{"id":"https://openalex.org/W4403789232","doi":"https://doi.org/10.1080/03639045.2024.2421198","title":"pH sensitive lipid polymeric hybrid nanoparticle (LPHNP) of paclitaxel and curcumin for targeted delivery in breast cancer","display_name":"pH sensitive lipid polymeric hybrid nanoparticle (LPHNP) of paclitaxel and curcumin for targeted delivery in breast cancer","publication_year":2024,"publication_date":"2024-10-02","ids":{"openalex":"https://openalex.org/W4403789232","doi":"https://doi.org/10.1080/03639045.2024.2421198","pmid":"https://pubmed.ncbi.nlm.nih.gov/39461888"},"language":"en","primary_location":{"id":"doi:10.1080/03639045.2024.2421198","doi":"https://doi.org/10.1080/03639045.2024.2421198","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03639045.2024.2421198","pdf_url":null,"source":{"id":"https://openalex.org/S162444473","display_name":"Drug Development and Industrial Pharmacy","issn_l":"0363-9045","issn":["0363-9045","1520-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development and Industrial Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018244372","display_name":"Hrishikesh Sarma","orcid":"https://orcid.org/0000-0002-5936-1375","observed_orcids":["https://orcid.org/0000-0002-5936-1375"]},"institutions":[{"id":"https://openalex.org/I4405257221","display_name":"Assam Science and Technology University","ror":"https://ror.org/05192rv21","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405257221"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hrishikesh Sarma","raw_affiliation_strings":["Pharmaceutics Research Lab, GIPS, Assam Science and Technology University, Guwahati, Assam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutics Research Lab, GIPS, Assam Science and Technology University, Guwahati, Assam, India","institution_ids":["https://openalex.org/I4405257221"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ankit Dutta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257221","display_name":"Assam Science and Technology University","ror":"https://ror.org/05192rv21","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405257221"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ankit Dutta","raw_affiliation_strings":["Pharmaceutics Research Lab, GIPS, Assam Science and Technology University, Guwahati, Assam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutics Research Lab, GIPS, Assam Science and Technology University, Guwahati, Assam, India","institution_ids":["https://openalex.org/I4405257221"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043229118","display_name":"Alakesh Bharali","orcid":"https://orcid.org/0000-0002-6475-9193","observed_orcids":["https://orcid.org/0000-0002-6475-9193"]},"institutions":[{"id":"https://openalex.org/I4405257221","display_name":"Assam Science and Technology University","ror":"https://ror.org/05192rv21","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405257221"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Alakesh Bharali","raw_affiliation_strings":["Advanced Drug Delivery Lab, School of Pharmaceutical Sciences, Girijananda Chowdhury University, Guwahati, Assam, India","Pharmaceutics Research Lab, GIPS, Assam Science and Technology University, Guwahati, Assam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Drug Delivery Lab, School of Pharmaceutical Sciences, Girijananda Chowdhury University, Guwahati, Assam, India","institution_ids":[]},{"raw_affiliation_string":"Pharmaceutics Research Lab, GIPS, Assam Science and Technology University, Guwahati, Assam, India","institution_ids":["https://openalex.org/I4405257221"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014388248","display_name":"Sheikh Sofiur Rahman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257221","display_name":"Assam Science and Technology University","ror":"https://ror.org/05192rv21","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405257221"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sheikh Sofiur Rahman","raw_affiliation_strings":["Pharmaceutics Research Lab, GIPS, Assam Science and Technology University, Guwahati, Assam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutics Research Lab, GIPS, Assam Science and Technology University, Guwahati, Assam, India","institution_ids":["https://openalex.org/I4405257221"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sunayana Baruah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunayana Baruah","raw_affiliation_strings":["Animal House Facility, Girijananda Chowdhury University, Guwahati, Assam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal House Facility, Girijananda Chowdhury University, Guwahati, Assam, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103144159","display_name":"Nikhil Biswas","orcid":"https://orcid.org/0000-0002-9630-1646","observed_orcids":["https://orcid.org/0000-0002-9630-1646"]},"institutions":[{"id":"https://openalex.org/I4405257221","display_name":"Assam