{"id":"https://openalex.org/W4403778663","doi":"https://doi.org/10.2147/ijn.s485084","title":"Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway","display_name":"Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403778663","doi":"https://doi.org/10.2147/ijn.s485084","pmid":"https://pubmed.ncbi.nlm.nih.gov/39479173"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s485084","doi":"https://doi.org/10.2147/ijn.s485084","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s485084","pdf_url":null,"source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2147/ijn.s485084","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100462165","display_name":"Dandan Wang","orcid":"https://orcid.org/0000-0002-5626-8968","observed_orcids":["https://orcid.org/0000-0002-5626-8968","https://orcid.org/0000-0003-3493-1615"]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]},{"id":"https://openalex.org/I16365422","display_name":"Hefei University of Technology","ror":"https://ror.org/02czkny70","country_code":"CN","type":"education","lineage":["https://openalex.org/I16365422"]},{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dandan Wang","raw_affiliation_strings":["School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, 230601, People's Republic of China","School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, 230011, People's Republic of China","State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, 230601, People's Republic of China","institution_ids":["https://openalex.org/I16365422"]},{"raw_affiliation_string":"School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, 230011, People's Republic of China","institution_ids":["https://openalex.org/I253932293"]},{"raw_affiliation_string":"State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, People's Republic of China","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081523200","display_name":"Jingguo Wang","orcid":"https://orcid.org/0000-0001-9527-3359","observed_orcids":["https://orcid.org/0000-0001-9527-3359"]},"institutions":[{"id":"https://openalex.org/I16365422","display_name":"Hefei University of Technology","ror":"https://ror.org/02czkny70","country_code":"CN","type":"education","lineage":["https://openalex.org/I16365422"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingguo Wang","raw_affiliation_strings":["School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, 230601, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, 230601, People's Republic of China","institution_ids":["https://openalex.org/I16365422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038077492","display_name":"Zequn Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zequn Yin","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230031, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230031, People's Republic of China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000091844","display_name":"Ke Qin Gong","orcid":"https://orcid.org/0000-0003-0337-297X","observed_orcids":["https://orcid.org/0000-0003-0337-297X"]},"institutions":[{"id":"https://openalex.org/I16365422","display_name":"Hefei University of Technology","ror":"https://ror.org/02czkny70","country_code":"CN","type":"education","lineage":["https://openalex.org/I16365422"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Gong","raw_affiliation_strings":["School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, 230601, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, 230601, People's Republic of China","institution_ids":["https://openalex.org/I16365422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321547","display_name":"Shuang Zhang","orcid":"https://orcid.org/0000-0001-6045-4934","observed_orcids":["https://orcid.org/0000-0001-6045-4934","https://orcid.org/0009-0005-3306-7564"]},"institutions":[{"id":"https://openalex.org/I16365422","display_name":"Hefei University of Technology","ror":"https://ror.org/02czkny70","country_code":"CN","type":"education","lineage":["https://openalex.org/I16365422"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Zhang","raw_affiliation_strings":["School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, 230601, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, 230601, People's Republic of China","institution_ids":["https://openalex.org/I16365422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047537045","display_name":"Zhengbao Zha","orcid":"https://orcid.org/0000-0003-3646-4969","observed_orcids":["https://orcid.org/0000-0003-3646-4969"]},"institutions":[{"id":"https://openalex.org/I16365422","display_name":"Hefei University of Technology","ror":"https://ror.org/02czkny70","country_code":"CN","type":"education","lineage":["https://openalex.org/I16365422"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengbao Zha","raw_affiliation_strings":["School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, 230601, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, 230601, People's Republic of China","institution_ids":["https://openalex.org/I16365422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028875731","display_name":"Yajun Duan","orcid":"https://orcid.org/0000-0002-3880-9070","observed_orcids":["https://orcid.org/0000-0002-3880-9070"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yajun