{"id":"https://openalex.org/W4403749170","doi":"https://doi.org/10.1016/j.ejca.2024.114603","title":"76 (PB064): E7386 enhances both lenvatinib and anti-PD1 antitumor activity in HCC","display_name":"76 (PB064): E7386 enhances both lenvatinib and anti-PD1 antitumor activity in HCC","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403749170","doi":"https://doi.org/10.1016/j.ejca.2024.114603"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejca.2024.114603","doi":"https://doi.org/10.1016/j.ejca.2024.114603","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejca.2024.114603","pdf_url":null,"source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001062200","display_name":"Agavni Mesropian","orcid":"https://orcid.org/0000-0002-0604-4755","observed_orcids":["https://orcid.org/0000-0002-0604-4755"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Mesropian Badalian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021169552","display_name":"Albert Gris\u2010Oliver","orcid":"https://orcid.org/0000-0003-1802-9541","observed_orcids":["https://orcid.org/0000-0003-1802-9541"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Gris-Oliver","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024316686","display_name":"Jordi Abril\u2010Fornaguera","orcid":"https://orcid.org/0000-0002-5871-4052","observed_orcids":["https://orcid.org/0000-0002-5871-4052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Abril-Fornaguera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021068605","display_name":"Marta Piqu\u00e9\u2010Gili","orcid":"https://orcid.org/0000-0003-4873-7776","observed_orcids":["https://orcid.org/0000-0003-4873-7776"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Piqu\u00e9-Gili","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093669087","display_name":"Mart\u00ed Torres-Marc\u00e9n","orcid":"https://orcid.org/0009-0007-2564-9139","observed_orcids":["https://orcid.org/0009-0007-2564-9139"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Torres-Marc\u00e9n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114401384","display_name":"David Camell-Raventos","orcid":"https://orcid.org/0009-0002-1591-7586","observed_orcids":["https://orcid.org/0009-0002-1591-7586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Camell-Ravent\u00f3s","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045427069","display_name":"Judit Peix","orcid":"https://orcid.org/0000-0001-8203-7656","observed_orcids":["https://orcid.org/0000-0001-8203-7656"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Peix","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"E. Fern\u00e1ndez-Mart\u00ednez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Fern\u00e1ndez-Mart\u00ednez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026803050","display_name":"Ugne Balaseviciute","orcid":"https://orcid.org/0000-0002-4256-4336","observed_orcids":["https://orcid.org/0000-0002-4256-4336"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U. Balaseviciute","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088127392","display_name":"J\u00falia Huguet\u2010Pradell","orcid":"https://orcid.org/0000-0003-1489-356X","observed_orcids":["https://orcid.org/0000-0003-1489-356X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Huguet-Pradell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059163581","display_name":"Ieva Keraite","orcid":"https://orcid.org/0000-0003-1974-9479","observed_orcids":["https://orcid.org/0000-0003-1974-9479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Keraite","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012214380","display_name":"Roger Esteban-Fabr\u00f3","orcid":"https://orcid.org/0000-0002-8173-3323","observed_orcids":["https://orcid.org/0000-0002-8173-3323"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Esteban-Fabr\u00f3","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040940969","display_name":"Roser Pinyol","orcid":"https://orcid.org/0000-0002-0288-6314","observed_orcids":["https://orcid.org/0000-0002-0288-6314"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Pinyol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077198687","display_name":"Marina B\u00e1rcena\u2010Varela","orcid":"https://orcid.org/0000-0001-7868-7939","observed_orcids":["https://orcid.org/0000-0001-7868-7939"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. B\u00e1rcena-Varela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042367169","display_name":"Katherine E. Lindblad","orcid":"https://orcid.org/0000-0001-6093-5578","observed_orcids":["https://orcid.org/0000-0001-6093-5578"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K.E. Lindblad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074303191","display_name":"Amaia Lujambio","orcid":"https://orcid.org/0000-0002-2798-1481","observed_orcids":["https://orcid.org/0000-0002-2798-1481"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Lujambio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072332593","display_name":"Ernesto Guccione","orcid":"https://orcid.org/0000-0001-7764-5307","observed_orcids":["https://orcid.org/0000-0001-7764-5307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Guccione","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088943845","display_name":"Swan N. Thung","orcid":"https://orcid.org/0000-0003-4407-2295","observed_orcids":["https://orcid.org/0000-0003-4407-2295"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S.N. Thung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021050825","display_name":"Daniela Sia","orcid":"https://orcid.org/0000-0002-9000-611X","observed_orcids":["https://orcid.org/0000-0002-9000-611X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Sia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052975894","display_name":"Josep Maria Llovet","orcid":"https://orcid.org/0000-0003-0547-2667","observed_orcids":["https://orcid.org/0000-0003-0547-2667"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.M. Llovet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3840,"currency":"USD","value_usd":3840},"apc_paid":null,"fwci":0.1778,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.51033514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"211","issue":null,"first_page":"114603","last_page":"114603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.08799999952316284,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lenvatinib","display_name":"lenvatinib","score":0.9900000095367432},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9679999947547913},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.703000009059906},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.7200000286102295},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C2776264508","wikidata":"https://www.wikidata.org/wiki/Q6523413","display_name":"Lenvatinib","level":4,"score":0.9858861565589905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6514847874641418},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4228220582008362},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.4134223461151123},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3715229034423828},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34803229570388794},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.15942329168319702}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ejca.2024.114603","doi":"https://doi.org/10.1016/j.ejca.2024.114603","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejca.2024.114603","pdf_url":null,"source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3108431937","https://openalex.org/W3107075415","https://openalex.org/W3030195102","https://openalex.org/W4414433688","https://openalex.org/W3032307940","https://openalex.org/W4410161242","https://openalex.org/W4309171777","https://openalex.org/W4307725079","https://openalex.org/W2901757914","https://openalex.org/W3088397061"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2024-10-25T00:00:00"}