Science and Technology University","ror":"https://ror.org/05192rv21","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405257221"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Nikhil Biswas","raw_affiliation_strings":["Advanced Drug Delivery Lab, School of Pharmaceutical Sciences, Girijananda Chowdhury University, Guwahati, Assam, India","Pharmaceutics Research Lab, GIPS, Assam Science and Technology University, Guwahati, Assam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Drug Delivery Lab, School of Pharmaceutical Sciences, Girijananda Chowdhury University, Guwahati, Assam, India","institution_ids":[]},{"raw_affiliation_string":"Pharmaceutics Research Lab, GIPS, Assam Science and Technology University, Guwahati, Assam, India","institution_ids":["https://openalex.org/I4405257221"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012348114","display_name":"Bhanu Pratap Sahu","orcid":"https://orcid.org/0000-0002-8036-6496","observed_orcids":["https://orcid.org/0000-0002-8036-6496"]},"institutions":[{"id":"https://openalex.org/I4405257221","display_name":"Assam Science and Technology University","ror":"https://ror.org/05192rv21","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405257221"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Bhanu P. Sahu","raw_affiliation_strings":["Advanced Drug Delivery Lab, School of Pharmaceutical Sciences, Girijananda Chowdhury University, Guwahati, Assam, India","Pharmaceutics Research Lab, GIPS, Assam Science and Technology University, Guwahati, Assam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Drug Delivery Lab, School of Pharmaceutical Sciences, Girijananda Chowdhury University, Guwahati, Assam, India","institution_ids":[]},{"raw_affiliation_string":"Pharmaceutics Research Lab, GIPS, Assam Science and Technology University, Guwahati, Assam, India","institution_ids":["https://openalex.org/I4405257221"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012348114","https://openalex.org/A5103144159"],"corresponding_institution_ids":["https://openalex.org/I4405257221"],"apc_list":null,"apc_paid":null,"fwci":1.3792,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.76616593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"50","issue":"10","first_page":"856","last_page":"864"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ph-responsive-drug-delivery","display_name":"pH-responsive drug delivery","score":0.8489999771118164},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9900000095367432},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/chitosan-coating","display_name":"chitosan coating","score":0.8840000033378601},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tumor-acidosis","display_name":"tumor acidosis","score":0.718999981880188},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.5690000057220459},{"id":"https://openalex.org/keywords/co-loading","display_name":"co-loading","score":0.4519999921321869},{"id":"https://openalex.org/keywords/nanoprecipitation","display_name":"nanoprecipitation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.3569999933242798}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.9126663208007812},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.8774282932281494},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5752867460250854},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5341320037841797},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5279577970504761},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5161846280097961},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4952985346317291},{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.49288415908813477},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.4727631211280823},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.42216306924819946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28140926361083984},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.230804443359375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18759530782699585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1537753939628601}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/03639045.2024.2421198","doi":"https://doi.org/10.1080/03639045.2024.2421198","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03639045.2024.2421198","pdf_url":null,"source":{"id":"https://openalex.org/S162444473","display_name":"Drug Development and Industrial Pharmacy","issn_l":"0363-9045","issn":["0363-9045","1520-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development and Industrial Pharmacy","raw_type":"journal-article"},{"id":"pmid:39461888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39461888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug development and industrial