{"id":"https://openalex.org/W4403771015","doi":"https://doi.org/10.46235/1028-7221-16689-cco","title":"Comparative characteristics of the blood cytokine profile in gastritis in schoolchildren with a family predisposition to gastric cancer and peptic ulcer","display_name":"Comparative characteristics of the blood cytokine profile in gastritis in schoolchildren with a family predisposition to gastric cancer and peptic ulcer","publication_year":2024,"publication_date":"2024-10-25","ids":{"openalex":"https://openalex.org/W4403771015","doi":"https://doi.org/10.46235/1028-7221-16689-cco"},"language":"en","primary_location":{"id":"doi:10.46235/1028-7221-16689-cco","doi":"https://doi.org/10.46235/1028-7221-16689-cco","is_oa":true,"landing_page_url":"https://doi.org/10.46235/1028-7221-16689-cco","pdf_url":null,"source":{"id":"https://openalex.org/S2764870017","display_name":"Russian Journal of Immunology","issn_l":"1028-7221","issn":["1028-7221","2782-7291"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":"https://openalex.org/P4310320535","host_organization_name":"Russian Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320535"],"host_organization_lineage_names":["Russian Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.46235/1028-7221-16689-cco","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005057947","display_name":"\u0422. \u0412. \u041f\u043e\u043b\u0438\u0432\u0430\u043d\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-3842-9147","observed_orcids":["https://orcid.org/0000-0003-3842-9147"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210088310","display_name":"Krasnoyarsk Scientific Center","ror":"https://ror.org/007ebp326","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210088310","https://openalex.org/I4210127387"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T. V. Polivanova","raw_affiliation_strings":["Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210088310","https://openalex.org/I4210127387"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020516396","display_name":"\u0412. \u0410. \u0412\u0448\u0438\u0432\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0002-1410-8747","observed_orcids":["https://orcid.org/0000-0002-1410-8747"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210088310","display_name":"Krasnoyarsk Scientific Center","ror":"https://ror.org/007ebp326","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210088310","https://openalex.org/I4210127387"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. A. Vshivkov","raw_affiliation_strings":["Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210088310","https://openalex.org/I4210127387"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30758683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"4","first_page":"939","last_page":"946"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11855","display_name":"Gastrointestinal disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastritis","display_name":"gastritis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/elementary-school-students","display_name":"elementary school students","score":0.7300000190734863},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6779999732971191},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.890999972820282},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9919999837875366},{"id":"https://openalex.org/keywords/helicobacter-pylori-infection","display_name":"Helicobacter pylori infection","score":0.972000002861023},{"id":"https://openalex.org/keywords/gastric-cancer-risk","display_name":"gastric cancer risk","score":0.6909999847412109},{"id":"https://openalex.org/keywords/early-onset-gastric-cancer","display_name":"early-onset gastric cancer","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7093126177787781},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6599264740943909},{"id":"https://openalex.org/C2779390736","wikidata":"https://www.wikidata.org/wiki/Q17095243","display_name":"Peptic","level":3,"score":0.5575413703918457},{"id":"https://openalex.org/C2778677798","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Gastritis","level":3,"score":0.5482731461524963},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5096309185028076},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5065311193466187},{"id":"https://openalex.org/C2780656511","wikidata":"https://www.wikidata.org/wiki/Q172941","display_name":"Peptic ulcer","level":2,"score":0.5062200427055359},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44859257340431213},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.4468666613101959},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3780282437801361},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.3519231081008911},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14514398574829102}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.46235/1028-7221-16689-cco","doi":"https://doi.org/10.46235/1028-7221-16689-cco","is_oa":true,"landing_page_url":"https://doi.org/10.46235/1028-7221-16689-cco","pdf_url":null,"source":{"id":"https://openalex.org/S2764870017","display_name":"Russian