{"id":"https://openalex.org/W4403752705","doi":"https://doi.org/10.1101/2024.10.22.619641","title":"Anemia and tissue hypoxia are major determinants of malarial hypelactatemia","display_name":"Anemia and tissue hypoxia are major determinants of malarial hypelactatemia","publication_year":2024,"publication_date":"2024-10-25","ids":{"openalex":"https://openalex.org/W4403752705","doi":"https://doi.org/10.1101/2024.10.22.619641"},"language":"en","primary_location":{"id":"doi:10.1101/2024.10.22.619641","doi":"https://doi.org/10.1101/2024.10.22.619641","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.10.22.619641","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/2024.10.22.619641","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003428452","display_name":"Athina Georgiadou","orcid":"https://orcid.org/0000-0002-0440-9335","observed_orcids":["https://orcid.org/0000-0002-0440-9335"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Athina Georgiadou","raw_affiliation_strings":["Imperial College London"],"raw_orcid":"https://orcid.org/0000-0002-0440-9335","affiliations":[{"raw_affiliation_string":"Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021886253","display_name":"Chae Eun Yoon","orcid":"https://orcid.org/0009-0009-3829-4853","observed_orcids":["https://orcid.org/0009-0009-3829-4853"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chae Eun Yoon","raw_affiliation_strings":["Imperial College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huanghehui Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Huanghehui Yu","raw_affiliation_strings":["Imperial College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William H. Pearson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William H. Pearson","raw_affiliation_strings":["London School of Hygiene & Tropical Medicine, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London School of Hygiene & Tropical Medicine, London","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114402581","display_name":"Aika Ueno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aika Ueno","raw_affiliation_strings":["Imperial College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029569258","display_name":"Stefan Ebmeier","orcid":"https://orcid.org/0000-0001-7570-7172","observed_orcids":["https://orcid.org/0000-0001-7570-7172"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stefan Ebmeier","raw_affiliation_strings":["Imperial College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025141902","display_name":"Gerald J Larrouy-Maumus","orcid":"https://orcid.org/0000-0001-6614-8698","observed_orcids":["https://orcid.org/0000-0001-6614-8698"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gerald J. Larrouy-Maumus","raw_affiliation_strings":["Imperial College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081054196","display_name":"Aubrey J. Cunnington","orcid":"https://orcid.org/0000-0002-1305-3529","observed_orcids":["https://orcid.org/0000-0002-1305-3529"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aubrey J. Cunnington","raw_affiliation_strings":["Imperial College London"],"raw_orcid":"https://orcid.org/0000-0002-1305-3529","affiliations":[{"raw_affiliation_string":"Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003428452"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperlactatemia","display_name":"hyperlactatemia","score":0.8740000128746033},{"id":"https://openalex.org/keywords/severe-malaria","display_name":"severe malaria","score":0.8450000286102295},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.9139999747276306},{"id":"https://openalex.org/keywords/tissue-hypoxia","display_name":"tissue hypoxia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lactate-clearance","display_name":"lactate clearance","score":0.890999972820282},{"id":"https://openalex.org/keywords/plasmodium-yoelii-17xl","display_name":"Plasmodium yoelii 17XL","score":0.9449999928474426},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/organ-dysfunction","display_name":"organ dysfunction","score":0.6850000023841858},{"id":"https://openalex.org/keywords/whole-blood-transfusion","display_name":"whole blood transfusion","score":0.8889999985694885},{"id":"https://openalex.org/keywords/artesunate","display_name":"artesunate","score":0.9929999709129333},{"id":"https://openalex.org/keywords/trefoil-factor-3","display_name":"TFF3","score":0.9739999771118164},{"id":"https://openalex.org/keywords/intestinal-injury","display_name":"intestinal injury","score":0.722000002861023},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.6880000233650208},{"id":"https://openalex.org/keywords/murine-malaria-model","display_name":"murine malaria model","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C3017916928","wikidata":"https://www.wikidata.org/wiki/Q105688","display_name":"Tissue hypoxia","level":3,"score":0.6964371800422668},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6751099824905396},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.6647704839706421},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.5148367285728455},{"id":"https://openalex.org/C2910886205","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malarial