pharmacy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W745358854","https://openalex.org/W1543790510","https://openalex.org/W2005452896","https://openalex.org/W2043176665","https://openalex.org/W2045496198","https://openalex.org/W2067915666","https://openalex.org/W2070803838","https://openalex.org/W2073949625","https://openalex.org/W2085131775","https://openalex.org/W2085289602","https://openalex.org/W2102699720","https://openalex.org/W2110624293","https://openalex.org/W2119703555","https://openalex.org/W2158004803","https://openalex.org/W2168144093","https://openalex.org/W2230774605","https://openalex.org/W2512370048","https://openalex.org/W2592522171","https://openalex.org/W2735861832","https://openalex.org/W2892122806","https://openalex.org/W2920032459","https://openalex.org/W2921389011","https://openalex.org/W2944182796","https://openalex.org/W2951620864","https://openalex.org/W2954354974","https://openalex.org/W2965032633","https://openalex.org/W2978666811","https://openalex.org/W2984395468","https://openalex.org/W2996573188","https://openalex.org/W3008096817","https://openalex.org/W3048850875","https://openalex.org/W3084220947","https://openalex.org/W3093178918","https://openalex.org/W3170076463","https://openalex.org/W3215543479","https://openalex.org/W4235739337","https://openalex.org/W4283067314","https://openalex.org/W4283400547","https://openalex.org/W4296676675","https://openalex.org/W4313205287","https://openalex.org/W4313443338","https://openalex.org/W4319790292","https://openalex.org/W4366769706","https://openalex.org/W4377097543","https://openalex.org/W4386592564","https://openalex.org/W4387296932","https://openalex.org/W4387402168","https://openalex.org/W4387737755","https://openalex.org/W4389580428","https://openalex.org/W4391281564","https://openalex.org/W4395672205","https://openalex.org/W4396221334","https://openalex.org/W4396612770","https://openalex.org/W4398238738"],"related_works":["https://openalex.org/W4255167325","https://openalex.org/W3155551263","https://openalex.org/W4231049302","https://openalex.org/W4409386147","https://openalex.org/W4391670227","https://openalex.org/W2782488296","https://openalex.org/W3161871940","https://openalex.org/W4405420441","https://openalex.org/W2071847433","https://openalex.org/W7148185145"],"abstract_inverted_index":{"Objective":[0],"The":[1,56,217],"study":[2],"aimed":[3],"at":[4],"designing":[5],"a":[6,85,90,175,183,199,209,225],"pH":[7,113,125],"sensitive":[8],"Lipid":[9],"polymeric":[10],"Hybrid":[11],"nanoparticle":[12],"(LPHNP)":[13],"for":[14,132,162,180,186,235,242],"targeted":[15],"release":[16,33,102,106,122,193],"of":[17,37,63,87,92,107,142,151,206,215,221],"Paclitaxel":[18],"(PTX)":[19,80],"and":[20,46,71,78,94,109,118,134,144,182,194,208,238],"Curcumin":[21],"(CUR)":[22,77],"in":[23,30,34,61,123,127,168,178,202,212],"breast":[24],"cancer.Significance":[25],"Such":[26],"systems":[27],"shall":[28],"result":[29],"controlled":[31,105,192],"triggered":[32],"acidic":[35],"microenvironment":[36],"tumor":[38,112],"cells":[39],"with":[40,75,174],"improved":[41,172],"pharmacokinetic":[42,166],"profile.Methods":[43],"Chitosan-coated":[44],"CUR":[45,108,135,143,153,181,207],"PTX":[47,110,133,145,155],"coloaded":[48],"pH-sensitive":[49],"LPHNPs":[50,73,147,190],"were":[51,59,81],"synthesized":[52,57],"employing":[53],"nanoprecipitation":[54],"technique.":[55],"NPs":[58],"characterized":[60],"terms":[62],"particle":[64],"size,":[65],"polydispersity":[66],"index":[67],"(PDI),":[68],"zeta":[69],"potential,":[70],"morphology.Results":[72],"co-loaded":[74],"curcumin":[76],"paclitaxel":[79],"successfully":[82],"formulated,":[83],"achieving":[84],"size":[86,234],"146":[88],"nm,":[89],"PDI":[91],"0.18,":[93],"an":[95],"entrapment":[96],"efficiency":[97],"exceeding":[98],"90%.":[99],"In":[100,164],"vitro":[101],"studies":[103,138],"demonstrated":[104,191],"under":[111],"conditions":[114],"showing":[115,148],"1.6":[116],"fold":[117,120],"1.7":[119],"higher":[121],"ABS":[124],"5":[126],"comparison":[128],"to":[129,159],"PBS":[130],"7.4":[131],"respectively.":[136],"MTT-assay":[137],"revealed":[139],"enhanced":[140],"cytotoxicity":[141],"as":[146,224],"IC50":[149],"value":[150],"free":[152],"&":[154],"480.06":[156],"\u00b5g/mL":[157,161],"decreasing":[158],"282.97":[160],"CS-CUR-PTX-LPHNPs.":[163],"vivo":[165],"evaluations":[167],"rats":[169],"confirmed":[170],"significantly":[171],"bioavailability,":[173],"3.8-fold":[176],"increase":[177,185,201,211],"AUC":[179],"6.6-fold":[184],"PTX.":[187],"Additionally,":[188],"the":[189,203,213],"prolonged":[195,239],"retention,":[196],"evidenced":[197],"by":[198],"2.2-fold":[200],"half-life":[204,214],"(t1/2)":[205],"1.3-fold":[210],"PTX.Conclusions:":[216],"results":[218],"underscores":[219],"potential":[220],"chitosan-coated":[222],"LPHNP":[223],"promising":[226],"delivery":[227],"platform,":[228],"offering":[229],"high":[230],"drug":[231],"loading,":[232],"optimal":[233],"cellular":[236],"penetration,":[237],"blood":[240],"circulation":[241],"cancer.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2024-10-27T00:00:00"}
