{"id":"https://openalex.org/W4403764448","doi":"https://doi.org/10.3390/biomedicines12112455","title":"Unraveling the Serotonergic Mechanism of Stress-Related Anxiety: Focus on Co-Treatment with Resveratrol and Selective Serotonin Reuptake Inhibitors","display_name":"Unraveling the Serotonergic Mechanism of Stress-Related Anxiety: Focus on Co-Treatment with Resveratrol and Selective Serotonin Reuptake Inhibitors","publication_year":2024,"publication_date":"2024-10-25","ids":{"openalex":"https://openalex.org/W4403764448","doi":"https://doi.org/10.3390/biomedicines12112455","pmid":"https://pubmed.ncbi.nlm.nih.gov/39595020","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11591826"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines12112455","doi":"https://doi.org/10.3390/biomedicines12112455","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines12112455","pdf_url":"https://www.mdpi.com/2227-9059/12/11/2455/pdf?version=1729852470","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/12/11/2455/pdf?version=1729852470","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002434862","display_name":"\u0412. \u042d. \u0426\u0435\u0439\u043b\u0438\u043a\u043c\u0430\u043d","orcid":"https://orcid.org/0000-0001-6430-030X","observed_orcids":["https://orcid.org/0000-0001-6430-030X"]},"institutions":[{"id":"https://openalex.org/I107640659","display_name":"South Ural State University","ror":"https://ror.org/03sfk2504","country_code":"RU","type":"education","lineage":["https://openalex.org/I107640659"]},{"id":"https://openalex.org/I137211346","display_name":"Chelyabinsk State University","ror":"https://ror.org/04s36qm86","country_code":"RU","type":"education","lineage":["https://openalex.org/I137211346"]},{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Vadim E. Tseilikman","raw_affiliation_strings":["Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia","Higher Medical and Biological School, South Ural State University, 454080 Chelyabinsk, Russia","Zelman Institute of Medicine and Psychology, Novosibirsk State University, 630090 Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia","institution_ids":["https://openalex.org/I137211346"]},{"raw_affiliation_string":"Higher Medical and Biological School, South Ural State University, 454080 Chelyabinsk, Russia","institution_ids":["https://openalex.org/I107640659"]},{"raw_affiliation_string":"Zelman Institute of Medicine and Psychology, Novosibirsk State University, 630090 Novosibirsk, Russia","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074662661","display_name":"Olga B. Tseilikman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107640659","display_name":"South Ural State University","ror":"https://ror.org/03sfk2504","country_code":"RU","type":"education","lineage":["https://openalex.org/I107640659"]},{"id":"https://openalex.org/I137211346","display_name":"Chelyabinsk State University","ror":"https://ror.org/04s36qm86","country_code":"RU","type":"education","lineage":["https://openalex.org/I137211346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olga B. Tseilikman","raw_affiliation_strings":["Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia","Higher Medical and Biological School, South Ural State University, 454080 Chelyabinsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia","institution_ids":["https://openalex.org/I137211346"]},{"raw_affiliation_string":"Higher Medical and Biological School, South Ural State University, 454080 Chelyabinsk, Russia","institution_ids":["https://openalex.org/I107640659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077910787","display_name":"Marina N. Karpenko","orcid":"https://orcid.org/0000-0002-1082-0059","observed_orcids":["https://orcid.org/0000-0002-1082-0059"]},"institutions":[{"id":"https://openalex.org/I4210126033","display_name":"Institute of Experimental Medicine","ror":"https://ror.org/0344x6030","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126033"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Marina N. Karpenko","raw_affiliation_strings":["Pavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia"],"raw_orcid":"https://orcid.org/0000-0002-1082-0059","affiliations":[{"raw_affiliation_string":"Pavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia","institution_ids":["https://openalex.org/I4210126033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026680139","display_name":"Dmitrii