,115,126,140,146,148,164,178,190,192,196,213,225],"related":[12],"dementias":[13],"(ADRD)":[14],"are":[15,228],"associated":[16,83],"with":[17,84],"changes":[18,30],"in":[19,25,29,31,171,235],"gut":[21,175,211],"microbiome.":[22],"These":[23,97],"alterations":[24],"organismal":[26],"composition":[27],"result":[28],"abundances":[33],"of":[34,120,138,220],"functions":[35],"encoded":[36],"by":[37,59,210],"microbial":[39,79,221],"community,":[40],"including":[41,134],"metabolic":[42],"capabilities,":[43],"which":[44],"likely":[45],"impact":[46,156,173],"host":[47,61,91],"mechanisms.":[49],"Gut":[50],"microbes":[51],"access":[52],"dietary":[53],"components":[54],"other":[56],"molecules":[57],"made":[58],"produce":[63],"metabolites":[64,80,122,153,222],"can":[66,127,154],"enter":[67],"circulation":[68],"cross":[70,123],"blood-brain":[72],"barrier":[73,176],"(BBB).":[74],"In":[75],"recent":[76],"years,":[77],"several":[78],"been":[82,87],"or":[85],"shown":[88],"to":[89,94],"influence":[90],"pathways":[92],"relevant":[93],"ADRD":[95,207,227],"pathology.":[96],"include":[98],"short":[99],"chain":[100],"fatty":[101],"acids,":[102,105],"secondary":[103],"bile":[104],"tryptophan":[106],"derivatives":[107],"(such":[108],"as":[109,182,184],"kynurenine,":[110],"serotonin,":[111],"tryptamine,":[112],"indoles),":[114],"trimethylamine/trimethylamine":[116],"N-oxide.":[117],"Notably,":[118],"some":[119],"these":[121,169],"BBB":[125,186],"various":[129],"effects":[130],"on":[131],"brain,":[133],"modulating":[135],"release":[137],"neurotransmitters":[139],"neuronal":[141,188],"function,":[142],"inducing":[143],"oxidative":[144],"stress":[145],"inflammation,":[147],"impacting":[149],"synaptic":[150],"function.":[151],"Microbial":[152],"also":[155,229],"central":[158],"nervous":[159,166],"system":[160,167],"through":[161],"immune,":[162],"enteroendocrine,":[163],"enteric":[165],"pathways,":[168],"perturbations":[170],"turn":[172],"function":[177],"peripheral":[179],"immune":[180],"responses,":[181],"well":[183],"integrity,":[187],"homeostasis":[189],"neurogenesis,":[191],"glial":[193],"cell":[194],"maturation":[195],"activation.":[197],"This":[198],"review":[199],"examines":[200],"evidence":[202],"supporting":[203],"notion":[205],"is":[208],"influenced":[209],"microbiota":[212],"its":[214],"metabolites.":[215],"The":[216],"potential":[217,233],"therapeutic":[218],"advantages":[219],"for":[223],"preventing":[224],"treating":[226],"discussed,":[230],"highlighting":[231],"their":[232],"role":[234],"developing":[236],"new":[237],"treatments.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":33},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-29T00:00:00"}