parasites","level":4,"score":0.4691060185432434},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.44143033027648926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29126468300819397},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2266055941581726},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.2170233130455017},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17569491267204285},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16435277462005615},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.12534257769584656},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.0775027871131897},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2024.10.22.619641","doi":"https://doi.org/10.1101/2024.10.22.619641","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.10.22.619641","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2024.10.22.619641","doi":"https://doi.org/10.1101/2024.10.22.619641","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.10.22.619641","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1571584684","https://openalex.org/W1985221934","https://openalex.org/W2014646796","https://openalex.org/W2021222670","https://openalex.org/W2062573649","https://openalex.org/W2075891899","https://openalex.org/W2116402706","https://openalex.org/W2117590566","https://openalex.org/W2155584216","https://openalex.org/W2240726636","https://openalex.org/W2255317057","https://openalex.org/W2312815413","https://openalex.org/W2415324947","https://openalex.org/W2524936271","https://openalex.org/W2605232511","https://openalex.org/W2766874071","https://openalex.org/W2782784427","https://openalex.org/W2795009906","https://openalex.org/W2808010791","https://openalex.org/W2892375818","https://openalex.org/W2896734093","https://openalex.org/W3121014404","https://openalex.org/W3159665643","https://openalex.org/W4221130204","https://openalex.org/W4224211509","https://openalex.org/W4318166483","https://openalex.org/W4324131435","https://openalex.org/W4362587979","https://openalex.org/W4385337101","https://openalex.org/W4389736224","https://openalex.org/W4390638966","https://openalex.org/W4391379888"],"related_works":["https://openalex.org/W3121014404","https://openalex.org/W2097931820","https://openalex.org/W2240726636","https://openalex.org/W9841291","https://openalex.org/W6902378967","https://openalex.org/W4390638966","https://openalex.org/W2337669408","https://openalex.org/W2524936271","https://openalex.org/W2113421490","https://openalex.org/W7171819553"],"abstract_inverted_index":{"Abstract":[0],"Hyperlactatemia,":[1],"a":[2,144,204],"key":[3],"marker":[4,205],"of":[5,47,62,108,151,160,183,206,221],"severe":[6,48,63,245],"malaria,":[7,49,224],"is":[8],"closely":[9,51],"linked":[10],"to":[11,28,58,69,82,177,233,241],"increased":[12,24,133],"mortality,":[13],"though":[14],"the":[15,60,113,181,218,234],"exact":[16],"mechanisms":[17],"remain":[18],"unclear.":[19],"It":[20],"may":[21,141],"result":[22],"from":[23,35],"lactate":[25,33,84,97,136,139,174,210],"production":[26],"due":[27],"tissue":[29,109,230],"hypoxia":[30,131],"or":[31],"reduced":[32,158],"clearance":[34,140,159,175],"organ":[36,67],"dysfunction.":[37],"This":[38],"study":[39],"used":[40],"Plasmodium":[41],"yoelii":[42],"17XL":[43],"(Py17XL)":[44],"murine":[45],"model":[46],"which":[50],"mimics":[52],"hyperlactatemia":[53,194,222],"seen":[54,119],"in":[55,85,112,186,212,223,244],"human":[56,213],"cases,":[57],"investigate":[59],"contributions":[61],"anemia":[64,72,101,185,228],"and":[65,88,116,123,135,153,193,209,229],"infection-related":[66],"dysfunction":[68,155],"hyperlactatemia.":[70,106],"Non-infectious":[71],"models":[73],"were":[74],"also":[75,142],"included":[76],"for":[77,236],"comparison.":[78],"Anemia":[79],"was":[80,118,195],"found":[81],"elevate":[83],"both":[86,239],"malaria-infected":[87],"non-infectious":[89],"models,":[90],"but":[91],"Py17XL":[92],"infected":[93,147],"mice":[94,148],"showed":[95,149],"higher":[96],"levels,":[98],"indicating":[99],"that":[100,130],"alone":[102],"doesn\u2019t":[103],"fully":[104],"explain":[105],"Evidence":[107],"hypoxia,":[110,231],"particularly":[111],"liver,":[114],"kidney,":[115],"gut,":[117],"with":[120,170],"hypoxyprobe":[121],"staining":[122],"upregulated":[124],"hypoxia-inducible":[125],"factor":[126,201],"1-alpha":[127],"(HIF-1\u03b1),":[128],"suggesting":[129],"drives":[132],"glycolysis":[134],"production.":[137],"Impaired":[138],"play":[143],"role,":[145],"as":[146],"signs":[150],"liver":[152],"kidney":[154],"accompanied":[156],"by":[157,197,227],"13":[161],"C":[162],"3":[163,202],"-labeled":[164],"sodium-L-Lactate.":[165],"Whole":[166],"blood":[167],"transfusion":[168],"combined":[169],"artesunate":[171,178],"significantly":[172],"improved":[173],"compared":[176],"alone,":[179],"underscoring":[180],"importance":[182],"addressing":[184],"treatment.":[187],"A":[188],"link":[189],"between":[190,199],"intestinal":[191],"damage":[192],"suggested":[196],"correlations":[198],"trefoil":[200],"(TFF3),":[203],"gut":[207],"injury,":[208],"levels":[211],"samples.":[214],"Our":[215],"findings":[216],"highlight":[217],"multifactorial":[219],"origin":[220],"driven":[225],"primarily":[226],"pointing":[232],"need":[235],"therapies":[237],"targeting":[238],"aspects":[240],"reduce":[242],"mortality":[243],"cases.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-25T00:00:00"}