S. Traktirov","orcid":"https://orcid.org/0000-0003-0424-6545","observed_orcids":["https://orcid.org/0000-0003-0424-6545"]},"institutions":[{"id":"https://openalex.org/I4210126033","display_name":"Institute of Experimental Medicine","ror":"https://ror.org/0344x6030","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126033"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitrii S. Traktirov","raw_affiliation_strings":["Pavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia"],"raw_orcid":"https://orcid.org/0000-0003-0424-6545","affiliations":[{"raw_affiliation_string":"Pavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia","institution_ids":["https://openalex.org/I4210126033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034806531","display_name":"Daria Alexeevna Obukhova","orcid":"https://orcid.org/0009-0002-4287-0808","observed_orcids":["https://orcid.org/0009-0002-4287-0808"]},"institutions":[{"id":"https://openalex.org/I4210126033","display_name":"Institute of Experimental Medicine","ror":"https://ror.org/0344x6030","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126033"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Daria A. Obukhova","raw_affiliation_strings":["Pavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia"],"raw_orcid":"https://orcid.org/0009-0002-4287-0808","affiliations":[{"raw_affiliation_string":"Pavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia","institution_ids":["https://openalex.org/I4210126033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069935277","display_name":"Vladislav A. Shatilov","orcid":"https://orcid.org/0000-0001-9405-0348","observed_orcids":["https://orcid.org/0000-0001-9405-0348"]},"institutions":[{"id":"https://openalex.org/I107640659","display_name":"South Ural State University","ror":"https://ror.org/03sfk2504","country_code":"RU","type":"education","lineage":["https://openalex.org/I107640659"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladislav A. Shatilov","raw_affiliation_strings":["Higher Medical and Biological School, South Ural State University, 454080 Chelyabinsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Higher Medical and Biological School, South Ural State University, 454080 Chelyabinsk, Russia","institution_ids":["https://openalex.org/I107640659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006769489","display_name":"Maxim S. Zhukov","orcid":"https://orcid.org/0009-0000-6347-6370","observed_orcids":["https://orcid.org/0009-0000-6347-6370"]},"institutions":[{"id":"https://openalex.org/I137211346","display_name":"Chelyabinsk State University","ror":"https://ror.org/04s36qm86","country_code":"RU","type":"education","lineage":["https://openalex.org/I137211346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maxim S. Zhukov","raw_affiliation_strings":["Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia","institution_ids":["https://openalex.org/I137211346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046555704","display_name":"\u041c\u0430\u043d\u0443\u0439\u043b\u043e\u0432 \u0413\u0435\u043d\u043d\u0430\u0434\u0438\u0439 \u0412\u0430\u043b\u0435\u0440\u044c\u0435\u0432\u0438\u0447","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107640659","display_name":"South Ural State University","ror":"https://ror.org/03sfk2504","country_code":"RU","type":"education","lineage":["https://openalex.org/I107640659"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Gennady V. Manuilov","raw_affiliation_strings":["Higher Medical and Biological School, South Ural State University, 454080 Chelyabinsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Higher Medical and Biological School, South Ural State University, 454080 Chelyabinsk, Russia","institution_ids":["https://openalex.org/I107640659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002423722","display_name":"Oleg N. Yegorov","orcid":"https://orcid.org/0000-0003-3747-5010","observed_orcids":["https://orcid.org/0000-0003-3747-5010"]},"institutions":[{"id":"https://openalex.org/I137211346","display_name":"Chelyabinsk State University","ror":"https://ror.org/04s36qm86","country_code":"RU","type":"education","lineage":["https://openalex.org/I137211346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Oleg N. Yegorov","raw_affiliation_strings":["Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia","institution_ids":["https://openalex.org/I137211346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108983133","display_name":"Maxim R. Aristov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137211346","display_name":"Chelyabinsk State