{"id":"https://openalex.org/W4403767130","doi":"https://doi.org/10.3390/cancers16213597","title":"Effect of Neoadjuvant Therapy on Endoluminal Vacuum-Assisted Closure Therapy (EVAC) for Anastomotic Leakage After Oesophagectomy","display_name":"Effect of Neoadjuvant Therapy on Endoluminal Vacuum-Assisted Closure Therapy (EVAC) for Anastomotic Leakage After Oesophagectomy","publication_year":2024,"publication_date":"2024-10-25","ids":{"openalex":"https://openalex.org/W4403767130","doi":"https://doi.org/10.3390/cancers16213597","pmid":"https://pubmed.ncbi.nlm.nih.gov/39518039","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11545023"},"language":"en","primary_location":{"id":"doi:10.3390/cancers16213597","doi":"https://doi.org/10.3390/cancers16213597","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers16213597","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cancers16213597","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114407792","display_name":"Catharina Fahrenkrog","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129877168","display_name":"Carl von Ossietzky Universit\u00e4t Oldenburg","ror":"https://ror.org/033n9gh91","country_code":"DE","type":"education","lineage":["https://openalex.org/I129877168"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Catharina Fahrenkrog","raw_affiliation_strings":["Universit\u00e4tsmedizin Oldenburg, Carl von Ossietzky Universit\u00e4t Oldenburg, 26129 Oldenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsmedizin Oldenburg, Carl von Ossietzky Universit\u00e4t Oldenburg, 26129 Oldenburg, Germany","institution_ids":["https://openalex.org/I129877168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047683223","display_name":"Sorin Miftode","orcid":"https://orcid.org/0000-0003-3071-8702","observed_orcids":["https://orcid.org/0000-0003-3071-8702"]},"institutions":[{"id":"https://openalex.org/I4210108766","display_name":"Klinikum Oldenburg","ror":"https://ror.org/01t0n2c80","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210108766"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sorin Miftode","raw_affiliation_strings":["Universit\u00e4tsklinik f\u00fcr Allgemein-und Viszeralchirurgie, Klinikum Oldenburg A\u00f6R, 26133 Oldenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinik f\u00fcr Allgemein-und Viszeralchirurgie, Klinikum Oldenburg A\u00f6R, 26133 Oldenburg, Germany","institution_ids":["https://openalex.org/I4210108766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114407793","display_name":"Ahmed Al-Mawsheki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108766","display_name":"Klinikum Oldenburg","ror":"https://ror.org/01t0n2c80","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210108766"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ahmed Al-Mawsheki","raw_affiliation_strings":["Universit\u00e4tsklinik f\u00fcr Allgemein-und Viszeralchirurgie, Klinikum Oldenburg A\u00f6R, 26133 Oldenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinik f\u00fcr Allgemein-und Viszeralchirurgie, Klinikum Oldenburg A\u00f6R, 26133 Oldenburg, Germany","institution_ids":["https://openalex.org/I4210108766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076849318","display_name":"Fadl Alfarawan","orcid":"https://orcid.org/0000-0002-9116-5016","observed_orcids":["https://orcid.org/0000-0002-9116-5016"]},"institutions":[{"id":"https://openalex.org/I4210108766","display_name":"Klinikum Oldenburg","ror":"https://ror.org/01t0n2c80","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210108766"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fadl Alfarawan","raw_affiliation_strings":["Universit\u00e4tsklinik f\u00fcr Allgemein-und Viszeralchirurgie, Klinikum Oldenburg A\u00f6R, 26133 Oldenburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9116-5016","affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinik f\u00fcr Allgemein-und Viszeralchirurgie, Klinikum Oldenburg A\u00f6R, 26133 Oldenburg, Germany","institution_ids":["https://openalex.org/I4210108766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114407794","display_name":"Stella Wilters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129877168","display_name":"Carl von Ossietzky Universit\u00e4t Oldenburg","ror":"https://ror.org/033n9gh91","country_code":"DE","type":"education","lineage":["https://openalex.org/I129877168"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stella Wilters","raw_affiliation_strings":["Universit\u00e4tsmedizin Oldenburg, Carl von Ossietzky Universit\u00e4t Oldenburg, 26129 Oldenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsmedizin