{"id":"https://openalex.org/W4403745430","doi":"https://doi.org/10.3389/fbioe.2024.1483279","title":"Navigating biosafety regulatory frameworks for genetic engineering in Africa: a focus on genome editing and gene drive technologies","display_name":"Navigating biosafety regulatory frameworks for genetic engineering in Africa: a focus on genome editing and gene drive technologies","publication_year":2024,"publication_date":"2024-10-24","ids":{"openalex":"https://openalex.org/W4403745430","doi":"https://doi.org/10.3389/fbioe.2024.1483279","pmid":"https://pubmed.ncbi.nlm.nih.gov/39512657","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11540646"},"language":"en","primary_location":{"id":"doi:10.3389/fbioe.2024.1483279","doi":"https://doi.org/10.3389/fbioe.2024.1483279","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2024.1483279","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1483279/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1483279/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038054953","display_name":"Tilahun Rabuma","orcid":"https://orcid.org/0000-0002-4764-1329","observed_orcids":["https://orcid.org/0000-0002-4764-1329"]},"institutions":[{"id":"https://openalex.org/I4210085988","display_name":"Wolkite University","ror":"https://ror.org/009msm672","country_code":"ET","type":"education","lineage":["https://openalex.org/I4210085988"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["ET","IT"],"is_corresponding":true,"raw_author_name":"Tilahun Rabuma","raw_affiliation_strings":["Department of Biotechnology, College of Natural and Computational Science, Wolkite University, Wolkite, Ethiopia","Regulatory Science Group, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, College of Natural and Computational Science, Wolkite University, Wolkite, Ethiopia","institution_ids":["https://openalex.org/I4210085988"]},{"raw_affiliation_string":"Regulatory Science Group, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086239993","display_name":"F\u00e9lix Moronta-Barrios","orcid":"https://orcid.org/0000-0002-9433-8576","observed_orcids":["https://orcid.org/0000-0002-9433-8576"]},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Felix Moronta-Barrios","raw_affiliation_strings":["Regulatory Science Group, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regulatory Science Group, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"last","author":{"id":null,"display_name":"Wendy Craig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Wendy Craig","raw_affiliation_strings":["Regulatory Science Group, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regulatory Science Group, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038054953"],"corresponding_institution_ids":["https://openalex.org/I4210085988","https://openalex.org/I91080651"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":7.0529,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.97947281,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"12","issue":null,"first_page":"1483279","last_page":"1483279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11426","display_name":"Genetically Modified Organisms Research","score":0.7134000062942505,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11426","display_name":"Genetically Modified Organisms Research","score":0.7134000062942505,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.23579999804496765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/2910","display_name":"Issues, ethics and legal aspects"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosafety-regulation","display_name":"biosafety regulation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.8550000190734863},{"id":"https://openalex.org/keywords/gene-drive","display_name":"gene drive","score":0.8090000152587891},{"id":"https://openalex.org/keywords/genetic-engineering-regulation","display_name":"genetic engineering regulation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/regulatory-framework","display_name":"regulatory framework","score":0.7250000238418579},{"id":"https://openalex.org/keywords/africa","display_name":"Africa","score":0.7049999833106995},{"id":"https://openalex.org/keywords/regulatory-capacity","display_name":"regulatory capacity","score":0.9200000166893005},{"id":"https://openalex.org/keywords/public-opposition","display_name":"public opposition","score":0.6209999918937683},{"id":"https://openalex.org/keywords/agricultural-biotechnology","display_name":"agricultural biotechnology","score":0.7170000076293945},{"id":"https://openalex.org/keywords/environmental-risk-assessment","display_name":"environmental risk assessment","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C52384281","wikidata":"https://www.wikidata.org/wiki/Q864713","display_name":"Biosafety","level":2,"score":0.9581475257873535},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.7611256837844849},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.5496467351913452},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5380672216415405},{"id":"https://openalex.org/C23837897","wikidata":"https://www.wikidata.org/wiki/Q159236","display_name":"Genetic engineering","level":3,"score":0.5326133966445923},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5069620609283447},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4897203743457794},{"id":"https://openalex.org/C191160116","wikidata":"https://www.wikidata.org/wiki/Q3423709","display_name":"Regulatory focus theory","level":3,"score":0.4879295527935028},{"id":"https://openalex.org/C207267971","wikidata":"https://www.wikidata.org/wiki/Q120208","display_name":"Emerging technologies","level":2,"score":0.4268611669540405},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.4259486794471741},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41589030623435974},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3451669216156006},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24040085077285767},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.21537894010543823},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.16210368275642395},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.06074002385139465},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbioe.2024.1483279","doi":"https://doi.org/10.3389/fbioe.2024.1483279","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2024.1483279","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1483279/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11540646","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11540646","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11540646/pdf/fbioe-12-1483279.