University","ror":"https://ror.org/04s36qm86","country_code":"RU","type":"education","lineage":["https://openalex.org/I137211346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maxim R. Aristov","raw_affiliation_strings":["Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia","institution_ids":["https://openalex.org/I137211346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114224373","display_name":"Ilya A. Lipatov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137211346","display_name":"Chelyabinsk State University","ror":"https://ror.org/04s36qm86","country_code":"RU","type":"education","lineage":["https://openalex.org/I137211346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ilya A. Lipatov","raw_affiliation_strings":["Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia","institution_ids":["https://openalex.org/I137211346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092906652","display_name":"Irina A. Buksha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137211346","display_name":"Chelyabinsk State University","ror":"https://ror.org/04s36qm86","country_code":"RU","type":"education","lineage":["https://openalex.org/I137211346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina A. Buksha","raw_affiliation_strings":["Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia","institution_ids":["https://openalex.org/I137211346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114406521","display_name":"Alexandr E. Epitashvili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137211346","display_name":"Chelyabinsk State University","ror":"https://ror.org/04s36qm86","country_code":"RU","type":"education","lineage":["https://openalex.org/I137211346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexandr E. Epitashvili","raw_affiliation_strings":["Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia","institution_ids":["https://openalex.org/I137211346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029174825","display_name":"Anton A. Pashkov","orcid":"https://orcid.org/0000-0002-2403-3136","observed_orcids":["https://orcid.org/0000-0002-2403-3136"]},"institutions":[{"id":"https://openalex.org/I4210157294","display_name":"Federal Neurosurgical Center Novosibirsk","ror":"https://ror.org/04tmsfn31","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210157294"]},{"id":"https://openalex.org/I91727514","display_name":"Novosibirsk State Technical University","ror":"https://ror.org/01b2f6h61","country_code":"RU","type":"education","lineage":["https://openalex.org/I91727514"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anton A. Pashkov","raw_affiliation_strings":["Department of Data Collection and Processing Systems, Novosibirsk State Technical University, 630048 Novosibirsk, Russia","Federal Neurosurgical Center, 630048 Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Data Collection and Processing Systems, Novosibirsk State Technical University, 630048 Novosibirsk, Russia","institution_ids":["https://openalex.org/I91727514"]},{"raw_affiliation_string":"Federal Neurosurgical Center, 630048 Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210157294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040708868","display_name":"Jurica Novak","orcid":"https://orcid.org/0000-0001-5744-6677","observed_orcids":["https://orcid.org/0000-0001-5744-6677"]},"institutions":[{"id":"https://openalex.org/I4210123216","display_name":"Ru\u0111er Bo\u0161kovi\u0107 Institute","ror":"https://ror.org/02mw21745","country_code":"HR","type":"facility","lineage":["https://openalex.org/I4210123216"]}],"countries":["HR"],"is_corresponding":true,"raw_author_name":"Jurica Novak","raw_affiliation_strings":["Centre for Informatics and Computing, Ru\u0111er Bo\u0161kovi\u0107 Institute, 10000 Zagreb, Croatia"],"raw_orcid":"https://orcid.org/0000-0001-5744-6677","affiliations":[{"raw_affiliation_string":"Centre for Informatics and Computing, Ru\u0111er Bo\u0161kovi\u0107 Institute, 10000 Zagreb, Croatia","institution_ids":["https://openalex.org/I4210123216"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5002434862","https://openalex.org/A5040708868"],"corresponding_institution_ids":["https://openalex.org/I107640659","https://openalex.org/I137211346","https://openalex.org/I188973947","https://openalex.org/I4210123216"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2955},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2955},"fwci":3.028,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.92305651,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"12","issue":"11","first_page":"2455","last_page":"2455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.8379999995231628},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.7789999842643738},{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.953000009059906},{"id":"https://openalex.org/keywords/5-ht3a-receptor","display_name":"5-HT3A