Oldenburg, Carl von Ossietzky Universit\u00e4t Oldenburg, 26129 Oldenburg, Germany","institution_ids":["https://openalex.org/I129877168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083444146","display_name":"Maximilian Bockhorn","orcid":"https://orcid.org/0000-0002-7027-6606","observed_orcids":["https://orcid.org/0000-0002-7027-6606"]},"institutions":[{"id":"https://openalex.org/I129877168","display_name":"Carl von Ossietzky Universit\u00e4t Oldenburg","ror":"https://ror.org/033n9gh91","country_code":"DE","type":"education","lineage":["https://openalex.org/I129877168"]},{"id":"https://openalex.org/I4210108766","display_name":"Klinikum Oldenburg","ror":"https://ror.org/01t0n2c80","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210108766"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Bockhorn","raw_affiliation_strings":["Universit\u00e4tsklinik f\u00fcr Allgemein-und Viszeralchirurgie, Klinikum Oldenburg A\u00f6R, 26133 Oldenburg, Germany","Universit\u00e4tsmedizin Oldenburg, Carl von Ossietzky Universit\u00e4t Oldenburg, 26129 Oldenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinik f\u00fcr Allgemein-und Viszeralchirurgie, Klinikum Oldenburg A\u00f6R, 26133 Oldenburg, Germany","institution_ids":["https://openalex.org/I4210108766"]},{"raw_affiliation_string":"Universit\u00e4tsmedizin Oldenburg, Carl von Ossietzky Universit\u00e4t Oldenburg, 26129 Oldenburg, Germany","institution_ids":["https://openalex.org/I129877168"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088450724","display_name":"Nader El-Sourani","orcid":"https://orcid.org/0000-0002-6146-7785","observed_orcids":["https://orcid.org/0000-0002-6146-7785"]},"institutions":[{"id":"https://openalex.org/I129877168","display_name":"Carl von Ossietzky Universit\u00e4t Oldenburg","ror":"https://ror.org/033n9gh91","country_code":"DE","type":"education","lineage":["https://openalex.org/I129877168"]},{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Nader El-Sourani","raw_affiliation_strings":["Klinik f\u00fcr Allgemein-, Viszeral-und Transplantationschirurgie, Universit\u00e4tsklinikum M\u00fcnster, 48149 M\u00fcnster, Germany","Universit\u00e4tsmedizin Oldenburg, Carl von Ossietzky Universit\u00e4t Oldenburg, 26129 Oldenburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6146-7785","affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Allgemein-, Viszeral-und Transplantationschirurgie, Universit\u00e4tsklinikum M\u00fcnster, 48149 M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]},{"raw_affiliation_string":"Universit\u00e4tsmedizin Oldenburg, Carl von Ossietzky Universit\u00e4t Oldenburg, 26129 Oldenburg, Germany","institution_ids":["https://openalex.org/I129877168"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088450724"],"corresponding_institution_ids":["https://openalex.org/I129877168","https://openalex.org/I4210103666"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":0.6392,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.63501854,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"16","issue":"21","first_page":"3597","last_page":"3597"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11658","display_name":"Esophageal and GI Pathology","score":0.14650000631809235,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anastomotic-leakage","display_name":"anastomotic leakage","score":0.968999981880188},{"id":"https://openalex.org/keywords/esophagectomy","display_name":"esophagectomy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.8980000019073486},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.6320000290870667},{"id":"https://openalex.org/keywords/treatment-success-rate","display_name":"treatment success rate","score":0.7730000019073486},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.769592821598053},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.6304594278335571},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5156337022781372},{"id":"https://openalex.org/C8443397","wikidata":"https://www.wikidata.org/wiki/Q15177","display_name":"Anastomosis","level":2,"score":0.5024218559265137},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3690226078033447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14756345748901367},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10271933674812317},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/cancers16213597","doi":"https://doi.org/10.3390/cancers16213597","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers16213597","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11545023","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11545023","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11545023/pdf/cancers-16-03597.