{"id":"https://openalex.org/W4403789303","doi":"https://doi.org/10.1016/s2213-2600(24)00217-0","title":"Nintedanib for patients with lymphangioleiomyomatosis: a phase 2, open-label, single-arm study","display_name":"Nintedanib for patients with lymphangioleiomyomatosis: a phase 2, open-label, single-arm study","publication_year":2024,"publication_date":"2024-10-25","ids":{"openalex":"https://openalex.org/W4403789303","doi":"https://doi.org/10.1016/s2213-2600(24)00217-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/39489895"},"language":"en","primary_location":{"id":"doi:10.1016/s2213-2600(24)00217-0","doi":"https://doi.org/10.1016/s2213-2600(24)00217-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2213-2600(24)00217-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210192742","display_name":"The Lancet Respiratory Medicine","issn_l":"2213-2600","issn":["2213-2600","2213-2619"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Respiratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071626680","display_name":"Sergio Alfonso Harari","orcid":"https://orcid.org/0000-0001-8629-7391","observed_orcids":["https://orcid.org/0000-0001-8629-7391"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210094922","display_name":"MultiMedica","ror":"https://ror.org/01h8ey223","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094922","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Sergio Harari","raw_affiliation_strings":["Division of Pulmonary and Respiratory Intermediate Care Unit, MultiMedica IRCCS, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. Electronic address: sergio.harari@unimi.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Respiratory Intermediate Care Unit, MultiMedica IRCCS, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. Electronic address: sergio.harari@unimi.it","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210094922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016213247","display_name":"Davide Elia","orcid":"https://orcid.org/0000-0002-7440-4978","observed_orcids":["https://orcid.org/0000-0002-7440-4978"]},"institutions":[{"id":"https://openalex.org/I4210094922","display_name":"MultiMedica","ror":"https://ror.org/01h8ey223","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094922","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Elia","raw_affiliation_strings":["Division of Pulmonary and Respiratory Intermediate Care Unit, MultiMedica IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Respiratory Intermediate Care Unit, MultiMedica IRCCS, Milan, Italy","institution_ids":["https://openalex.org/I4210094922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017716537","display_name":"Antonella Caminati","orcid":"https://orcid.org/0000-0002-6414-3460","observed_orcids":["https://orcid.org/0000-0002-6414-3460"]},"institutions":[{"id":"https://openalex.org/I4210094922","display_name":"MultiMedica","ror":"https://ror.org/01h8ey223","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094922","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonella Caminati","raw_affiliation_strings":["Division of Pulmonary and Respiratory Intermediate Care Unit, MultiMedica IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Respiratory Intermediate Care Unit, MultiMedica IRCCS, Milan, Italy","institution_ids":["https://openalex.org/I4210094922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020503463","display_name":"Jens Geginat","orcid":"https://orcid.org/0000-0003-4813-0384","observed_orcids":["https://orcid.org/0000-0003-4813-0384"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210160365","display_name":"Istituto Nazionale Genetica Molecolare","ror":"https://ror.org/05rb1q636","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210160365"]},{"id":"https://openalex.org/I4405268613","display_name":"Fondazione Romeo ed Enrica Invernizzi","ror":"https://ror.org/01hmx0351","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4405268613"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jens Geginat","raw_affiliation_strings":["Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; Fondazione Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; Fondazione Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210160365","https://openalex.org/I4405268613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022008360","display_name":"Francesca Luisi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094922","display_name":"MultiMedica","ror":"https://ror.org/01h8ey223","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094922","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Luisi","raw_affiliation_strings":["Division of Pulmonary and Respiratory Intermediate Care Unit, MultiMedica IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Respiratory Intermediate Care Unit, MultiMedica IRCCS, Milan, Italy","institution_ids":["https://openalex.org/I4210094922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048676751","display_name":"Giuseppe Pelosi","orcid":"https://orcid.org/0000-0003-4725-4692","observed_orcids":["https://orcid.org/0000-0003-4725-4692"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210094922","display_name":"MultiMedica","ror":"https://ror.org/01h8ey223","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094922","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Pelosi","raw_affiliation_strings":["Inter-hospital Pathology Division, MultiMedica IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inter-hospital Pathology Division, MultiMedica IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210094922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005861184","display_name":"Claudia Specchia","orcid":"https://orcid.org/0000-0002-1443-7874","observed_orcids":["https://orcid.org/0000-0002-1443-7874"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Specchia","raw_affiliation_strings":["Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110593249","display_name":"Olga Torre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094922","display_name":"MultiMedica","ror":"https://ror.org/01h8ey223","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094922","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Olga Torre","raw_affiliation_strings":["Division of Pulmonary and Respiratory Intermediate Care Unit, MultiMedica IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Respiratory Intermediate Care Unit, MultiMedica IRCCS, Milan, Italy","institution_ids":["https://openalex.org/I4210094922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102502832","display_name":"Roberta Trevisan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094922","display_name":"MultiMedica","ror":"https://ror.org/01h8ey223","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094922","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Trevisan","raw_affiliation_strings":["Department of