{"id":"https://openalex.org/W4403738538","doi":"https://doi.org/10.7717/peerj.18334","title":"Association analysis of MTHFR (rs1801133 and rs1801131) gene polymorphism towards the development of type 2 diabetes mellitus in Dali area population from Yunnan Province, China","display_name":"Association analysis of MTHFR (rs1801133 and rs1801131) gene polymorphism towards the development of type 2 diabetes mellitus in Dali area population from Yunnan Province, China","publication_year":2024,"publication_date":"2024-10-24","ids":{"openalex":"https://openalex.org/W4403738538","doi":"https://doi.org/10.7717/peerj.18334","pmid":"https://pubmed.ncbi.nlm.nih.gov/39465169","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11512809"},"language":"en","primary_location":{"id":"doi:10.7717/peerj.18334","doi":"https://doi.org/10.7717/peerj.18334","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.18334","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7717/peerj.18334","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100765918","display_name":"Yongxin Liu","orcid":"https://orcid.org/0000-0003-1832-9835","observed_orcids":["https://orcid.org/0000-0003-1832-9835","https://orcid.org/0000-0002-6506-7148"]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongxin Liu","raw_affiliation_strings":["School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101201222","display_name":"Genyuan Pu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Genyuan Pu","raw_affiliation_strings":["School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033718472","display_name":"Caiting Yang","orcid":"https://orcid.org/0000-0003-0342-3407","observed_orcids":["https://orcid.org/0000-0003-0342-3407"]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caiting Yang","raw_affiliation_strings":["School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100745213","display_name":"Yuqing Wang","orcid":"https://orcid.org/0000-0001-9320-3517","observed_orcids":["https://orcid.org/0000-0001-9320-3517","https://orcid.org/0009-0009-2301-6623"]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqing Wang","raw_affiliation_strings":["School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kaitai Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaitai Jin","raw_affiliation_strings":["School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shengrong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengrong Wang","raw_affiliation_strings":["School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052169513","display_name":"Xiao Liang","orcid":"https://orcid.org/0000-0001-5476-8304","observed_orcids":["https://orcid.org/0000-0001-5476-8304","https://orcid.org/0009-0008-7329-0965"]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Liang","raw_affiliation_strings":["School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068547794","display_name":"Shenghe Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shenghe Hu","raw_affiliation_strings":["The First Affiliated Hospital of Dali University, Dali, Yunnan, China, Dali, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Dali University, Dali, Yunnan, China, Dali, China","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102225086","display_name":"Shuguang Sun","orcid":"https://orcid.org/0000-0002-0272-8340","observed_orcids":["https://orcid.org/0000-0002-0272-8340"]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuguang Sun","raw_affiliation_strings":["The First Affiliated Hospital of Dali University, Dali, Yunnan, China, Dali, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Dali University, Dali, Yunnan, China, Dali, China","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037290126","display_name":"Mingming Lai","orcid":"https://orcid.org/0000-0003-1157-1004","observed_orcids":["https://orcid.org/0000-0003-1157-1004"]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingming Lai","raw_affiliation_strings":["School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Dali University, Dali, Yunnan, China, Dali, China","institution_ids":["https://openalex.org/I6593398"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037290126","https://openalex.org/A5102225086"],"corresponding_institution_ids":["https://openalex.org/I6593398"],"apc_list":{"value":1395,"currency":"USD","value_usd":1395},"apc_paid":{"value":1395,"currency":"USD","value_usd":1395},"fwci":2.0892,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.8410735,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"12","issue":null,"first_page":"e18334","last_page":"e18334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mthfr","display_name":"MTHFR","score":0.875},{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mthfr-a1298c-polymorphism","display_name":"MTHFR