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Bioeng Biotechnol","raw_type":"Text"},{"id":"pmid:39512657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39512657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioengineering and biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b152b44d4f1e453d8bab6e37a6fd7a81","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b152b44d4f1e453d8bab6e37a6fd7a81","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbioe.2024.1483279","doi":"https://doi.org/10.3389/fbioe.2024.1483279","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2024.1483279","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1483279/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","display_name":"Peace, justice, and strong institutions","score":0.5473999977111816},{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.5378999710083008},{"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals","score":0.5217000246047974}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403745430.pdf","grobid_xml":"https://content.openalex.org/works/W4403745430.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W2026404593","https://openalex.org/W2041252272","https://openalex.org/W2128836133","https://openalex.org/W2396982015","https://openalex.org/W2522858740","https://openalex.org/W2770381481","https://openalex.org/W2772061551","https://openalex.org/W2806605174","https://openalex.org/W2888908334","https://openalex.org/W2898360999","https://openalex.org/W2900182369","https://openalex.org/W2901379639","https://openalex.org/W2901847409","https://openalex.org/W2918119738","https://openalex.org/W2920135474","https://openalex.org/W2923666109","https://openalex.org/W2947294918","https://openalex.org/W2956817672","https://openalex.org/W2964834871","https://openalex.org/W2970335864","https://openalex.org/W3009463204","https://openalex.org/W3022190767","https://openalex.org/W3026348495","https://openalex.org/W3042837626","https://openalex.org/W3043944292","https://openalex.org/W3048624196","https://openalex.org/W3093113145","https://openalex.org/W3094210104","https://openalex.org/W3099407617","https://openalex.org/W3106562819","https://openalex.org/W3137210406","https://openalex.org/W3137704073","https://openalex.org/W3163368167","https://openalex.org/W3178584946","https://openalex.org/W3188324280","https://openalex.org/W3194092558","https://openalex.org/W3195180448","https://openalex.org/W3198810747","https://openalex.org/W3207402154","https://openalex.org/W3217143729","https://openalex.org/W4200601439","https://openalex.org/W4205106790","https://openalex.org/W4206773310","https://openalex.org/W4211239777","https://openalex.org/W4211263798","https://openalex.org/W4214867556","https://openalex.org/W4280596617","https://openalex.org/W4280600116","https://openalex.org/W4280609619","https://openalex.org/W4283366424","https://openalex.org/W4286715961","https://openalex.org/W4289643727","https://openalex.org/W4293047657","https://openalex.org/W4297906654","https://openalex.org/W4313124204","https://openalex.org/W4313559306","https://openalex.org/W4315650269","https://openalex.org/W4317567176","https://openalex.org/W4318473700","https://openalex.org/W4324303451","https://openalex.org/W4361287641","https://openalex.org/W4377690717","https://openalex.org/W4379798513","https://openalex.org/W4386709910","https://openalex.org/W4388932416","https://openalex.org/W4390061104","https://openalex.org/W4392649433","https://openalex.org/W4392805456","https://openalex.org/W4392956105","https://openalex.org/W4395041633","https://openalex.org/W4402314222"],"related_works":["https://openalex.org/W7164022267","https://openalex.org/W2593954672","https://openalex.org/W4411234837","https://openalex.org/W7167285297","https://openalex.org/W7171630626","https://openalex.org/W7213969918","https://openalex.org/W4408379774","https://openalex.org/W3140940033","https://openalex.org/W2123016296","https://openalex.org/W2883273322"],"abstract_inverted_index":{"Genome":[0],"editing":[1,68,184],"and":[2,21,35,51,69,80,91,101,128,135,185,193],"gene":[3,70,186],"drive":[4,71,187],"technologies":[5,72,188],"are":[6,29,121,176],"increasingly":[7],"gaining":[8],"attraction":[9],"in":[10,18,31,73,148,196],"Africa,":[11],"with":[12,163],"researchers":[13],"exploring":[14],"their":[15,117],"potential":[16,181],"applications":[17],"agriculture,":[19],"health":[20,192],"the":[22,33,47,57,63,142,168,180,194],"environment.":[23],"Acknowledging":[24],"that":[25,108],"robust":[26],"regulatory":[27,54,64,78,118,149,172],"frameworks":[28,65,175],"crucial":[30],"facilitating":[32],"development":[34,127,147],"utilization":[36],"of":[37,53,170,182],"these":[38,155],"technologies,":[39],"informed":[40],"decision-making":[41],"is,":[42],"however,":[43],"being":[44],"impeded":[45],"by":[46,93],"fragmented":[48],"information":[49],"availability":[50],"readiness":[52],"authorities":[55],"on":[56,154],"continent.":[58],"Objectives:":[59],"This":[60],"study":[61,158],"investigates":[62],"governing":[66],"genome":[67,183],"African":[74,112,161],"countries,":[75],"identifies":[76],"common":[77],"challenges":[79],"proposes":[81],"actionable":[82],"solutions.":[83],"Methods:":[84],"Primary":[85],"data":[86],"were":[87],"collected":[88],"through":[89],"questionnaires":[90],"complemented":[92],"analysing":[94],"existing":[95],"biosafety":[96],"regulations":[97],"from":[98],"online":[99],"databases":[100],"scientific":[102],"literature.":[103],"Results:":[104],"Our":[105],"findings":[106,140],"suggest":[107],"while":[109,189],"a":[110],"few":[111],"countries":[113],"have":[114],"recently":[115],"updated":[116],"frameworks,":[119],"many":[120],"still":[122],"under":[123],"discussion.":[124],"Challenges":[125],"to":[126,166],"implementation":[129],"include":[130],"limited":[131],"resources,":[132],"expertise,":[133],"awareness,":[134],"public":[136],"resistance.":[137],"Conclusion:":[138],"The":[139],"underscore":[141],"urgent":[143],"need":[144],"for":[145,178],"further":[146],"capacities.":[150],"By":[151],"shedding":[152],"light":[153],"challenges,":[156],"our":[157],"could":[159],"provide":[160],"regulators":[162],"valuable":[164],"insights":[165],"guide":[167],"formulation":[169],"effective":[171],"frameworks.":[173],"Such":[174],"essential":[177],"harnessing":[179],"safeguarding":[190],"human":[191],"environment":[195],"Africa.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-25T00:00:00"}