Duan","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230031, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-3880-9070","affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230031, People's Republic of China","institution_ids":["https://openalex.org/I126520041"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.7832,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.74288882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"Volume 19","issue":null,"first_page":"10839","last_page":"10856"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11286","display_name":"Polyoxometalates: Synthesis and Applications","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyoxometalates","display_name":"polyoxometalates","score":0.9980000257492065},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9449999928474426},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ampk-signaling","display_name":"AMPK signaling","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/hepatic-lipotoxicity","display_name":"hepatic lipotoxicity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/methionine-and-choline-deficient-diet","display_name":"methionine-choline-deficient diet","score":0.9449999928474426},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9710000157356262},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/srebp-1c","display_name":"SREBP-1c","score":0.8870000243186951},{"id":"https://openalex.org/keywords/srebp-2","display_name":"SREBP2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7409999966621399},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7009999752044678},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.7896590232849121},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6660158038139343},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.6020076274871826},{"id":"https://openalex.org/C2991928575","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver dysfunction","level":2,"score":0.5083820223808289},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4909415543079376},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.45770832896232605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.447598934173584},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.42484793066978455},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3597410023212433},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35656505823135376},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3280043601989746},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27484869956970215},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.26019173860549927},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2376977801322937},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.230329692363739},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.19824102520942688},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19561359286308289},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18150433897972107}],"mesh":[{"descriptor_ui":"D000099294","descriptor_name":"Polyoxometalates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002796","descriptor_name":"Choline Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002796","descriptor_name":"Choline Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002796","descriptor_name":"Choline Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002796","descriptor_name":"Choline Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002796","descriptor_name":"Choline Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017973","descriptor_name":"Tungsten Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017973","descriptor_name":"Tungsten Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017973","descriptor_name":"Tungsten Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017973","descriptor_name":"Tungsten Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017973","descriptor_name":"Tungsten Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.2147/ijn.s485084","doi":"https://doi.org/10.2147/ijn.s485084","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s485084","pdf_url":null,"source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmid:39479173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39479173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11522013","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11522013","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmh:oai:dovepress.com/96698","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/polyoxometalates-ameliorate-metabolic-dysfunction-associated-steatotic-peer-reviewed-fulltext-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijn.s485084","doi":"https://doi.org/10.2147/ijn.s485084","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s485084","pdf_url":null,"source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5699999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1772109929","https://openalex.org/W1865130935","https://openalex.org/W1967286688","https://openalex.org/W1973163466","https://openalex.org/W1985592156","https://openalex.org/W1989601885","https://openalex.org/W1996821192","https://openalex.org/W2003066513","https://openalex.org/W2012636160","https://openalex.org/W2016294119