Journal of Immunology","issn_l":"1028-7221","issn":["1028-7221","2782-7291"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":"https://openalex.org/P4310320535","host_organization_name":"Russian Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320535"],"host_organization_lineage_names":["Russian Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.46235/1028-7221-16689-cco","doi":"https://doi.org/10.46235/1028-7221-16689-cco","is_oa":true,"landing_page_url":"https://doi.org/10.46235/1028-7221-16689-cco","pdf_url":null,"source":{"id":"https://openalex.org/S2764870017","display_name":"Russian Journal of Immunology","issn_l":"1028-7221","issn":["1028-7221","2782-7291"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":"https://openalex.org/P4310320535","host_organization_name":"Russian Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320535"],"host_organization_lineage_names":["Russian Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2051508921","https://openalex.org/W2130114151","https://openalex.org/W2183787411","https://openalex.org/W2604704361","https://openalex.org/W2786780633","https://openalex.org/W2939247829","https://openalex.org/W3119503871","https://openalex.org/W3134510042","https://openalex.org/W3174856727","https://openalex.org/W4210990885","https://openalex.org/W4313214985","https://openalex.org/W4321097803","https://openalex.org/W4387931618"],"related_works":["https://openalex.org/W3089883590","https://openalex.org/W3204889924","https://openalex.org/W2302352734","https://openalex.org/W4291633085","https://openalex.org/W3199975325","https://openalex.org/W2080359839","https://openalex.org/W2044558016","https://openalex.org/W2420397006","https://openalex.org/W2419602176","https://openalex.org/W1980491377"],"abstract_inverted_index":{"The":[0,35,108,119,138],"formation":[1,24,39],"of":[2,4,44,56,70,78,98,104,110,121,146,167,181,244,252,273,276,319,329,332],"diseases":[3],"the":[5,10,18,42,54,96,99,124,225,242,274,330],"gastric":[6,33,71,100,188,253,324],"and":[7,66,73,101,161,187,213,261,302,323,342],"duodenum":[8],"in":[9,59,62,123,152,176,195,199,224,259,264,266,284,297,313],"adult":[11],"population":[12],"begins":[13],"at":[14],"school":[15],"age.":[16],"Among":[17],"leading":[19],"risk":[20],"factors":[21],"for":[22,37],"their":[23,38],"are":[25,327],"family":[26,68,317],"predisposition":[27],"(to":[28],"peptic":[29,74,321],"ulcer":[30,147,203,270,300],"disease":[31,183],"(PU),":[32],"cancer).":[34],"basis":[36],"is":[40,46,235,248,307],"gastritis,":[41,336],"course":[43],"which":[45,247],"actively":[47],"influenced":[48],"by":[49,116,136,250],"cytokines.":[50],"Aim.":[51],"To":[52],"study":[53,139],"characteristics":[55],"cytokine":[57],"levels":[58],"blood":[60,125],"serum":[61],"schoolchildren":[63,80,142,177],"with":[64,81,92,143,154,162,164,178,201,206,268,289,299,315,335],"gastritis":[65,105,291,304],"a":[67,144,149,165,179,257,316],"history":[69,318],"cancer":[72,168,189],"ulcer.":[75],"A":[76,193],"total":[77],"179":[79],"gastroenterological":[82],"complaints":[83],"were":[84],"examined.":[85],"All":[86],"subjects":[87],"underwent":[88],"an":[89,221,262,282],"endoscopic":[90],"examination":[91],"biopsies":[93],"taken":[94],"from":[95],"antrum":[97],"morphological":[102,117],"confirmation":[103],"(Sydney":[106],"classification).":[107],"presence":[109],"H.":[111,207,229,239,343],"pylori":[112,208,230,240,344],"was":[113,134,174,197,256],"also":[114],"determined":[115,135],"method.":[118],"level":[120,243],"cytokines":[122,334],"(IL-2,":[126],"IL-4,":[127],"IL-8,":[128],"IL-18,":[129],"IL-":[130],"1\u03b2,":[131],"IFN\u03b1,":[132],"TNF\u03b1)":[133],"ELISA.":[137],"found":[140,198],"that":[141,237],"burden":[145,166,180,301],"had":[148],"decreased":[150],"IL-1\u03b2":[151,196,219,245,260],"comparison":[153],"children":[155,163,200,267,298,314],"without":[156,214],"aggravation":[157],"(p":[158,169,184,190,210,216,286,309],"=":[159,170,185,191,211,217,287,310],"0.005),":[160],"0.030).":[171],"Also,":[172],"IFN\u03b1":[173,265],"increased":[175,308],"ulcerative":[182],"0.001)":[186],"0.038).":[192],"decrease":[194,258],"aggravated":[202,269],"disease,":[204,271],"both":[205,320],"infection":[209,241],"0.048)":[212],"it":[215,234],"0.043).":[218],"plays":[220],"important":[222],"role":[223],"immune":[226],"response":[227],"to":[228],"infection.":[231,345],"In":[232,278,295],"addition,":[233,279,296],"known":[236],"during":[238],"increases,":[246],"accompanied":[249],"inhibition":[251],"acidity.":[254],"There":[255],"increase":[263,283],"regardless":[272],"activity":[275,292,341],"inflammation.":[277],"they":[280],"observed":[281],"TNF\u03b1":[285],"0.04)":[288],"high":[290,303],"(stage":[293],"2-3).":[294],"activity,":[305],"IL-4":[306],"0.018).":[311],"Thus,":[312],"ulcers":[322],"cancer,":[325],"there":[326],"features":[328],"association":[331],"specific":[333],"as":[337,339],"well":[338],"its":[340]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}