receptor","score":0.9670000076293945},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.9480000138282776},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/paroxetine","display_name":"paroxetine","score":0.8730000257492065},{"id":"https://openalex.org/keywords/sertraline","display_name":"sertraline","score":1.0},{"id":"https://openalex.org/keywords/monoamine-oxidase-a","display_name":"monoamine oxidase A","score":0.8190000057220459},{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.9150184392929077},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.6447442770004272},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.6282044649124146},{"id":"https://openalex.org/C99631742","wikidata":"https://www.wikidata.org/wiki/Q22290476","display_name":"Reuptake","level":4,"score":0.5473334193229675},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5306699872016907},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5182280540466309},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.502617359161377},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.49316686391830444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37237393856048584},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3392617702484131},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3214167654514313},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.29144030809402466},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.26782500743865967},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1767044961452484},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06056249141693115},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines12112455","doi":"https://doi.org/10.3390/biomedicines12112455","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines12112455","pdf_url":"https://www.mdpi.com/2227-9059/12/11/2455/pdf?version=1729852470","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11591826","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11591826","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11591826/pdf/biomedicines-12-02455.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:39595020","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39595020","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:68deddff70164d609d86141359f06efc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/68deddff70164d609d86141359f06efc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 12, Iss 11, p 2455 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines12112455","doi":"https://doi.org/10.3390/biomedicines12112455","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines12112455","pdf_url":"https://www.mdpi.com/2227-9059/12/11/2455/pdf?version=1729852470","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403764448.pdf","grobid_xml":"https://content.openalex.org/works/W4403764448.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W127048576","https://openalex.org/W142084402","https://openalex.org/W194835070","https://openalex.org/W204189666","https://openalex.org/W1545261781","https://openalex.org/W1654836155","https://openalex.org/W1972571114","https://openalex.org/W1973544773","https://openalex.org/W1981144487","https://openalex.org/W1987972424","https://openalex.org/W1988394540","https://openalex.org/W1992073263","https://openalex.org/W1992301171","https://openalex.org/W1994234270","https://openalex.org/W2000627347","https://openalex.org/W2001177487","https://openalex.org/W2003831663","https://openalex.org/W2005855977","https://openalex.org/W2025249605","https://openalex.org/W2030081504","https://openalex.org/W2041749675","https://openalex.org/W2046315961","https://openalex.org/W2051005796","https://openalex.org/W2053720210","https://openalex.org/W2063799404","https://openalex.org/W2068255218","https://openalex.org/W2073003972","https://openalex.org/W2086021563","https://openalex.org/W2086812703","https://openalex.org/W2087857447","https://openalex.org/W2089487873","https://openalex.org/W2096361448","https://openalex.org/W2099238156","https://openalex.org/W2105950428","https://openalex.org/W2107181326","https://