{"id":"https://openalex.org/W4403739033","doi":"https://doi.org/10.1177/25158163241292307","title":"Constipation as a possible predictor of poor treatment response in chronic migraine: A retrospective study of anti-calcitonin gene-related peptide (anti-CGRP) monoclonal antibodies and the impact of switching","display_name":"Constipation as a possible predictor of poor treatment response in chronic migraine: A retrospective study of anti-calcitonin gene-related peptide (anti-CGRP) monoclonal antibodies and the impact of switching","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4403739033","doi":"https://doi.org/10.1177/25158163241292307"},"language":"en","primary_location":{"id":"doi:10.1177/25158163241292307","doi":"https://doi.org/10.1177/25158163241292307","is_oa":true,"landing_page_url":"https://doi.org/10.1177/25158163241292307","pdf_url":null,"source":{"id":"https://openalex.org/S4210193149","display_name":"Cephalalgia Reports","issn_l":"2515-8163","issn":["2515-8163"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cephalalgia Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/25158163241292307","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041817508","display_name":"Sena Uzun","orcid":"https://orcid.org/0000-0003-1219-161X","observed_orcids":["https://orcid.org/0000-0003-1219-161X"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sena Uzun","raw_affiliation_strings":["Department of Clinical Sciences of Malm\u00f6 and Lund, Lund University, Lund, Sweden","Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Sciences, Lund University, Lund, Sweden","Sk\u00e5Neuro Neurology Clinic, Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-1219-161X","affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences of Malm\u00f6 and Lund, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Sciences, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Sk\u00e5Neuro Neurology Clinic, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091990384","display_name":"Ulf Frejvall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ulf Frejvall","raw_affiliation_strings":["Sk\u00e5Neuro Neurology Clinic, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sk\u00e5Neuro Neurology Clinic, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007939686","display_name":"Per Petersson","orcid":"https://orcid.org/0000-0001-6697-0171","observed_orcids":["https://orcid.org/0000-0001-6697-0171"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per Petersson","raw_affiliation_strings":["Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Sciences, Lund University, Lund, Sweden","The Group for Integrative Neurophysiology, Department of Medical Translational Biology, Ume\u00e5 University, Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Sciences, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"The Group for Integrative Neurophysiology, Department of Medical Translational Biology, Ume\u00e5 University, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033799839","display_name":"G\u00fcrdal \u015eahin","orcid":"https://orcid.org/0000-0002-9998-5983","observed_orcids":["https://orcid.org/0000-0002-9998-5983"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"G\u00fcrdal Sahin","raw_affiliation_strings":["Department of Clinical Sciences of Malm\u00f6 and Lund, Lund University, Lund, Sweden","Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Sciences, Lund University, Lund, Sweden","Sk\u00e5Neuro Neurology Clinic, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences of Malm\u00f6 and Lund, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Sciences, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Sk\u00e5Neuro Neurology Clinic, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033799839"],"corresponding_institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":0.7308,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.65594626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"7","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/constipation","display_name":"constipation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/chronic-migraine","display_name":"chronic migraine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anti-cgrp-monoclonal-antibodies","display_name":"CGRP monoclonal antibodies","score":0.9909999966621399},{"id":"https://openalex.org/keywords/erenumab","display_name":"erenumab","score":0.9330000281333923},{"id":"https://openalex.org/keywords/fremanezumab","display_name":"fremanezumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/galcanezumab","display_name":"galcanezumab","score":1.0},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7940000295639038},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5929999947547913},{"id":"https://openalex.org/keywords/treatment-switching","display_name":"treatment switching","score":0.7020000219345093},{"id":"https://openalex.org/keywords/predictors-of-treatment-response","display_name":"predictors of treatment response","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C163170386","wikidata":"https://www.wikidata.org/wiki/Q419432","display_name":"Calcitonin gene-related peptide","level":4,"score":0.9311317205429077},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.631582498550415},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.6098348498344421},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6008133888244629},{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.5987432599067688},{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.5464850068092346},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.5040368437767029},{"id":"https://openalex.org/C3017955636","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Chronic