{"id":"https://openalex.org/W4403748245","doi":"https://doi.org/10.1701/4357.43476","title":"Tirbanibulina nel grande campo di cancerizzazione: nuovo approccio per il trattamento sequenziale di aree contigue","display_name":"Tirbanibulina nel grande campo di cancerizzazione: nuovo approccio per il trattamento sequenziale di aree contigue","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403748245","doi":"https://doi.org/10.1701/4357.43476","pmid":"https://pubmed.ncbi.nlm.nih.gov/39446005"},"language":"en","primary_location":{"id":"doi:10.1701/4357.43476","doi":"https://doi.org/10.1701/4357.43476","is_oa":true,"landing_page_url":"https://doi.org/10.1701/4357.43476","pdf_url":"https://www.recentiprogressi.it/r.php?&v=4357&a=43476&l=357544&f=allegati/04357_2024_10/fulltext/RPM_1024.CC02_Caso clinico - Nazzaro.pdf","source":{"id":"https://openalex.org/S2754753105","display_name":"Recenti Progressi in Medicina","issn_l":"0034-1193","issn":["0034-1193"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recenti Progressi in Medicina","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.recentiprogressi.it/r.php?&v=4357&a=43476&l=357544&f=allegati/04357_2024_10/fulltext/RPM_1024.CC02_Caso clinico - Nazzaro.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051723579","display_name":"Gianluca Nazzaro","orcid":"https://orcid.org/0000-0001-8534-6497","observed_orcids":["https://orcid.org/0000-0001-8534-6497"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gianluca Nazzaro","raw_affiliation_strings":["SC Dermatologia, Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico, Milano - Dipartimento di Fisiopatologia medico-chirurgica e dei trapianti, Universit\u00e0 di Milano"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SC Dermatologia, Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico, Milano - Dipartimento di Fisiopatologia medico-chirurgica e dei trapianti, Universit\u00e0 di Milano","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051723579"],"corresponding_institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24393906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"115","issue":"10","first_page":"42e","last_page":"45e"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11868","display_name":"Cancer and Skin Lesions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tirbanibulin","display_name":"tirbanibulin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/actinic-keratosis","display_name":"actinic keratosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/field-cancerization","display_name":"field cancerization","score":0.902999997138977},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma-prevention","display_name":"squamous cell carcinoma prevention","score":0.8600000143051147},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6729999780654907},{"id":"https://openalex.org/keywords/scalp","display_name":"scalp","score":0.503000020980835},{"id":"https://openalex.org/keywords/nose","display_name":"nose","score":0.8360000252723694},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C60120401","wikidata":"https://www.wikidata.org/wiki/Q17119253","display_name":"Field cancerization","level":3,"score":0.9381746053695679},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.5955274701118469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3753727972507477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18572989106178284},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13161969184875488},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.06727674603462219},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012535","descriptor_name":"Scalp","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012535","descriptor_name":"Scalp","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012535","descriptor_name":"Scalp","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012535","descriptor_name":"Scalp","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012535","descriptor_name":"Scalp","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055623","descriptor_name":"Keratosis, Actinic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055623","descriptor_name":"Keratosis, Actinic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055623","descriptor_name":"Keratosis, Actinic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055623","descriptor_name":"Keratosis, Actinic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055623","descriptor_name":"Keratosis, Actinic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055623","descriptor_name":"Keratosis, Actinic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055623","descriptor_name":"Keratosis, Actinic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055623","descriptor_name":"Keratosis, Actinic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055623","descriptor_name":"Keratosis, Actinic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055623","descriptor_name":"Keratosis, Actinic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1701/4357.43476","doi":"https://doi.org/10.1701/4357.43476","is_oa":true,"landing_page_url":"https://doi.org/10.1701/4357.43476","pdf_url":"https://www.recentiprogressi.it/r.php?&v=4357&a=43476&l=357544&f=allegati/04357_2024_10/fulltext/RPM_1024.CC02_Caso clinico - Nazzaro.pdf","source":{"id":"https://openalex.org/S2754753105","display_name":"Recenti Progressi in Medicina","issn_l":"0034-1193","issn":["0034-1193"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recenti Progressi in Medicina","raw_type":"journal-article"},{"id":"pmid:39446005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39446005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recenti progressi in medicina","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1701/4357.43476","doi":"https://doi.org/10.1701/4357.43476","is_oa":true,"landing_page_url":"https://doi.org/10.1701/4357.43476","pdf_url":"https://www.recentiprogressi.it/r.php?&v=4357&a=43476&l=357544&f=allegati/04357_2024_10/fulltext/RPM_1024.CC02_Caso clinico - Nazzaro.pdf","source":{"id":"https://openalex.org/S2754753105","display_name":"Recenti Progressi in Medicina","issn_l":"0034-1193","issn":["0034-1193"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recenti Progressi in Medicina","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403748245.pdf","grobid_xml":"https://content.openalex.org/works/W4403748245.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Actinic":[0,175],"keratosis":[1],"(AK)":[2],"is":[3,38,56],"a":[4,41,49,70,96,124,138,171],"common":[5],"cutaneous":[6],"keratinocyte":[7],"dysplasia":[8],"characterized":[9],"by":[10],"the":[11,32,53,62,67,76,103,118,130,162,168,174],"abnormal":[12],"proliferation":[13],"of":[14,34,43,69,88,105,113,127,144,173],"atypical":[15],"epidermal":[16],"keratinocytes;":[17],"an":[18,85,106],"area":[19],"that":[20,90],"presents":[21],"photoinduced":[22],"subclinical":[23,63],"changes,":[24],"similar":[25],"to":[26,134,158,184],"those":[27],"found":[28],"in":[29,129,146],"AKs,":[30],"on":[31,161,167],"periphery":[33],"clinically":[35],"visible":[36],"AKs":[37],"defined":[39],"as":[40,59],"field":[42,77,126],"cancerization.":[44],"Its":[45],"treatment,":[46],"rather":[47],"than":[48],"treatment":[50,140,150],"aimed":[51],"at":[52,117],"single":[54],"lesion,":[55],"more":[57],"recommended":[58],"it":[60],"manages":[61],"damage":[64],"and":[65,94,120,132,154,164,178],"prevents":[66],"onset":[68],"possible":[71],"squamous":[72,114],"cell":[73,115],"carcinoma.":[74],"Among":[75],"therapies,":[78],"tirbanibulin":[79,145],"has":[80],"recently":[81],"been":[82],"introduced":[83],"with":[84,141,170],"innovative":[86],"mechanism":[87],"action":[89],"determines":[91],"cellular":[92],"apoptosis":[93],"consequently":[95],"poor":[97],"local":[98],"inflammatory":[99],"reaction.":[100],"We":[101],"present":[102],"case":[104],"82-year-old":[107],"patient,":[108],"known":[109],"for":[110],"previous":[111],"removals":[112],"carcinomas":[116],"vertex":[119],"currently":[121],"suffering":[122],"from":[123,182],"large":[125],"cancerization":[128],"nose":[131,163],"scalp,":[133,169],"whom":[135],"we":[136],"proposed":[137],"sequential":[139],"three":[142],"cycles":[143],"contiguous":[147],"areas.":[148],"The":[149],"was":[151],"well":[152],"tolerated":[153],"allowed":[155],"complete":[156],"clearance":[157],"be":[159],"obtained":[160],">":[165],"95%":[166],"reduction":[172],"Keratosis":[176],"Area":[177],"Severity":[179],"Index":[180],"(AKASI)":[181],"9.4":[183],"1.4.":[185]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