A1298C polymorphism","score":0.9959999918937683},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7900000214576721},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.6650000214576721},{"id":"https://openalex.org/keywords/folate-metabolism","display_name":"folate metabolism","score":0.9259999990463257},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9739999771118164},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9490000009536743},{"id":"https://openalex.org/keywords/yunnan","display_name":"Yunnan","score":0.8659999966621399},{"id":"https://openalex.org/keywords/genetic-association-studies","display_name":"genetic association studies","score":0.6399999856948853},{"id":"https://openalex.org/keywords/ethnic-differences-in-genetic-risk","display_name":"ethnic differences in genetic risk","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.7744253277778625},{"id":"https://openalex.org/C191935318","wikidata":"https://www.wikidata.org/wiki/Q148","display_name":"China","level":2,"score":0.579494059085846},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5569100379943848},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.5305464863777161},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5278795957565308},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5257107615470886},{"id":"https://openalex.org/C76252995","wikidata":"https://www.wikidata.org/wiki/Q3395645","display_name":"Gene polymorphism","level":4,"score":0.4633531868457794},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45101502537727356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37858855724334717},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.37672749161720276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33497875928878784},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2080059051513672},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.19277462363243103},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1808113157749176},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.12294399738311768},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.7717/peerj.18334","doi":"https://doi.org/10.7717/peerj.18334","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.18334","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11512809","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11512809","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11512809/pdf/peerj-12-18334.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"Text"},{"id":"pmid:39465169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39465169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b437a705658146088a90215a0c31df1a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b437a705658146088a90215a0c31df1a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PeerJ, Vol 12, p e18334 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7717/peerj.18334","doi":"https://doi.org/10.7717/peerj.18334","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.18334","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320325826","display_name":"Dali University","ror":"https://ror.org/02y7rck89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403738538.pdf","grobid_xml":"https://content.openalex.org/works/W4403738538.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1569693056","https://openalex.org/W1972288532","https://openalex.org/W1976205360","https://openalex.org/W1990001163","https://openalex.org/W2003670147","https://openalex.org/W2027105868","https://openalex.org/W2030526970","https://openalex.org/W2033718750","https://openalex.org/W2053918541","https://openalex.org/W2064483915","https://openalex.org/W2084478682","https://openalex.org/W2098793673","https://openalex.org/W2099201471","https://openalex.org/W2129316761","https://openalex.org/W2129549687","https://openalex.org/W2140174229","https://openalex.org/W2150552700","https://openalex.org/W2158629792","https://openalex.org/W2339719708","https://openalex.org/W2806521060","https://openalex.org/W2928424285","https://openalex.org/W2954433041","https://openalex.org/W2956598593","https://openalex.org/W2971456522","https://openalex.org/W2982341232","https://openalex.org/W3023519822","https://openalex.org/W3043221223","https