Radiology, MultiMedica IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, MultiMedica IRCCS, Milan, Italy","institution_ids":["https://openalex.org/I4210094922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002275396","display_name":"Chiara Vasco","orcid":"https://orcid.org/0000-0002-3788-778X","observed_orcids":["https://orcid.org/0000-0002-3788-778X"]},"institutions":[{"id":"https://openalex.org/I4210160365","display_name":"Istituto Nazionale Genetica Molecolare","ror":"https://ror.org/05rb1q636","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210160365"]},{"id":"https://openalex.org/I4405268613","display_name":"Fondazione Romeo ed Enrica Invernizzi","ror":"https://ror.org/01hmx0351","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4405268613"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Vasco","raw_affiliation_strings":["Fondazione Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy","institution_ids":["https://openalex.org/I4210160365","https://openalex.org/I4405268613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041552962","display_name":"Maurizio Zompatori","orcid":"https://orcid.org/0000-0002-1823-9955","observed_orcids":["https://orcid.org/0000-0002-1823-9955"]},"institutions":[{"id":"https://openalex.org/I4210094922","display_name":"MultiMedica","ror":"https://ror.org/01h8ey223","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094922","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Zompatori","raw_affiliation_strings":["Department of Radiology, MultiMedica IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, MultiMedica IRCCS, Milan, Italy","institution_ids":["https://openalex.org/I4210094922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037190293","display_name":"Roberto Cassandro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094922","display_name":"MultiMedica","ror":"https://ror.org/01h8ey223","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094922","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Cassandro","raw_affiliation_strings":["Division of Pulmonary and Respiratory Intermediate Care Unit, MultiMedica IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Respiratory Intermediate Care Unit, MultiMedica IRCCS, Milan, Italy","institution_ids":["https://openalex.org/I4210094922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5071626680"],"corresponding_institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210094922"],"apc_list":{"value":6300,"currency":"USD","value_usd":6300},"apc_paid":null,"fwci":4.4817,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.95620843,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"12","first_page":"967","last_page":"974"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13759","display_name":"Medical Imaging and Pathology Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphangioleiomyomatosis","display_name":"lymphangioleiomyomatosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nintedanib","display_name":"nintedanib","score":1.0},{"id":"https://openalex.org/keywords/multikinase-inhibitor","display_name":"multikinase inhibitor","score":0.8629999756813049},{"id":"https://openalex.org/keywords/pdgfr-inhibition","display_name":"PDGFR inhibition","score":0.8970000147819519},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.7450000047683716},{"id":"https://openalex.org/keywords/tuberous-sclerosis-complex","display_name":"tuberous sclerosis complex","score":0.8709999918937683},{"id":"https://openalex.org/keywords/lung-function-decline","display_name":"lung function decline","score":0.781000018119812},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.8669999837875366},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6259999871253967},{"id":"https://openalex.org/keywords/women-of-reproductive-age","display_name":"women of reproductive age","score":0.7080000042915344},{"id":"https://openalex.org/keywords/treatment-naive-patients","display_name":"treatment-naive patients","score":0.4350000023841858},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8420000076293945},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9607909917831421},{"id":"https://openalex.org/C2780171596","wikidata":"https://www.wikidata.org/wiki/Q15149723","display_name":"Nintedanib","level":4,"score":0.9450204968452454},{"id":"https://openalex.org/C2779997425","wikidata":"https://www.wikidata.org/wiki/Q1878759","display_name":"Lymphangioleiomyomatosis","level":3,"score":0.7950170040130615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42458462715148926},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.0},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018192","descriptor_name":"Lymphangioleiomyomatosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s2213-2600(24)00217-0","doi":"https://doi.org/10.1016/s2213-2600(24)00217-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2213-2600(24)00217-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210192742","display_name":"The Lancet Respiratory Medicine","issn_l":"2213-2600","issn":["2213-2600","2213-2619"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Respiratory Medicine","raw_type":"journal-article"},{"id":"pmid:39489895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39489895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet. Respiratory medicine","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unibs.it:11379/615241","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11379/615241","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306257","display_name":"Boehringer Ingelheim","ror":"https://ror.org/05kffp613"},{"id":"https://openalex.org/F4320310441","display_name":"Boehringer Ingelheim","ror":"https://ror.org/00q32j219"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W2038028072","https://openalex.org/W2039493274","https://openalex.org/W2077075372","https://openalex.org/W2099927259","https://openalex.org/W2102318070","https://openalex.org/W2138871107","https://openalex.org/W2142387449","https://openalex.org/W2145804860","https://openalex.org/W2146421823","https://openalex.org/W2147028601","https://openalex.org/W2160200374","https://openalex.org/W2164344519","https://openalex.org/W2189528859","https://openalex.org/W2520077507","https://openalex.org/W2974960379","https://openalex.org/W3156020756","https://openalex.org/W3164957708","https://openalex.org/W3197400466","https://openalex.org/W4315798390","https://openalex.org/W4367668318"],"related_works":["https://openalex.org/W4387979696","https://openalex.org/W3037869553","https://openalex.org/W2147028601","https://openalex.org/W7161595878","https://openalex.org/W2330161206","https://openalex.org/W2900987959","https://openalex.org/W3160358127","https://openalex.org/W2324694366","https://openalex.org/W4416639572","https://openalex.org/W2511653609"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2024-10-27T00:00:00"}