{"id":"https://openalex.org/W4403748232","doi":null,"title":"The Therapeutic Role of Genistein in Perimenopausal and Postmenopausal Women.","display_name":"The Therapeutic Role of Genistein in Perimenopausal and Postmenopausal Women.","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403748232","pmid":"https://pubmed.ncbi.nlm.nih.gov/39445324","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11495164"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11495164","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11495164","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11495164/pdf/jcad_17_10_45.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Aesthet Dermatol","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11495164/pdf/jcad_17_10_45.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090696379","display_name":"Mark S. Nestor","orcid":"https://orcid.org/0000-0002-8978-7932","observed_orcids":["https://orcid.org/0000-0002-8978-7932"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210086612","display_name":"Center for Clinical and Cosmetic Research","ror":"https://ror.org/002tpp543","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark S Nestor","raw_affiliation_strings":["All authors are with the Center for Clinical and Cosmetic Research in Aventura, Florida","Dr. Nestor is additionally with the Department of Dermatology and Cutaneous Surgery at the University of Miami Miller School of Medicine in Miami, Florida and the Department of Surgery, Division of Plastic Surgery at the University of Miami Miller School of Medicine in Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All authors are with the Center for Clinical and Cosmetic Research in Aventura, Florida","institution_ids":["https://openalex.org/I4210086612"]},{"raw_affiliation_string":"Dr. Nestor is additionally with the Department of Dermatology and Cutaneous Surgery at the University of Miami Miller School of Medicine in Miami, Florida and the Department of Surgery, Division of Plastic Surgery at the University of Miami Miller School of Medicine in Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090906574","display_name":"Vishnu Bhupalam","orcid":"https://orcid.org/0009-0009-5045-0310","observed_orcids":["https://orcid.org/0009-0009-5045-0310"]},"institutions":[{"id":"https://openalex.org/I4210086612","display_name":"Center for Clinical and Cosmetic Research","ror":"https://ror.org/002tpp543","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vishnu Bhupalam","raw_affiliation_strings":["All authors are with the Center for Clinical and Cosmetic Research in Aventura, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All authors are with the Center for Clinical and Cosmetic Research in Aventura, Florida","institution_ids":["https://openalex.org/I4210086612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111078365","display_name":"Nardin Awad","orcid":"https://orcid.org/0009-0003-4614-910X","observed_orcids":["https://orcid.org/0009-0003-4614-910X"]},"institutions":[{"id":"https://openalex.org/I4210086612","display_name":"Center for Clinical and Cosmetic Research","ror":"https://ror.org/002tpp543","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nardin Awad","raw_affiliation_strings":["All authors are with the Center for Clinical and Cosmetic Research in Aventura, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All authors are with the Center for Clinical and Cosmetic Research in Aventura, Florida","institution_ids":["https://openalex.org/I4210086612"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037034190","display_name":"John D. Hetzel","orcid":"https://orcid.org/0000-0002-7406-0781","observed_orcids":["https://orcid.org/0000-0002-7406-0781"]},"institutions":[{"id":"https://openalex.org/I4210086612","display_name":"Center for Clinical and Cosmetic Research","ror":"https://ror.org/002tpp543","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D Hetzel","raw_affiliation_strings":["All authors are with the Center for Clinical and Cosmetic Research in Aventura, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All authors are with the Center for Clinical and Cosmetic Research in Aventura, Florida","institution_ids":["https://openalex.org/I4210086612"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2083,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.79490385,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"17","issue":"10","first_page":"45","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":1.0},{"id":"https://openalex.org/keywords/isoflavones","display_name":"isoflavones","score":0.9860000014305115},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.8410000205039978},{"id":"https://openalex.org/keywords/perimenopausal-women","display_name":"perimenopausal women","score":0.9490000009536743},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":1.0},{"id":"https://openalex.org/keywords/hot-flashes","display_name":"hot