openalex.org/W2108460717","https://openalex.org/W2110654827","https://openalex.org/W2117297654","https://openalex.org/W2121403816","https://openalex.org/W2123733014","https://openalex.org/W2133444149","https://openalex.org/W2135190897","https://openalex.org/W2138075066","https://openalex.org/W2153655311","https://openalex.org/W2199386545","https://openalex.org/W2288150943","https://openalex.org/W2469942047","https://openalex.org/W2563926210","https://openalex.org/W2897084961","https://openalex.org/W2898451802","https://openalex.org/W2904487322","https://openalex.org/W2905365975","https://openalex.org/W2958619441","https://openalex.org/W2970453706","https://openalex.org/W2989571042","https://openalex.org/W2997576446","https://openalex.org/W3005036587","https://openalex.org/W3019450407","https://openalex.org/W3081418474","https://openalex.org/W3103846925","https://openalex.org/W3126884725","https://openalex.org/W3154373779","https://openalex.org/W3177252462","https://openalex.org/W3200117368","https://openalex.org/W4214495941","https://openalex.org/W4223920603","https://openalex.org/W4309713814","https://openalex.org/W4310289082","https://openalex.org/W4322499944","https://openalex.org/W4367047305","https://openalex.org/W4382790283","https://openalex.org/W4386879634","https://openalex.org/W4388641323","https://openalex.org/W4392825876","https://openalex.org/W4394757096","https://openalex.org/W4394767113","https://openalex.org/W4395011848","https://openalex.org/W4396580667","https://openalex.org/W4398156328","https://openalex.org/W4401924802","https://openalex.org/W4402412117"],"related_works":["https://openalex.org/W4412364415","https://openalex.org/W4402412117","https://openalex.org/W7117537834","https://openalex.org/W2899563690","https://openalex.org/W7126230420","https://openalex.org/W7207811578","https://openalex.org/W1977765205","https://openalex.org/W2003831663","https://openalex.org/W7140239604","https://openalex.org/W602775765"],"abstract_inverted_index":{"Background/Objectives:":[0],"In":[1],"post-traumatic":[2],"stress":[3,50,55,96],"disorder":[4],"(PTSD),":[5],"anxiety-like":[6],"symptoms":[7],"are":[8,23,172],"often":[9],"associated":[10],"with":[11,90,151],"elevated":[12,30],"noradrenaline":[13],"levels":[14,105],"and":[15,65,80,92,106,110,132,142,153,163,168,179,202],"decreased":[16],"serotonin.":[17],"Selective":[18],"serotonin":[19,31,60,62,104,121,162],"reuptake":[20],"inhibitors":[21],"(SSRIs)":[22],"frequently":[24],"used":[25],"to":[26,72,99,116,125],"treat":[27],"anxiety,":[28],"but":[29,138],"has":[32],"been":[33],"observed":[34],"in":[35,70,103,175],"some":[36],"anxiety":[37,43,118,141,189],"disorders.":[38,190],"This":[39],"study":[40],"investigates":[41],"stress-induced":[42],"as":[44],"an":[45],"immediate":[46],"effect":[47],"of":[48,76,108,166],"chronic":[49],"exposure":[51,97],"using":[52],"the":[53,156,198],"predator":[54],"paradigm.":[56],"Methods:":[57],"We":[58],"examined":[59],"levels,":[61,122],"transporter":[63],"(SERT),":[64],"5-HT3A":[66,111,133,169],"receptor":[67,112,170],"gene":[68],"expression":[69,134,165],"response":[71],"stress.":[73],"The":[74],"effects":[75],"SSRIs":[77,114,137,180],"(paroxetine,":[78],"sertraline)":[79],"resveratrol":[81,91,152],"on":[82,195],"these":[83,182],"parameters":[84],"were":[85],"also":[86],"analyzed,":[87],"alongside":[88],"co-treatment":[89],"sertraline.":[93],"Results:":[94],"Chronic":[95],"led":[98],"a":[100],"significant":[101],"increase":[102],"upregulation":[107],"SERT":[109,127,131,167],"expression.":[113,128,149],"failed":[115],"prevent":[117],"or":[119],"reduce":[120],"partly":[123],"due":[124],"suppressed":[126],"Resveratrol":[129,178],"downregulated":[130],"less":[135],"than":[136],"effectively":[139],"reduced":[140],"restored":[143],"serotonin,":[144],"likely":[145],"by":[146],"upregulating":[147],"MAO-A":[148],"Co-treatment":[150],"sertraline":[154],"produced":[155],"strongest":[157],"anxiolytic":[158,205],"effect.":[159],"Conclusions:":[160],"Elevated":[161],"increased":[164],"genes":[171],"key":[173],"factors":[174],"stress-related":[176],"anxiety.":[177],"target":[181],"mechanisms,":[183],"suggesting":[184],"potential":[185],"therapeutic":[186],"strategies":[187],"for":[188],"Future":[191],"research":[192],"will":[193],"focus":[194],"further":[196],"elucidating":[197],"serotonergic":[199],"mechanisms":[200],"involved":[201],"identifying":[203],"new":[204],"drug":[206],"targets.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-10-26T00:00:00"}