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:39518039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39518039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/cancers16213597","doi":"https://doi.org/10.3390/cancers16213597","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers16213597","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403767130.pdf","grobid_xml":"https://content.openalex.org/works/W4403767130.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1922694287","https://openalex.org/W1984242303","https://openalex.org/W2036137891","https://openalex.org/W2061520492","https://openalex.org/W2087484885","https://openalex.org/W2089404812","https://openalex.org/W2144173184","https://openalex.org/W2147938868","https://openalex.org/W2207624802","https://openalex.org/W2316681338","https://openalex.org/W2537524499","https://openalex.org/W2547072279","https://openalex.org/W2567502793","https://openalex.org/W2775574711","https://openalex.org/W2810449930","https://openalex.org/W2894734505","https://openalex.org/W2938774982","https://openalex.org/W2944086856","https://openalex.org/W2968189052","https://openalex.org/W3092920941","https://openalex.org/W3124418674","https://openalex.org/W3128691787","https://openalex.org/W3129520512","https://openalex.org/W3196773247","https://openalex.org/W3203122363","https://openalex.org/W3207248162","https://openalex.org/W3207255407","https://openalex.org/W4211125721","https://openalex.org/W4281669451","https://openalex.org/W4292295061","https://openalex.org/W4317622324","https://openalex.org/W4376959236","https://openalex.org/W4379616436","https://openalex.org/W4386649078","https://openalex.org/W4388517056","https://openalex.org/W4400414119"],"related_works":["https://openalex.org/W4292295061","https://openalex.org/W2945877532","https://openalex.org/W4400414119","https://openalex.org/W4404282061","https://openalex.org/W2795726992","https://openalex.org/W4395034384","https://openalex.org/W2894734505","https://openalex.org/W4306179118","https://openalex.org/W2976857420","https://openalex.org/W4402145207"],"abstract_inverted_index":{"Background:":[0],"Anastomotic":[1],"leakage":[2],"(AL)":[3],"is":[4],"a":[5,20,34,47],"dreaded":[6],"complication":[7],"after":[8,66,226],"oesophagectomy.":[9,227],"Endoluminal":[10],"vacuum-assisted":[11],"closure":[12],"therapy":[13,36,158],"(EVAC)":[14],"has":[15],"been":[16],"increasingly":[17],"used":[18],"as":[19,75],"first-line":[21],"treatment":[22,112,187],"for":[23,64,185,224],"AL.":[24],"We":[25,45],"aimed":[26],"to":[27],"identify":[28],"any":[29],"potential":[30],"adverse":[31],"effects":[32],"of":[33,79,82,95,101,107,157,170,212,220],"neoadjuvant":[35,111],"(chemotherapy":[37],"(CT)":[38],"or":[39,210],"radiochemotherapy":[40],"(RCT))":[41],"on":[42,222],"EVAC.":[43],"Methods:":[44],"performed":[46],"retrospective":[48],"cohort":[49],"study":[50],"at":[51],"our":[52],"tertiary":[53],"centre":[54],"between":[55],"2013":[56],"and":[57,88,105,155,182],"2024.":[58],"All":[59],"patients":[60,97],"who":[61],"underwent":[62],"EVAC":[63,223],"AL":[65,225],"oesophagectomy":[67],"were":[68,90,98],"included":[69],"in":[70,86,119],"this":[71],"study.":[72],"Parameters":[73],"such":[74],"success":[76,139,208],"rate,":[77],"length":[78,156,211],"therapy,":[80],"number":[81,169],"sponges":[83,171],"needed,":[84],"changes":[85],"treatment,":[87],"survival":[89,121,123],"analysed.":[91],"Results:":[92],"A":[93],"total":[94],"29":[96],"included,":[99],"19":[100],"whom":[102,108],"received":[103,109],"CT/RCT":[104,125,221],"10":[106],"no":[110,116,217],"(NT).":[113],"There":[114],"was":[115],"significant":[117,218],"difference":[118],"patient":[120],"(30-day":[122],"rate":[124,140,209],"n":[126,132,142,148,189,195],"=":[127,133,137,143,149,153,166,180,190,196,200],"1":[128,134,197],"(5.3%)":[129],"vs.":[130,146,160,163,174,177,193],"NT":[131,147,161,175,194,203],"(10%),":[135,198],"p":[136,152,165,179,199],"0.632),":[138],"(CT/RCT":[141,159,173,188],"15":[144],"(78.9%)":[145],"9":[150],"(90%),":[151],"0.454),":[154],"24.11":[162],"23.8,":[164],"0.681),":[167],"the":[168,183,207],"required":[172],"6.26":[176],"6.6,":[178],"0.835),":[181],"need":[184],"changing":[186],"5":[191],"(26.3%)":[192],"0.303).":[201],"Conclusions:":[202],"did":[204],"not":[205],"affect":[206],"therapy.":[213],"Thus,":[214],"we":[215],"found":[216],"influence":[219]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-26T00:00:00"}