flashes","score":0.906000018119812},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.9879999756813049},{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cardiovascular-health","display_name":"cardiovascular health","score":0.6790000200271606},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.8690000176429749},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":0.8830000162124634},{"id":"https://openalex.org/keywords/photoprotection","display_name":"photoprotection","score":0.8960000276565552},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8610000014305115},{"id":"https://openalex.org/keywords/skin-cancer-prevention","display_name":"skin cancer prevention","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.8927580118179321},{"id":"https://openalex.org/C3018603563","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Postmenopausal women","level":2,"score":0.7196959853172302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4956740140914917},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28134527802467346}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:11495164","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11495164","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11495164/pdf/jcad_17_10_45.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Aesthet Dermatol","raw_type":"Text"},{"id":"pmid:39445324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39445324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical and aesthetic dermatology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11495164","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11495164","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11495164/pdf/jcad_17_10_45.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Aesthet Dermatol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403748232.pdf","grobid_xml":"https://content.openalex.org/works/W4403748232.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W6583719","https://openalex.org/W262902856","https://openalex.org/W1270828534","https://openalex.org/W1907086960","https://openalex.org/W2095901867","https://openalex.org/W2100045361","https://openalex.org/W2128453129","https://openalex.org/W2128629246","https://openalex.org/W2401104026","https://openalex.org/W2411215584"],"related_works":["https://openalex.org/W2982590924","https://openalex.org/W2999211795","https://openalex.org/W2626649577","https://openalex.org/W4410104144","https://openalex.org/W2031652952","https://openalex.org/W3029995341","https://openalex.org/W2144921993","https://openalex.org/W4239279955","https://openalex.org/W1976695523","https://openalex.org/W3021411174"],"abstract_inverted_index":{"Objective:":[0],"We":[1],"sought":[2],"to":[3,52,124,162,173],"review":[4],"the":[5,53,111],"biology":[6],"and":[7,19,32,39,41,47,63,72,76,93,130,135,156,167,179,190],"clinical":[8],"benefits":[9,101,149],"of":[10,74,153],"genistein,":[11],"a":[12,81,142,151,159,184],"plant-derived":[13],"isoflavone":[14],"with":[15,116,148],"emphasis":[16],"on":[17,25,29],"perimenopausal":[18,166],"postmenopausal":[20,168,191],"women.":[21,169,192],"The":[22],"focus":[23],"is":[24],"assessing":[26],"its":[27],"impact":[28],"skin":[30,77,120,133,180],"health":[31],"aesthetics":[33],"as":[34,36,66,141],"well":[35],"bone":[37,69,104,177],"density":[38,70,106],"cardiovascular":[40,85,175],"metabolic":[42],"functions.":[43],"Methods:":[44],",":[45],"animal,":[46],"human":[48],"studies.":[49],"Results:":[50],"According":[51],"current":[54],"literature,":[55],"genistein":[56,122],"demonstrates":[57],"efficacy":[58],"in":[59,102,165],"mitigating":[60],"menopausal":[61,154],"signs":[62,155],"symptoms":[64],"such":[65],"hot":[67],"flashes,":[68],"loss":[71],"rate":[73],"osteoporosis,":[75],"aging.":[78],"It":[79,98],"shows":[80],"protective":[82],"effect":[83],"against":[84],"diseases":[86],"by":[87],"improving":[88,174],"lipid":[89],"profiles,":[90],"weight":[91],"changes,":[92],"reducing":[94],"low-density":[95],"lipoprotein":[96],"cholesterol.":[97],"also":[99],"displays":[100],"increasing":[103],"mineral":[105],"but":[107],"has":[108],"not":[109],"displayed":[110],"side":[112],"effects":[113],"commonly":[114],"associated":[115],"estrogen":[117,144,163],"replacement.":[118],"Regarding":[119],"health,":[121,176],"appears":[123],"enhance":[125],"photoprotection,":[126],"wound":[127],"healing,":[128],"elasticity,":[129],"hydration,":[131],"inhibits":[132],"cancer,":[134],"reduces":[136],"wrinkles.":[137],"Conclusion:":[138],"Genistein":[139],"acts":[140],"selective":[143],"receptor":[145],"modulator":[146],"(SERM)":[147],"across":[150],"spectrum":[152],"symptoms,":[157],"presenting":[158],"viable":[160],"alternative":[161],"replacement":[164],"Its":[170],"utility":[171],"extends":[172],"density,":[178],"quality,":[181],"making":[182],"it":[183],"comprehensive":[185],"treatment":[186],"option":[187],"for":[188],"peri":[189]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-10-25T00:00:00"}