://openalex.org/W3054063710","https://openalex.org/W3093692434","https://openalex.org/W3095895781","https://openalex.org/W3097384753","https://openalex.org/W3110306642","https://openalex.org/W3124720381","https://openalex.org/W3130333914","https://openalex.org/W3164808548","https://openalex.org/W3186085185","https://openalex.org/W3195925410","https://openalex.org/W4200418449","https://openalex.org/W4200539286","https://openalex.org/W4210915654","https://openalex.org/W4212989811","https://openalex.org/W4234393699","https://openalex.org/W4285172048","https://openalex.org/W4293250490","https://openalex.org/W4307240323","https://openalex.org/W4308123313","https://openalex.org/W4313382518","https://openalex.org/W4375865779","https://openalex.org/W4386151915","https://openalex.org/W4387865633","https://openalex.org/W4391735756"],"related_works":["https://openalex.org/W4409628750","https://openalex.org/W7219122021","https://openalex.org/W2026824411","https://openalex.org/W7131094036","https://openalex.org/W2982341232","https://openalex.org/W2351701224","https://openalex.org/W2042588195","https://openalex.org/W2098793673","https://openalex.org/W2092833361","https://openalex.org/W2386875026"],"abstract_inverted_index":{"Background":[0],"Type":[1],"2":[2],"diabetes":[3],"mellitus":[4],"(T2DM)":[5],"is":[6,36],"a":[7,14],"common":[8],"complex":[9],"metabolic":[10],"disorder":[11],"that":[12,138,222,307],"exhibits":[13],"strong":[15],"genetic":[16,111,309],"predisposition.":[17],"5,10-methylenetetrahydrofolate":[18],"reductase":[19],"(MTHFR)":[20],"regulates":[21],"folate":[22],"metabolism,":[23],"which":[24],"has":[25],"been":[26],"proposed":[27],"to":[28,45],"be":[29],"associated":[30,165,318],"with":[31,79,166,224,271,319],"T2DM,":[32],"although":[33],"the":[34,47,62,65,87,95,102,114,134,139,149,159,167,175,185,192,212,228,257,261,275,286,308,323,326],"relationship":[35],"inconsistent":[37],"among":[38],"different":[39],"geographical":[40],"areas.":[41],"This":[42,73],"study":[43,75,136,305],"aimed":[44],"investigate":[46],"effects":[48,109],"of":[49,64,90,94,110,113,133,170,194,206,215,233,240,256,280,285,311,325,329],"MTHFR":[50,96,115,160,186,207,234,281,296,312],"C677T":[51,161,208,235,313],"(rs1801133)":[52],"and":[53,81,126,148,209,247,263,298,314],"A1298C":[54,187,210,282,315],"(rs1801131)":[55],"loci":[56],"polymorphisms":[57,98,297],"on":[58,117],"T2DM":[59,80,118,225,272,320],"susceptibility":[60,321],"in":[61,68,269,301,322],"population":[63,324],"Dali":[66,88,327],"area":[67,89,328],"Yunnan":[69,91,330],"Province,":[70,331],"China.":[71,332],"Methods":[72],"case-control":[74],"included":[76],"445":[77],"patients":[78,223,270],"272":[82],"healthy":[83],"control":[84],"individuals":[85],"from":[86],"Province.":[92],"Genotyping":[93],"gene":[97,116],"was":[99,292],"performed":[100],"using":[101,122],"competitive":[103],"allele-specific":[104],"PCR":[105],"(KASP)":[106],"method.":[107],"The":[108,131,197],"variations":[112,310],"risk":[119,300],"were":[120,163,266],"evaluated":[121],"odds":[123,169,193,214],"ratios":[124],"(OR)":[125],"95%":[127],"confidence":[128],"intervals.":[129],"Results":[130],"results":[132],"present":[135],"revealed":[137],"TT":[140,231],"genotype":[141,177,232,279],"(OR":[142,152,178,200],"=":[143,146,153,156,179,182,201,204],"1.750,":[144],"P":[145,155,181,203],"0.030)":[147,205],"T":[150],"allele":[151],"1.252,":[154],"0.047)":[157],"at":[158,184],"locus":[162,188],"considerably":[164,267],"increased":[168,191,213],"developing":[171,195,216],"T2DM.":[172,196,217,302],"In":[173],"addition,":[174],"CC":[176,258,276],"3.132,":[180],"0.032)":[183],"also":[189],"substantially":[190,237],"T-A":[198],"haplotype":[199],"1.305,":[202],"exhibited":[211],"Biochemical":[218],"index":[219],"analyses":[220],"showed":[221],"who":[226,273],"carried":[227,274],"CT":[229],"or":[230,277],"expressed":[236],"higher":[238,268],"levels":[239,265],"fasting":[241],"blood":[242],"glucose":[243],"(FBG),":[244],"homocysteine":[245],"(Hcy),":[246],"tumor":[248],"necrosis":[249],"factor-alpha":[250],"(TNF-":[251],"\u03b1":[252],")":[253],"than":[254,283],"those":[255,284],"genotype.":[259,288],"Moreover,":[260],"FBG":[262],"Hcy":[264],"AC":[278],"AA":[287],"No":[289],"obvious":[290],"association":[291],"observed":[293],"between":[294],"these":[295],"cardiovascular":[299],"Conclusion":[303],"Our":[304],"suggests":[306],"are":[316],"significantly":[317]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2024-10-25T00:00:00"}