{"id":"https://openalex.org/W4403763290","doi":"https://doi.org/10.1016/j.ejca.2024.114727","title":"209 (PB197): Novel tumor microenvironment ameliorator E7130 shows substantial combination efficacy with enzalutamide in a preclinical model of castration-resistant prostate cancer.","display_name":"209 (PB197): Novel tumor microenvironment ameliorator E7130 shows substantial combination efficacy with enzalutamide in a preclinical model of castration-resistant prostate cancer.","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403763290","doi":"https://doi.org/10.1016/j.ejca.2024.114727"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejca.2024.114727","doi":"https://doi.org/10.1016/j.ejca.2024.114727","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejca.2024.114727","pdf_url":null,"source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027731344","display_name":"Takanori Abe","orcid":"https://orcid.org/0000-0001-6209-9446","observed_orcids":["https://orcid.org/0000-0001-6209-9446"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Abe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101845266","display_name":"Ken Ito","orcid":"https://orcid.org/0000-0002-6997-4271","observed_orcids":["https://orcid.org/0000-0002-6997-4271"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Ito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084458929","display_name":"Ismah\u00e8ne Benza\u00efd","orcid":"https://orcid.org/0000-0002-0903-9054","observed_orcids":["https://orcid.org/0000-0002-0903-9054","https://orcid.org/0000-0001-9935-4236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Benzaid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081712369","display_name":"Marc Hillairet de Boisferon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.H. de Boisferon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025592445","display_name":"Yoshito Kishi","orcid":"https://orcid.org/0000-0001-5612-350X","observed_orcids":["https://orcid.org/0000-0001-5612-350X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Kishi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010137912","display_name":"Bruce A. Littlefield","orcid":"https://orcid.org/0000-0002-4296-5316","observed_orcids":["https://orcid.org/0000-0002-4296-5316"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B.A. Littlefield","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027725072","display_name":"Osamu Asano","orcid":"https://orcid.org/0000-0003-2934-1741","observed_orcids":["https://orcid.org/0000-0003-2934-1741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. Asano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3840,"currency":"USD","value_usd":3840},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30087966,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"211","issue":null,"first_page":"114727","last_page":"114727"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzalutamide","display_name":"enzalutamide","score":0.949999988079071},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9330000281333923},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9769999980926514},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9810000061988831},{"id":"https://openalex.org/keywords/preclinical-models","display_name":"preclinical models","score":0.5630000233650208},{"id":"https://openalex.org/keywords/androgen-receptor-antagonists","display_name":"androgen receptor antagonists","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.9776278734207153},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8621814250946045},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7019086480140686},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.49490875005722046},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47115862369537354},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42748260498046875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36021187901496887},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3583267331123352},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.08265256881713867}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ejca.2024.114727","doi":"https://doi.org/10.1016/j.ejca.2024.114727","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejca.2024.114727","pdf_url":null,"source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3140068379","https://openalex.org/W2399335461","https://openalex.org/W2577002061","https://openalex.org/W2909459146","https://openalex.org/W2988682365","https://openalex.org/W4312900827","https://openalex.org/W2512470145","https://openalex.org/W2900098040","https://openalex.org/W4415649453","https://openalex.org/W3204363552"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2024-10-26T00:00:00"}