constipation","level":3,"score":0.48461970686912537},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.43471741676330566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.376117467880249},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.37468278408050537},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35536321997642517},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.284610778093338},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24126148223876953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13962522149085999},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06317910552024841}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1177/25158163241292307","doi":"https://doi.org/10.1177/25158163241292307","is_oa":true,"landing_page_url":"https://doi.org/10.1177/25158163241292307","pdf_url":null,"source":{"id":"https://openalex.org/S4210193149","display_name":"Cephalalgia Reports","issn_l":"2515-8163","issn":["2515-8163"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cephalalgia Reports","raw_type":"journal-article"},{"id":"pmh:oai:DiVA.org:umu-231314","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-231314","pdf_url":"https://umu.diva-portal.org/smash/get/diva2:1910664/FULLTEXT01","source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:616079f3cc784d17a17d5b15e375c274","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/616079f3cc784d17a17d5b15e375c274","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cephalalgia Reports, Vol 7 (2024)","raw_type":"article"},{"id":"pmh:oai:lup.lub.lu.se:eb1cd8a6-ed5f-48e9-8814-3351d83123c8","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/eb1cd8a6-ed5f-48e9-8814-3351d83123c8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 2515-8163","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1177/25158163241292307","doi":"https://doi.org/10.1177/25158163241292307","is_oa":true,"landing_page_url":"https://doi.org/10.1177/25158163241292307","pdf_url":null,"source":{"id":"https://openalex.org/S4210193149","display_name":"Cephalalgia Reports","issn_l":"2515-8163","issn":["2515-8163"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cephalalgia Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1566703209","display_name":"The corticostriatal system in health and disease","funder_award_id":"2021-01769","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403739033.pdf","grobid_xml":"https://content.openalex.org/works/W4403739033.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W2001650386","https://openalex.org/W2085595272","https://openalex.org/W2342528407","https://openalex.org/W2608751463","https://openalex.org/W2793051137","https://openalex.org/W2801085490","https://openalex.org/W2948005364","https://openalex.org/W2970814103","https://openalex.org/W2984274085","https://openalex.org/W3049501725","https://openalex.org/W3164684737","https://openalex.org/W4205200610","https://openalex.org/W4280515869","https://openalex.org/W4281924753","https://openalex.org/W4308634506","https://openalex.org/W4377940893","https://openalex.org/W4390779512","https://openalex.org/W4399272926"],"related_works":["https://openalex.org/W4410565032","https://openalex.org/W4302773941","https://openalex.org/W4365459857","https://openalex.org/W4406013114","https://openalex.org/W4313678746","https://openalex.org/W4365450955","https://openalex.org/W4296031904","https://openalex.org/W7136655444","https://openalex.org/W4402515682","https://openalex.org/W4364352667"],"abstract_inverted_index":{"Background":[0],"There":[1],"is":[2,169,185],"a":[3,9,27,36,53,71,170,191],"growing":[4],"awareness":[5],"of":[6,12,38,56,127,149,174],"constipation":[7,25,81,157],"being":[8],"side":[10,28,172],"effect":[11,29,173,183],"anti-calcitonin":[13],"gene-related":[14],"peptide":[15],"(anti-CGRP)":[16],"monoclonal":[17],"antibodies":[18],"(mAbs).":[19],"This":[20],"study":[21],"aims":[22],"to":[23,107,119,125,147],"assess":[24],"as":[26,35],"and":[30,67,80,94,110,198],"explore":[31],"its":[32],"potential":[33,192],"role":[34],"predictor":[37],"treatment":[39,132,196],"response":[40,197],"in":[41,161,180],"chronic":[42],"migraine":[43,78],"(CM)":[44],"patients":[45,57],"treated":[46,60],"with":[47,58,61,103,178],"anti-CGRP":[48,62,175],"mAbs.":[49],"Methods":[50],"We":[51],"conducted":[52],"retrospective":[54],"analysis":[55],"CM":[59],"mAbs":[63],"between":[64,194],"January":[65],"2019":[66],"December":[68],"2022":[69],"at":[70],"single":[72],"center.":[73],"Data":[74],"on":[75],"patient":[76],"demographics,":[77],"characteristics,":[79],"were":[82,159],"reviewed.":[83],"Results":[84],"Among":[85,113],"317":[86],"patients,":[87,115],"192":[88],"received":[89,92,96],"erenumab,":[90],"94":[91],"fremanezumab,":[93],"31":[95],"galcanezumab.":[97],"Constipation":[98,168],"was":[99],"significantly":[100],"more":[101],"common":[102],"erenumab":[104,114,179],"(51.5%)":[105],"compared":[106],"fremanezumab":[108],"(4.2%)":[109],"galcanezumab":[111],"(12.9%).":[112],"24.4%":[116],"switched":[117,123,131],"due":[118,124,146],"constipation,":[120,199],"while":[121],"19.2%":[122],"lack/loss":[126,148],"effectiveness.":[128],"Patients":[129],"who":[130],"experienced":[133],"milder":[134],"symptoms":[135],"(":[136,151,163],"p":[137,152,164],"<":[138],"0.0001)":[139],"without":[140],"compromising":[141],"effectiveness,":[142],"even":[143],"when":[144],"switching":[145],"effectiveness":[150],"=":[153,165],"0.0068).":[154],"Importantly,":[155],"severe":[156],"rates":[158],"higher":[160],"non-responders":[162],"0.036).":[166],"Conclusion":[167],"notable":[171],"mAbs,":[176],"particularly":[177],"CM.":[181],"Side":[182],"monitoring":[184],"consequently":[186],"crucial.":[187],"Our":[188],"findings":[189],"suggest":[190],"link":[193],"poor":[195],"warranting":[200],"further":[201],"research":[202],"into":[203],"the":[204],"underlying":[205],"mechanisms.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-25T00:00:00"}