{"id":"https://openalex.org/W4403748227","doi":"https://doi.org/10.1701/4357.43480","title":"Eterogeneit\u00e0 tumorale intra-paziente ed efficacia di sacituzumab govitecan","display_name":"Eterogeneit\u00e0 tumorale intra-paziente ed efficacia di sacituzumab govitecan","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403748227","doi":"https://doi.org/10.1701/4357.43480","pmid":"https://pubmed.ncbi.nlm.nih.gov/39446009"},"language":"en","primary_location":{"id":"doi:10.1701/4357.43480","doi":"https://doi.org/10.1701/4357.43480","is_oa":true,"landing_page_url":"https://doi.org/10.1701/4357.43480","pdf_url":"https://www.recentiprogressi.it/r.php?&v=4357&a=43480&l=357548&f=allegati/04357_2024_10/fulltext/RPM_1024.CC06_Caso clinico - Fontana.pdf","source":{"id":"https://openalex.org/S2754753105","display_name":"Recenti Progressi in Medicina","issn_l":"0034-1193","issn":["0034-1193"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline"],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recenti Progressi in Medicina","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.recentiprogressi.it/r.php?&v=4357&a=43480&l=357548&f=allegati/04357_2024_10/fulltext/RPM_1024.CC06_Caso clinico - Fontana.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101821292","display_name":"Andrea Fontana","orcid":"https://orcid.org/0000-0003-2496-2506","observed_orcids":["https://orcid.org/0000-0003-2496-2506"]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Fontana","raw_affiliation_strings":["UO Oncologia universitaria, Azienda Ospedaliero-Universitaria Pisana, Pisa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UO Oncologia universitaria, Azienda Ospedaliero-Universitaria Pisana, Pisa","institution_ids":["https://openalex.org/I4210165410"]}]},{"author_position":"last","author":{"id":null,"display_name":"Federica Pantaleo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Pantaleo","raw_affiliation_strings":["UO Oncologia universitaria, Azienda Ospedaliero-Universitaria Pisana, Pisa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UO Oncologia universitaria, Azienda Ospedaliero-Universitaria Pisana, Pisa","institution_ids":["https://openalex.org/I4210165410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210165410"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16647979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"115","issue":"10","first_page":"57e","last_page":"60e"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sacituzumab-govitecan","display_name":"sacituzumab govitecan","score":0.9200000166893005},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.7170000076293945},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.6700000166893005},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.7369999885559082},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.7170000076293945},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.7089999914169312},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.4359999895095825},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6358354687690735},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5673802495002747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2614281475543976}],"mesh":[{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1701/4357.43480","doi":"https://doi.org/10.1701/4357.43480","is_oa":true,"landing_page_url":"https://doi.org/10.1701/4357.43480","pdf_url":"https://www.recentiprogressi.it/r.php?&v=4357&a=43480&l=357548&f=allegati/04357_2024_10/fulltext/RPM_1024.CC06_Caso clinico - Fontana.pdf","source":{"id":"https://openalex.org/S2754753105","display_name":"Recenti Progressi in Medicina","issn_l":"0034-1193","issn":["0034-1193"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline"],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recenti Progressi in Medicina","raw_type":"journal-article"},{"id":"pmid:39446009","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39446009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recenti progressi in medicina","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1701/4357.43480","doi":"https://doi.org/10.1701/4357.43480","is_oa":true,"landing_page_url":"https://doi.org/10.1701/4357.43480","pdf_url":"https://www.recentiprogressi.it/r.php?&v=4357&a=43480&l=357548&f=allegati/04357_2024_10/fulltext/RPM_1024.CC06_Caso clinico - Fontana.pdf","source":{"id":"https://openalex.org/S2754753105","display_name":"Recenti Progressi in Medicina","issn_l":"0034-1193","issn":["0034-1193"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline"],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recenti Progressi in Medicina","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403748227.pdf","grobid_xml":"https://content.openalex.org/works/W4403748227.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Il":[0,80],"carcinoma":[1,57],"mammario":[2,58],"triplo":[3],"negativo":[4],"(TNBC)":[5],"in":[6,25,71,93],"fase":[7],"avanzata":[8],"\u00e8":[9,31],"una":[10,33,51,69,102,115],"condizione":[11],"clinica":[12],"che":[13],"fino":[14],"a":[15,63,68],"poco":[16],"tempo":[17],"fa":[18],"presentava":[19],"un":[20,39],"limitato":[21],"panorama":[22],"terapeutico.":[23],"Recentemente,":[24],"questo":[26],"setting":[27],"di":[28,50,56,65,73,78,87,101,105,111,117],"pazienti":[29],"si":[30],"aggiunta":[32],"nuova":[34],"opzione":[35],"terapeutica":[36],"rappresentata":[37],"da":[38,108,124],"anticorpo":[40],"farmaco":[41],"coniugato:":[42],"il":[43,47,126],"sacituzumab":[44],"govitecan.":[45],"Presentiamo":[46],"caso":[48,81],"clinico":[49],"paziente":[52],"con":[53,76],"diagnosi":[54],"iniziale":[55],"HR+/HER2":[59],"negativo,":[60],"sottoposta":[61],"poi,":[62],"distanza":[64],"qualche":[66],"anno,":[67],"biopsia":[70],"sede":[72],"metastasi":[74],"epatica":[75],"evidenza":[77],"TNBC.":[79],"esposto":[82],"dimostra":[83],"come":[84],"durante":[85],"l\u2019evoluzione":[86],"malattia":[88,106,118],"le":[89],"caratteristiche":[90],"biologiche,":[91],"e":[92,128],"particolare":[94],"l\u2019assetto":[95],"recettoriale,":[96],"possano":[97],"mutare,":[98],"rendendo":[99],"conto":[100],"importante":[103],"eterogeneit\u00e0":[104],"intra-paziente;":[107],"qui":[109],"l\u2019importanza":[110],"effettuare,":[112],"qualora":[113],"fattibile,":[114],"ricaratterizzazione":[116],"al":[119],"momento":[120],"della":[121],"progressione,":[122],"cos\u00ec":[123],"personalizzare":[125],"trattamento":[127],"scegliere":[129],"la":[130],"terapia":[131],"pi\u00f9":[132],"efficace.":[133]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}