","https://openalex.org/W2022267544","https://openalex.org/W2028175614","https://openalex.org/W2034641256","https://openalex.org/W2042444876","https://openalex.org/W2048790924","https://openalex.org/W2048954429","https://openalex.org/W2053026149","https://openalex.org/W2056728315","https://openalex.org/W2061864595","https://openalex.org/W2067872036","https://openalex.org/W2077645437","https://openalex.org/W2085097924","https://openalex.org/W2109420297","https://openalex.org/W2116613046","https://openalex.org/W2123856468","https://openalex.org/W2141007767","https://openalex.org/W2146544786","https://openalex.org/W2149113518","https://openalex.org/W2413144011","https://openalex.org/W2466770606","https://openalex.org/W2478735184","https://openalex.org/W2513893629","https://openalex.org/W2521805632","https://openalex.org/W2607592153","https://openalex.org/W2610037213","https://openalex.org/W2696298149","https://openalex.org/W2744982526","https://openalex.org/W2755540671","https://openalex.org/W2763871199","https://openalex.org/W2769374409","https://openalex.org/W2808519915","https://openalex.org/W2810629608","https://openalex.org/W2888859009","https://openalex.org/W2890019747","https://openalex.org/W2905491630","https://openalex.org/W2906748726","https://openalex.org/W2967911867","https://openalex.org/W2977666365","https://openalex.org/W2980024760","https://openalex.org/W2994912142","https://openalex.org/W3005522739","https://openalex.org/W3084460068","https://openalex.org/W3099567402","https://openalex.org/W3107603533","https://openalex.org/W3108262002","https://openalex.org/W3110236069","https://openalex.org/W4310974966"],"related_works":["https://openalex.org/W4323320733","https://openalex.org/W12249326","https://openalex.org/W2365906682","https://openalex.org/W1970339330","https://openalex.org/W2045273766","https://openalex.org/W4328014552","https://openalex.org/W4403451462","https://openalex.org/W4328024876","https://openalex.org/W2889039229","https://openalex.org/W4400914691"],"abstract_inverted_index":{"Introduction:":[0],"Metabolic":[1],"dysfunction-associated":[2,38],"steatotic":[3],"liver":[4,11,71,144],"disease":[5,72],"(MASLD),":[6],"the":[7,25,49,123,129,192,206,214,232],"most":[8],"prevalent":[9],"chronic":[10],"disorder,":[12],"has":[13],"garnered":[14],"increasing":[15],"attention":[16],"globally":[17],"owing":[18],"to":[19,83,93,121,195,238],"its":[20],"associated":[21],"health":[22],"complications.":[23],"However,":[24],"lack":[26],"of":[27,34,51,66,126,131,208,216,234],"available":[28],"therapeutic":[29,252],"medications":[30],"and":[31,97,104,106,116,146,172,180,187,227],"inadequate":[32],"management":[33],"complications":[35],"in":[36,53,73,128,137,140,149,155,185,257],"metabolic":[37,100],"steatohepatitis":[39],"(MASH)":[40],"present":[41],"significant":[42,138],"challenges.":[43],"There":[44],"are":[45],"little":[46],"studies":[47],"evaluating":[48],"effectiveness":[50],"POM":[52,127,134,165,174,212,248],"treating":[54],"MASLD.":[55,67,112,132],"In":[56],"this":[57],"study,":[58],"we":[59],"synthesized":[60],"polyoxometalates":[61],"(POM)":[62],"for":[63],"potential":[64],"treatment":[65,130,175],"Methods:":[68],"We":[69],"induced":[70],"mice":[74,150],"using":[75],"two":[76],"approaches:":[77],"feeding":[78,87],"a":[79,88,152,156,250],"high-fat":[80],"diet":[81,92],"(HFD)":[82],"establish":[84],"MASLD":[85,259],"or":[86],"methionine-choline":[89],"deficient":[90],"(MCD)":[91],"induce":[94],"hepatic":[95,147,168],"lipotoxicity":[96],"MASH.":[98],"Various":[99],"parameters":[101],"were":[102,109,119],"detected,":[103],"biochemical":[105],"histological":[107],"evaluations":[108],"conducted":[110],"on":[111],"Western":[113],"blotting,":[114],"qRT-PCR":[115],"immunofluorescence":[117],"assays":[118],"used":[120],"elucidate":[122],"molecular":[124],"mechanism":[125],"Results:":[133],"therapy":[135],"resulted":[136],"improvements":[139],"weight":[141],"gain,":[142],"dyslipidemia,":[143],"injury,":[145],"steatosis":[148],"fed":[151],"HFD.":[153],"Notably,":[154],"more":[157],"severe":[158],"dietary-induced":[159],"MASH":[160],"model":[161],"with":[162,254],"MCD":[163],"diet,":[164],"significantly":[166],"attenuated":[167,177],"lipid":[169,183,197,217],"accumulation,":[170],"inflammation,":[171],"fibrosis.":[173],"effectively":[176],"palmitic":[178],"acid":[179,241],"oleic":[181],"acid-induced":[182],"accumulation":[184],"HepG2":[186],"Huh7":[188],"cells":[189],"by":[190,202,211],"targeting":[191],"AMPK":[193,203,209],"pathway":[194],"regulate":[196],"metabolism,":[198],"which":[199],"was":[200],"confirmed":[201],"inhibitor.":[204],"Additionally,":[205],"activation":[207],"signaling":[210],"suppressed":[213],"expression":[215,233],"synthesis":[218],"genes,":[219],"including":[220],"sterol":[221],"regulatory":[222],"element-binding":[223],"protein":[224],"1c":[225],"(SREBP1c)":[226],"SREBP2,":[228],"while":[229],"concurrently":[230],"upregulating":[231],"sirtuin":[235],"1":[236],"(SIRT1)":[237],"promote":[239],"fatty":[240],"oxidation.":[242],"Conclusion:":[243],"These":[244],"findings":[245],"suggest":[246],"that":[247],"is":[249],"promising":[251],"strategy":[253],"high":[255],"efficacy":[256],"multiple":[258],"models.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
